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Perspective January 2019

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

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Justine R. Smith; Jacob Pe'er; Rubens N. Belfort; Fatima Cardoso; Richard D. Carvajal; Carlos Carvalho; Sarah E. Coupland; Laurence Desjardins; Jasmine H. Francis; Brenda L. Gallie; Dan S. Gombos; Hans E. Grossniklaus; Steffen Heegaard; Martine J. Jager; Swathi Kaliki; Bruce R. Ksander; Markus Maeurer; Eduardo Moreno; Jose S. Pulido; Bettina Ryll; Arun D. Singh; Junyang Zhao; António Parreira; David J. Wilson; Joan M. O'Brien
TAGS: carcinogenesis, medical oncology, ophthalmology, tumorigenesis, vision research, intraocular melanoma, neoplasms, cancer, eye cancer
Trans. Vis. Sci. Tech.. 2019; 8(1):9. doi: https://doi.org/10.1167/tvst.8.1.9

Anatomy and Pathology/Oncology February 2018

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

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Jinfeng Cao; Niels J. Brouwer; Ekaterina S. Jordanova; Marina Marinkovic; Sjoerd G. van Duinen; Nadine E. de Waard; Bruce R. Ksander; Arend Mulder; Frans H. J. Claas; Mirjam H. M. Heemskerk; Martine J. Jager
TAGS: human leukocyte antigens, programmed cell death 1 ligand 1, malignant melanoma of conjunctiva, human leukocyte antigen class i, cell lines
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1005-1015. doi: https://doi.org/10.1167/iovs.17-23209

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2015

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

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Simona L. Schlereth; Sandra Iden; Melina Mescher; Bruce R. Ksander; Jacobus J. Bosch; Claus Cursiefen; Ludwig M. Heindl
TAGS: cyclin-dependent kinase 4, malignant melanoma of conjunctiva, melanoma, mice, neoplasms, neoplasm metastasis, lung, injections, lymphatic vessels, lymph nodes
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5965-5973. doi: https://doi.org/10.1167/iovs.15-17290

ARVO Annual Meeting Abstract June 2015

Abcb5-positive retinal pigment epithelial cells are required for normal retinal development and ageing

Bruce R Ksander; Ruth Lewis; Brian J Wilson; Gretchen Berg; Markus Hermann Frank; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1486. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy treatment with AAV-soluble Fas ligand protects retinal ganglion cells during development of Glaucoma

Anitha Krishnan; Fei Fei; Alexander Jones; Bruce R Ksander; Ann Marshak Rothstein; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2594. doi:

ARVO Annual Meeting Abstract June 2015

Preventing glaucoma by blocking activation of the NLRP3 inflammasome in the optic nerve head

Fei Fei; Anitha Krishnan; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3485. doi:

ARVO Annual Meeting Abstract June 2015

HLA class I expression in cell lines derived from conjunctival melanoma and retinoblastoma using allele-specific monoclonal antibodies and flow cytometry

Rind Smesseim; Jinfeng Cao; T Huibertus Van Essen; Arend Mulder; Elsbeth van Zeeburg; Bruce R Ksander; Martine J Jager

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):68. doi:

ARVO Annual Meeting Abstract June 2015

Vascular normalization: A novel method for inhibiting vascular leakage in age-related macular degeneration

Adarsha Koirala; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4800. doi:

Anatomy and Pathology/Oncology April 2015

A Murine Model for Metastatic Conjunctival Melanoma

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Nadine E. de Waard; Jinfeng Cao; Sean P. McGuire; Paraskevi E. Kolovou; Ekaterina S. Jordanova; Bruce R. Ksander; Martine J. Jager
TAGS: cell lines, malignant melanoma of conjunctiva, neoplasm metastasis, neoplasms, transplantation, heterologous, mice, s100b protein, recurrence, antibodies, severe combined immunodeficiency
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2325-2333. doi: https://doi.org/10.1167/iovs.14-15239

Biochemistry and Molecular Biology October 2014

Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos

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Wietske van der Ent; Claudia Burrello; Amina F. A. S. Teunisse; Bruce R. Ksander; Pieter A. van der Velden; Martine J. Jager; Aart G. Jochemsen; B. Ewa Snaar-Jagalska
TAGS: cell lines, dasatinib, embryo, intraocular melanoma, transplantation, heterologous, zebrafish, neoplasms
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6612-6622. doi: https://doi.org/10.1167/iovs.14-15202

Includes: Supplemental Content

Retina July 2014

Uveal Melanoma Cell Growth Is Inhibited by Aminoimidazole Carboxamide Ribonucleotide (AICAR) Partially Through Activation of AMP-Dependent Kinase

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Ahmad Al-Moujahed; Fotini Nicolaou; Katarzyna Brodowska; Thanos D. Papakostas; Anna Marmalidou; Bruce R. Ksander; Joan W. Miller; Evangelos Gragoudas; Demetrios G. Vavvas
TAGS: aica ribonucleotide, intraocular melanoma, phosphotransferases, cell growth
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4175-4185. doi: https://doi.org/10.1167/iovs.13-12856

