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ARVO Annual Meeting Abstract June 2024

Rise in oxidative stress following lysosomal compromine of RPE cells is eliminated by acid nanoparticles

Claire H Mitchell; Jiaqi Li; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):435.

ARVO Annual Meeting Abstract June 2024

Pro-inflammatory cytokine IL-1β leads to axonal degeneration and RGC death, is released by retinal microglia, and is primed and activated by P2X7 receptor stimulation following IOP elevation

Wennan Lu; Puttipong Sripinun; Keith Compagno; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1665.

ARVO Annual Meeting Abstract June 2024

Mechanosensitive PIEZO1 and PIEZO2 channels in the RPE and in axons of RGCs may initiate cellular responses to tissue stretch

Puttipong Sripinun; Lily P. See; Venkata R M Chavali; Vrathasha Vrathasha; Jie He; Joan O’Brien; Wennan Lu; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6716.

ARVO Annual Meeting Abstract June 2023

Lysosomal membrane repair and lysophagy following lysosomal damage in RPE cells

Claire H Mitchell; Wennan Lu; Marly Rubin; Néstor Más Goméz

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5385.

ARVO Annual Meeting Abstract June 2022

Exosome release from RPE cells increased by lysosomal compromise

Claire H Mitchell; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4617 – F0409.

ARVO Annual Meeting Abstract June 2021

Photoreceptor death and RPE oxidative stress model of chloroquine retinopathy

Wennan Lu; Assraa Hassan Jassim; Nestor Mas Gomez; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2714.

ARVO Annual Meeting Abstract June 2021

TRPML1 channels activation facilitates lysosomal exocytosis and reduces autofluorescent lysosomal accumulations, opsin retention and lipid peroxidation in RPE cells compromised by chloroquine

Nestor Mas Gomez; Wennan Lu; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3026.

ARVO Annual Meeting Abstract June 2020

Mechanical strain results causes cytoskeletal remodeling and cellular elastinopathy in primary optic nerve head astrocytes

Simon Kaja; Evan B Stubbs; Claire H Mitchell; Anita K. Ghosh

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):992.

ARVO Annual Meeting Abstract June 2020

Retinal pigment epithelial cells “bulk up” when they “pump iron”: lipid and endolysosome accumulation with mechanistic connection to macular degeneration

Kevin Zhang; Bailey Baumann; Ahab Alnemri; Ying Song; Venkata R M Chavali; Claire H Mitchell; Joshua L Dunaief

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1422.

ARVO Annual Meeting Abstract June 2020

Induced pluripotent stem cell derived retinal ganglion cells as in vitro model to study molecular pathobiology in Glaucoma.

Venkata R M Chavali; Jie He; Sonika Rathi; Jason Mills; Claire H Mitchell; Joan M O'Brien

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3796.

ARVO Annual Meeting Abstract July 2019

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Anitha Krishnan; Malvika Dua; Claire H Mitchell; Wennan Lu; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2256.

ARVO Annual Meeting Abstract July 2019

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Meredith S Gregory-Ksander; Wennan Lu; Claire H Mitchell; Andrew Kocab; David N Zacks; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2257.

ARVO Annual Meeting Abstract July 2019

Life beyond death; beneficial signaling by the P2X7 receptor

Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4201.

ARVO Annual Meeting Abstract July 2019

Sustained oral delivery of ticagrelor (Brilinta) protects against retinal degeneration

Wennan Lu; Keith Campagno; Leif Carlsson; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):49.

Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. https://doi.org/10.1167/iovs.19-27241

ARVO Annual Meeting Abstract July 2018

Linking stressed astrocytes to activated microglia through purinergic signaling

Claire H Mitchell; Keith Campagno; Farraj Albalawi; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6034.

ARVO Annual Meeting Abstract July 2018

IL-1β is released by retinal microglial cells in response to ATP and can damage retinal ganglion cells

Wennan Lu; Keith Campagno; Farraj Albalawi; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3729.

ARVO Annual Meeting Abstract June 2017

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Wennan Lu; Alan M Laties; Leif Carlsson; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2034.

ARVO Annual Meeting Abstract June 2017

Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4 -/- mice

Nestor Mas Gomez; Wennan Lu; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1053.

ARVO Annual Meeting Abstract June 2017

Increased IOP primes the NLRP3 inflammasome and increases IL-1β levels

Claire H Mitchell; Farraj Albalawi; Wennan Lu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):851.

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Rise in oxidative stress following lysosomal compromine of RPE cells is eliminated by acid nanoparticles

Pro-inflammatory cytokine IL-1β leads to axonal degeneration and RGC death, is released by retinal microglia, and is primed and activated by P2X7 receptor stimulation following IOP elevation

Mechanosensitive PIEZO1 and PIEZO2 channels in the RPE and in axons of RGCs may initiate cellular responses to tissue stretch

Lysosomal membrane repair and lysophagy following lysosomal damage in RPE cells

Exosome release from RPE cells increased by lysosomal compromise

Photoreceptor death and RPE oxidative stress model of chloroquine retinopathy

TRPML1 channels activation facilitates lysosomal exocytosis and reduces autofluorescent lysosomal accumulations, opsin retention and lipid peroxidation in RPE cells compromised by chloroquine

Mechanical strain results causes cytoskeletal remodeling and cellular elastinopathy in primary optic nerve head astrocytes

Retinal pigment epithelial cells “bulk up” when they “pump iron”: lipid and endolysosome accumulation with mechanistic connection to macular degeneration

Induced pluripotent stem cell derived retinal ganglion cells as in vitro model to study molecular pathobiology in Glaucoma.

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Life beyond death; beneficial signaling by the P2X7 receptor

Sustained oral delivery of ticagrelor (Brilinta) protects against retinal degeneration

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

Linking stressed astrocytes to activated microglia through purinergic signaling

IL-1β is released by retinal microglial cells in response to ATP and can damage retinal ganglion cells

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4 -/- mice

Increased IOP primes the NLRP3 inflammasome and increases IL-1β levels

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