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ARVO Annual Meeting Abstract June 2022

A 6-Month GLP Toxicology Study of a Novel Hydrogel-based, Axitinib Intravitreal Implant (OTX-TKI) in Non-Human Primates

Chintan Patel; Erica Kahn; Megan Priem; Joe Iacona; Andrew Vanslette; Erik Wong; Charles D Blizzard; Peter K Jarrett; Michael Goldstein; Rabia Gurses-Ozden

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):298 – F0101. doi:

ARVO Annual Meeting Abstract June 2022

A Safety and Pharmacokinetic Study of a Novel Hydrogel-based Axitinib Intravitreal Implant (OTX-TKI) in Non-Human Primates

Erica Kahn; Chintan Patel; Megan Priem; Joe Iacona; Andrew Vanslette; Erik Wong; Charles D Blizzard; Peter K Jarrett; Michael Goldstein; Rabia Gurses-Ozden

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):297 – F0100. doi:

ARVO Annual Meeting Abstract June 2022

Safety and Pharmacodynamic Assessment of Repeated Intracameral Travoprost Implant Administration in Beagle Dogs

Charles D Blizzard; Chintan Patel; Jeremy Hartman; Sean Serell; Kevin Yeh; Andrew Vanslette; Peter K Jarrett; Michael Goldstein; Rabia Gurses-Ozden

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2852 – A0375. doi:

ARVO Annual Meeting Abstract June 2022

Pharmacokinetics of a Hydrogel-based Nepafenac Intracanalicular Insert in Canines

Oktay Uzun; Ankita Desai; Sanjani Ray; Chintan Patel; Charles D Blizzard; Peter K Jarrett; Michael Goldstein

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):447. doi:

ARVO Annual Meeting Abstract June 2022

Pharmacokinetics of a Hydrogel-based Besifloxacin Intracanalicular Insert in Canines

Megan Priem; Ankita Desai; Chintan Patel; Charles D Blizzard; Peter K Jarrett; Michael Goldstein

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2128 – F0144. doi:

ARVO Annual Meeting Abstract June 2020

Inflammatory cytokine analysis of ocular fluids from a primate model of chronic vascular leakage and neovascularization

Chintan Patel; Donnicia James; Wenzheng Hu; Robin J Goody; Rahel Zulliger; Gabriella Widmer; Peter D Westenskow; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5395. doi:

ARVO Annual Meeting Abstract July 2019

Targeting neurovascular injury: Arginase 1 promotes angiogenic repair and limits neurodegeneration

Ruth B Caldwell; Abdelrahman Y Fouda; Zhimin Xu; Jutamas Suwanpradid; Modesto Rojas; Esraa Shosha; Chintan Patel; Ji Xing; S. Priya Narayanan; Robert W. Caldwell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3258. doi:

ARVO Annual Meeting Abstract July 2019

Characterization of DL-2-aminoadipic acid-induced histopathological changes in nonhuman primate retina

Shervin Liddie; Chintan Patel; Wenzheng Hu; Robin J Goody; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5993. doi:

ARVO Annual Meeting Abstract July 2019

Optimization of trabecular meshwork laser strategy to achieve sustained 2-3X intraocular pressure elevation and glaucomatous optic neuropathy in primates

Wenzheng Hu; Chintan Patel; Jamila Martin; Vernard Woodley; Jordan Attwood; Tatiana Corey; Merissa O'connor; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):645. doi:

ARVO Annual Meeting Abstract July 2019

Multiphoton microscopy for three dimensional histology of retinal whole mounts

Chintan Patel; Rick Torres; Eben Olson; Michael Levene; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):183. doi:

ARVO Annual Meeting Abstract July 2019

Quantification of fluorescein leakage induced by DL-2-aminoadipic acid in an experimental model of chronic neovascular leakage

Robin J Goody; Anish Kurian; Akeem Browne; Eleanor Demmons; Darnel Allen; Chintan Patel; Wenzheng Hu; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):200. doi:

ARVO Annual Meeting Abstract July 2018

A primate model of sustained retinal detachment

Chintan Patel; Jordan Attwood; Demetrios G. Vavvas; Matthew S Lawrence; David N. Zacks

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4243. doi:

ARVO Annual Meeting Abstract July 2018

Persistent leaking in long term follow-up in the primate model of DL-2-aminoadipic acid-induced retinal neovascularization and vascular leakage

Wenzheng Hu; Donnicia James; Vernard Woodley; Chintan Patel; Anish Kurian; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5483. doi:

