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Genetics July 2019

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma

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Adriana I. Iglesias; Jue Sheng Ong; Anthony P. Khawaja; Puya Gharahkhani; Milly S. Tedja; Virginie J. M. Verhoeven; Pieter W. M. Bonnemaijer; Roger C. W. Wolfs; Terri L. Young; Nomdo M. Jansonius; Jamie E. Craig; Dwight Stambolian; Cornelia M. van Duijn; Stuart MacGregor; Caroline C. W. Klaver; for the International Glaucoma Genetics Consortium (IGGC) and Consortium for Refractive Error and Myopia (CREAM)
TAGS: myopia, open-angle glaucoma, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3142-3149. doi: 10.1167/iovs.18-26231

Includes: Supplemental Content

Genetics October 2017

A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma

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Mohsen Ghanbari; Adriana I. Iglesias; Henriët Springelkamp; Cornelia M. van Duijn; M. Arfan Ikram; Abbas Dehghan; Stefan J. Erkeland; Caroline C. W. Klaver; Magda A. Meester-Smoor; for the International Glaucoma Genetics Consortium (IGGC)
TAGS: glaucoma, open-angle glaucoma, genetics, endophenotype, micrornas
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5368-5377. doi: 10.1167/iovs.17-22410

Includes: Supplemental Content

Glaucoma June 2017

Genetic African Ancestry Is Associated With Central Corneal Thickness and Intraocular Pressure in Primary Open-Angle Glaucoma

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Pieter W. M. Bonnemaijer; Colin Cook; Abhishek Nag; Christopher J. Hammond; Cornelia M. van Duijn; Hans G. Lemij; Caroline C. W. Klaver; Alberta A. H. J. Thiadens
TAGS: open-angle glaucoma, cornea, genetics, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3172-3180. doi: 10.1167/iovs.17-21716

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Identification of plasma metabolites associated with intraocular pressure in a Dutch family-based study

Adriana I Iglesias; Henriet Springelkamp; Sven van der Lee; Ayse Demirkan; Aswin Verhoeven; Gerd Schmitz; Ko Willems van Dijk; Thomas Hankemeier; Caroline C W Klaver; Cornelia M van Duijn

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3655. doi:

ARVO Annual Meeting Abstract June 2015

Analyses of whole genome sequencing and imputed datasets identify a rare variant associated with intraocular pressure within the TMCO1 gene

Abhishek Nag; Henriet Springelkamp; Adriana I Iglesias; Wishal Ramdas; Najaf Amin; Caroline C W Klaver; Cornelia M van Duijn; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4379. doi:

ARVO Annual Meeting Abstract June 2015

Gene by gene interaction analyses identifies evidence of epistasis and new candidate genes that influence intraocular pressure in the general population

Pirro G Hysi; Adriana I Iglesias; Stuart MacGregor; David A Mackey; Rene Hoehn; Ching-Yu Cheng; Tien Yin Wong; Janey L Wiggs; Christopher J Hammond; Cornelia M van Duijn; International Glaucoma Genetics Consortium

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5817. doi:

Genetics October 2014

Direct-to-Consumer Personal Genome Testing for Age-Related Macular Degeneration

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Gabriëlle H. S. Buitendijk; Najaf Amin; Albert Hofman; Cornelia M. van Duijn; Johannes R. Vingerling; Caroline C. W. Klaver
TAGS: dna, genome, risk assessment, age-related macular degeneration, genetic screening, genotype determination
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6167-6174. doi: 10.1167/iovs.14-15142

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Common mechanisms underlying intraocular pressure identified in functional analysis of gene lists from genome-wide association study results in IGGC cohorts

Cristina Venturini; Jamie E Craig; Norbert Pfeiffer; Cornelia M van Duijn; Janey L Wiggs; Tin Aung; David A Mackey; Ananth C Viswanathan; Christopher J Hammond; Internatiol Glaucoma Genetics Consortium- IGGC

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1662. doi:

Genetics February 2013

Identification of a Candidate Gene for Astigmatism

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Margarida C. Lopes; Pirro G. Hysi; Virginie J. M. Verhoeven; Stuart Macgregor; Alex W. Hewitt; Grant W. Montgomery; Phillippa Cumberland; Johannes R. Vingerling; Terri L. Young; Cornelia M. van Duijn; Ben Oostra; Andre G. Uitterlinden; Jugnoo S. Rahi; David A. Mackey; Caroline C. W. Klaver; Toby Andrew; Christopher J. Hammond
TAGS: astigmatism, cohort studies, candidate disease gene
Invest. Ophthalmol. Vis. Sci.. 2013; 54(2):1260-1267. doi: 10.1167/iovs.12-10463

Genetics March 2012

A Genetic Epidemiologic Study of Candidate Genes Involved in the Optic Nerve Head Morphology

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Andrea C. Gasten; Wishal D. Ramdas; Linda Broer; Leonieke M. E. van Koolwijk; M. Kamran Ikram; Paulus T. V. M. de Jong; Yurii S. Aulchenko; Roger C. Wolfs; Albert Hofman; Fernando Rivadeneira; Andre G. Uitterlinden; Ben A. Oostra; Hans G. Lemij; Caroline C. W. Klaver; Nomdo M. Jansonius; Johannes R. Vingerling; Cornelia M. van Duijn
TAGS: cohort studies, epidemiologic studies, genes, optic disk, single nucleotide polymorphism, genetics, morphology, candidate disease gene, language morphology
Invest. Ophthalmol. Vis. Sci.. 2012; 53(3):1485-1491. doi: 10.1167/iovs.11-7384

