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Genetics November 2021

ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers

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Sahar Gelfman; Dominique Monnet; Ann J. Ligocki; Thierry Tabary; Arden Moscati; Xiaodong Bai; Jan Freudenberg; Blerta Cooper; Jack A. Kosmicki; Sarah Wolf; Manuel A. R. Ferreira; John Overton; Jonathan Weyne; Eli A. Stahl; Aris Baras; Carmelo Romano; Jacques H. M. Cohen; Giovanni Coppola; Antoine Brézin; for the Regeneron Genetics Center
TAGS: alleles, human leukocyte antigens, vitiliginous chorioretinitis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):3. doi: https://doi.org/10.1167/iovs.62.14.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

An AAV vector carrying a chimeric photopigment for evaluating gene therapy methods in Old World primates

Rachel Barborek; Jessica Rowlan; James Kuchenbecker; Dragos Rezeanu; Marcus Mazzaferri; Briyana Bembry; Jose Rojas; Yajun Tang; Carmelo Romano; Jay Neitz; Maureen Neitz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2785. doi:

ARVO Annual Meeting Abstract June 2021

Identification and spatial distribution of novel molecular features of adult human corneal cell subtypes

Guillermo Lehmann; Ann J Ligocki; Wen Fury; Christian Gutierrez; Christina Adler; Tao Yang; Min Ni; Yu Bai; Yi Wei; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):687. doi:

ARVO Annual Meeting Abstract June 2021

Suprachoroidal space injection of AAV provides widespread gene expression in the mouse eye.

Shireen Khattak; Matthew-Mina Reyad; Duo Sun; Yang Liu; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1193. doi:

ARVO Annual Meeting Abstract June 2021

A novel method to rapidly expand and perform single cell sequencing on T cells from vitreous biopsies

Raquel Deering; Wen Fury; Sunil K. Srivastava; Se Jeong; Sumit Sharma; Kimberly Baynes; Ashley Lowe; Michael Ramos; Evangelia Malahias; Christina Adler; Min Ni; Yi Wei; Mickey Atwal; Carmelo Romano; Gavin Thurston; jonathan weyne

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3463. doi:

ARVO Annual Meeting Abstract June 2021

Intravitreal administration, but not systemic administration, of VEGF Mini-Trap effectively inhibits neovascularization in the Oxygen Induced Retinopathy (OIR) in mice

Eunice Cheung; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3293. doi:

ARVO Annual Meeting Abstract June 2021

An Aflibercept-derived Mini-VEGF-Trap as a Potential Next-Generation VEGF Inhibitor

Raymond Wilson Leidich; Krunal Patel; Ashique Rafique; Annabel Romero Hernandez; Matthew Franklin; Miguel Lazo; Aynur Hermann; Gitanjali Sharma; Yiming Zhao; Hunter Chen; Nina Liu; Michael Rosconi; Carmelo Romano; William Olson; Neil Stahl

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):204. doi:

ARVO Annual Meeting Abstract July 2019

Systemic anti- IL6R antibody administration limits infiltrating leukocytes in pericyte depletion model in mice.

Eunice Cheung; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):243. doi:

ARVO Annual Meeting Abstract July 2019

Retinal physiological changes in Thyroid Stimulating Hormone Receptor Knock Out mice

Adrianna Latuszek; Rajeevalochan Wudali; Ying Hu; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3116. doi:

ARVO Annual Meeting Abstract July 2019

Intracameral Administration of AAV Serotypes and their Ocular Tissue Tropism

Anabel Doumad; Blerta Cooper; Kristin Mathias; Sven Moller-Tank; Ann Ligocki; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3365. doi:

ARVO Annual Meeting Abstract July 2019

Effect of triamcinolone in a rabbit model of sustained retinal neovascularization and leak.

Bibiana Iglesias; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3669. doi:

ARVO Annual Meeting Abstract July 2019

Intravitreal injection of NPR1 antibody in humanized NPR1 mice lowers intraocular pressure

Ming Yuan; Hua Yang; Gaurang Patel; Adrianna Latuszek; Ying Hu; William Poueymirou; Jingtai Cao; William Olson; Brian Zambrowicz; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3771. doi:

ARVO Annual Meeting Abstract July 2019

NPR expression in eyes of different mammalian species by RNAscope@

Hua Yang; Ming Yuan; Gaurang Patel; Adrianna Latuszek; Ying Hu; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5142. doi:

ARVO Annual Meeting Abstract July 2018

Aflibercept in combination with nesvacumab (anti-Ang2) induces vascular remodeling in a rabbit model of pathological neovascularization.

