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Perspective July 2018

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

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Jacque L. Duncan; Eric A. Pierce; Amy M. Laster; Stephen P. Daiger; David G. Birch; John D. Ash; Alessandro Iannaccone; John G. Flannery; José A. Sahel; Donald J. Zack; Marco A. Zarbin; and the Foundation Fighting Blindness Scientific Advisory Board
TAGS: mutation, genetics, genes, animal model, retinal degeneration, comprehension
Trans. Vis. Sci. Tech.. 2018; 7(4):6. doi: 10.1167/tvst.7.4.6

ARVO Annual Meeting Abstract July 2018

Large-scale Whole-organism Phenotypic Screen Identifies Rod Cell Neuroprotectants Effective in Zebrafish and Mouse Models of Retinitis Pigmentosa

Liyun Zhang; Conan Chen; Jiang Qian; Hongkai Ji; Donald J Zack; Justin Hanes; David Ackerley; Baerbel Rohrer; Jeff S Mumm

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):980. doi:

ARVO Annual Meeting Abstract July 2018

Identification of a retinal neuroprotective kinase inhibitor with preferential activity against DLK compared to LZK

Derek Stuart Welsbie; Hartmut Schirok; Katherine Mitchell; Michael Koch; Byung-Jin Kim; Mario Lobell; Amit K Patel; Simon Holton; Dmitrij Hristodorov; Julian Esteve-Rudd; Cynthia Berlinicke; Carsten Terjung; Baranda S. Hansen; Nicolas Werbeck; William Schubert; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2493. doi:

ARVO Annual Meeting Abstract July 2018

Identification of MAP4K4/GSK-3 as a parallel acting pathway with DLK/LZK signaling to control cell death programs in retinal ganglion cells

Amit K Patel; Katherine Mitchell; Baranda Hansen; Cindy Berlinicke; Miranda Montgomery; Risa Broyer; Donald J Zack; Derek Stuart Welsbie

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2612. doi:

ARVO Annual Meeting Abstract July 2018

Single-Cell Transcriptome Profiling of Human Stem Cell-Derived Retinal Ganglion Cells in a Dominant Optic Atrophy Model

Jie Cheng; Melissa Liu; Aniruddha M. Kaushik; Xiaoli Chang; Yukan Duan; Liben Chen; Jeff (Tza-Huei) Wang; Cynthia Berlinicke; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1988. doi:

ARVO Annual Meeting Abstract July 2018

Epithelial to mesenchymal transition of human stem cell-derived retinal pigment epithelium cells modulates expression of axonal guidance molecules

Srinivas Rao Sripathi; Melissa M Liu; Ming-Wen Hu; Jun Wan; Jie Cheng; Joseph L Mertz; Cynthia Berlinicke; Julien Maruotti; Karl Wahlin; Jiang Qian; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4002. doi:

ARVO Annual Meeting Abstract July 2018

Polymeric Nanoparticles: A promising platform for gene delivery to RPE monolayers

Bibhudatta Mishra; David R. Wilson; Srinivas R. Sripathi; Yuan Rui; Mark P. Suprenant; Baranda S. Hansen; Cynthia Berlinicke; Jordan Green; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2466. doi:

ARVO Annual Meeting Abstract July 2018

Single-cell transcriptomic analysis of human and murine NRL-null retinas

Alyssa Kallman; Elizabeth E Capowski; Aniruddha M. Kaushik; Melissa Liu; Baranda S. Hansen; Liben Chen; Jie Cheng; Karl Wahlin; Ming-Wen Hu; Loyal A Goff; Jiang Qian; Cynthia Berlinicke; Jeff (Tza-Huei) Wang; David M Gamm; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3105. doi:

ARVO Annual Meeting Abstract July 2018

Genetic deletion of DLK and LZK reduce colchicine-induced cell death in human s tem cell-derived retinal ganglion cells

Pingwu Zhang; Yukan Duan; Jie Cheng; Cynthia Berlinicke; Amit K Patel; Derek Stuart Welsbie; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6152. doi:

Glaucoma February 2018

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

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Jessica N. Cooke Bailey; Puya Gharahkhani; Jae H. Kang; Mariusz Butkiewicz; David A. Sullivan; Robert N. Weinreb; Hugues Aschard; R. Rand Allingham; Allison Ashley-Koch; Richard K. Lee; Sayoko E. Moroi; Murray H. Brilliant; Gadi Wollstein; Joel S. Schuman; John H. Fingert; Donald L. Budenz; Tony Realini; Terry Gaasterland; William K. Scott; Kuldev Singh; Arthur J. Sit; Robert P. Igo, Jr; Yeunjoo E. Song; Lisa Hark; Robert Ritch; Douglas J. Rhee; Douglas Vollrath; Donald J. Zack; Felipe Medeiros; Thasarat S. Vajaranant; Daniel I. Chasman; William G. Christen; Margaret A. Pericak-Vance; Yutao Liu; Peter Kraft; Julia E. Richards; Bernard A. Rosner; Michael A. Hauser; Jamie E. Craig; Kathryn P. Burdon; Alex W. Hewitt; David A. Mackey; Jonathan L. Haines; Stuart MacGregor; Janey L. Wiggs; Louis R. Pasquale; for the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
TAGS: testosterone, metabolism, polymorphism, glaucoma, genes, open-angle glaucoma, datasets
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):629-636. doi: 10.1167/iovs.17-22708

