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ARVO Annual Meeting Abstract June 2021

Perifoveal Chorioretinal Atrophy Following Subretinal Injection of Voretigene Neparvovec-rzyl for RPE65-mediated Leber Congenital Amaurosis

William S Gange; Robert A Sisk; Cagri G Besirli; Thomas C Lee; Mark Borchert; Jesse Sengillo; Carlos Mendoza; Audina M Berrocal; Aaron Nagiel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3292. doi:

ARVO Annual Meeting Abstract June 2021

Modulation of pyruvate kinase M2 activity as a therapy in a primary RPE cell culture model of proliferative vitreoretinopathy

Katie Xiaoou Li; Moloy T. Goswami; Qitao Zhang; Hima Bindu Durumutla; Sraboni Chaudhury; Cagri G Besirli; Jason Miller; Thomas J Wubben

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2213. doi:

ARVO Annual Meeting Abstract June 2021

HK2 and PKM2 deletion leads to outer segment shortening and photoreceptor degeneration

Eric Weh; Katie Xiaoou Li; Heather Hager; Sarah Sheskey; Thomas J Wubben; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2985. doi:

ARVO Annual Meeting Abstract June 2021

Quantitative Analysis of VEGF in Infant Tears as a Biomarker for ROP

Omar Moinuddin; Jessie Magnani; Sanjana Sathrasala; Mercy Pawar; Rebecca Vartanian; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3257. doi:

ARVO Annual Meeting Abstract June 2021

Glutaminase deficiency disrupts the bioenergetic and antioxidant fidelity of photoreceptors to induce rapid degeneration

Moloy Goswami; Eric Weh; Hima Bindu Durmutla; Heather Hager; Sraboni Chaudhury; costas lyssiotis; Cagri G Besirli; Thomas J Wubben

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3075. doi:

ARVO Annual Meeting Abstract June 2020

Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database

Emily Ann Eton; Thomas J Wubben; Cagri G Besirli; Peiying Hua; Brendan McGeehan; Brian L VanderBeek

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2993. doi:

ARVO Annual Meeting Abstract June 2020

Development of novel pyruvate kinase muscle isoform 2 (PKM2) activators for photoreceptor neuroprotection

Thomas J Wubben; Jason C Rech; Mercy D Pawar; Eric Weh; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4938. doi:

Review June 2020

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

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Debra A. Thompson; Alessandro Iannaccone; Robin R. Ali; Vadim Y. Arshavsky; Isabelle Audo; James W. B. Bainbridge; Cagri G. Besirli; David G. Birch; Kari E. Branham; Artur V. Cideciyan; Steven P. Daiger; Deniz Dalkara; Jacque L. Duncan; Abigail T. Fahim; John G. Flannery; Roberto Gattegna; John R. Heckenlively; Elise Heon; K. Thiran Jayasundera; Naheed W. Khan; Henry Klassen; Bart P. Leroy; Robert S. Molday; David C. Musch; Mark E. Pennesi; Simon M. Petersen-Jones; Eric A. Pierce; Rajesh C. Rao; Thomas A. Reh; Jose A. Sahel; Dror Sharon; Paul A. Sieving; Enrica Strettoi; Paul Yang; David N. Zacks; The Monaciano Consortium
TAGS: outcome measures, retinal diseases, surrogate endpoints, genetics, vision, natural history, ethics, gene therapy
Trans. Vis. Sci. Tech.. 2020; 9(7):2. doi: https://doi.org/10.1167/tvst.9.7.2

Articles September 2019

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

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Hakan Demirci; Naziha Slimani; Mercy Pawar; Ronald E. Kumon; Prem Vaishnava; Cagri G. Besirli
TAGS: ferumoxytol, hyperthermia, nanoparticles, neoplasms, retinoblastoma, epithelial cells
Trans. Vis. Sci. Tech.. 2019; 8(5):18. doi: https://doi.org/10.1167/tvst.8.5.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Potential cancer therapy for activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

Thomas Wubben; Mercy D Pawar; Eric Weh; Zuzanna Lutrzykowska; Andrew Smith; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5178. doi:

ARVO Annual Meeting Abstract July 2019

Protective role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in photoreceptor death

Mercy D Pawar; Taichi Suzuki; Kevin Toolan; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6606. doi:

