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Retinal Cell Biology March 2025

Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen

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Erika M. Shaw; David M. Anderson; Ramesh Periasamy; Kevin L. Schey; Christine A. Curcio; Daniel M. Lipinski
TAGS: drusen, suidae, age-related macular degeneration, pigment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):18. https://doi.org/10.1167/iovs.66.3.18

Includes: Supplemental Content

Retina January 2025

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

PDF

Christine A. Curcio; Jeffrey D. Messinger; Andreas Berlin; Kenneth R. Sloan; D. Scott McLeod; Malia M. Edwards; Jacques Bijon; K. Bailey Freund
TAGS: age-related macular degeneration, age-related macular degeneration, nonexudative, atrophic condition of skin, atrophy, autofluorescence, drusen, fundus autofluorescence imaging, histology, pathology, clinical, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):49. https://doi.org/10.1167/iovs.66.1.49

Includes: Multimedia, Supplemental Content

Retina December 2024

Band Visibility in High-Resolution Optical Coherence Tomography Assessed With a Custom Review Tool and Updated, Histology-Derived Nomenclature

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Lukas Goerdt; Thomas A. Swain; Deepayan Kar; Gerald McGwin; Andreas Berlin; Mark E. Clark; Cynthia Owsley; Kenneth R. Sloan; Christine A. Curcio
TAGS: eye, histology, optical coherence tomography, retina, software, reliability, volume electron microscopy, diagnostic imaging
Trans. Vis. Sci. Tech.. 2024; 13(12):19. https://doi.org/10.1167/tvst.13.12.19

Includes: Multimedia, Supplemental Content

Retina August 2024

Extent and Topography of Subretinal Drusenoid Deposits Associate With Rod-Mediated Vision in Aging and AMD: ALSTAR2 Baseline

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Lukas Goerdt; Mohymina Amjad; Thomas A. Swain; Gerald McGwin; Mark E. Clark; Cynthia Owsley; Kenneth R. Sloan; Christine A. Curcio; Deepayan Kar
TAGS: digestive tract decontamination, rod photoreceptors, vision, eye, aging
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):25. https://doi.org/10.1167/iovs.65.10.25

Includes: Supplemental Content

Retina August 2024

Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT

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Jungeun Won; Hiroyuki Takahashi; Stefan B. Ploner; Wenke Karbole; Omar Abu-Qamar; Antonio Yaghy; Anna Marmalidou; Stephanie Kaiser; Yunchan Hwang; Junhong Lin; Andre Witkin; Shilpa Desai; Caroline R. Baumal; Andreas Maier; Christine A. Curcio; Nadia K. Waheed; James G. Fujimoto
TAGS: age-related macular degeneration, aging, biological response modifiers, epithelium, eye, pigment, volume, motion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):18. https://doi.org/10.1167/iovs.65.10.18

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging July 2024

Choriocapillaris Impairment, Visual Function, and Distance to Fovea in Aging and Age-Related Macular Degeneration: ALSTAR2 Baseline

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Deepayan Kar; Mohymina Amjad; Giulia Corradetti; Thomas A. Swain; Mark E. Clark; Gerald McGwin, Jr.; Kenneth R. Sloan; Cynthia Owsley; SriniVas R. Sadda; Christine A. Curcio
TAGS: age-related macular degeneration, aging, fovea centralis, vision, impairment, rod photoreceptors, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):40. https://doi.org/10.1167/iovs.65.8.40

ARVO Annual Meeting Abstract June 2024

Outer Retinal Thickness is Associated with Cognitive Function in Normal Aging to Intermediate Age-related Macular Degeneration (AMD)

Cynthia Owsley; Gerald McGwin; Thomas A. Swain; Mark E Clark; Tracy N Thomas; Lucas Goerdt; Kenneth R Sloan; Emily Trittschuh; Yu Jiang; Julia Owen; Cecilia S Lee; Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2267.

