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Cornea October 2024

Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

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Ebru Yaman; Nicole Heyer; Cintia S. de Paiva; Mary Ann Stepp; Stephen C. Pflugfelder; Jehan Alam
TAGS: cornea, mice, rna, small cytoplasmic, heterogeneity, sequence analysis, rna, rna-seq, genes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):29. https://doi.org/10.1167/iovs.65.12.29

Includes: Supplemental Content

Immunology and Microbiology July 2024

Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease–Like Lacrimal Gland Pathology

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Kaitlin K. Scholand; Jeremias Galletti; Wolfgang Haap; Tiago Santos-Ferreira; Christoph Ullmer; Cintia S. de Paiva
TAGS: autoimmunity, cathepsins, mice, sjogren's syndrome, pathology, t-lymphocytes, lacrimal gland, cornea
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):26. https://doi.org/10.1167/iovs.65.8.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

CD4 + T cells drive corneal nerve damage but are dispensable for corneal epitheliopathy development in the context of dry eye

Alexia Vereertbrugghen; Manuela Pizzano; Agostina Cernutto; Florencia Sabbione; Irene Angelica Keitelman; Carolina Maiumi Shiromizu; Douglas Vera Aguilar; Federico Fuentes; Mirta Nilda Giordano; Analia Trevani; Cintia S De Paiva; Jeremias Gaston Galletti

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):985.

ARVO Annual Meeting Abstract June 2024

Conjunctival transcriptome changes in Sjögren Syndrome and non-Sjögren Syndrome aqueous-tear-deficient dry eye

Cintia S De Paiva; Stephen C Pflugfelder; Zhiyuan Yu; Robert Britton; Laura Schaefer; Kaitlin Scholand

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):412.

ARVO Annual Meeting Abstract June 2024

Single cell analysis of desiccation induced changes in cornea immune cell populations

Jahan Alam; Ebru Yaman; Gerda Cristal Villalba Silva; Rui Chen; Cintia S De Paiva; Mary Ann Stepp; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2908.

ARVO Annual Meeting Abstract June 2024

Recombinant extracellular domain Klotho-α attenuates senescence in human corneal epithelial cells

Lois Kim; Wonsuk Choi; Amy Tran; Cintia S De Paiva; Ajay Sharma

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2015.

ARVO Annual Meeting Abstract June 2024

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Na Lin; XIN CHEN; Haixia Liu; Cintia S De Paiva; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5720.

ARVO Annual Meeting Abstract June 2024

Ocular, oral and gut microbiomes characterization of patients with Stevens-Johnson Syndrome compared to Sjogren Syndrome and healthy patients

Talita Trevizani Rocchetti; Luciana Frizon; Ana Luisa Hofling-Lima; Denise Freitas; Cintia S De Paiva; Paulo J.M. Bispo; José Álvaro Pereira Gomes

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5609.

ARVO Annual Meeting Abstract June 2024

Specificity matters: Strategies to enhance data accuracy in single-cell RNA sequencing of lacrimal glands

Vanessa DELCROIX; Olivier Mauduit; Cintia S De Paiva; Helen P Makarenkova

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6545.

ARVO Annual Meeting Abstract June 2024

Exploring the Transformative Effects of Calorie Restriction on the Lacrimal Gland

Olivier Mauduit; Kaitlin Scholand; Laura Schaefer; Vanessa DELCROIX; Zhiyuan Yu; Helen P Makarenkova; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6544.

ARVO Annual Meeting Abstract June 2024

Fluorescence lifetime imaging of aged murine lacrimal glands shows multiple metabolic changes

Jason Junge; Minchang Choi; Cindy Toscano; Maria Edman; Cintia S De Paiva; Sarah Hamm-Alvarez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6589.

