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ARVO Annual Meeting Abstract June 2020

Characterization of the ageing of human primary RPE cells using single-cell RNA sequencing

Imre Lengyel; Oisín Cappa; David A Simpson; Eszter Emri

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2269.

ARVO Annual Meeting Abstract June 2020

Single-Cell RNA Sequencing of Lamina Cribrosa Fibroblasts in Glaucoma

Caoimhe Normile; Mustapha Irnaten; David A Simpson; Oisín Cappa; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2002.

ARVO Annual Meeting Abstract July 2019

Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma

Neeru Amrita Vallabh; Brian Lane; David A Simpson; Marc Fuchs; Anshoo Choudhary; David Criddle; Robert Cheeseman; Colin Willoughby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1613.

ARVO Annual Meeting Abstract July 2019

Genome-wide Transcriptome Profiling of Human Trabecular Meshwork Cells treated with Dexamethasone

Srinivasan Senthilkumari; Karen Lester; Brian Lane; Kasia Whysall; Carl Sheridon; David A Simpson; Krishnadas S R; Muthukkaruppan VR; Colin Willoughby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5669.

Physiology and Pharmacology October 2016

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

PDF

Mary K. McGahon; José A. Fernández; Durga P. Dash; Jon McKee; David A. Simpson; Alex V. Zholos; J. Graham McGeown; Tim M. Curtis
TAGS: arteriole, cations, constriction procedure, hypotonicity
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5637-5647. https://doi.org/10.1167/iovs.16-20279

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

Margaret Dellett; Eoin Brown; Jasenka Guduric-Fuchs; Reinhold Medina; David A Simpson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3658.

ARVO Annual Meeting Abstract September 2016

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFxxxb isoforms

David A Simpson; Stephen Bridgett; Margaret Dellett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4785.

ARVO Annual Meeting Abstract April 2014

Deciphering the genetic architecture of retinitis pigmentosa through a combination of panel and whole exome sequencing

Feng Wang; Li Zhao; Hui Wang; David A Simpson; Stephen P Daiger; Silvestri Giuliana; Kang Zhang; Robert K Koenekoop; Ruifang Sui; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3269.

Biochemistry and Molecular Biology December 2013

Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid

PDF

Sudha Priya Soundara Pandi; Mei Chen; Jasenka Guduric-Fuchs; Heping Xu; David Arthur Simpson
TAGS: choroid, micrornas, retina, mice
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):8140-8151. https://doi.org/10.1167/iovs.13-12631

Includes: Supplemental Content

Genetics August 2013

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

PDF

Judith Lechner; Ha Ae Bae; Jasenka Guduric-Fuchs; Aine Rice; Gowthaman Govindarajan; Salina Siddiqui; Layal Abi Farraj; Shea Ping Yip; Maurice Yap; Manoranjan Das; Emmanuelle Souzeau; Doug Coster; Richard A. Mills; Richard Lindsay; Tony Phillips; Paul Mitchell; Manir Ali; Chris F. Inglehearn; Periasamy Sundaresan; Jamie E. Craig; David A. Simpson; Kathryn P. Burdon; Colin E. Willoughby
TAGS: keratoconus, mutation, mutation analysis, myopia
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5266-5272. https://doi.org/10.1167/iovs.13-12035

Genetics May 2013

Mutational Spectrum of the ZEB1 Gene in Corneal Dystrophies Supports a Genotype–Phenotype Correlation

PDF

Judith Lechner; Durga P. Dash; Dorota Muszynska; Mohsen Hosseini; Fani Segev; Sonia George; David G. Frazer; Jonathan E. Moore; Stephen B. Kaye; Terri Young; David A. Simpson; Amanda J. Churchill; Elise Héon; Colin E. Willoughby
TAGS: cornea, genes, genotype-phenotype associations, hereditary corneal dystrophy, keratoconus, keratocytes, mutation, phenotype, proteins, mutation analysis
Invest. Ophthalmol. Vis. Sci.. 2013; 54(5):3215-3223. https://doi.org/10.1167/iovs.13-11781

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Direct Sequencing of miR-184 and miR-205 in Sporadic Keratoconus

Judith Lechner; Durga Dash; Kathryn P. Burdon; Jamie E. Craig; Aine Rice; Chris F. Inglehearn; David A. Simpson; Colin E. Willoughby

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4219.

ARVO Annual Meeting Abstract March 2012

Functional Analyses and Expression Profiling of Keratoconic Keratocytes Harbouring a Heterozygous Missense Mutation in the Zinc Finger E-box binding gene 1 (ZEB1)

Dorota Muszynska; Judith Lechner; Durga P. Dash; Jonathan E. Moore; David A. Simpson; Colin E. Willoughby

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4220.