ARVO Annual Meeting Abstract June 2024

Thinning of outer retina is associated with decreased hippocampal volume and cortical thinning in Alzheimer’s disease related areas

Yu Jiang; Thomas A. Swain; Christine Mac Donald; Ariel Rokem; Julia P Owen; Gerald McGwin; Christine A Curcio; Kenneth R Sloan; Emily H Trittschuh; Swati Rane Levendovszky; Mark E Clark; Cynthia Owsley; Cecilia S Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):446.

ARVO Annual Meeting Abstract June 2024

Validation of the Low Luminance Questionnaire (LLQ) in Normal Aging and Early and Intermediate Age-related Macular Degeneration (AMD)

Thomas A. Swain; Scott S Snyder; Catherine A Cukras; Christine A Curcio; Gerald McGwin; Cynthia Owsley

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3343.

ARVO Annual Meeting Abstract June 2024

The SD-OCT correlates of fundus autofluorescence in geographic atrophy: a comprehensive point-to-point analysis of fundus autofluorescence with SD-OCT using phase 3 trials DERBY and OAKS.

Konstantinos Balaskas; Bart Liefers; Robbert Struyven; siegfried wagner; Sophie Glinton; Gongyu Zhang; Livia Faes; Veronika Lipkova; Gunjan Naik; Pallavi Bagga; Praveen J Patel; Alex McKeown; Lukas Scheibler; Christine A Curcio; Dun Jack Fu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):449.

ARVO Annual Meeting Abstract June 2024

Clinicopathological features of retinal glial and choroidal changes in an eye with multi-focal geographic atrophy.

Malia Michelle Edwards; D. Scott McLeod; Imran Ahmed Bhutto; Jeffrey Messinger; Andreas Berlin; Jacques Bijon; K Bailey Freund; Christine A Curcio

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):763.

ARVO Annual Meeting Abstract June 2024

Rod-mediated dark adaptation (RMDA) at 5° is correlated with subretinal drusenoid deposit (SDD) area in eyes with and without age-related macular degeneration (AMD): ALSTAR2 baseline

Mohymina Amjad; Thomas A. Swain; Gerald McGwin; Kenneth R Sloan; Cynthia Owsley; Christine A Curcio; Deepayan Kar

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2295.

ARVO Annual Meeting Abstract June 2024

Histology of fundus autofluorescence (FAF) in multifocal geographic atrophy (GA) with thick choroid in age-related macular degeneration (AMD)

Christine A Curcio; Jeffrey Messinger; Andreas Berlin; Malia Michelle Edwards; D. Scott McLeod; Jacques Bijon; K. Bailey Freund

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2284.

ARVO Annual Meeting Abstract June 2024

Spatially resolved lipidomics analysis of the soft drusen in human donor retina with age-related macular degeneration

Ankita Kotnala; David M. G. Anderson; Zhen Wang; Lukasz G. Migas; Dongfeng Cao; Jeffrey Messinger; Thomas Ach; Raf Van de Plas; Christine A Curcio; Kevin L Schey

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3807.

ARVO Annual Meeting Abstract June 2024

Volume Electron Microscopy Reconstruction of Human Subfoveal Bruch’s Membrane/Choriocapillaris Transport Complex

Maximilian Lindell; Deepayan Kar; Jeffrey Messinger; Yeon Jin Kim; Orin Packer; Ursula Schmidt-Erfurth; Michael Marsh; Dennis M Dacey; Christine A Curcio; Andreas Pollreisz

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4951.

Retina May 2024

Probing Deposit-Driven Age-Related Macular Degeneration Via Thicknesses of Outer Retinal Bands and Choroid: ALSTAR2 Baseline

PDF

Mehdi Emamverdi; Charles Vatanatham; Sohaib Fasih-Ahmad; Ziyuan Wang; Zubin Mishra; Anjal Jain; Anushika Ganegoda; Mark E. Clark; Abbas Habibi; Maryam Ashrafkhorasani; Cynthia Owsley; Christine A. Curcio; Zhihong J. Hu; SriniVas R. Sadda
TAGS: age-related macular degeneration, choroid, digestive tract decontamination, drusen, eye, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):17. https://doi.org/10.1167/iovs.65.5.17