Bibiana Iglesias; Thomas MacPherson; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1447. doi:

ARVO Annual Meeting Abstract July 2018

Effect of Anti-Human C5 Antibodies on Ocular Inflammation in Experimental Autoimmune Uveitis in Humanized C5 Mice Aixu Sun, Henry Chen, Hua Yang, Adrianna Latuszek, Ying Hu, Pamela Krueger, Tammy Huang, Jingtai Cao, Carmelo Romano Regeneron Pharmaceuticals, Inc. Tarrytown, NY

Aixu Sun; Henry Chen; Hua Yang; Adrianna Latuszek; Ying Hu; Pamela Krueger; Tammy Huang; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2534. doi:

ARVO Annual Meeting Abstract July 2018

Wild Type and Mutant Retinoschisin Subunits Co-assemble When Expressed in the Same Cells

Duo Sun; Yang Liu; Nicole Zazzarino; Jifang Tao; Joel Martin; William Olson; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3050. doi:

ARVO Annual Meeting Abstract July 2018

Neuroprotective effect of TrkB agonist antibody in humanized TrkB rat

Henry Chen; Adrianna Latuszek; Ying Hu; Jeffrey Lee; William Poueymirou; Jingtai Cao; William Olson; Brian Zambrowicz; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6134. doi:

ARVO Annual Meeting Abstract July 2018

VEGFR1 inhibition hinders developmental retinal vessel outgrowth in pups and reduces pathological neovascularization in OIR model in mice

Eunice Cheung; Jingtai Cao; Carmelo Romano

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5461. doi:

Retina February 2018

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration

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Jingtai Cao; Thomas C. MacPherson; Bibiana V. Iglesias; Yang Liu; Natasha Tirko; George D. Yancopoulos; Stanley J. Wiegand; Carmelo Romano
TAGS: aflibercept, eye, injections, oryctolagus cuniculus, retinal neovascularization, diagnostic imaging, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1033-1044. doi: https://doi.org/10.1167/iovs.17-22897

ARVO Annual Meeting Abstract September 2016

In vivo assessment of the impact of neutralizing antibodies on intravitreal AAV2.7m8 administration

Annahita Keravala; Kathryn W Woodburn; Sharmila Vijay; Carmelo Romano; Stanley J Wiegand; Andrew Murphy; Thomas Walter Chalberg; Mehdi Gasmi

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):782. doi:

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ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers

An AAV vector carrying a chimeric photopigment for evaluating gene therapy methods in Old World primates

Identification and spatial distribution of novel molecular features of adult human corneal cell subtypes

Suprachoroidal space injection of AAV provides widespread gene expression in the mouse eye.

A novel method to rapidly expand and perform single cell sequencing on T cells from vitreous biopsies

Intravitreal administration, but not systemic administration, of VEGF Mini-Trap effectively inhibits neovascularization in the Oxygen Induced Retinopathy (OIR) in mice

An Aflibercept-derived Mini-VEGF-Trap as a Potential Next-Generation VEGF Inhibitor

Systemic anti- IL6R antibody administration limits infiltrating leukocytes in pericyte depletion model in mice.

Retinal physiological changes in Thyroid Stimulating Hormone Receptor Knock Out mice

Intracameral Administration of AAV Serotypes and their Ocular Tissue Tropism

Effect of triamcinolone in a rabbit model of sustained retinal neovascularization and leak.

Intravitreal injection of NPR1 antibody in humanized NPR1 mice lowers intraocular pressure

NPR expression in eyes of different mammalian species by RNAscope@

Aflibercept in combination with nesvacumab (anti-Ang2) induces vascular remodeling in a rabbit model of pathological neovascularization.

Effect of Anti-Human C5 Antibodies on Ocular Inflammation in Experimental Autoimmune Uveitis in Humanized C5 Mice Aixu Sun, Henry Chen, Hua Yang, Adrianna Latuszek, Ying Hu, Pamela Krueger, Tammy Huang, Jingtai Cao, Carmelo Romano Regeneron Pharmaceuticals, Inc. Tarrytown, NY

Wild Type and Mutant Retinoschisin Subunits Co-assemble When Expressed in the Same Cells

Neuroprotective effect of TrkB agonist antibody in humanized TrkB rat

VEGFR1 inhibition hinders developmental retinal vessel outgrowth in pups and reduces pathological neovascularization in OIR model in mice

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration

In vivo assessment of the impact of neutralizing antibodies on intravitreal AAV2.7m8 administration

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