ARVO Annual Meeting Abstract July 2018

Reproducibility and inter-animal variability of electroretinography measures in African green monkeys

Jordan D Attwood; Vernard Woodley; Chintan Patel; Anish Kurian; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5530. doi:

ARVO Annual Meeting Abstract July 2018

Characterization of ocular anatomical and electrophysiological differences between young and geriatric African green monkeys

Shervin Liddie; Chintan Patel; Vernard Woodley; Jordan Attwood; Akeem Browne; Matthew S Lawrence

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5847. doi:

Retina May 2018

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

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Hanfang Zhang; Farlyn Z. Hudson; Zhimin Xu; Rebekah Tritz; Modesto Rojas; Chintan Patel; Stephen B. Haigh; Zsuzsanna Bordán; David A. Ingram; David J. Fulton; Neal L. Weintraub; Ruth B. Caldwell; Brian K. Stansfield
TAGS: endothelial cells, neovascularization, pathologic, neurofibromatosis type 1 protein, retinal neovascularization, vascular endothelial growth factor a, mice, oxygen, hypoxia, proto-oncogene proteins c-akt, retinal diseases
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2520-2528. doi: https://doi.org/10.1167/iovs.17-22588

ARVO Annual Meeting Abstract June 2017

Overexpression of spermine oxidase increases neuronal death and glial activation in a model of retinal excitotoxicity

PRAHALATHAN PICHAVARAM; Chintan Patel; Zhimin Xu; Esraa Shosha; Manuela Cervelli; Ruth B Caldwell; S. Priya Narayanan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5891. doi:

ARVO Annual Meeting Abstract June 2017

Arginase 2 deletion prevents optic nerve crush-induced retinal degeneration

Ruth B Caldwell; Zhimin Xu; S. Priya Narayanan; Tahira Lemtalsi; Chintan Patel; Esraa Shosha; William Caldwell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1760. doi:

ARVO Annual Meeting Abstract June 2017

Overexpression of spermine oxidase in retinal neurons aggravates vascular injury in a model of retinopathy of prematurity

Chintan Patel; PRAHALATHAN PICHAVARAM; Manuela Cervelli; Ruth B Caldwell; S. Priya Narayanan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3463. doi:

ARVO Annual Meeting Abstract September 2016

Treatment with polyamine oxidase inhibitor reduces excitotoxicity-mediated retinal neuro-inflammation

Chintan Patel; Prahalathan Pichavaram; Zhimin Xu; Esraa Shosha; Ruth B Caldwell; S.Priya Narayanan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4416. doi:

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A 6-Month GLP Toxicology Study of a Novel Hydrogel-based, Axitinib Intravitreal Implant (OTX-TKI) in Non-Human Primates

A Safety and Pharmacokinetic Study of a Novel Hydrogel-based Axitinib Intravitreal Implant (OTX-TKI) in Non-Human Primates

Safety and Pharmacodynamic Assessment of Repeated Intracameral Travoprost Implant Administration in Beagle Dogs

Pharmacokinetics of a Hydrogel-based Nepafenac Intracanalicular Insert in Canines

Pharmacokinetics of a Hydrogel-based Besifloxacin Intracanalicular Insert in Canines

Inflammatory cytokine analysis of ocular fluids from a primate model of chronic vascular leakage and neovascularization

Targeting neurovascular injury: Arginase 1 promotes angiogenic repair and limits neurodegeneration

Characterization of DL-2-aminoadipic acid-induced histopathological changes in nonhuman primate retina

Optimization of trabecular meshwork laser strategy to achieve sustained 2-3X intraocular pressure elevation and glaucomatous optic neuropathy in primates

Multiphoton microscopy for three dimensional histology of retinal whole mounts

Quantification of fluorescein leakage induced by DL-2-aminoadipic acid in an experimental model of chronic neovascular leakage

A primate model of sustained retinal detachment

Persistent leaking in long term follow-up in the primate model of DL-2-aminoadipic acid-induced retinal neovascularization and vascular leakage

Reproducibility and inter-animal variability of electroretinography measures in African green monkeys

Characterization of ocular anatomical and electrophysiological differences between young and geriatric African green monkeys

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

Overexpression of spermine oxidase increases neuronal death and glial activation in a model of retinal excitotoxicity

Arginase 2 deletion prevents optic nerve crush-induced retinal degeneration

Overexpression of spermine oxidase in retinal neurons aggravates vascular injury in a model of retinopathy of prematurity

Treatment with polyamine oxidase inhibitor reduces excitotoxicity-mediated retinal neuro-inflammation

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