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ARVO Annual Meeting Abstract June 2022

Exosome release from RPE cells increased by lysosomal compromise

Claire H Mitchell; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4617 – F0409. doi:

ARVO Annual Meeting Abstract June 2021

Photoreceptor death and RPE oxidative stress model of chloroquine retinopathy

Wennan Lu; Assraa Hassan Jassim; Nestor Mas Gomez; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2714. doi:

ARVO Annual Meeting Abstract June 2021

TRPML1 channels activation facilitates lysosomal exocytosis and reduces autofluorescent lysosomal accumulations, opsin retention and lipid peroxidation in RPE cells compromised by chloroquine

Nestor Mas Gomez; Wennan Lu; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3026. doi:

ARVO Annual Meeting Abstract June 2020

Mechanical strain results causes cytoskeletal remodeling and cellular elastinopathy in primary optic nerve head astrocytes

Simon Kaja; Evan B Stubbs; Claire H Mitchell; Anita K. Ghosh

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):992. doi:

ARVO Annual Meeting Abstract June 2020

Retinal pigment epithelial cells “bulk up” when they “pump iron”: lipid and endolysosome accumulation with mechanistic connection to macular degeneration

Kevin Zhang; Bailey Baumann; Ahab Alnemri; Ying Song; Venkata R M Chavali; Claire H Mitchell; Joshua L Dunaief

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1422. doi:

ARVO Annual Meeting Abstract June 2020

Induced pluripotent stem cell derived retinal ganglion cells as in vitro model to study molecular pathobiology in Glaucoma.

Venkata R M Chavali; Jie He; Sonika Rathi; Jason Mills; Claire H Mitchell; Joan M O'Brien

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3796. doi:

ARVO Annual Meeting Abstract July 2019

Sustained oral delivery of ticagrelor (Brilinta) protects against retinal degeneration

Wennan Lu; Keith Campagno; Leif Carlsson; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):49. doi:

ARVO Annual Meeting Abstract July 2019

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Anitha Krishnan; Malvika Dua; Claire H Mitchell; Wennan Lu; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2256. doi:

ARVO Annual Meeting Abstract July 2019

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Meredith S Gregory-Ksander; Wennan Lu; Claire H Mitchell; Andrew Kocab; David N Zacks; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2257. doi:

ARVO Annual Meeting Abstract July 2019

Life beyond death; beneficial signaling by the P2X7 receptor

Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4201. doi:

Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. doi: https://doi.org/10.1167/iovs.19-27241

ARVO Annual Meeting Abstract July 2018

IL-1β is released by retinal microglial cells in response to ATP and can damage retinal ganglion cells

Wennan Lu; Keith Campagno; Farraj Albalawi; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3729. doi:

ARVO Annual Meeting Abstract July 2018

Linking stressed astrocytes to activated microglia through purinergic signaling

Claire H Mitchell; Keith Campagno; Farraj Albalawi; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6034. doi:

ARVO Annual Meeting Abstract June 2017

Increased IOP primes the NLRP3 inflammasome and increases IL-1β levels

Claire H Mitchell; Farraj Albalawi; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):851. doi:

ARVO Annual Meeting Abstract June 2017

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Wennan Lu; Alan M Laties; Leif Carlsson; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2034. doi:

ARVO Annual Meeting Abstract June 2017

Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4 -/- mice

Nestor Mas Gomez; Wennan Lu; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1053. doi:

ARVO Annual Meeting Abstract September 2016

Increased inflammasome priming and microglial activation in a mouse model of chloroquine retinopathy

Wennan Lu; Nestor Mas Gomez; Alan M Laties; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2237. doi:

ARVO Annual Meeting Abstract September 2016

Priming of the NLRP3 inflammasome in optic nerve head astrocytes by mechanical strain and stimulation of the P2X7 receptor

Claire H Mitchell; Farraj Albalawi; Jason Lim; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3009. doi:

ARVO Annual Meeting Abstract September 2016

Autophagy in retinal degenerations

Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Compromised phagosome maturation underlies defective RPE clearance in an in vitro model of Smith-Lemli-Opitz Syndrome

Sriganesh Ramachandra Rao; Nestor Mas Gomez; Bruce A. Pfeffer; Aryn Rowsam; Claire H Mitchell; Steven J Fliesler

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6035. doi:

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Exosome release from RPE cells increased by lysosomal compromise

Photoreceptor death and RPE oxidative stress model of chloroquine retinopathy

TRPML1 channels activation facilitates lysosomal exocytosis and reduces autofluorescent lysosomal accumulations, opsin retention and lipid peroxidation in RPE cells compromised by chloroquine

Mechanical strain results causes cytoskeletal remodeling and cellular elastinopathy in primary optic nerve head astrocytes

Retinal pigment epithelial cells “bulk up” when they “pump iron”: lipid and endolysosome accumulation with mechanistic connection to macular degeneration

Induced pluripotent stem cell derived retinal ganglion cells as in vitro model to study molecular pathobiology in Glaucoma.

Sustained oral delivery of ticagrelor (Brilinta) protects against retinal degeneration

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Life beyond death; beneficial signaling by the P2X7 receptor

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

IL-1β is released by retinal microglial cells in response to ATP and can damage retinal ganglion cells

Linking stressed astrocytes to activated microglia through purinergic signaling

Increased IOP primes the NLRP3 inflammasome and increases IL-1β levels

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4 -/- mice

Increased inflammasome priming and microglial activation in a mouse model of chloroquine retinopathy

Priming of the NLRP3 inflammasome in optic nerve head astrocytes by mechanical strain and stimulation of the P2X7 receptor

Autophagy in retinal degenerations

Compromised phagosome maturation underlies defective RPE clearance in an in vitro model of Smith-Lemli-Opitz Syndrome

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