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Anatomy and Pathology/Oncology July 2024

Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status

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Maria Chiara Gelmi; Arnoud H. de Ru; Peter A. van Veelen; Rayman T. N. Tjokrodirijo; Marc-Henri Stern; Alexandre Houy; Robert M. Verdijk; T. H. Khanh Vu; Bruce R. Ksander; Jolanda Vaarwater; Emine Kilic; Erwin Brosens; Martine J. Jager
TAGS: cell lines, intraocular melanoma, mutation, proteins, rna, messenger, bap1 gene, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):37. https://doi.org/10.1167/iovs.65.8.37

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

Yuancheng Ryan Lu; Margarete Karg; Lindsey A Chew; Kat Kajderowicz; Daisy Y Shu; Xiaojie Qiu; Nasrin Refaian; Shintaro Shirahama; Zhengping Hu; Tessa Bertozzi; David Sinclair; Magali Saint-Geniez; Patricia A D'Amore; Catherine Bowes Rickman; Bruce Ksander; Jonathan Weissman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5307.

ARVO Annual Meeting Abstract June 2024

Characterisation of a novel ABCB5-expressing limbal mesenchymal stem cell population and its role in corneal (lymph)angiogenesis and immune privilege

Maria Notara; Berbang Meshko; Thomas Volatier; Mark Andreas Kluth; Christoph Ganss; Markus Hermann Frank; Natasha Frank; Bruce Ksander; Claus Cursiefen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):500.

ARVO Annual Meeting Abstract June 2023

Non-human primate laser-induced NAION model for assessing neuro-rejuvenating gene therapies

Madhura Shah; Drenushe Krasniqi; Meredith S Gregory-Ksander; Sharon Rosenzweig-Lipson; Kasia Broniowska; Michel Wathier; Joan Mannick; Jennifer Cermak; Margarete Karg; Shintaro Shirahama; Nasrin Refaian; Yuancheng Lu; Bruce Ksander; Matthew Lawrence; David Sinclair; Joseph F. Rizzo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5223.

ARVO Annual Meeting Abstract June 2023

Epigenetic reprogramming to rejuvenate retinal ganglion cells and sustainably reverse glaucoma-induced vision loss

Yuancheng Ryan Lu; Margarete Karg; Emma M. Hoffmann; James C. Cameron; May Moorefield; Maleeka Shrestha; Yinjie Guo; Joan Mannick; Jennifer Cermak; Michel Wathier; Meredith S Gregory-Ksander; David Sinclair; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2841.

ARVO Annual Meeting Abstract June 2023

Epigenetic reprogramming- A novel gene therapy that restores vision loss in a nonhuman primate model of NAION

Bruce Ksander; Madhura Shah; Drenushe Krasniqi; Meredith S Gregory-Ksander; Sharon Rosenzweig-Lipson; Kasia Broniowska; Michel Wathier; Joan Mannick; Jennifer Cermak; Margarete Karg; Shintaro Shirahama; Nasrin Refaian; Yuancheng Lu; Matthew Lawrence; Joseph F. Rizzo; David Sinclair

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):474.

ARVO Annual Meeting Abstract June 2023

YAP1 regulates cell size of limbal BCAM-positive transit amplifying cells.

Yuzuru Sasamoto; Bruce Ksander; Markus Hermann Frank; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):969.

ARVO Annual Meeting Abstract June 2023

Metastatic spread from primary eye tumor after enucleation in a Uveal Melanoma orthotopic human to mouse xenograft model

Alice van den Broek; Nasrin Refaian; Cindy Hoppe; T.H. Khanh Vu; Martine J Jager; Bruce Ksander; Margarete Karg

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):895.

ARVO Annual Meeting Abstract June 2023

Local antigen-presenting cells and restimulation of T cells during uveitis

Shintaro Shirahama; Yoko Okunuki; May Yue Lee; Meredith S Gregory-Ksander; Kip M Connor; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2456.

ARVO Annual Meeting Abstract June 2023

Partial epigenetic reprogramming of RPE cells reverses age and rejuvenates mitochondrial metabolism

Margarete Karg; Daisy Y Shu; Yuancheng Lu; yue He; James C. Cameron; Jonathan S. Weissman; George W Bell; David Sinclair; Magali Saint-Geniez; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2966.

ARVO Annual Meeting Abstract June 2022

MHC class II positive retinal microglia exacerbate uveitis by activating infiltrating T cells

Shintaro Shirahama; May Yue Lee; Yoko Okunuki; Kip M Connor; Meredith S Gregory-Ksander; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2684.