Physiology and Pharmacology June 2024

The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation

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Minchang Choi; Cindy Toscano; Maria C. Edman; Cintia S. de Paiva; Sarah F. Hamm-Alvarez
TAGS: aging, langer-giedion syndrome, lipids, macrophages, mice, niemann-pick disease, type c, mice, inbred c57bl, proteins, fluorescent antibody technique, lacrimal gland
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):1. https://doi.org/10.1167/iovs.65.6.1

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology May 2024

Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing

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Anmar Abu-Romman; Kaitlin K. Scholand; Gowthaman Govindarajan; Zhiyuan Yu; Sonali Pal-Ghosh; Mary A. Stepp; Cintia S. de Paiva
TAGS: cornea, debridement, epithelium, mice, wound healing, wounds and injuries, corneal epithelium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):21. https://doi.org/10.1167/iovs.65.5.21

Includes: Supplemental Content

Anatomy and Pathology/Oncology August 2023

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

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Jeremias G. Galletti; Kaitlin K. Scholand; Claudia M. Trujillo-Vargas; Wolfgang Haap; Tiago Santos-Ferreira; Christoph Ullmer; Zhiyuan Yu; Cintia S. de Paiva
TAGS: aging, cathepsins, dry eye syndromes, mice, phenotype, diet
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):7. https://doi.org/10.1167/iovs.64.11.7

Includes: Supplemental Content

Cornea & External Disease June 2023

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

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Stephen P. Yoon; Zhiyuan Yu; Stephen C. Pflugfelder; Cintia S. de Paiva
TAGS: proteins, sjogren's syndrome, keratoconjunctivitis sicca
Trans. Vis. Sci. Tech.. 2023; 12(6):8. https://doi.org/10.1167/tvst.12.6.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Dry Eye Disease: Understanding the biological contributions of Aging and Sex

Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4754.

ARVO Annual Meeting Abstract June 2023

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Stephen C Pflugfelder; Jahan Alam; Cintia S. De Paiva; De-Quan Li; Ghasem Yasdanpanah; Kaitlyn Xiong; Zhen Zhong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):681.

ARVO Annual Meeting Abstract June 2023

Regulatory T cells are essential for controlling autoimmune eye and lacrimal gland pathogenic cells

Kaitlin Scholand; Jeremias Gaston Galletti; Gowthaman Govindarajan; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):176.

ARVO Annual Meeting Abstract June 2023

SINGLE CELL ATLAS OF THE ADULT LACRIMAL GLAND UNCOVERS CELLULAR COMPLEXITY, PROGENITOR-LIKE CELLS AND SEXUAL DIMORPHISM

Vanessa DELCROIX; Olivier Mauduit; Hyun Soo Lee; Anastasiia Ivanova; Takeshi Umazume; Sarah Knox; Cintia S. De Paiva; Darlene A Dartt; Helen P Makarenkova

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):164.

ARVO Annual Meeting Abstract June 2023

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress

Laura Schaefer; Stephen C Pflugfelder; Robert Britton; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):697.

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Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease–Like Lacrimal Gland Pathology

CD4 + T cells drive corneal nerve damage but are dispensable for corneal epitheliopathy development in the context of dry eye

Conjunctival transcriptome changes in Sjögren Syndrome and non-Sjögren Syndrome aqueous-tear-deficient dry eye

Single cell analysis of desiccation induced changes in cornea immune cell populations

Recombinant extracellular domain Klotho-α attenuates senescence in human corneal epithelial cells

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Ocular, oral and gut microbiomes characterization of patients with Stevens-Johnson Syndrome compared to Sjogren Syndrome and healthy patients

Specificity matters: Strategies to enhance data accuracy in single-cell RNA sequencing of lacrimal glands

Exploring the Transformative Effects of Calorie Restriction on the Lacrimal Gland

Fluorescence lifetime imaging of aged murine lacrimal glands shows multiple metabolic changes

The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation

Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing

Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

Dry Eye Disease: Understanding the biological contributions of Aging and Sex

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Regulatory T cells are essential for controlling autoimmune eye and lacrimal gland pathogenic cells

SINGLE CELL ATLAS OF THE ADULT LACRIMAL GLAND UNCOVERS CELLULAR COMPLEXITY, PROGENITOR-LIKE CELLS AND SEXUAL DIMORPHISM

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress

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