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ARVO Annual Meeting Abstract June 2023

Remarkable metabolic resilience of rod photoreceptors against reduced OXPHOS caused by chronically active HIF transcription factors

Christian Grimm; Vyara Todorva; Mia F Stauffacher; Luca Ravotto; Sarah Nötzli; Duygu Karademir; Lynn Jenny Alix Ebner; Cornelia Imsand; Luca Merolla; Stefanie Hauck; Marijana Samardzija; Aiman S Saab; L Felipe Barros; Bruno Weber

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3216.

ARVO Annual Meeting Abstract June 2022

Single-cell RNA sequencing of the hypoxic retina identifies an oxygen-dependent isoform switch in RNA-binding proteins and a cone-specific motor protein

Lynn Jenny Alix Ebner; Duygu Karademir; Florian Peters; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4613 – F0405.

ARVO Annual Meeting Abstract June 2021

Single-cell RNA sequencing reveals early responses to degeneration in rods and cones of the rd10 retina

Duygu Karademir; Vyara Todorova; Marijana Samardzija; Lynn Jenny Alix Ebner; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):461.

ARVO Annual Meeting Abstract June 2021

Downregulation of ABCA1 in iPSC-derived RPE cells impaired cholesterol efflux leading to intracellular lipid accumulation

Florian Peters; David Grubich Atac; Wolfgang Berger; Anneke I Den Hollander; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):248.

ARVO Annual Meeting Abstract June 2021

Innovative drug candidates for the treatment of glaucoma

Weder Bruce; Julian Behr; Esra Lone; Reto Naef; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2748.

ARVO Annual Meeting Abstract June 2021

Retinal deficiency of MMACHC does not lead to an ocular phenotype in mice

Eva Kiessling; Viktor Kozich; Jakub Krijt; Sarah Noetzli; Matthias Baumgartner; Sean Froese; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1663.

ARVO Annual Meeting Abstract June 2021

Transcriptomic Analysis of the Mouse Retina after Acute and Chronic Normobaric and Hypobaric Hypoxia

Lynn Jenny Alix Ebner; Marijana Samardzija; Federica Storti; Vyara Todorova; Duygu Karademir; Julian Behr; Fraser Simpson; Markus Thiersch; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3007.

ARVO Annual Meeting Abstract July 2018

HDAC inhibition protects degenerating cones in the cpfl1 mouse by increasing H3K27 and H3K9 tri-methylation

Dragana Trifunovic; Klaudija Masarini; Christian Grimm; Marius Ueffing; Marijana Samardzija

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4447.

ARVO Annual Meeting Abstract July 2018

HIF1A is the responsible factor for cone degeneration and subretinal neovascularization in a mouse model of chronic hypoxia

Maya Barben; Christian Schori; Christian Grimm; Marijana Samardzija

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):965.

ARVO Annual Meeting Abstract July 2018

The ABCA1/G1 lipid-efflux pathway in the retinal pigment epithelium (RPE): a role in development of age-related macular degeneration (AMD)?

Federica Storti; Katrin Klee; Regula Steiner; Thorsten Hornemann; Joshua L Dunaief; Arnold von Eckardstein; Jürgen Fingerle; Cyrille Maugeais; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2454.

ARVO Annual Meeting Abstract July 2018

Loss of Translocator Protein 18 kDa (TSPO) in the retinal pigment epithelium (RPE) of mice may lead to impaired visual function and abnormal RPE morphology

Katrin Klee; Federica Storti; Joshua L Dunaief; Thomas Langmann; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2460.

Special Issue June 2018

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

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Christian Schori; Christian Trachsel; Jonas Grossmann; Ioanna Zygoula; Daniel Barthelmes; Christian Grimm
TAGS: diabetes mellitus, enzyme-linked immunosorbent assay, exudative age-related macular degeneration, proteins, proteome, retinal diseases, vitreous body, proteomics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD31-AMD40. https://doi.org/10.1167/iovs.18-24122

Includes: Supplemental Content

Genetics October 2016

A Novel Method Combining Vitreous Aspiration and Intravitreal AAV2/8 Injection Results in Retina-Wide Transduction in Adult Mice

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Romain Da Costa; Carsten Röger; Jasmin Segelken; Maya Barben; Christian Grimm; John Neidhardt
TAGS: endotracheal aspiration, injections, mice, pulmonary aspiration, retina, vitreous body, aspirations (psychology), inspiration, eye, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5326-5334. https://doi.org/10.1167/iovs.16-19701

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Slowing and prevention of vision loss in Retinitis Pigmentosa of the 'Protein Logistics Disease' type

Mathias W Seeliger; Susanne C Beck; Marina Garcia Garrido; Vithiyanjali Sothilingam; Regine Muehlfriedel; Marijana Samardzija; Christian Grimm; Peter Humphries; G Jane Farrar; Peter Carmeliet; Naoyuki Tanimoto

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2735.

