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ARVO Annual Meeting Abstract June 2025

Investigating the role of Vitamin D in the pathology of glucocorticoid-induced ocular hypertension (GC-OHT).

Pinkal Patel; Gaurang Patel; Eldon E Geisert; J Cameron Millar; Stacy Curry; Sherri Feris; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2992.

ARVO Annual Meeting Abstract June 2025

Knock-down of Glucocorticoid Receptor Beta (GRβ) Enhances the Ocular Hypertensive Response to Dexamethasone in C57BL/6J Mice

J Cameron Millar; Pinkal Patel; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2991.

ARVO Annual Meeting Abstract June 2024

Murine Aqueous Outflow Facility as Measured by Constant Flow or Constant Pressure Infusion Diminishes in a Time-Dependent Manner Following Enucleation

J Cameron Millar; Sam Yacoub

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1265.

ARVO Annual Meeting Abstract June 2024

Glucocorticoid-induced pathology in human trabecular meshwork potentially involves alteration of the epigenetic landscape via select long non-coding RNAs (LncRNA).

Pinkal Patel; Gaurang Patel; J Cameron Millar; Eldon E Geisert; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3581.

ARVO Annual Meeting Abstract June 2024

Enhancing mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration.

Prabhavathi Maddineni; Bindu Kodati; J Cameron Millar; Sam Yacoub; Yogapriya Sundaresan; Balasankara Reddy Kaipa; Abbot F Clark; Gulab.S Zode

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4879.

ARVO Annual Meeting Abstract June 2023

Comparison of Effects Upon Intraocular Inflammation and Murine Aqueous Humor Dynamics Parameters of Intravitreal Injection of Ad5.CMV.hTGFβ 2 C226/228S and LV.hTGFβ 2 C226/228S

J Cameron Millar; Shruti V Patil; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3478.

ARVO Annual Meeting Abstract June 2023

Mouse strain differences in development of glucocorticoid-induced ocular hypertension

Pinkal D Patel; Gaurang Patel; Eldon E Geisert; J Cameron Millar; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):411.

ARVO Annual Meeting Abstract June 2022

Viral delivery approaches for CRISPR/Cas9-based knockdown of the Myocilin gene in Trabecular Meshwork

Shruti V Patil; Sam Yacoub; Bindu Kodati; Bhavani Nagarajan; J Cameron Millar; Ramesh B Kasetti; Stacy Curry; Charles Kiehlbauch; Charles C. Searby; Qihong Zhang; Abbot F Clark; Val C. Sheffield; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):87 – A0060.

ARVO Annual Meeting Abstract June 2022

Schlemm canal-targeted Tie2 knockdown (SC-Tie2 KD) as mouse model of adult-onset human glaucoma

Alejandra Bosco; Cesar O Romero; Joon Schwakopf; Oleg Yarishkin; J Cameron Millar; Michael Steele; David Krizaj; Monica L Vetter

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1848.

Glaucoma February 2022

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models

PDF

Uttio Roy Chowdhury; J. Cameron Millar; Bradley H. Holman; Kjersten J. Anderson; Peter I. Dosa; Gavin W. Roddy; Michael P. Fautsch
TAGS: animal model, intraocular pressure, mice, ocular hypertension, diazoxide, katp channels, eye, steroids
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):15. https://doi.org/10.1167/iovs.63.2.15

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

PDF

Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

A novel mouse model of TGFβ2-induced ocular hypertension using lentiviral gene delivery

Shruti V Patil; Ramesh B Kasetti; Charles Kiehlbauch; J Cameron Millar; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):493.

Glaucoma May 2021

ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice

PDF

Avani A. Mody; J. Cameron Millar; Abbot F. Clark
TAGS: aqueous humor, hypertension, intraocular pressure, mice, ocular hypertension, intravitreal injections, regulation, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):3. https://doi.org/10.1167/iovs.62.6.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Increased expression of the chronic ER stress-induced transcriptional factor, ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Ramesh Kasetti; Pinkal Patel; Prabhavathi Maddineni; Shruti Patil; Charles Kiehlbauch; J Cameron Millar; Charles Searby; Val C Sheffield; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1236.

