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ARVO Annual Meeting Abstract June 2024

Ferroptosis, Extracellular Vesicles and Circulating Tumor DNA as Potential Biomarkers for Uveal Melanoma Prognostication

Valentina Tonelotto; Eve O'Reilly; Marcel Costa-Garcia; Kieran Wynne; Valerie O'Neill; Patrick Murtagh; Ellie Swords; Laura Ivers; Flordeliza Calacsan; Luisa Weiss; Patricia Maguire; Joseph M. Piulats; John Crown; Paula Calvert; Noel Horgan; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1472.

ARVO Annual Meeting Abstract June 2024

Novel in vivo models of optic atrophy show pathological changes in mitochondrial structure and function

Elin Strachan; Eugene Dillon; Benjamin Delprat; Breandan N Kennedy; Niamh C O'Sullivan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2553.

ARVO Annual Meeting Abstract June 2024

A Water Soluble Quininib Analogue Blocks Metabolic Activity and Proliferation of OMM2.5 Metastatic Uveal Melanoma Cells

Breandan N Kennedy; Eavan McLoughlin; Alina Qaisar; Amelia Cassaday; Marzia Pendino; Simeone Marcone; Jacintha O'Sullivan; Niamh O'Boyle; Valentina Tonelotto

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2258.

ARVO Annual Meeting Abstract June 2024

Targeting Uveal Melanoma with a Potent Cannabinoid:Insights from Cells, Orthotopic Patient-Derived Xenograft, and Patient Biopsies.

Marzia Pendino; Sandra Garcia Mulero; Simeone Marcone; Fiona O’Connell; Eugene Dillon; Kieran Wynne; Valentina Tonelotto; Cristina Casalou; Laura Ivers; John Crown; Paula Calvert; Susan Kennedy; Jacintha O'Sullivan; Alberto Villanueva; Joseph M. Piulats; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2257.

ARVO Annual Meeting Abstract June 2024

Using CRISPR rgra and rgrb zebrafish knockouts to understand the biological role of RGR-opsin

Grace Ruddin; Tess McCann; Ailis L Moran; Rebecca Ward; John Fehilly; Joanna J Kaylor; Roxana A Radu; Gabriel H Travis; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4703.

ARVO Annual Meeting Abstract June 2024

Generating humanized transgenic zebrafish lines to investigate the pathogenicity of RLBP1 and RAB28 variants

John Fehilly; Rebecca Ward; Alicia Gómez Sánchez; Elin Strachan; Ailis L Moran; Grace Ruddin; Carly Higgins; Maeve Murdock; Joanna J Kaylor; Roxana A Radu; Gabriel H Travis; Stephen Carter; Ross F Collery; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4701.

ARVO Annual Meeting Abstract June 2024

Investigating the cellular and molecular mechanisms of the emc1 -/- zebrafish model of inherited retinal dystrophy

Tess McCann; Ciara Walsh; Husvinee Sundaramurthi; Ruth Mulholland; Yolanda Alvarez; Milton English; Margaret Starostik; Anand Swaroop; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4700.

ARVO Annual Meeting Abstract June 2023

Ocular phenotypes in CRISPR rlbp1b -/- zebrafish provide a screening platform for evaluating the pathogenicity of human RLBP1 variants using humanised transgenic lines

John D Fehilly; Rebecca Ward; Alicia Gómez Sánchez; Elin Strachan; Grace Ruddin; Ross F Collery; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4886.

ARVO Annual Meeting Abstract June 2023

Novel in vivo Models of Opa1 Deficiency: Reduced Visual Acuity in Zebrafish, Reduced Lifespan in Flies

Elin Strachan; Niamh C O'Sullivan; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4863.

ARVO Annual Meeting Abstract June 2023

The metastatic uveal melanoma cell line OMM2.5 displays selective sensitivity to the synthetic cannabinoid HU-210

Marzia Pendino; Valentina Tonelotto; Sandra Garcia Mulero; Rebeca Sanz Pamplona; Simone Marcone; Fiona O’Connell; Eugene T. Dillion; Cristina Casalou; Desmond J Tobin; Jacintha O'Sullivan; Alberto Villanueva; Josep M. Piulats; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):903.

ARVO Annual Meeting Abstract June 2023

1,4-dihydroxy Quininib Activates Ferroptosis Pathways in OMM2.5 cells: Implications for Treatment of Metastatic Uveal Melanoma.

Valentina Tonelotto; Kaelin F. Smith; Kayleigh Slater; Eve O'Reilly; Eugene T. Dillon; Federica Tramer; Sabina Passamonti; Luca Vanella; Marcel Costa-García; Rosa Bosch; Josep M. Piulats; Alberto Villanueva; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1254.

ARVO Annual Meeting Abstract June 2023

Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis

Breandan N Kennedy; Alicia Gómez Sánchez; Patrizia Colucci; Ailis Moran; Alexandro Moya López; Basilio Colligris; Yolanda Alvarez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4440.

