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Retinal Cell Biology August 2023

Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells

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M. Helena Cardoso; Michael J. Hall; Thomas Burgoyne; Pedro Fale; Tina Storm; Cristina Escrevente; Pedro Antas; Miguel C. Seabra; Clare E. Futter
TAGS: cathepsin d, chloroquine, lysosomes, retinal pigment cell, platypnea orthodeoxia syndrome, gold
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):10. https://doi.org/10.1167/iovs.64.11.10

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

TFEB-mediated reduction of autofluorescent granule load in retinal pigment epithelium

Miguel Seabra; Ana S. Falcao; Mafalda Lopes-da-Silva; Pedro Antas; Ana C. Fradinho; Luisa Lemos; Thomas Ciossek; Paul Nicklin; Clare Futter; Sandra Tenreiro

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):311 – F0114.

ARVO Annual Meeting Abstract June 2022

Morphological heterogeneity of the lysosomes of the retinal pigment epithelium

Clare Futter; Thomas Burgoyne; Pedro Fale; Tina Storm; Miguel Seabra; Michael Hall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3034 – F0405.

Retinal Cell Biology July 2021

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

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Cristina Escrevente; Ana S. Falcão; Michael J. Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel M. Mesquita; Inês S. Ferreira; M. Helena Cardoso; Daniela Oliveira; Ana C. Fradinho; Thomas Ciossek; Paul Nicklin; Clare E. Futter; Sandra Tenreiro; Miguel C. Seabra
TAGS: granules, lipofuscin, lysosomes, pathophysiology, retinal pigment epithelium, cathepsin d, flow cytometry, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):39. https://doi.org/10.1167/iovs.62.9.39

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

Miguel Seabra; Cristina Escrevente; Ana Sofia Falcão; Michael J Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel Mesquita; Inês Ferreira; Helena Cardoso; Ana Fradinho; Clare E Futter; Sandra Tenreiro

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3278.

ARVO Annual Meeting Abstract July 2019

Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration

Miguel Seabra; M. Helena Cardoso; Michael Hall; A. Sofia Falcão; Cristina Escrevente; Pedro Antas; Gabriela V. Santos; Sandra Tenreiro; Clare E. Futter

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1246.

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. https://doi.org/10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

Retinal Cell Biology January 2019

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

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Tina Storm; Thomas Burgoyne; Joshua L. Dunaief; Erik I. Christensen; Clare Futter; Rikke Nielsen
TAGS: ablation, ldl-receptor related protein 2, retinal degeneration, mice, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):322-330. https://doi.org/10.1167/iovs.18-25667

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2017

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Miguel C Seabra; Matthew Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1039.

ARVO Annual Meeting Abstract September 2016

KCNJ13 -related energy crisis: Mitochondrial dynamics in the retinal degeneration zebrafish model.

Dhani Tracey-White; Maria Toms; Dhakshi Muhundhakumar; Matthew Smart; Thomas Burgoyne; Glen Jeffery; Clare Futter; Andrew Webster; Mariya Moosajee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2743.

ARVO Annual Meeting Abstract June 2015

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Tanya Tolmachova; Diogo A. Feleciano; Clare E. Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2321.

ARVO Annual Meeting Abstract April 2014

Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia

Dhani Tracey-White; Valerie De Luca; Clare Futter; Anthony T Moore; Andrew Webster; Miguel C Seabra; Christian P Hamel; Vasiliki Kalatzis; Mariya Moosajee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3302.

ARVO Annual Meeting Abstract April 2014

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Tanya Tolmachova; Diogo A Feleciano; Silene Wavre-Shapton; Martin J Evans; Clare Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3459.

ARVO Annual Meeting Abstract April 2014

Mechanisms of photoreceptor degeneration in choroideremia

Ingrid Porpino Meschede; Tanya Tolmachova; Miguel C Seabra; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4367.

ARVO Annual Meeting Abstract March 2012

Thermoreversible PLGA-PEG-PLGA Copolymer Hydrogel As A Carrier For Descemet’s Membrane Endothelial Keratoplasty (DMEK)

Naing L. Tint; Amritpaul Dhillon; Roozbeh Qodratnama; Matt Hayes; Clare Futter; Felicity R. Rose; Bruce D. Allan

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):65.

ARVO Annual Meeting Abstract March 2012

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Clare Futter; Ingrid P. Meschede; Silene T. Wavre; Mafalda Lopes Da Silva; Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3701.

Biochemistry and Molecular Biology October 2010

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

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Tanya Tolmachova; Silene T. Wavre-Shapton; Alun R. Barnard; Robert E. MacLaren; Clare E. Futter; Miguel C. Seabra
TAGS: choroideremia, mice, mice, knockout, photoreceptors, retinal pigment epithelium, tissue degeneration, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4913-4920. https://doi.org/10.1167/iovs.09-4892

Lens September 2005

Interaction with Collagen IV Protects Lens Epithelial Cells from Fas-Dependent Apoptosis by Stimulating the Production of Soluble Survival Factors

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Clare E. Futter; Jonathan G. Crowston; Bruce D. S. Allan
TAGS: apoptosis, collagen type iv, culture media, conditioned, lens epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2005; 46(9):3256-3262. https://doi.org/10.1167/iovs.05-0086

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Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells

TFEB-mediated reduction of autofluorescent granule load in retinal pigment epithelium

Morphological heterogeneity of the lysosomes of the retinal pigment epithelium

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

KCNJ13 -related energy crisis: Mitochondrial dynamics in the retinal degeneration zebrafish model.

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Mechanisms of photoreceptor degeneration in choroideremia

Thermoreversible PLGA-PEG-PLGA Copolymer Hydrogel As A Carrier For Descemet’s Membrane Endothelial Keratoplasty (DMEK)

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

Interaction with Collagen IV Protects Lens Epithelial Cells from Fas-Dependent Apoptosis by Stimulating the Production of Soluble Survival Factors

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