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Retina August 2020

A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

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Siddharth Narendran; Felipe Pereira; Praveen Yerramothu; Ivana Apicella; Shao-bin Wang; Akhil Varshney; Kirstie L. Baker; Kenneth M. Marion; Meenakshi Ambati; Vidya L. Ambati; Kameshwari Ambati; Srinivas R. Sadda; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: atrophy, choroidal neovascularization, metabolites, rna, tissue degeneration, zidovudine, epithelium, lasers
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):4. doi: https://doi.org/10.1167/iovs.61.10.4

Retinal Cell Biology May 2020

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice

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Ryan D. Makin; Dionne Argyle; Shuichiro Hirahara; Yosuke Nagasaka; Mei Zhang; Zhen Yan; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand
TAGS: choroidal neovascularization, exercise, mice
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):52. doi: https://doi.org/10.1167/iovs.61.5.52

Includes: Supplemental Content

Retinal Cell Biology December 2018

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

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Ryan D. Makin; Ivana Apicella; Yosuke Nagasaka; Hiroki Kaneko; Stephen D. Turner; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand
TAGS: endothelial cells, endothelium, phenotype
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5795-5802. doi: https://doi.org/10.1167/iovs.18-25215

ARVO Annual Meeting Abstract June 2017

Shear stress governs choroidal endothelial cell proliferation and homeostasis

Bradley D Gelfand; Senyou An; Whitney Yu; Rou Chen; Jun Yao; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1102. doi:

ARVO Annual Meeting Abstract June 2017

Endogenous complementary DNA in age-related macular degeneration

Shinichi Fukuda; Tetsuhiro Yasuma; Benjamin J Fowler; Bradley D Gelfand; Nagaraj Kerur; Reo Yasuma; Brian Werner; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5262. doi:

ARVO Annual Meeting Abstract September 2016

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Nagaraj Kerur; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Daipayan Banerjee; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):486. doi:

ARVO Annual Meeting Abstract September 2016

Role of interferon signaling in Alu RNA-induced AMD

Daipayan Banerjee; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Nagaraj Kerur; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):487. doi:

ARVO Annual Meeting Abstract September 2016

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Reo Yasuma; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4517. doi:

ARVO Annual Meeting Abstract September 2016

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Nagaraj Kerur; Ana Bastos-Carvalho; Younghee Kim; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4518. doi:

ARVO Annual Meeting Abstract September 2016

Hypoxia signaling pathways in retinal pigment epithelium require Alu RNA

Charles B Wright; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5813. doi:

ARVO Annual Meeting Abstract September 2016

Dicer1 deficiency in atrophic and neovascular age-related macular degeneration

Bradley D Gelfand; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Shinichi Fukuda; Junichi Fukuhara; Younghee Kim; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6551. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Takako Fukuhara; Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6552. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi:

Retinal Cell Biology November 2015

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

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Takeshi Mizutani; Benjamin J. Fowler; Younghee Kim; Reo Yasuma; Laura A. Krueger; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: choroidal neovascularization, lasers, mice, nucleoside reverse transcriptase inhibitors, vascular endothelial growth factor a, p2rx7 gene
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7122-7129. doi: https://doi.org/10.1167/iovs.15-17440

ARVO Annual Meeting Abstract June 2015

A novel mouse model of neovascular AMD due to Dicer1 deficiency

Bradley D Gelfand; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3379. doi:

ARVO Annual Meeting Abstract June 2015

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Shengjian Li; Benjamin J Fowler; Ana Bastos-Carvalho; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4211. doi:

ARVO Annual Meeting Abstract June 2015

Next Generation Sequencing of Mobile Genetic Elements in Dry Age-Related Macular Degeneration

Mark Ellsworth Kleinman; Joel T Lowery; Chen Liu; Benjamin J Fowler; Dingyuan Lou; Subhash C Prajapati; Bradley D Gelfand; Mehdi Keddache; Jinze Liu; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4212. doi:

ARVO Annual Meeting Abstract April 2014

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Reo Yasuma; Sasha Bogdanovich; Younghee Kim; Tetsuhiro Yasuma; Takeshi Mizutani; Ana Bastos-Carvalho; Benjamin Fowler; shengjian li; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1190. doi:

ARVO Annual Meeting Abstract April 2014

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

Benjamin Fowler; Younghee Kim; Yoshio Hirano; Nagaraj Kerur; Valeria Tarallo; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1735. doi:

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A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

Shear stress governs choroidal endothelial cell proliferation and homeostasis

Endogenous complementary DNA in age-related macular degeneration

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Role of interferon signaling in Alu RNA-induced AMD

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Hypoxia signaling pathways in retinal pigment epithelium require Alu RNA

Dicer1 deficiency in atrophic and neovascular age-related macular degeneration

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

A novel mouse model of neovascular AMD due to Dicer1 deficiency

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Next Generation Sequencing of Mobile Genetic Elements in Dry Age-Related Macular Degeneration

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

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