ARVO Annual Meeting Abstract June 2022

Developing a Zebrafish Model of Dominant Optic Atrophy

Elin Strachan; Breandan N Kennedy; Niamh O'Sullivan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1589 – A0378.

ARVO Annual Meeting Abstract June 2022

Visual behaviour-based screening of a randomised chemical library identifies small molecules that restore vision.

Breandan N Kennedy; John Fehilly; Marc Cerrada-Gimenez; Simon Kaja; Giedrius Kalesnykas; Robert Scoffin; Justine O'Brien

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):680 – F0134.

ARVO Annual Meeting Abstract June 2022

Elucidating Intrinsic and Extrinsic Regulators of Outer Segment Phagocytosis in Zebrafish

Ailis Moran; John Fehilly; Eugene Dillon; Michelle Carey; oliver blacque; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1904 – A0050.

ARVO Annual Meeting Abstract June 2022

Exploring The Therapeutic Potential of Ergolide as An Anti-Cancer Agent for Uveal Melanoma

Valentina Tonelotto; Husvinee Sundaramurthi; Simone Marcone; Lasse Jensen; Giricz Zoltán; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2358 – A0027.

ARVO Annual Meeting Abstract June 2022

CysLT 1 antagonist, 1,4-dihydroxy quininib, alters the secretion of inflammatory mediators from primary uveal melanoma explants and reduces ATP5B expression in a metastatic xenograft model.

Kayleigh Slater; Rosa Bosch; Chowdhury Arif Jahangir; Arman Rahman; Fiona O'Connell; Josep M. Piulats; Sarah E Coupland; Valerie O'Neill; Noel Horgan; Jacintha O'Sullivan; William Gallagher; Alberto Villanueva; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2352 – A0021.

ARVO Annual Meeting Abstract June 2022

Evaluating Cannabinoid Receptors as A Therapeutic Target for Uveal Melanoma

Marzia Pendino; Sandra Garcia Mulero; Rebecca Sanz Pamplona; Simone Marcone; Kayleigh Slater; Josep M. Piulats; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3577 – A0006.

ARVO Annual Meeting Abstract June 2021

Deciphering the role of Rab28 in cone vision and outer segment phagocytosis

Ailis Moran; Stephen P Carter; Joanna J Kaylor; Roxana A Radu; Alicia Gómez Sánchez; Gabriel H Travis; Oliver E. Blacque; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2978.

ARVO Annual Meeting Abstract June 2021

Effects of cigarette smoke extract on the zebrafish visual system

Alicia Gómez Sánchez; Basilio Colligris; Yolanda Álvarez Teruel; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3163.

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Ferroptosis, Extracellular Vesicles and Circulating Tumor DNA as Potential Biomarkers for Uveal Melanoma Prognostication

Novel in vivo models of optic atrophy show pathological changes in mitochondrial structure and function

A Water Soluble Quininib Analogue Blocks Metabolic Activity and Proliferation of OMM2.5 Metastatic Uveal Melanoma Cells

Targeting Uveal Melanoma with a Potent Cannabinoid:Insights from Cells, Orthotopic Patient-Derived Xenograft, and Patient Biopsies.

Using CRISPR rgra and rgrb zebrafish knockouts to understand the biological role of RGR-opsin

Generating humanized transgenic zebrafish lines to investigate the pathogenicity of RLBP1 and RAB28 variants

Investigating the cellular and molecular mechanisms of the emc1 -/- zebrafish model of inherited retinal dystrophy

Ocular phenotypes in CRISPR rlbp1b -/- zebrafish provide a screening platform for evaluating the pathogenicity of human RLBP1 variants using humanised transgenic lines

Novel in vivo Models of Opa1 Deficiency: Reduced Visual Acuity in Zebrafish, Reduced Lifespan in Flies

The metastatic uveal melanoma cell line OMM2.5 displays selective sensitivity to the synthetic cannabinoid HU-210

1,4-dihydroxy Quininib Activates Ferroptosis Pathways in OMM2.5 cells: Implications for Treatment of Metastatic Uveal Melanoma.

Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis

Developing a Zebrafish Model of Dominant Optic Atrophy

Visual behaviour-based screening of a randomised chemical library identifies small molecules that restore vision.

Elucidating Intrinsic and Extrinsic Regulators of Outer Segment Phagocytosis in Zebrafish

Exploring The Therapeutic Potential of Ergolide as An Anti-Cancer Agent for Uveal Melanoma

CysLT 1 antagonist, 1,4-dihydroxy quininib, alters the secretion of inflammatory mediators from primary uveal melanoma explants and reduces ATP5B expression in a metastatic xenograft model.

Evaluating Cannabinoid Receptors as A Therapeutic Target for Uveal Melanoma

Deciphering the role of Rab28 in cone vision and outer segment phagocytosis

Effects of cigarette smoke extract on the zebrafish visual system

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