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Journal Articles (5)
Meeting Abstract (5)

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Investigative Ophthalmology & Visual Science (10)

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ARVO Annual Meeting Abstract (5)
Retinal Cell Biology (3)
Biochemistry and Molecular Biology (1)
Lens (1)

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Eye Anatomy and Disorders (4)
Biochemistry and Molecular Biology (3)
Genetics (3)
Retinal Cell Biology (3)
Immunology and Microbiology (2)
Retina (2)
Lens (1)

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retinal pigment cell (3)
cathepsin d (2)
lysosomes (2)
mice (2)
retinal pigment epithelium (2)
apoptosis (1)
chloroquine (1)
choroideremia (1)
collagen type iv (1)
culture media, conditioned (1)

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Retinal Cell Biology August 2023

Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells

PDF

M. Helena Cardoso; Michael J. Hall; Thomas Burgoyne; Pedro Fale; Tina Storm; Cristina Escrevente; Pedro Antas; Miguel C. Seabra; Clare E. Futter
TAGS: cathepsin d, chloroquine, lysosomes, retinal pigment cell, platypnea orthodeoxia syndrome, gold
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):10. https://doi.org/10.1167/iovs.64.11.10

Includes: Supplemental Content

Retinal Cell Biology July 2021

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

PDF

Cristina Escrevente; Ana S. Falcão; Michael J. Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel M. Mesquita; Inês S. Ferreira; M. Helena Cardoso; Daniela Oliveira; Ana C. Fradinho; Thomas Ciossek; Paul Nicklin; Clare E. Futter; Sandra Tenreiro; Miguel C. Seabra
TAGS: granules, lipofuscin, lysosomes, pathophysiology, retinal pigment epithelium, cathepsin d, flow cytometry, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):39. https://doi.org/10.1167/iovs.62.9.39

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

Miguel Seabra; Cristina Escrevente; Ana Sofia Falcão; Michael J Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel Mesquita; Inês Ferreira; Helena Cardoso; Ana Fradinho; Clare E Futter; Sandra Tenreiro

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3278.

ARVO Annual Meeting Abstract July 2019

Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration

Miguel Seabra; M. Helena Cardoso; Michael Hall; A. Sofia Falcão; Cristina Escrevente; Pedro Antas; Gabriela V. Santos; Sandra Tenreiro; Clare E. Futter

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1246.

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

PDF

Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. https://doi.org/10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2015

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Tanya Tolmachova; Diogo A. Feleciano; Clare E. Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2321.

Biochemistry and Molecular Biology October 2010

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

PDF

Tanya Tolmachova; Silene T. Wavre-Shapton; Alun R. Barnard; Robert E. MacLaren; Clare E. Futter; Miguel C. Seabra
TAGS: choroideremia, mice, mice, knockout, photoreceptors, retinal pigment epithelium, tissue degeneration, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4913-4920. https://doi.org/10.1167/iovs.09-4892

ARVO Annual Meeting Abstract April 2009

Prenylation Defect in the RPE Exacerbates Photoreceptor Degeneration in Choroideremia Mice

T. Tolmachova; S. T. M. M. Wavre; D. C. Tracey-White; C. E. Futter; M. C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):1937.

ARVO Annual Meeting Abstract May 2007

Eye Pigmentation Defect in Rab38-Deficient Chocolate Mice Results From the Short Time Frame of Melanogenesis in the Retinal Pigment Epithelium

V. S. Lopes; C. Wasmeier; M. C. Seabra; C. E. Futter

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3053.

Lens September 2005

Interaction with Collagen IV Protects Lens Epithelial Cells from Fas-Dependent Apoptosis by Stimulating the Production of Soluble Survival Factors

PDF

Clare E. Futter; Jonathan G. Crowston; Bruce D. S. Allan
TAGS: apoptosis, collagen type iv, culture media, conditioned, lens epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2005; 46(9):3256-3262. https://doi.org/10.1167/iovs.05-0086

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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