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Glaucoma February 2018

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

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Baiyun Liu; Jason I. Kilpatrick; Bartlomiej Lukasz; Suzanne P. Jarvis; Fiona McDonnell; Deborah M. Wallace; Abbot F. Clark; Colm J. O'Brien
TAGS: actins, cribriform plate, cues, glaucoma, phenotype, vinculin, myofibroblasts, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):803-814. doi: https://doi.org/10.1167/iovs.17-22400

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract April 2014

Modulation of the fibrotic response of the human lamina cribrosa cell to cyclical mechanical stretch using the Rho kinase inhibitor Y-27632

Olya Pokrovskaya; Deborah M Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5032. doi:

ARVO Annual Meeting Abstract April 2014

The Role of Hypoxia in Inducing Aberrant Epigenetic and Fibrotic States in Glaucoma

Fiona McDonnell; Abbot F Clark; Colm J O'Brien; Deborah M Wallace

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5716. doi:

Glaucoma December 2013

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

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Deborah M. Wallace; Abbot F. Clark; Kenneth E. Lipson; Darrell Andrews; John K. Crean; Colm J. O'Brien
TAGS: antibodies, body tissue, connective tissue growth factor, cribriform plate, extracellular matrix, glaucoma, growth factor, open-angle glaucoma, trabecular meshwork, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):7836-7848. doi: https://doi.org/10.1167/iovs.13-12494

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Differential Expression of Key Epigenetic Re-programming Genes in Human Lamina Cribrosa Cells in Glaucoma

Colm J. O'Brien; Fiona McDonnell; Abbot F. Clark; Deborah M. Wallace

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2810. doi:

ARVO Annual Meeting Abstract March 2012

The Retinal Pigment Epithelial Cell: Potential Mediator of Lamina Cribrosa Extracellular Matrix Remodelling and Optic Disc Cupping in Glaucoma?

Emily L. Hughes; John G. Browne; Deborah M. Wallace; John K. Crean; Colm J. O'Brien

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2826. doi:

ARVO Annual Meeting Abstract March 2012

Anti-Connective Tissue Growth Factor Antibody Therapy Combats Expression of Fibrotic Genes in Glaucoma

Deborah M. Wallace; Abbot F. Clark; Noelynn Oliver; John K. Crean; Colm J. O'Brien

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6945. doi:

ARVO Annual Meeting Abstract April 2011

Lipofuscin Accumulation and Autophagy in Human Lamina Cribrosa Cells

Elizabeth M. McElnea; Barry Quill; Neil Docherty; Deborah M. Wallace; Mustapha Irnaten; Michael Farrell; Colm O'Brien

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2677. doi:

ARVO Annual Meeting Abstract April 2011

Reduced Anti-Oxidant Potential in Human Lamina Cribrosa Cells from Glaucoma Donors

Deborah M. Wallace; Elizabeth M. McElnea; Barry D. Quill; Mustapha Irnaten; Abbot F. Clark; Colm J. O'Brien

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4591. doi:

Glaucoma June 2010

Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma

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Edward W. Dervan; Hong Chen; Su Ling Ho; Nikola Brummel; Jasmin Schmid; David Toomey; Margarita Haralambova; Edith Gould; Deborah M. Wallace; Jochen H. M. Prehn; Colm J. O'Brien; Derek Murphy
TAGS: autoantibodies, exfoliation syndrome, proteins, antigens, dna, complementary
Invest. Ophthalmol. Vis. Sci.. 2010; 51(6):2968-2975. doi: https://doi.org/10.1167/iovs.09-4898

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2010

Verapamil Blocks Mechanical Strain Induced Upregulation of TGF-β1 mRNA in Lamina Cribrosa Cells

B. D. Quill; N. G. Docherty; D. M. Wallace; C. J. O'Brien; A. F. Clark

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3168. doi:

ARVO Annual Meeting Abstract April 2010

The Innate Immune Response to Subretinal RPE Allografts

T. M. Holmes; K. P. Kennelly; D. M. Wallace; D. J. Keegan

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):832. doi:

ARVO Annual Meeting Abstract April 2010

Investigating the Role of Toll-Like Receptor 4 in Subretinal Graft Cell Loss

D. J. Keegan; T. M. Holmes; D. M. Wallace; K. P. Kennelly

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):835. doi:

ARVO Annual Meeting Abstract April 2010

The Relationship Between Oxidative Stress, Calcium Homeostasis and Extracellular Matrix Remodeling in Human Lamina Cribrosa Cells

W. F. Siah; D. M. Wallace; A. F. Clark; J. G. Flanagan; C. J. O'Brien

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):2705. doi:

ARVO Annual Meeting Abstract April 2010

Optimizing Graft Preparation for Subretinal Cell Transplantation

K. P. Kennelly; D. M. Wallace; T. M. Holmes; D. J. Keegan

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):5240. doi:

ARVO Annual Meeting Abstract April 2010

Evidence of Mitochondrial Dysfunction and Oxidative Stress in Glaucomatous Human Lamina Cribrosa Cells: Lipofuscin Accumulation

E. M. McElnea; B. D. Quill; N. G. Docherty; D. M. Wallace; M. Irnaten; M. Farrell; C. J. O'Brien

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):6112. doi:

Biochemistry and Molecular Biology October 2008

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

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Jeremy C. O'Connor; Deborah M. Wallace; Colm J. O'Brien; Thomas G. Cotter
TAGS: antioxidants, catalase, genes, retinal ganglion cells, tumor suppressor genes, enzymes, disease susceptibility, oxidation-reduction, retina
Invest. Ophthalmol. Vis. Sci.. 2008; 49(10):4237-4244. doi: https://doi.org/10.1167/iovs.08-1963

ARVO Annual Meeting Abstract May 2008

The Tumor Suppressor Gene p53: Is It Neuroprotectant for the Retinal Ganglion Cell?

J. C. O'Connor; D. M. Wallace; C. J. O'Brien; T. G. Cotter

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):2071. doi:

ARVO Annual Meeting Abstract May 2007

A Novel Antioxidant Role of the Tumour Suppressor p53 in the Retina

J. C. O'Connor; D. M. Wallace; C. J. O' Brien; T. G. Cotter

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):237. doi:

Biochemistry and Molecular Biology July 2006

Histone Deacetylase Activity Regulates Apaf-1 and Caspase 3 Expression in the Developing Mouse Retina

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Deborah M. Wallace; Maryanne Donovan; Thomas G. Cotter
TAGS: apoptotic protease-activating factor 1, caspase-3, histone deacetylase, retina, mice, dna
Invest. Ophthalmol. Vis. Sci.. 2006; 47(7):2765-2772. doi: https://doi.org/10.1167/iovs.05-1383

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Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

Modulation of the fibrotic response of the human lamina cribrosa cell to cyclical mechanical stretch using the Rho kinase inhibitor Y-27632

The Role of Hypoxia in Inducing Aberrant Epigenetic and Fibrotic States in Glaucoma

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

Differential Expression of Key Epigenetic Re-programming Genes in Human Lamina Cribrosa Cells in Glaucoma

The Retinal Pigment Epithelial Cell: Potential Mediator of Lamina Cribrosa Extracellular Matrix Remodelling and Optic Disc Cupping in Glaucoma?

Anti-Connective Tissue Growth Factor Antibody Therapy Combats Expression of Fibrotic Genes in Glaucoma

Lipofuscin Accumulation and Autophagy in Human Lamina Cribrosa Cells

Reduced Anti-Oxidant Potential in Human Lamina Cribrosa Cells from Glaucoma Donors

Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma

Verapamil Blocks Mechanical Strain Induced Upregulation of TGF-β1 mRNA in Lamina Cribrosa Cells

The Innate Immune Response to Subretinal RPE Allografts

Investigating the Role of Toll-Like Receptor 4 in Subretinal Graft Cell Loss

The Relationship Between Oxidative Stress, Calcium Homeostasis and Extracellular Matrix Remodeling in Human Lamina Cribrosa Cells

Optimizing Graft Preparation for Subretinal Cell Transplantation

Evidence of Mitochondrial Dysfunction and Oxidative Stress in Glaucomatous Human Lamina Cribrosa Cells: Lipofuscin Accumulation

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

The Tumor Suppressor Gene p53: Is It Neuroprotectant for the Retinal Ganglion Cell?

A Novel Antioxidant Role of the Tumour Suppressor p53 in the Retina

Histone Deacetylase Activity Regulates Apaf-1 and Caspase 3 Expression in the Developing Mouse Retina

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