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ARVO Annual Meeting Abstract June 2025

The 'Common Soil' Hypothesis in AMD: Cardiovascular disease, diabetes and hypertension within E3 Consortium

Jeroen Vermeulen; Haras Mhmud; Joëlle E. Vergroesen; Maryam Kavousi; Geir Bertelsen; Anthony Khawaja; Iris Heid; Caroline Brandl; Jost B. Jonas; Yara T E Lechanteur; Carel C B Hoyng; Louis Arnould; Fotis Topouzis; Rita Alexandra Coimbra; Caroline C W Klaver

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):278.

ARVO Annual Meeting Abstract June 2025

Baseline Characteristics of Adolescent Stargardt Disease Subjects Participating in a Phase 3 Study of Tinlarebant (DRAGON Trial)

Ruifang Sui; Isabelle Audo; P Belin; Paul S Bernstein; Catherine Cassiman; Qing Chang; Ta-Ching Chen; Thomas Edwards; Nicolas Feltgen; John R Grigg; philipp herrmann; Carel C B Hoyng; Yih-Shiou Hwang; christinen kay; Laura Kuehlewein; Bart Peter Leroy; LS Leung; Kai Ma; Michel Michaelides; abhishek sharma; James E Self; R Wong; Hendrik P Scholl; Nathan L Mata

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1463.

ARVO Annual Meeting Abstract June 2025

Performing a second photodynamic therapy in recurrent central serous chorioretinopathy

Femke Van den Tillaart; Anahid Komrojan; Carel C B Hoyng; José P. Martinez Ciriano; Suzanne Yzer

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2451.

ARVO Annual Meeting Abstract June 2025

Retinal Sensitivity Decline Rate is Equally in Both Eyes of Patients with USH2A- related Retinitis Pigmentosa

Mechteld C.S. van Olden; Jeroen A.A.H. Pas; Jack Weeda; Ronald J.E. Pennings; Carel C B Hoyng; Suzanne Yzer

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3138.

ARVO Annual Meeting Abstract June 2025

Associations between disease progression, structural biomarkers and polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Lukas Schlößer; Jan Henrik Terheyden; Charlotte Behning; Hannah Klinkhammer; Davide Garzone; Marlene Sassmannshausen; Sarah Thiele; Steffen Schmitz-Valckenberg; Carel C B Hoyng; Clara Sánchez; Matthias Schmid; Ulrich F O Luhmann; Nadia Zakaria; Sergio Leal; Frank G Holz; Robert Patrick Finger

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3674.

Retina April 2025

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

PDF

Jeroen A. A. H. Pas; Catherina H. Z. Li; Filip Van den Broeck; Patty P. A. Dhooge; Julie De Zaeytijd; Rob W. J. Collin; Bart P. Leroy; Carel B. Hoyng
TAGS: age of onset, atrophy, abca4 gene, stargardt's disease, mutation, growth rate
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):76. https://doi.org/10.1167/iovs.66.4.76

Includes: Supplemental Content

Immunology and Microbiology February 2025

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

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Lude Moekotte; Joke H. de Boer; Sanne Hiddingh; Aafke de Ligt; Xuan-Thanh-An Nguyen; Carel B. Hoyng; Chris F. Inglehearn; Martin McKibbin; Tina M. Lamey; Jennifer A. Thompson; Fred K. Chen; Terri L. McLaren; Alaa AlTalbishi; Daan M. Panneman; Erica G. M. Boonen; Sandro Banfi; Béatrice Bocquet; Isabelle Meunier; Elfride De Baere; Robert Koenekoop; Monika Ołdak; Carlo Rivolta; Lisa Roberts; Raj Ramesar; Rasa Strupaitė-Šileikienė; Susanne Kohl; G. Jane Farrar; Marion van Vugt; Jessica van Setten; Susanne Roosing; L. Ingeborgh van den Born; Camiel J. F. Boon; Maria M. van Genderen; Jonas J. W. Kuiper
TAGS: complement system proteins, hereditary retinal dystrophy, plasma, proteins, genotype, proteome, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):55. https://doi.org/10.1167/iovs.66.2.55

Includes: Supplemental Content

Retina October 2024

Endpoints and Design for Clinical Trials in USH2A -Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study