Includes: Supplemental Content

Retina May 2024

Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration

PDF

Cynthia Owsley; Gerald McGwin, Jr.; Thomas A. Swain; Mark E. Clark; Tracy N. Thomas; Lukas Goerdt; Kenneth R. Sloan; Emily H. Trittschuh; Yu Jiang; Julia P. Owen; Cecilia S. Lee; Christine A. Curcio
TAGS: age-related macular degeneration, aging, cognition, cognitive ability, mental processes, retina, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):16. https://doi.org/10.1167/iovs.65.5.16

Review March 2024

Age-Related Macular Degeneration, a Mathematically Tractable Disease

PDF

Christine A. Curcio; Deepayan Kar; Cynthia Owsley; Kenneth R. Sloan; Thomas Ach
TAGS: age-related macular degeneration, aging, drusen, eye, fovea centralis, lutein, macula lutea, photoreceptors, retina, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):4. https://doi.org/10.1167/iovs.65.3.4

Includes: Supplemental Content

Retina February 2024

Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration – ALSTAR2 Baseline

PDF

Sohaib Fasih-Ahmad; Ziyuan Wang; Zubin Mishra; Charles Vatanatham; Mark E. Clark; Thomas A. Swain; Christine A. Curcio; Cynthia Owsley; SriniVas R. Sadda; Zhihong Jewel Hu
TAGS: age-related macular degeneration, biological markers, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):1. https://doi.org/10.1167/iovs.65.2.1

Includes: Supplemental Content

Retina January 2024

Spectral Analysis of Human Retinal Pigment Epithelium Cells in Healthy and AMD Eyes

PDF

Leonie Bourauel; Marc Vaisband; Leon von der Emde; Katharina Bermond; Ioana Sandra Tarau; Rainer Heintzmann; Frank G. Holz; Christine A. Curcio; Jan Hasenauer; Thomas Ach
TAGS: eye, granules, retinal pigment cell, spectrum analysis, retinal pigment epithelium, lipofuscin, autofluorescence, donors, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):10. https://doi.org/10.1167/iovs.65.1.10

Includes: Supplemental Content

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Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

Band Visibility in High-Resolution Optical Coherence Tomography Assessed With a Custom Review Tool and Updated, Histology-Derived Nomenclature

Extent and Topography of Subretinal Drusenoid Deposits Associate With Rod-Mediated Vision in Aging and AMD: ALSTAR2 Baseline

Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT

Choriocapillaris Impairment, Visual Function, and Distance to Fovea in Aging and Age-Related Macular Degeneration: ALSTAR2 Baseline

Outer Retinal Thickness is Associated with Cognitive Function in Normal Aging to Intermediate Age-related Macular Degeneration (AMD)

Thinning of outer retina is associated with decreased hippocampal volume and cortical thinning in Alzheimer’s disease related areas

Validation of the Low Luminance Questionnaire (LLQ) in Normal Aging and Early and Intermediate Age-related Macular Degeneration (AMD)

The SD-OCT correlates of fundus autofluorescence in geographic atrophy: a comprehensive point-to-point analysis of fundus autofluorescence with SD-OCT using phase 3 trials DERBY and OAKS.

Clinicopathological features of retinal glial and choroidal changes in an eye with multi-focal geographic atrophy.

Rod-mediated dark adaptation (RMDA) at 5° is correlated with subretinal drusenoid deposit (SDD) area in eyes with and without age-related macular degeneration (AMD): ALSTAR2 baseline

Histology of fundus autofluorescence (FAF) in multifocal geographic atrophy (GA) with thick choroid in age-related macular degeneration (AMD)

Spatially resolved lipidomics analysis of the soft drusen in human donor retina with age-related macular degeneration

Volume Electron Microscopy Reconstruction of Human Subfoveal Bruch’s Membrane/Choriocapillaris Transport Complex

Probing Deposit-Driven Age-Related Macular Degeneration Via Thicknesses of Outer Retinal Bands and Choroid: ALSTAR2 Baseline

Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration

Age-Related Macular Degeneration, a Mathematically Tractable Disease

Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration – ALSTAR2 Baseline

Spectral Analysis of Human Retinal Pigment Epithelium Cells in Healthy and AMD Eyes

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