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Role for dual leucine zipper kinase in human embryonic stem cell-derived retinal ganglion cell death signaling

Derek Stuart Welsbie; Katherine L. Mitchell; Valentin Sluch; Pingwu Zhang; Amit Patel; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2952. doi:

ARVO Annual Meeting Abstract June 2017

Neuroprotective effects of the protein kinase inhibitors, SBJ-051 and sunitinib in light-induced photoreceptor cell death

Byung-Jin Kim; Tomohiro Masuda; Bhavna J Antony; Derek Stuart Welsbie; Melissa Liu; Reji Nair; Thomas D Bannister; Jerry L Prince; Timothy P Spicer; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5889. doi:

ARVO Annual Meeting Abstract June 2017

Screen for Small Molecules that Promote Myelination of Human Stem Cell Derived Oligodenrocytes

xitiz chamling; Valentin Sluch; Karl J Wahlin; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5903. doi:

ARVO Annual Meeting Abstract June 2017

Use of Human Stem Cell-derived RGCs to Study the Mechanism of Optineurin-associated Glaucoma

Arupratan Das; Valentin Sluch; Chung-ha O. Davis; Nicholas Marsh-Armstrong; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2536. doi:

ARVO Annual Meeting Abstract June 2017

Differential Expression Analysis of Gene and Transcript Abundance for Single Cell RNA-Seq Data using STAR and HISAT Aligners.

Julius Ngwa; Robert Wojciechowski; Donald J Zack; Terri Beaty; Ingo Ruczinski

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1850. doi:

ARVO Annual Meeting Abstract June 2017

Nanoparticle based transfection of hard-to-transfect primary photoreceptor cells

Bibhudatta Mishra; David R Wilson; Yuan Rui; Mark P. Suprenant; Baranda S. Hansen; Cynthia Berlinicke; Jordan J Green; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):363. doi:

ARVO Annual Meeting Abstract June 2017

Modeling of autosomal dominant optic atrophy with human embryonic stem cell derived retinal ganglion cells by CRISPR-Cas9 mediated editing of OPA1

Jie Cheng; Cynthia A Berlinicke; Valentin Sluch; Xitiz Chamling; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1363. doi:

ARVO Annual Meeting Abstract June 2017

Extensive Axonal Outgrowth and Pathfinding from Retinal Ganglion Cells Derived From Human Pluripotent Stem Cells

Clarisse Fligor; Akshayalakshmi Sridhar; Valentin Sluch; Donald J Zack; Daniel Suter; Jason S Meyer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1370. doi:

ARVO Annual Meeting Abstract June 2017

Single cell RNA-seq provides insights into mechanisms driving photoreceptor development and degeneration

Melissa M Liu; Ming-Wen Hu; Cynthia A Berlinicke; Jiang Qian; Loyal Goff; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4775. doi:

ARVO Annual Meeting Abstract June 2017

Whole and phosphoproteome analysis of epithelial to mesenchymal transition in ES derived RPE

Joseph Mertz; Srinivas Sripathi; Xu Yang; Noriko Esumi; Hui Zhang; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5260. doi:

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Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

Large-scale Whole-organism Phenotypic Screen Identifies Rod Cell Neuroprotectants Effective in Zebrafish and Mouse Models of Retinitis Pigmentosa

Identification of a retinal neuroprotective kinase inhibitor with preferential activity against DLK compared to LZK

Identification of MAP4K4/GSK-3 as a parallel acting pathway with DLK/LZK signaling to control cell death programs in retinal ganglion cells

Single-Cell Transcriptome Profiling of Human Stem Cell-Derived Retinal Ganglion Cells in a Dominant Optic Atrophy Model

Epithelial to mesenchymal transition of human stem cell-derived retinal pigment epithelium cells modulates expression of axonal guidance molecules

Polymeric Nanoparticles: A promising platform for gene delivery to RPE monolayers

Single-cell transcriptomic analysis of human and murine NRL-null retinas

Genetic deletion of DLK and LZK reduce colchicine-induced cell death in human s tem cell-derived retinal ganglion cells

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Role for dual leucine zipper kinase in human embryonic stem cell-derived retinal ganglion cell death signaling

Neuroprotective effects of the protein kinase inhibitors, SBJ-051 and sunitinib in light-induced photoreceptor cell death

Screen for Small Molecules that Promote Myelination of Human Stem Cell Derived Oligodenrocytes

Use of Human Stem Cell-derived RGCs to Study the Mechanism of Optineurin-associated Glaucoma

Differential Expression Analysis of Gene and Transcript Abundance for Single Cell RNA-Seq Data using STAR and HISAT Aligners.

Nanoparticle based transfection of hard-to-transfect primary photoreceptor cells

Modeling of autosomal dominant optic atrophy with human embryonic stem cell derived retinal ganglion cells by CRISPR-Cas9 mediated editing of OPA1

Extensive Axonal Outgrowth and Pathfinding from Retinal Ganglion Cells Derived From Human Pluripotent Stem Cells

Single cell RNA-seq provides insights into mechanisms driving photoreceptor development and degeneration

Whole and phosphoproteome analysis of epithelial to mesenchymal transition in ES derived RPE

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