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Clinical and Epidemiologic Research June 2025

Myopia Development During Transition From Kindergarten to Early Grades in Elementary School: Population-Based Evidence From an Epidemic Area in Taiwan

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Yu-Chieh Yang; Der-Chong Tsai; Shao-You Fang; Hsin-Yu Yang; Chiao-Yu Wang; Chia-Wei Lee; Pei-Wei Huang; Mong-Ping Shyong; Yen-Lin Chen; Nai-Wei Hsu
TAGS: child, elementary schools, kindergartens, myopia, taiwan, epidemics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):48. https://doi.org/10.1167/iovs.66.6.48

Includes: Supplemental Content

Retina June 2025

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

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Mariko Sasaki; Kai Xiong Cheong; Crystal Chun Yuen Chong; Marco Yu; Akiko Hanyuda; Kenya Yuki; Kazuno Negishi; Sawako Hashimoto; Kohta Fujiwara; Kohei Sonoda; Ya Xing Wang; Fei Gao; Anyarak Amornpetchsathaporn; Methaphon Chainakul; Ramyaa Srinivasan; Rehana Khan; Rajiv Raman; Paisan Ruamviboonsuk; Sung Ho Kim; Su Jeong Song; Mohammad Hassan Emamian; Hassan Hashemi; Akbar Fotouhi; Juping Liu; Xiaorong Li; Jost B. Jonas; Chui Ming Gemmy Cheung; Tien Yin Wong; Ching-Yu Cheng; Yih Chung Tham; Yasuo Yanagi; Anna Cheng Sim Tan
TAGS: age-related macular degeneration, asian, epidemiology, eye, meta-analysis, choroid, smoking
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):36. https://doi.org/10.1167/iovs.66.6.36

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit June 2025

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

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Huy Nguyen; Russell B. Fletcher; Tom Lopez; Elizabeth Whisler; Kelsey R. Logas; Navrose Dhaliwal; Timothy Suen; Mengrui Zhang; Archana Dilip; Tom Z. Yuan; Hayoung Go; Jay Ye; Parthasarathy Sampathkumar; Nick Suen; Hui Chen; Wen-Chen Yeh; Yang Li; Yorick Post
TAGS: lacrimal gland, ligation, acinar cells, mice, body tissue, wounds and injuries, organoids
Trans. Vis. Sci. Tech.. 2025; 14(6):19. https://doi.org/10.1167/tvst.14.6.19

Includes: Supplemental Content

Artificial Intelligence May 2025

Grading of Foveal Hypoplasia Using Deep Learning on Retinal Fundus Images

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Tsung-Ying Tsai; Ying-Feng Chang; Eugene Yu-Chuan Kang; Kuan-Jen Chen; Nan-Kai Wang; Laura Liu; Yih-Shiou Hwang; Chi-Chun Lai; Sin-You Chen; Jenhui Chen; Chao-Sung Lai; Wei-Chi Wu
TAGS: deep learning, foveal hypoplasia, datasets, clinicians
Trans. Vis. Sci. Tech.. 2025; 14(5):18. https://doi.org/10.1167/tvst.14.5.18

Includes: Supplemental Content

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Immunology and Microbiology May 2025

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

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Qiurong Zhu; Maryam Shayan; Rachel M. Huckfeldt; Yihe Chen
TAGS: interleukin-15, interleukin-7, memory, t-lymphocytes, uveitis, mice, neutralization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):9. https://doi.org/10.1167/iovs.66.5.9

Includes: Supplemental Content

Immunology and Microbiology May 2025

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

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Luis Longoria-Gonzalez; Phillip S. Coburn; Roger Astley; Yan Chen; Michelle C. Callegan
TAGS: endophthalmitis, eye, infections, mice, pathogenesis, staphylococcus aureus
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):11. https://doi.org/10.1167/iovs.66.5.11

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Development of a natural wideview 3D scene fMRI dataset for modeling human spatial cognition

Joseph Obriot; Pei-Yin Chen; Atsushi Wada
TAGS: cognition, datasets, functional magnetic resonance imaging, posters
Journal of Vision. 2025; 25(5):16. https://doi.org/10.1167/jov.25.5.16

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Retina February 2025

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

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Yijing Chen; Xiaoya Zhang; Yanli Zhang; Shian Zhang; Yu Huo; Yubo Wu; Lijun Shen; Jianbo Mao
TAGS: anti-vascular endothelial growth factor therapy, aqueous humor, exudative age-related macular degeneration, metabolites, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):37. https://doi.org/10.1167/iovs.66.2.37

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Retinal Cell Biology January 2025

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

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Qi Liu; Ling-Xiao Xia; Wan-Zhao Yi; Ya-Ni Wu; Shuo-Shuo Gu; Jian-Ying Chen; Ting-Ting Liu; Ying-Hui Lu; Yu-Hong Cui; Jing Meng; Hong-Wei Pan
TAGS: cyclin d1, endothelial cells, proto-oncogene proteins c-akt, retinal neovascularization, cell cycle, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):66. https://doi.org/10.1167/iovs.66.1.66

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

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Yanping Chen; Ruilin Xiong; Jian Zhang; Shaopeng Yang; Huangdong Li; Ziyu Zhu; Peiyuan Wang; Mingguang He; Yingfeng Zheng; Wei Wang
TAGS: adult, child, eye, incidence, myopia, vision, visual impairment, blindness, world health organization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):2. https://doi.org/10.1167/iovs.66.1.2

Includes: Supplemental Content

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

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Myopia Development During Transition From Kindergarten to Early Grades in Elementary School: Population-Based Evidence From an Epidemic Area in Taiwan

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

Grading of Foveal Hypoplasia Using Deep Learning on Retinal Fundus Images

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Temporal Contour Integration Deficits in Children With Amblyopia

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Poster Session: Development of a natural wideview 3D scene fMRI dataset for modeling human spatial cognition

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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