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

A new conjunctival melanoma model of primary and metastatic tumor growth

Jinfeng Cao; Nadine de Waard; Aat A Mulder; Bruce R Ksander; Martine Jager

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5439. doi:

ARVO Annual Meeting Abstract April 2014

Regulation of vascular leakage by Fas Ligand: Distinguishing the role of soluble from membrane FasL in unique knock-in mice with laser-induced choroidal neovascularization

Adarsha Koirala; Ann Marshak-Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):80. doi:

ARVO Annual Meeting Abstract April 2014

Soluble Fas ligand is a neuroprotective molecule critical in restricting glaucomatous damage to retinal ganglion cells

Anitha Krishnan; Alexander Jones; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2194. doi:

Retinal Cell Biology January 2013

NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration

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Wen Allen Tseng; Thuzar Thein; Kati Kinnunen; Kameran Lashkari; Meredith S. Gregory; Patricia A. D'Amore; Bruce R. Ksander
TAGS: age-related macular degeneration, caspase-1, inflammasomes, retinal pigment cell, immunoblotting, cytotoxicity, lysosomes, bodily secretions, otitis media with effusion
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):110-120. doi: https://doi.org/10.1167/iovs.12-10655

ARVO Annual Meeting Abstract March 2012

Open Angle Glaucoma In Soluble Guanylate Cyclase α1-deficient Mice And Its Association With The Gucy1a3/gucy1b3 Locus In Humans

Emmanuel S. Buys; Yu-Chieh Ko; Jae-Hee Kang; Douglas Rhee; Peter Brouckaert; Janey L. Wiggs; Meredith S. Gregory-Ksander; Louis R. Pasquale; Kenneth D. Bloch; Bruce R. Ksander

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5295. doi:

ARVO Annual Meeting Abstract March 2012

Protective Role of Soluble FasL in Photoreceptor Cell Loss

Dimosthenis Mantopoulos; Yusuke Murakami; George Trichonas; Meredith S. Gregory-Ksander; Dean Cestari; Bruce R. Ksander; Demetrios Vavvas

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6361. doi:

ARVO Annual Meeting Abstract April 2011

Accelerated Glaucoma And Increased Neurotoxicity In DBA/2J Mice That Cannot Cleave Fas Ligand

Bruce R. Ksander; Alexander Jones; Simon W. John; Ann Marshak-Rothstein; Meredith S. Gregory

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2449. doi:

ARVO Annual Meeting Abstract April 2011

Cleavage of Fas Ligand Regulates Vessel Leakage in Laser Induced CNV

Carolin Milojcic; Dimosthenis Mantopoulos; Demetrios Vavvas; Andrea Giani; Ann Marshak-Rothstein; Frank G. Holz; Bruce R. Ksander; Meredith S. Gregory

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2300. doi:

Immunology and Microbiology January 2011

Spontaneous Bacterial Keratitis in CD36 Knockout Mice

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Julia Klocke; Rita N. Barcia; Susan Heimer; Elke Cario; James Zieske; Michael S. Gilmore; Bruce R. Ksander; Meredith S. Gregory
TAGS: bacterial keratitis, cd36 antigens, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2011; 52(1):256-263. doi: https://doi.org/10.1167/iovs.10-5566

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Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

Abcb5-positive retinal pigment epithelial cells are required for normal retinal development and ageing

Gene therapy treatment with AAV-soluble Fas ligand protects retinal ganglion cells during development of Glaucoma

Preventing glaucoma by blocking activation of the NLRP3 inflammasome in the optic nerve head

HLA class I expression in cell lines derived from conjunctival melanoma and retinoblastoma using allele-specific monoclonal antibodies and flow cytometry

Vascular normalization: A novel method for inhibiting vascular leakage in age-related macular degeneration

A Murine Model for Metastatic Conjunctival Melanoma

Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos

Uveal Melanoma Cell Growth Is Inhibited by Aminoimidazole Carboxamide Ribonucleotide (AICAR) Partially Through Activation of AMP-Dependent Kinase

A new conjunctival melanoma model of primary and metastatic tumor growth

Regulation of vascular leakage by Fas Ligand: Distinguishing the role of soluble from membrane FasL in unique knock-in mice with laser-induced choroidal neovascularization

Soluble Fas ligand is a neuroprotective molecule critical in restricting glaucomatous damage to retinal ganglion cells

NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration

Open Angle Glaucoma In Soluble Guanylate Cyclase α1-deficient Mice And Its Association With The Gucy1a3/gucy1b3 Locus In Humans

Protective Role of Soluble FasL in Photoreceptor Cell Loss

Accelerated Glaucoma And Increased Neurotoxicity In DBA/2J Mice That Cannot Cleave Fas Ligand

Cleavage of Fas Ligand Regulates Vessel Leakage in Laser Induced CNV

Spontaneous Bacterial Keratitis in CD36 Knockout Mice

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