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Maureen G. Maguire; David G. Birch; Jacque L. Duncan; Allison R. Ayala; Lauren N. Ayton; Janet K. Cheetham; Peiyao Cheng; Todd A. Durham; Frederick L. Ferris, III; Carel B. Hoyng; Rachel M. Huckfeldt; Glenn J. Jaffe; Christine Kay; Eleonora M. Lad; Bart P. Leroy; Wendi Liang; Lee S. McDaniel; Michele Melia; Michel Michaelides; Mark E. Pennesi; José-Alain Sahel; Lassana Samarakoon; on behalf of the REDI Working Group and the Foundation Fighting Blindness Clinical Consortium Investigator Group
TAGS: cohort studies, eye, natural history, outcome measures, retinal degeneration, sample size, surrogate endpoints, vision, united states food and drug administration, perimetry
Trans. Vis. Sci. Tech.. 2024; 13(10):15. https://doi.org/10.1167/tvst.13.10.15

Includes: Supplemental Content

Artificial Intelligence September 2024

Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

PDF

Coen de Vente; Philippe Valmaggia; Carel B. Hoyng; Frank G. Holz; Mohammad M. Islam; Caroline C. W. Klaver; Camiel J. F. Boon; Steffen Schmitz-Valckenberg; Adnan Tufail; Marlene Saßmannshausen; Clara I. Sánchez; on behalf of the MACUSTAR Consortium
TAGS: datasets, deep learning, eye, retinal atrophy, retinal pigment epithelium, biological markers, cohort studies, training
Trans. Vis. Sci. Tech.. 2024; 13(9):11. https://doi.org/10.1167/tvst.13.9.11

Includes: Supplemental Content

Genetics August 2024

Frequency and Genetic Spectrum of Inherited Retinal Dystrophies in a Large Dutch Pediatric Cohort: The RD5000 Consortium

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Pam A. T. Heutinck; L. Ingeborgh van den Born; Maikel Vermeer; Adriana I. Iglesias Gonzales; Carel B. Hoyng; Jan Willem R. Pott; Hester Y. Kroes; Mary J. van Schooneveld; Camiel J. F. Boon; Maria M. van Genderen; Astrid S. Plomp; Yvonne de Jong-Hesse; Michelle B. van Egmond-Ebbeling; Lies H. Hoefsloot; Arthur A. Bergen; Caroline C. W. Klaver; Magda A. Meester-Smoor; Alberta A. H. J. Thiadens; Virginie J. M. Verhoeven
TAGS: child, cohort studies, dutch, genetics, hereditary retinal dystrophy, pediatrics, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):40. https://doi.org/10.1167/iovs.65.10.40

Includes: Supplemental Content

Retina June 2024

Unveiling Statins and Genetics in Age-Related Macular Degeneration: The Coimbra Eye Study—Report 9

PDF

Patrícia Barreto; Cláudia Farinha; Rita Coimbra; Maria Luz Cachulo; Joana Barbosa Melo; Yara Lechanteur; Carel B. Hoyng; José Cunha-Vaz; Rufino Silva
TAGS: age-related macular degeneration, eye, statins, genetics, study report
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):38. https://doi.org/10.1167/iovs.65.6.38

ARVO Annual Meeting Abstract June 2024

CDHR1- associated retinal degeneration: clinical phenotypes, natural history and molecular genetics from 135 cases

Imran H Yusuf; Richard Caswell; Stephen H Tsang; Carmen Ayuso; Dror Sharon; Juliana M F Sallum; Carel C B Hoyng; Petra Liskova; Ajoy Vincent; Madhavan Jagadeesan; Bart Peter Leroy; Jose Millán; Smaragda Kamakari; Andrew Webster; Robert E MacLaren; Peter Charbel Issa

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2132.

ARVO Annual Meeting Abstract June 2024

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Lukas Schloesser; Jan Henrik Terheyden; Charlotte Behning; Hannah Klinkhammer; Davide Garzone; Marlene Sassmannshausen; Steffen Schmitz-Valckenberg; Carel C B Hoyng; Clarisa Sanchez; Ulrich F O Luhmann; Klaus-Peter Moll; Sergio Leal; Matthias Schmid; Frank G Holz; Robert Finger

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):378.

ARVO Annual Meeting Abstract June 2024

Visual functioning and generic health in Stargardt disease (STGD1): a cross-sectional study

Catherina Li; Jeroen A.A.H. Pas; Francesco Cinque; Nathalie M Bax; Stanley Lambertus; Lena Ye; Patty P.A. Dhooge; Carel C B Hoyng; Caroline M van Heugten

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1829.