ARVO Annual Meeting Abstract April 2011

Risk Ratio Of Incident Late Age-related Macular Degeneration For Cfh And Arms2 In The Population-based Rotterdam Study

Gabrielle Buitendijk; Lintje Ho; Cornelia M. van Duijn; Albert Hofman; Paulus T. de Jong; Johannes R. Vingerling; Caroline C. Klaver

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5233. doi:

ARVO Annual Meeting Abstract April 2011

A Genome-wide Association Study Identifies A Novel Locus Influencing Optic Disc Size On Chromosome 22q13.1

Eranga N. Vithana; Chiea C. Khor; Wishal D. Ramdas; Belinda K. Cornes; Johannes R. Vingerling; Caroline C. Klaver; E-Shyong Tai; Tien Y. Wong; Cornelia M. van Duijn; Tin Aung

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5876. doi:

Clinical and Epidemiologic Research October 2009

Association of Cognitive Functioning with Retinal Nerve Fiber Layer Thickness

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Leonieke M. E. van Koolwijk; Dominiek D. G. Despriet; Cornelia M. Van Duijn; Ben A. Oostra; John C. van Swieten; Inge de Koning; Caroline C. W. Klaver; Hans G. Lemij
TAGS: mental processes, cognitive ability, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2009; 50(10):4576-4580. doi: 10.1167/iovs.08-3181

Clinical and Epidemiologic Research November 2008

Cataract Surgery and the Risk of Aging Macula Disorder: The Rotterdam Study

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Lintje Ho; Sharmila S. Boekhoorn; Liana; Cornelia M. van Duijn; André G. Uitterlinden; Albert Hofman; Paulus T. V. M. de Jong; Theo Stijnen; Johannes R. Vingerling
TAGS: aging, cataract surgery, macula lutea, eye, macula densa
Invest. Ophthalmol. Vis. Sci.. 2008; 49(11):4795-4800. doi: 10.1167/iovs.08-2066

Glaucoma August 2007

Genetic Contributions to Glaucoma: Heritability of Intraocular Pressure, Retinal Nerve Fiber Layer Thickness, and Optic Disc Morphology

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Leonieke M. E. van Koolwijk; Dominiek D. G. Despriet; Cornelia M. van Duijn; Luba M. Pardo Cortes; Johannes R. Vingerling; Yurii S. Aulchenko; Ben A. Oostra; Caroline C. W. Klaver; Hans G. Lemij
TAGS: glaucoma, optic disk, genetics, intraocular pressure, morphology, heterogeneity of variance, retinal nerve fiber layer, language morphology, neuroretinal rim
Invest. Ophthalmol. Vis. Sci.. 2007; 48(8):3669-3676. doi: 10.1167/iovs.06-1519

Clinical and Epidemiologic Research March 2007

Estrogen Receptor α Gene Polymorphisms Associated with Incident Aging Macula Disorder

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Sharmila S. Boekhoorn; Johannes R. Vingerling; André G. Uitterlinden; Joyce B. J. Van Meurs; Cornelia M. van Duijn; Huibert A. P. Pols; Albert Hofman; Paulus T. V. M. de Jong
TAGS: aging, smoking, polymorphism, follow-up, genes, genotype, haplotypes, macula lutea, estrogen receptors
Invest. Ophthalmol. Vis. Sci.. 2007; 48(3):1012-1017. doi: 10.1167/iovs.06-0577

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Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma

A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma

Genetic African Ancestry Is Associated With Central Corneal Thickness and Intraocular Pressure in Primary Open-Angle Glaucoma

Identification of plasma metabolites associated with intraocular pressure in a Dutch family-based study

Analyses of whole genome sequencing and imputed datasets identify a rare variant associated with intraocular pressure within the TMCO1 gene

Gene by gene interaction analyses identifies evidence of epistasis and new candidate genes that influence intraocular pressure in the general population

Direct-to-Consumer Personal Genome Testing for Age-Related Macular Degeneration

Common mechanisms underlying intraocular pressure identified in functional analysis of gene lists from genome-wide association study results in IGGC cohorts

Identification of a Candidate Gene for Astigmatism

A Genetic Epidemiologic Study of Candidate Genes Involved in the Optic Nerve Head Morphology

Risk Ratio Of Incident Late Age-related Macular Degeneration For Cfh And Arms2 In The Population-based Rotterdam Study

A Genome-wide Association Study Identifies A Novel Locus Influencing Optic Disc Size On Chromosome 22q13.1

Association of Cognitive Functioning with Retinal Nerve Fiber Layer Thickness

Cataract Surgery and the Risk of Aging Macula Disorder: The Rotterdam Study

Genetic Contributions to Glaucoma: Heritability of Intraocular Pressure, Retinal Nerve Fiber Layer Thickness, and Optic Disc Morphology

Estrogen Receptor α Gene Polymorphisms Associated with Incident Aging Macula Disorder

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