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Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

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Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

ARVO Annual Meeting Abstract June 2024

Novel Protective Effects of Ectoine on Ocular Surface Inflammation in a Murine Dry Eye Model

XIN CHEN; Na Lin; Jinmiao Li; Haixia Liu; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3608.

ARVO Annual Meeting Abstract June 2024

Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro

Zhao Liu; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5755.

ARVO Annual Meeting Abstract June 2024

Novel role and regulatory mechanism of IL-36 family cytokines in dry eye models in vitro and in vivo

De-Quan Li; Jinmiao Li; XIN CHEN; Na Lin; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5737.

ARVO Annual Meeting Abstract June 2024

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Na Lin; XIN CHEN; Haixia Liu; Cintia S De Paiva; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5720.

ARVO Annual Meeting Abstract June 2023

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics

De-Quan Li; Jin-Miao Li; Fang Bian; Xin Chen; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):971.

ARVO Annual Meeting Abstract June 2023

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Stephen C Pflugfelder; Jahan Alam; Cintia S. De Paiva; De-Quan Li; Ghasem Yasdanpanah; Kaitlyn Xiong; Zhen Zhong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):681.

ARVO Annual Meeting Abstract June 2022

Single cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes.

Jahan Alam; Ghasem Yazdanpanah; Nicholas Borcherding; Rinki Ratnapriya; Cintia S De Paiva; De-Quan Li; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):857.

ARVO Annual Meeting Abstract June 2022

IL-37 prevents corneal barrier disruption by inhibiting TNF-α/CTSS signaling in primary human corneal epithelial cells under hyperosmotic stress

De-Quan Li; Yun Zhang; Jinmiao Li; Xin Chen; Stephen C Pflugfelder; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1977 – A0307.

ARVO Annual Meeting Abstract June 2022

Reduced RXRα signaling increases dry eye disease inducing γδT17 cells in the conjunctiva

Stephen C Pflugfelder; Jahan Alam; Ghasem Yazdanpanah; Rinki Ratnapriya; Nicholas Borcherding; Cintia S De Paiva; De-Quan Li; Rodrigo Guimaraes de Souza; Zhiyuan Yu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2276.

Cornea July 2021

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

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Jin-Miao Li; Sangbae Kim; Yun Zhang; Fang Bian; Jiaoyue Hu; Rong Lu; Stephen C. Pflugfelder; Rui Chen; De-Quan Li
TAGS: teller acuity cards, trigeminal autonomic cephalalgias, genes, epithelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):36. https://doi.org/10.1167/iovs.62.9.36

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

De-Quan Li; Jinmiao Li; Sangbae Kim; Jongsu Choi; Fang Bian; Stephen C Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):861.

ARVO Annual Meeting Abstract June 2021

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Jinmiao Li; Yun zhang; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1293.

Cornea August 2020

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

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Zhao Liu; Ding Chen; Xin Chen; Fang Bian; Wenjuan Qin; Ning Gao; Yangyan Xiao; Jinmiao Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: autophagy, inflammation, stress, trehalose, corneal epithelial cells, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):26. https://doi.org/10.1167/iovs.61.10.26

ARVO Annual Meeting Abstract June 2020

Hyperosmolarity disrupts corneal barrier via TNF-α-induced Cathepsin S with suppressed anti-inflammatory cytokine IL-37 in primary human corneal epithelial cells

Jinmiao Li; Yun Zhang; Stephen Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):146.

ARVO Annual Meeting Abstract June 2020

Single-Cell Transcriptomics Reveals Novel Cell Types in Human Limbus Where Corneal Epithelial Stem Cells Reside

De-Quan Li; Sangbae Kim; Jinmiao Li; Jongsu Choi; Yun Zhang; Jiaoyue Hu; Stephen Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4348.

ARVO Annual Meeting Abstract July 2019

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Yun Zhang; Xin Chen; Ruzhi Deng; Wei Chi; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6722.

ARVO Annual Meeting Abstract July 2019

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

De-Quan Li; Ruzhi Deng; Xin Chen; Ning Gao; Jiaoyue Hu; Yun Zhang; Fang Bian; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1348.

ARVO Annual Meeting Abstract July 2018

Limbal Stem Cells Promote Corneal Epithelial Regeneration by GDNF/Survivin/CRM1 Signaling Pathway

Wenjuan Qin; Yangluowa Qu; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3871.

ARVO Annual Meeting Abstract July 2018

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

Ning Gao; Zhao Liu; XIN Chen; Ding Chen; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3277.

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Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

Novel Protective Effects of Ectoine on Ocular Surface Inflammation in a Murine Dry Eye Model

Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro

Novel role and regulatory mechanism of IL-36 family cytokines in dry eye models in vitro and in vivo

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Single cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes.

IL-37 prevents corneal barrier disruption by inhibiting TNF-α/CTSS signaling in primary human corneal epithelial cells under hyperosmotic stress

Reduced RXRα signaling increases dry eye disease inducing γδT17 cells in the conjunctiva

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Hyperosmolarity disrupts corneal barrier via TNF-α-induced Cathepsin S with suppressed anti-inflammatory cytokine IL-37 in primary human corneal epithelial cells

Single-Cell Transcriptomics Reveals Novel Cell Types in Human Limbus Where Corneal Epithelial Stem Cells Reside

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

Limbal Stem Cells Promote Corneal Epithelial Regeneration by GDNF/Survivin/CRM1 Signaling Pathway

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

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