ARVO Annual Meeting Abstract June 2024

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Tobias Peters; Katarina Stingl; Wolfgang Klein; Mario G Fsadni; Nils Meland; Patty P.A. Dhooge; Camiel Boon; Andrew Lotery; Maurizio Battaglia Parodi; Philipp Herrmann; Frank G Holz; Steffen Schmitz-Valckenberg; Philipp Möller; Carel C B Hoyng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2205.

ARVO Annual Meeting Abstract June 2024

Natural Course of Atrophy Growth Rate on Fundus Autofluorescence in a Large Cohort of Stargardt Patients

Jeroen Adrianus Antonius Hendrikus Pas; Catherina Li; Filip Van Den Broeck; Patty P.A. Dhooge; Julie De Zaeytijd; Bart Peter Leroy; Rob Collin; Carel C B Hoyng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3828.

ARVO Annual Meeting Abstract June 2024

Sequencing 105 macula disease-associated genes in an AMD cohort highlights the involvement of PRPH2 , BEST1 and RP1 in AMD-mimicking diseases.

Rebekkah Hitti-Malin; Anna Tracewska; Carel C B Hoyng; Caroline C W Klaver; Yara Lechanteur; Anneke I. Den Hollander; Björn Bakker; Erica G.M. Boonen; Susanne Roosing; Frans Cremers

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4662.

ARVO Annual Meeting Abstract June 2024

Association between the genetic risk score and extramacular drusen in an age-related macular degeneration cohort - The Coimbra Eye Study

Rita Coimbra; Claudia Farinha; Patrícia Barreto; Maria da Luz Cachulo; José Cunha-Vaz; Yara Lechanteur; Carel C B Hoyng; Rufino Silva

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4389.

ARVO Annual Meeting Abstract June 2024

Uncovering statins with genetics in age-related macular degeneration

Patrícia Barreto; Claudia Farinha; Rita Coimbra; Maria da Luz Cachulo; Joana Melo; Carel C B Hoyng; Yara Lechanteur; José Cunha-Vaz; Rufino Silva

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4355.

ARVO Annual Meeting Abstract June 2024

Retinal Degeneration Associated With RPGRIP1: A Phenotypic Spectrum, and Genotype–Phenotype Correlation.

Hind Almushattat; Michalis Georgiou; Jonathan Hensman; Filip Van Den Broeck; Carel C B Hoyng; Alberta Thiadens; L. Ingeborgh van den Born; Maria Genderen; Bart Peter Leroy; Michel Michaelides; Camiel Boon

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5121.

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The 'Common Soil' Hypothesis in AMD: Cardiovascular disease, diabetes and hypertension within E3 Consortium

Baseline Characteristics of Adolescent Stargardt Disease Subjects Participating in a Phase 3 Study of Tinlarebant (DRAGON Trial)

Performing a second photodynamic therapy in recurrent central serous chorioretinopathy

Retinal Sensitivity Decline Rate is Equally in Both Eyes of Patients with USH2A- related Retinitis Pigmentosa

Associations between disease progression, structural biomarkers and polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

Endpoints and Design for Clinical Trials in USH2A -Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study

Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

Frequency and Genetic Spectrum of Inherited Retinal Dystrophies in a Large Dutch Pediatric Cohort: The RD5000 Consortium

Unveiling Statins and Genetics in Age-Related Macular Degeneration: The Coimbra Eye Study—Report 9

CDHR1- associated retinal degeneration: clinical phenotypes, natural history and molecular genetics from 135 cases

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Visual functioning and generic health in Stargardt disease (STGD1): a cross-sectional study

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Natural Course of Atrophy Growth Rate on Fundus Autofluorescence in a Large Cohort of Stargardt Patients

Sequencing 105 macula disease-associated genes in an AMD cohort highlights the involvement of PRPH2 , BEST1 and RP1 in AMD-mimicking diseases.

Association between the genetic risk score and extramacular drusen in an age-related macular degeneration cohort - The Coimbra Eye Study

Uncovering statins with genetics in age-related macular degeneration

Retinal Degeneration Associated With RPGRIP1: A Phenotypic Spectrum, and Genotype–Phenotype Correlation.

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