ARVO Annual Meeting Abstract March 2012

Characterisation of the Effect of miR-26a Upon Global mRNA Expression in Bovine Retinal Microvascular Endothelial Cells

David A. Simpson; Anna O' Connor; Jasenka Guduric-Fuchs; Tim M. Curtis

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5133.

Physiology and Pharmacology May 2011

VEGF-Induced Retinal Angiogenic Signaling Is Critically Dependent on Ca 2+ Signaling by Ca 2+ /Calmodulin-Dependent Protein Kinase II

PDF

Elayappan Banumathi; Anna O'Connor; Sangiliyandi Gurunathan; David A. Simpson; J. Graham McGeown; Tim M. Curtis
TAGS: angiogenesis, vascular endothelial growth factor a, signal transduction, calcium-calmodulin-dependent protein kinases, calmodulin, signal transduction pathways, signal pathway
Invest. Ophthalmol. Vis. Sci.. 2011; 52(6):3103-3111. https://doi.org/10.1167/iovs.10-6574

ARVO Annual Meeting Abstract April 2011

Deep Sequencing Reveals Predominant Expression of a Small Number of MicroRNAs in Bovine Retinal Endothelial Cells

Anna O'Connor; Jasenka Guduric-Fuchs; Elayappan Banumathi; Angela Cullen; Timothy M. Curtis; David A. Simpson

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1422.

ARVO Annual Meeting Abstract April 2010

Mutation Detection in 46 Retinitis Pigmentosa (RP) Genes Using Targeted Sequence Capture and Next Generation Sequencing

D. A. Simpson; G. R. Clark; S. Alexander; G. Silvestri; C. Willoughby

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):1653.

ARVO Annual Meeting Abstract April 2010

Next-Generation Sequencing Reveals Regulation of the microRNA Transcriptome During in vitro Differentiation of a Retinoblastoma Cell Line

L. J. Harwood; J. Guduric-Fuchs; A. O'Connor; D. A. Simpson

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):6443.

ARVO Annual Meeting Abstract April 2010

Alternative Splicing of the Erythropoietin Receptor (EPOR) in the Normal Retina

A. Krishnakumar; D. P. Dash; D. A. Simpson; A. W. Stitt; C. E. Willoughby

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):5997.

ARVO Annual Meeting Abstract April 2010

Targeted Sequence Capture and Next Generation Sequencing of a 5Mb Region on Chromosome 15q Previously Linked to Keratoconus

C. E. Willoughby; D. P. Dash; G. Silvestri; J. Jackson; D. G. Frazer; A. E. Hughes; D. A. C. Simpson

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):4644.

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Characterization of the ageing of human primary RPE cells using single-cell RNA sequencing

Single-Cell RNA Sequencing of Lamina Cribrosa Fibroblasts in Glaucoma

Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma

Genome-wide Transcriptome Profiling of Human Trabecular Meshwork Cells treated with Dexamethasone

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFxxxb isoforms

Deciphering the genetic architecture of retinitis pigmentosa through a combination of panel and whole exome sequencing

Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

Mutational Spectrum of the ZEB1 Gene in Corneal Dystrophies Supports a Genotype–Phenotype Correlation

Direct Sequencing of miR-184 and miR-205 in Sporadic Keratoconus

Functional Analyses and Expression Profiling of Keratoconic Keratocytes Harbouring a Heterozygous Missense Mutation in the Zinc Finger E-box binding gene 1 (ZEB1)

Characterisation of the Effect of miR-26a Upon Global mRNA Expression in Bovine Retinal Microvascular Endothelial Cells

VEGF-Induced Retinal Angiogenic Signaling Is Critically Dependent on Ca 2+ Signaling by Ca 2+ /Calmodulin-Dependent Protein Kinase II

Deep Sequencing Reveals Predominant Expression of a Small Number of MicroRNAs in Bovine Retinal Endothelial Cells

Mutation Detection in 46 Retinitis Pigmentosa (RP) Genes Using Targeted Sequence Capture and Next Generation Sequencing

Next-Generation Sequencing Reveals Regulation of the microRNA Transcriptome During in vitro Differentiation of a Retinoblastoma Cell Line

Alternative Splicing of the Erythropoietin Receptor (EPOR) in the Normal Retina

Targeted Sequence Capture and Next Generation Sequencing of a 5Mb Region on Chromosome 15q Previously Linked to Keratoconus

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