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ARVO Annual Meeting Abstract June 2022

Molecular pathology of the glaucomatous optic nerve head

Colleen M McDowell; Emma K Geiduschek

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2705 – A0069. doi:

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

A20 may alter the fibrotic response within the trabecular meshwork by attenuating TGFβ2-TLR4 signaling crosstalk

Philip Mzyk; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):486. doi:

ARVO Annual Meeting Abstract June 2021

Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork and optic nerve head damage in mice

Colleen M McDowell; Timur Mavlyutov

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2345. doi:

ARVO Annual Meeting Abstract June 2020

A20 may be involved in TGFβ2-TLR4 signaling crosstalk within the trabecular meshwork

Philip Mzyk; Humberto Hernandez; Tasneem Putliwala Sharma; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3461. doi:

ARVO Annual Meeting Abstract June 2020

Characterization of PRG4 expression, localization, and function in trabecular meshwork cells

Colleen M McDowell; Timur Mavlyutov; Alyssa Morin; Emily Anne Hicks; Aftab Taiyab; Alarifi Abdulaziz; Gregory Jay; Heather Sheardown; Tannin Schmidt

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3458. doi:

ARVO Annual Meeting Abstract July 2019

TLR4 signaling in the human trabecular meshwork

Colleen M McDowell; Tasneem Putliwala Sharma

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5135. doi:

ARVO Annual Meeting Abstract July 2019

Modulating human intraocular and intracranial pressure using the ex-vivo Translaminar Autonomous System

Tasneem Putliwala Sharma; Abbot F Clark; Husain Lohawala; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2247. doi:

ARVO Annual Meeting Abstract July 2018

Crosstalk Between TGFβ2 and TLR4 in the Trabecular Meshwork

Amanda L. Roberts; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4712. doi:

ARVO Annual Meeting Abstract July 2018

TLR4 signaling in the human trabecular meshwork and optic nerve head

Colleen M McDowell; Tasneem Putliwala Sharma

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4713. doi:

ARVO Annual Meeting Abstract July 2018

Novel Ex-Vivo Translaminar Autonomous System to study effects of Intraocular and Intracranial pressure differential on Human Retinal Ganglion Cells.

Tasneem Putliwala Sharma; Abbot F. Clark; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1214. doi:

Glaucoma April 2018

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

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Humberto Hernandez; J. Cameron Millar; Stacy M. Curry; Abbot F. Clark; Colleen M. McDowell
TAGS: activins, extracellular matrix, mice, tissue membrane, trabecular meshwork, eye, fibronectins, ocular hypertension, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2154-2166. doi: https://doi.org/10.1167/iovs.17-23282

Includes: Supplemental Content

Glaucoma March 2017

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork

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Humberto Hernandez; Wanda E. Medina-Ortiz; Tomi Luan; Abbot F. Clark; Colleen M. McDowell
TAGS: signal transduction, toll-like receptor 4, trabecular meshwork, transforming growth factors, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1811-1823. doi: https://doi.org/10.1167/iovs.16-21331

ARVO Annual Meeting Abstract September 2016

RGC death in a mouse model of congenital glaucoma

Steffi Daniel; Michael G Anderson; Abbot F Clark; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2521. doi:

ARVO Annual Meeting Abstract September 2016

Tissue transglutaminase causes intraocular pressure elevation in mice

Urmimala Raychaudhuri; J Cameron Millar; Colleen M McDowell; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4683. doi:

ARVO Annual Meeting Abstract September 2016

Effect of BAMBI expression on intraocular pressure and aqueous humor outflow facility in mice

Humberto Hernandez; J Cameron Millar; Abbot F Clark; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6452. doi:

ARVO Annual Meeting Abstract September 2016

Crosstalk between TGFβ2 and TLR4 in the trabecular meshwork

Colleen M McDowell; Humberto Hernandez; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

Glaucoma August 2015

Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling

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Colleen M. McDowell; Humberto Hernandez; Weiming Mao; Abbot F. Clark
TAGS: eye, mice, ocular hypertension, signal transduction, smad3 gene, intraocular pressure, proteins, injections
Invest. Ophthalmol. Vis. Sci.. 2015; 56(9):5485-5492. doi: https://doi.org/10.1167/iovs.15-16993

ARVO Annual Meeting Abstract June 2015

Retina ganglion cell subtype specific cell death following optic nerve crush in mice

Steffi Daniel; Andrew Huberman; Abbot F Clark; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2442. doi:

Glaucoma June 2014

Monitoring Retinal Morphologic and Functional Changes in Mice Following Optic Nerve Crush

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Yang Liu; Colleen M. McDowell; Zhang Zhang; Holly E. Tebow; Robert J. Wordinger; Abbot F. Clark
TAGS: mice, optic nerve, cell count, electroretinography, retina
Invest. Ophthalmol. Vis. Sci.. 2014; 55(6):3766-3774. doi: https://doi.org/10.1167/iovs.14-13895

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Molecular pathology of the glaucomatous optic nerve head

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

A20 may alter the fibrotic response within the trabecular meshwork by attenuating TGFβ2-TLR4 signaling crosstalk

Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork and optic nerve head damage in mice

A20 may be involved in TGFβ2-TLR4 signaling crosstalk within the trabecular meshwork

Characterization of PRG4 expression, localization, and function in trabecular meshwork cells

TLR4 signaling in the human trabecular meshwork

Modulating human intraocular and intracranial pressure using the ex-vivo Translaminar Autonomous System

Crosstalk Between TGFβ2 and TLR4 in the Trabecular Meshwork

TLR4 signaling in the human trabecular meshwork and optic nerve head

Novel Ex-Vivo Translaminar Autonomous System to study effects of Intraocular and Intracranial pressure differential on Human Retinal Ganglion Cells.

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork

RGC death in a mouse model of congenital glaucoma

Tissue transglutaminase causes intraocular pressure elevation in mice

Effect of BAMBI expression on intraocular pressure and aqueous humor outflow facility in mice

Crosstalk between TGFβ2 and TLR4 in the trabecular meshwork

Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling

Retina ganglion cell subtype specific cell death following optic nerve crush in mice

Monitoring Retinal Morphologic and Functional Changes in Mice Following Optic Nerve Crush

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