ARVO Annual Meeting Abstract June 2020

Impaired TRPV4-eNOS signaling in glaucomatous trabecular meshwork contributes to elevation of intraocular pressure

Pinkal Patel; Ramesh Kasetti; Prabhavathi Maddineni; J Cameron Millar; Yen-Lin Chen; Swapnil K Sonkusare; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2784.

ARVO Annual Meeting Abstract July 2019

Activation of TRPV4 channels reduces IOP and improves outflow facility by regulating eNOS dependent NO release from the TM

Pinkal D Patel; Ramesh Kasetti; prabhavathi maddineni; J Cameron Millar; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6473.

Glaucoma May 2019

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

PDF

Gaurang C. Patel; J. Cameron Millar; Abbot F. Clark
TAGS: glaucoma, glucocorticoid receptors, glucocorticoids, medication therapy management, mice, ocular hypertension, trans-activation (genetics), intraocular pressure, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1967-1978. https://doi.org/10.1167/iovs.18-26383

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Mouse Eye Perfusion In-Vivo Versus Ex-Vivo: Influence on Aqueous Outflow Facility

J Cameron Millar; Navita N Lopez; Urmimala Raychaudhuri; Abbot F. Clark

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1655.

ARVO Annual Meeting Abstract July 2018

TRPV4-mediated regulation of intraocular pressure and outflow facility in mouse model of glucocorticoid-induced ocular hypertension

Pinkal Patel; J Cameron Millar; Ramesh Kasetti; prabhavathi maddineni; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4728.

ARVO Annual Meeting Abstract July 2018

Glucocorticoid-Induced Ocular Hypertension in Mice Requires Glucocorticoid Receptor Transactivation Activity

Abbot F. Clark; J Cameron Millar; Gaurang Patel

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6037.

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Investigating the role of Vitamin D in the pathology of glucocorticoid-induced ocular hypertension (GC-OHT).

Knock-down of Glucocorticoid Receptor Beta (GRβ) Enhances the Ocular Hypertensive Response to Dexamethasone in C57BL/6J Mice

Murine Aqueous Outflow Facility as Measured by Constant Flow or Constant Pressure Infusion Diminishes in a Time-Dependent Manner Following Enucleation

Glucocorticoid-induced pathology in human trabecular meshwork potentially involves alteration of the epigenetic landscape via select long non-coding RNAs (LncRNA).

Enhancing mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration.

Comparison of Effects Upon Intraocular Inflammation and Murine Aqueous Humor Dynamics Parameters of Intravitreal Injection of Ad5.CMV.hTGFβ 2 C226/228S and LV.hTGFβ 2 C226/228S

Mouse strain differences in development of glucocorticoid-induced ocular hypertension

Viral delivery approaches for CRISPR/Cas9-based knockdown of the Myocilin gene in Trabecular Meshwork

Schlemm canal-targeted Tie2 knockdown (SC-Tie2 KD) as mouse model of adult-onset human glaucoma

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

A novel mouse model of TGFβ2-induced ocular hypertension using lentiviral gene delivery

ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice

Increased expression of the chronic ER stress-induced transcriptional factor, ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Impaired TRPV4-eNOS signaling in glaucomatous trabecular meshwork contributes to elevation of intraocular pressure

Activation of TRPV4 channels reduces IOP and improves outflow facility by regulating eNOS dependent NO release from the TM

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

Mouse Eye Perfusion In-Vivo Versus Ex-Vivo: Influence on Aqueous Outflow Facility

TRPV4-mediated regulation of intraocular pressure and outflow facility in mouse model of glucocorticoid-induced ocular hypertension

Glucocorticoid-Induced Ocular Hypertension in Mice Requires Glucocorticoid Receptor Transactivation Activity

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