ARVO Annual Meeting Abstract July 2019

Survey of Intravitreal Injection Practice Patterns among Retina Specialists

Stephen J Smith; Therese Sassalos; Nish Patel; Chris Andrews; David C Musch; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):109. doi:

ARVO Annual Meeting Abstract July 2019

Photoreceptor Metabolic Reprogramming in an In-Vivo Model of NaIO3 Induced Retinal Degeneration

Omar Moinuddin; Eric Weh; Zuzanna Lutrzykowska; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1679. doi:

ARVO Annual Meeting Abstract July 2019

The neuroprotective role of Hexokinase 2 in photoreceptor survival

Eric Weh; Zuzanna Lutrzykowska; Mercy D Pawar; Heather Hager; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1721. doi:

Articles May 2019

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

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Tapan P. Patel; Tyson N. Kim; Gina Yu; Vaidehi S. Dedania; Philip Lieu; Cynthia X. Qian; Cagri G. Besirli; Hakan Demirci; Todd Margolis; Daniel A. Fletcher; Yannis M. Paulus
TAGS: cell phones, diagnostic imaging, fundus photography, pediatrics, retinal diseases, retinal imaging, child, retina
Trans. Vis. Sci. Tech.. 2019; 8(3):29. doi: https://doi.org/10.1167/tvst.8.3.29

Retina July 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

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Lee Kiang; Bing X. Ross; Jingyu Yao; Sumathi Shanmugam; Chris A. Andrews; Sean Hansen; Cagri G. Besirli; David N. Zacks; Steven F. Abcouwer
TAGS: cytokine, inflammatory response, mice, microglia, retinal detachment, vitreous body, retina, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3767-3778. doi: https://doi.org/10.1167/iovs.18-24489

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Clinical feasibility of ultra-rapid, non-pharmacologic anesthesia for intravitreal injection in patients receiving anti-VEGF treatment

Cagri G Besirli; Stephen Smith; Kevin Pipe; Gunho Kim; David N. Zacks; Thomas W. Gardner; Anjali Shah

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1618. doi:

ARVO Annual Meeting Abstract July 2018

PI3K and MEK Signaling and Effects of Kinase Inhibitors in a Retinoblastoma Cell Model

Andrew Smith; Mercy Pawar; Marcian E Van Dort; Stefanie Galbán; Greg Thurber; Brian D Ross; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1629. doi:

ARVO Annual Meeting Abstract July 2018

Selective death of Y79 retinoblastoma cells by magnetic hyperthermia via caspase dependent apoptotic pathway

Mercy D Pawar; Naziha Slimani; Zeynep Gursel Ozkurt; Ronald Tackett; Ronald Edward Kumon; Prem Vaishnava; Cagri G Besirli; Hakan Demirci

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1631. doi:

ARVO Annual Meeting Abstract July 2018

Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration

Thomas Wubben; Mercy Pawar; Andrew Smith; Kevin Toolan; Heather Hager; Cagri G Besirli

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4448. doi:

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Perifoveal Chorioretinal Atrophy Following Subretinal Injection of Voretigene Neparvovec-rzyl for RPE65-mediated Leber Congenital Amaurosis

Modulation of pyruvate kinase M2 activity as a therapy in a primary RPE cell culture model of proliferative vitreoretinopathy

HK2 and PKM2 deletion leads to outer segment shortening and photoreceptor degeneration

Quantitative Analysis of VEGF in Infant Tears as a Biomarker for ROP

Glutaminase deficiency disrupts the bioenergetic and antioxidant fidelity of photoreceptors to induce rapid degeneration

Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database

Development of novel pyruvate kinase muscle isoform 2 (PKM2) activators for photoreceptor neuroprotection

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE-19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle

Potential cancer therapy for activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

Protective role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in photoreceptor death

Survey of Intravitreal Injection Practice Patterns among Retina Specialists

Photoreceptor Metabolic Reprogramming in an In-Vivo Model of NaIO3 Induced Retinal Degeneration

The neuroprotective role of Hexokinase 2 in photoreceptor survival

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

Clinical feasibility of ultra-rapid, non-pharmacologic anesthesia for intravitreal injection in patients receiving anti-VEGF treatment

PI3K and MEK Signaling and Effects of Kinase Inhibitors in a Retinoblastoma Cell Model

Selective death of Y79 retinoblastoma cells by magnetic hyperthermia via caspase dependent apoptotic pathway

Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration

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