ARVO Annual Meeting Abstract September 2016

Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?

Christian Grimm; Maya Barben; Divya Ail; Brigitt Kast; Christian Schori; Christina Giger-Lange; Stylianos Michalakis; Marijana Samardzija

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract September 2016

Sodium 4-Phenylbutyrate Improves Cone Survival and Function in a Mouse Model for Leber Congenital Amaurosis

Songhua Li; Marijana Samardzija; Zhihui Yang; Christian Grimm; Minghao Jin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3623.

Retinal Cell Biology December 2015

Measuring In Vivo Free Radical Production by the Outer Retina

PDF

Bruce A. Berkowitz; Bryce X. Bredell; Christopher Davis; Marijana Samardzija; Christian Grimm; Robin Roberts
TAGS: free radicals, magnetic resonance imaging, oxidative stress, retina, iodates, sodium, superoxides, mice, diabetes mellitus
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):7931-7938. https://doi.org/10.1167/iovs.15-18420

ARVO Annual Meeting Abstract June 2015

Targeting the translocator protein (18kDa) (TSPO) prevents microglia reactivity and protects from from light induced retinal degeneration

Rebecca Scholz; Alexander Aslanidis; Marcus Karlstetter; Khalid Rashid; Christian Grimm; Thomas Langmann; Experimental Immunology of the eye (Langmann)

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):430.

ARVO Annual Meeting Abstract June 2015

A chronic hypoxia-like response leads to cone degeneration

Maya Barben; Christian Schori; Christian Grimm; Marijana Samardzija

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4645.

ARVO Annual Meeting Abstract June 2015

Attempts to increase protein level, membrane-association, and isomerase activity of R91W RPE65 in mouse model

Songhua Li; Marijana Samardzija; Zhihui Yang; Christian Grimm; Minghao Jin

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5454.

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Remarkable metabolic resilience of rod photoreceptors against reduced OXPHOS caused by chronically active HIF transcription factors

Single-cell RNA sequencing of the hypoxic retina identifies an oxygen-dependent isoform switch in RNA-binding proteins and a cone-specific motor protein

Single-cell RNA sequencing reveals early responses to degeneration in rods and cones of the rd10 retina

Downregulation of ABCA1 in iPSC-derived RPE cells impaired cholesterol efflux leading to intracellular lipid accumulation

Innovative drug candidates for the treatment of glaucoma

Retinal deficiency of MMACHC does not lead to an ocular phenotype in mice

Transcriptomic Analysis of the Mouse Retina after Acute and Chronic Normobaric and Hypobaric Hypoxia

HDAC inhibition protects degenerating cones in the cpfl1 mouse by increasing H3K27 and H3K9 tri-methylation

HIF1A is the responsible factor for cone degeneration and subretinal neovascularization in a mouse model of chronic hypoxia

The ABCA1/G1 lipid-efflux pathway in the retinal pigment epithelium (RPE): a role in development of age-related macular degeneration (AMD)?

Loss of Translocator Protein 18 kDa (TSPO) in the retinal pigment epithelium (RPE) of mice may lead to impaired visual function and abnormal RPE morphology

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

A Novel Method Combining Vitreous Aspiration and Intravitreal AAV2/8 Injection Results in Retina-Wide Transduction in Adult Mice

Slowing and prevention of vision loss in Retinitis Pigmentosa of the 'Protein Logistics Disease' type

Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?

Sodium 4-Phenylbutyrate Improves Cone Survival and Function in a Mouse Model for Leber Congenital Amaurosis

Measuring In Vivo Free Radical Production by the Outer Retina

Targeting the translocator protein (18kDa) (TSPO) prevents microglia reactivity and protects from from light induced retinal degeneration

A chronic hypoxia-like response leads to cone degeneration

Attempts to increase protein level, membrane-association, and isomerase activity of R91W RPE65 in mouse model

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