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Physiology and Pharmacology February 2018

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
TAGS: complement system proteins, complement activation, complement factor d, animal model, plasma, body tissue, eye, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):940-951. doi: https://doi.org/10.1167/iovs.17-22605

ARVO Annual Meeting Abstract June 2017

A topical VEGF inhibitor optimized for ocular indications

Stephen H Poor; Christopher Adams; Chad E Bigelow; Debby Long; Penny Yao; Elizabeth Fassbender; Siyuan Shen; Jim Chastain; Yubin Qiu; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1975. doi:

ARVO Annual Meeting Abstract June 2017

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Sha-Mei Liao; Natasha Buchanan; John Demirs; Barrett Leehy; Casey Lewis; Junzheng Yang; Vanessa Davis; Nalini V Rangaswamy; Maura Crowley; Karen Anderson; Chad E Bigelow; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1625. doi:

ARVO Annual Meeting Abstract September 2016

The Ins2 Akita diabetic mouse lacks advanced retinopathy complications

Melissa J Prentiss; Timothy Drew; Joanna Vrouvlianis; John Demirs; Hui Li; Natasha Buchanan; Bruce D Jaffee; Viral Kansara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5427. doi:

ARVO Annual Meeting Abstract September 2016

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Maura Crowley; Omar Delgado; Karen Anderson; Wei Zheng; Holger Sellner; Nello Mainolfi; Muneto Mogi; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):482. doi:

ARVO Annual Meeting Abstract September 2016

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Stephen H Poor; Yubin Qiu; Adrian Will-Orrego; Elizabeth Fassbender; Siyuan Shen; Maura Crowley; Sha-Mei Liao; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):484. doi:

ARVO Annual Meeting Abstract September 2016

Non-invasive in vivo fluorescence imaging method enables ocular pharmacokinetics assessment of intravitreally administered biologics in rabbits

Viral Kansara; Debby Long; Timothy Drew; Farid Sari-Sarraf; Radhika Sharma; Hidetomo Imase; Qiying Hu; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2209. doi:

ARVO Annual Meeting Abstract September 2016

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Sha-Mei Liao; casey lewis; Omar Delgado; Maura Crowley; Natasha Buchanan; Wei Zheng; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2629. doi:

ARVO Annual Meeting Abstract September 2016

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

Adrian Will-Orrego; Sha-Mei Liao; Yubin Qiu; Elizabeth Fassbender; Siyuan Shen; Namrata Kotagiri; Bruce D Jaffee; Stephen H Poor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3323. doi:

ARVO Annual Meeting Abstract September 2016

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Karen Anderson; Sha-Mei Liao; Juergen Maibaum; Frederic Cumin; Omar Delgado; Andrea De Erkenez; Fang Liu; Upendra Argikar; Ron Newton; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4440. doi:

ARVO Annual Meeting Abstract September 2016

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

Wei Zheng; Sokhom S. Pin; Shubh Dhillon; Zachary Zwirko; Pavan Lingala; Peter Skewes-Cox; Oleg Iartchouk; Bruce D Jaffee; Thaddeus P Dryja; Kathryn McAllister

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4788. doi:

ARVO Annual Meeting Abstract June 2015

Weekly oral delivery of a vascular endothelial growth factor receptor (VEGFR) inhibitor compound optimized for ocular exposure improves safety and maintains efficacy compared to daily dosing

Yubin Qiu; Siyuan Shen; Elizabeth S Fassbender; Amber Woolfenden; Debby Long; Ron Newton; Erik Meredith; Bruce D Jaffee; Stephen H Poor; Ophthalmology, Novartis Institutes for BioMedical Research, Inc.

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):151. doi:

ARVO Annual Meeting Abstract June 2015

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

Omar Delgado; Maura Crowley; Wei Zheng; Casey Lewis; Kathryn McAllister; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3093. doi:

ARVO Annual Meeting Abstract June 2015

A vascular endothelial growth factor receptor inhibitor (VEGFRi) achieves topical efficacy in rat and monkey models of choroidal neovascularization (CNV)

Stephen H Poor; Yubin Qiu; Amber Woolfenden; Debby Long; Christopher M Adams; Jason Elliott; Vinayak Hosagrahara; Jeremy M Sivak; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3380. doi:

ARVO Annual Meeting Abstract June 2015

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Shawn M Hanks; Joanna Vrouvlianis; Barrett Leehy; Maura Crowley; Michael Maker; Sha-Mei Liao; Bruce D Jaffee; Chad E Bigelow

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3553. doi:

ARVO Annual Meeting Abstract June 2015

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Steve Louie; Karen Anderson; Hui Li; Debby Long; Sha-Mei Liao; Bruce D Jaffee; Michael Stefanidakis

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4700. doi:

Retina October 2014

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

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Stephen H. Poor; Yubin Qiu; Elizabeth S. Fassbender; Siyuan Shen; Amber Woolfenden; Andrea Delpero; Yong Kim; Natasha Buchanan; Thomas C. Gebuhr; Shawn M. Hanks; Erik L. Meredith; Bruce D. Jaffee; Thaddeus P. Dryja
TAGS: choroidal neovascularization, lasers, light coagulation, mice, reliability
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6525-6534. doi: https://doi.org/10.1167/iovs.14-15067

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Sha-Mei Liao; Natasha M Buchanan; John T Demirs; Karen L Anderson; Shawn M Hanks; Chad E Bigelow; Melinda Hubbard; Wei Zheng; Kathryn H McAllister; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):71. doi:

ARVO Annual Meeting Abstract April 2014

Recombinant adeno-associated viral vector (rAAV)-mediated expression of RLBP1 (CRALBP) rescues the dark adaptation defect in a mouse model of RLBP1-associated retinal degeneration

Vivian W Choi; Chad E Bigelow; Terri L McGee; Akshata N Gujar; Hui Li; Shawn Hanks; Joanna Vrouvlianis; Thaddeus P Dryja; Bruce D Jaffee; Seshidhar Reddy Police

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):835. doi:

ARVO Annual Meeting Abstract April 2014

Quantifying Hyperglycemia-Associated Retinal Changes via Optical Coherence Tomography in Mice with Streptozotocin-Induced Diabetes

Shawn Hanks; Joanna Vrouvlianis; Barrett Leehy; Steve Louie; Michael P Maker; Nalini V Rangaswamy; John T Demirs; Michael Stefanidakis; Bruce D Jaffee; Chad E Bigelow

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4931. doi:

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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

A topical VEGF inhibitor optimized for ocular indications

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

The Ins2 Akita diabetic mouse lacks advanced retinopathy complications

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Non-invasive in vivo fluorescence imaging method enables ocular pharmacokinetics assessment of intravitreally administered biologics in rabbits

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

Weekly oral delivery of a vascular endothelial growth factor receptor (VEGFR) inhibitor compound optimized for ocular exposure improves safety and maintains efficacy compared to daily dosing

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

A vascular endothelial growth factor receptor inhibitor (VEGFRi) achieves topical efficacy in rat and monkey models of choroidal neovascularization (CNV)

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Recombinant adeno-associated viral vector (rAAV)-mediated expression of RLBP1 (CRALBP) rescues the dark adaptation defect in a mouse model of RLBP1-associated retinal degeneration

Quantifying Hyperglycemia-Associated Retinal Changes via Optical Coherence Tomography in Mice with Streptozotocin-Induced Diabetes

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