ARVO Annual Meeting Abstract June 2022

Sex and Age-Related Changes in RPE Morphology and Function in Mice

Margarete Karg; Emma Hoffmann; Drenushe Krasniqi; Daisy Y Shu; May Moorefield; Hannah Philipose; Bruce Ksander; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3481.

ARVO Annual Meeting Abstract June 2022

Transit-amplifying cell genes CAV1 and CAV2 are required to maintain corneal epithelial phenotype.

Yuzuru Sasamoto; Shoko Kiritoshi; Catherine Lee; Bruce Ksander; Markus Hermann Frank; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3638 – A0203.

ARVO Annual Meeting Abstract June 2022

A micro-contoured contact lens for delivering 3D-printed ABCB5-positive stem cells for corneal regeneration

Catherine Lee; Yuzuru Sasamoto; Wonhye Lee; Jennifer Kunes; Bruce Ksander; Markus Hermann Frank; Christine W Sindt; Seung-Schik Yoo; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3628 – A0193.

ARVO Annual Meeting Abstract June 2021

In vivo epigenetic reprogramming reverses the age-induced morphological decline of retinal pigment epithelial cells

Margarete Karg; Yuancheng Lu; Emma Hoffmann; Hannah Philipose; David Sinclair; Bruce Ksander; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3283.

ARVO Annual Meeting Abstract June 2021

3D-printed ABCB5-positive stem cells for treating bilateral limbal stem cell deficiency

Catherine Lee; Wonhye Lee; Jennifer Kunes; Yuzuru Sasamoto; Bruce Ksander; Markus H Frank; Seung-Schik Yoo; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):950.

ARVO Annual Meeting Abstract June 2021

Regulation of SARS-CoV2 viral entry-related proteins in human ocular surface epithelium

Yuzuru Sasamoto; Catherine Lee; Masahito Yoshihara; Gabrielle Martin; Bruce Ksander; Markus H Frank; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):930.

ARVO Annual Meeting Abstract June 2020

Inflammatory damage to the limbal stem cells after acute ocular injury: Protection with TNF-α inhibition

Chengxin Zhou; Fengyang Lei; Bruce Ksander; Claes H Dohlman; James Chodosh; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):371.

ARVO Annual Meeting Abstract June 2020

Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming

Bruce Ksander; Yuancheng Lu; Anitha Krishnan; Benedikt Brommer; Xiao Tian; Margarita Meer; Daniel Vera; Chen Wang; Qiurui Zeng; Doudou Yu; Steve Horvath; Meredith S Gregory-Ksander; Zhigang He; David Sinclair

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2364.

ARVO Annual Meeting Abstract June 2020

Midkine is a tumor cell survival factor that displays metastatic and therapeutic resistance functions in uveal melanoma

Margarete Karg; Lukas John; Narin Refaian; Christian Büttner; Tanja Rottmar; Jonas Sommer; Barbara Bock; Yazid Resheq; Bruce Ksander; Ludwig M Heindl; Andreas Mackensen; Jacobus Bosch

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4024.

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Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status

Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

Characterisation of a novel ABCB5-expressing limbal mesenchymal stem cell population and its role in corneal (lymph)angiogenesis and immune privilege

Non-human primate laser-induced NAION model for assessing neuro-rejuvenating gene therapies

Epigenetic reprogramming to rejuvenate retinal ganglion cells and sustainably reverse glaucoma-induced vision loss

Epigenetic reprogramming- A novel gene therapy that restores vision loss in a nonhuman primate model of NAION

YAP1 regulates cell size of limbal BCAM-positive transit amplifying cells.

Metastatic spread from primary eye tumor after enucleation in a Uveal Melanoma orthotopic human to mouse xenograft model

Local antigen-presenting cells and restimulation of T cells during uveitis

Partial epigenetic reprogramming of RPE cells reverses age and rejuvenates mitochondrial metabolism

MHC class II positive retinal microglia exacerbate uveitis by activating infiltrating T cells

Sex and Age-Related Changes in RPE Morphology and Function in Mice

Transit-amplifying cell genes CAV1 and CAV2 are required to maintain corneal epithelial phenotype.

A micro-contoured contact lens for delivering 3D-printed ABCB5-positive stem cells for corneal regeneration

In vivo epigenetic reprogramming reverses the age-induced morphological decline of retinal pigment epithelial cells

3D-printed ABCB5-positive stem cells for treating bilateral limbal stem cell deficiency

Regulation of SARS-CoV2 viral entry-related proteins in human ocular surface epithelium

Inflammatory damage to the limbal stem cells after acute ocular injury: Protection with TNF-α inhibition

Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming

Midkine is a tumor cell survival factor that displays metastatic and therapeutic resistance functions in uveal melanoma

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