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Physiology and Pharmacology February 2018

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
TAGS: animal model, complement activation, complement factor d, complement system proteins, eye, mice, proteins, plasma, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):940-951. doi: https://doi.org/10.1167/iovs.17-22605

ARVO Annual Meeting Abstract June 2017

A topical VEGF inhibitor optimized for ocular indications

Stephen H Poor; Christopher Adams; Chad E Bigelow; Debby Long; Penny Yao; Elizabeth Fassbender; Siyuan Shen; Jim Chastain; Yubin Qiu; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1975. doi:

ARVO Annual Meeting Abstract June 2017

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Sha-Mei Liao; Natasha Buchanan; John Demirs; Barrett Leehy; Casey Lewis; Junzheng Yang; Vanessa Davis; Nalini V Rangaswamy; Maura Crowley; Karen Anderson; Chad E Bigelow; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1625. doi:

ARVO Annual Meeting Abstract September 2016

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Maura Crowley; Omar Delgado; Karen Anderson; Wei Zheng; Holger Sellner; Nello Mainolfi; Muneto Mogi; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):482. doi:

ARVO Annual Meeting Abstract September 2016

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Stephen H Poor; Yubin Qiu; Adrian Will-Orrego; Elizabeth Fassbender; Siyuan Shen; Maura Crowley; Sha-Mei Liao; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):484. doi:

ARVO Annual Meeting Abstract September 2016

Non-invasive in vivo fluorescence imaging method enables ocular pharmacokinetics assessment of intravitreally administered biologics in rabbits

Viral Kansara; Debby Long; Timothy Drew; Farid Sari-Sarraf; Radhika Sharma; Hidetomo Imase; Qiying Hu; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2209. doi:

ARVO Annual Meeting Abstract September 2016

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Sha-Mei Liao; casey lewis; Omar Delgado; Maura Crowley; Natasha Buchanan; Wei Zheng; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2629. doi:

ARVO Annual Meeting Abstract September 2016

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

Adrian Will-Orrego; Sha-Mei Liao; Yubin Qiu; Elizabeth Fassbender; Siyuan Shen; Namrata Kotagiri; Bruce D Jaffee; Stephen H Poor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3323. doi:

ARVO Annual Meeting Abstract September 2016

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Karen Anderson; Sha-Mei Liao; Juergen Maibaum; Frederic Cumin; Omar Delgado; Andrea De Erkenez; Fang Liu; Upendra Argikar; Ron Newton; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4440. doi:

ARVO Annual Meeting Abstract September 2016

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

Wei Zheng; Sokhom S. Pin; Shubh Dhillon; Zachary Zwirko; Pavan Lingala; Peter Skewes-Cox; Oleg Iartchouk; Bruce D Jaffee; Thaddeus P Dryja; Kathryn McAllister

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4788. doi:

ARVO Annual Meeting Abstract September 2016

The Ins2 Akita diabetic mouse lacks advanced retinopathy complications

Melissa J Prentiss; Timothy Drew; Joanna Vrouvlianis; John Demirs; Hui Li; Natasha Buchanan; Bruce D Jaffee; Viral Kansara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5427. doi:

ARVO Annual Meeting Abstract June 2015

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

Omar Delgado; Maura Crowley; Wei Zheng; Casey Lewis; Kathryn McAllister; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3093. doi:

ARVO Annual Meeting Abstract June 2015

A vascular endothelial growth factor receptor inhibitor (VEGFRi) achieves topical efficacy in rat and monkey models of choroidal neovascularization (CNV)

Stephen H Poor; Yubin Qiu; Amber Woolfenden; Debby Long; Christopher M Adams; Jason Elliott; Vinayak Hosagrahara; Jeremy M Sivak; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3380. doi:

ARVO Annual Meeting Abstract June 2015

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Shawn M Hanks; Joanna Vrouvlianis; Barrett Leehy; Maura Crowley; Michael Maker; Sha-Mei Liao; Bruce D Jaffee; Chad E Bigelow

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3553. doi:

ARVO Annual Meeting Abstract June 2015

Weekly oral delivery of a vascular endothelial growth factor receptor (VEGFR) inhibitor compound optimized for ocular exposure improves safety and maintains efficacy compared to daily dosing

Yubin Qiu; Siyuan Shen; Elizabeth S Fassbender; Amber Woolfenden; Debby Long; Ron Newton; Erik Meredith; Bruce D Jaffee; Stephen H Poor; Ophthalmology, Novartis Institutes for BioMedical Research, Inc.

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):151. doi:

ARVO Annual Meeting Abstract June 2015

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Steve Louie; Karen Anderson; Hui Li; Debby Long; Sha-Mei Liao; Bruce D Jaffee; Michael Stefanidakis

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4700. doi:

Retina October 2014

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

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Stephen H. Poor; Yubin Qiu; Elizabeth S. Fassbender; Siyuan Shen; Amber Woolfenden; Andrea Delpero; Yong Kim; Natasha Buchanan; Thomas C. Gebuhr; Shawn M. Hanks; Erik L. Meredith; Bruce D. Jaffee; Thaddeus P. Dryja
TAGS: choroidal neovascularization, lasers, light coagulation, mice, reliability
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6525-6534. doi: https://doi.org/10.1167/iovs.14-15067

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Intravitreal (IVT) injection exacerbates murine choroidal neovascularization (CNV) area by a MYD88 dependent mechanism

Elizabeth Fassbender; Yubin Qiu; Siyuan Shen; Amber Woolfenden; Andrea Delpero; Yong Kim; Bruce D Jaffee; Stephen H Poor

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1194. doi:

ARVO Annual Meeting Abstract April 2014

A mouse model to assess gene therapy for RLBP1-associated retinal dystrophy

Chad E Bigelow; Shawn M Hanks; Joanna Vrouvlianis; Oliver Turner; Gregory Argentieri; George Bounoutas; Vivian W Choi; Thaddeus P Dryja; Seshidhar Reddy Police; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1640. doi:

ARVO Annual Meeting Abstract April 2014

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Sha-Mei Liao; Natasha M Buchanan; John T Demirs; Karen L Anderson; Shawn M Hanks; Chad E Bigelow; Melinda Hubbard; Wei Zheng; Kathryn H McAllister; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):71. doi:

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Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

A topical VEGF inhibitor optimized for ocular indications

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Non-invasive in vivo fluorescence imaging method enables ocular pharmacokinetics assessment of intravitreally administered biologics in rabbits

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

The Ins2 Akita diabetic mouse lacks advanced retinopathy complications

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

A vascular endothelial growth factor receptor inhibitor (VEGFRi) achieves topical efficacy in rat and monkey models of choroidal neovascularization (CNV)

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Weekly oral delivery of a vascular endothelial growth factor receptor (VEGFR) inhibitor compound optimized for ocular exposure improves safety and maintains efficacy compared to daily dosing

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

Intravitreal (IVT) injection exacerbates murine choroidal neovascularization (CNV) area by a MYD88 dependent mechanism

A mouse model to assess gene therapy for RLBP1-associated retinal dystrophy

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

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