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Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Cornea & External Disease November 2024

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

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Hao-Yu Wang; Dan Shen; Meng-Ying Qi; Chen Qiao; Lan Ke; Mingwu Wang; Qing-Yan Zeng
TAGS: blepharitis, eyelid, mites, ocular surfaces, eyelid margin, follow-up
Trans. Vis. Sci. Tech.. 2024; 13(11):22. https://doi.org/10.1167/tvst.13.11.22

ARVO Annual Meeting Abstract June 2024

Regulatory T cells promotes corneal epithelial wound healing through exosomal CD47

Chao Wei; Yaoyao Yu; Shengqian Dou; Li Ma; Weiyun Shi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):67.

ARVO Annual Meeting Abstract June 2024

Pegcetacoplan vs avacincaptad pegol in geographic atrophy: an anchored matching-adjusted indirect comparison of three phase 3 trials

Marco A Zarbin; Paul Hahn; David Eichenbaum; Dilsher Dhoot; Daniel Jones; Michele Intorcia; Priyanka Bobbili; Rose Chang; Maryaline Catillon; Chunyi Xu; Kirthana Sarathy; Mei Sheng Duh; Varun Chaudhary; Sujata P Sarda

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6487.

Biochemistry and Molecular Biology April 2024

Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease

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Yang Tang; Shengqian Dou; Chao Wei; Ziwen Sun; Di Sun; Qingjun Zhou; Lixin Xie
TAGS: acinar cells, cell nucleus, dry eye syndromes, genes, heterogeneity, immunologic cells, lacrimal gland, langer-giedion syndrome, mice, scopolamine
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):46. https://doi.org/10.1167/iovs.65.4.46

Includes: Supplemental Content

Cornea March 2024

NEAT1 Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway

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Tian Sang; Yani Wang; Zhiqing Wang; Di Sun; Shengqian Dou; Yaoyao Yu; Xiaoyun Wang; Can Zhao; Qun Wang
TAGS: cornea, cyclic amp, epithelium, signal pathway, signal transduction pathways, wound healing, mice, inflammation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):10. https://doi.org/10.1167/iovs.65.3.10

Includes: Supplemental Content

Cornea March 2022

Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction

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Chen Chen; Bin Zhang; Junfa Xue; Zongyi Li; Shengqian Dou; Huilin Chen; Qun Wang; Mingli Qu; Huifeng Wang; Yuan Zhang; Luqin Wan; Qingjun Zhou; Lixin Xie
TAGS: cornea, corneal endothelium, diabetes mellitus, endothelial dysfunction, stress, mice, endothelial cells, mitochondria, corneal edema, endoplasmic reticulum
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):4. https://doi.org/10.1167/iovs.63.3.4

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

NGM621 is a Potent Inhibitory Anti-Complement C3 Antibody in Development for Treatment of Geographic Atrophy

Alexander Loktev; Iris Ngan; Kalyani Mondal; Yan Wang; Jian Luo; Darrin Lindhout; Bin Fan; Raj Haldankar; Jie Tang; Husam Younis; David Shen; Hui Tian; Zhonghao Liu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1798.

ARVO Annual Meeting Abstract June 2020

Efficacy of Complement C3 Inhibition in Preclinical Models of Wet Age-related Macular Degeneration (AMD)

Wei-Sheng Chen; Benbo Song; Mary-Kamala Isoka; Maria Bogachek; Betty Li; Kalyani Mondal; Yan Wang; Serena Leong; Darrin Lindhout; Bin Fan; Raj Haldankar; Jie Tang; David Shen; Hui Tian; Zhonghao Liu; Alexander Loktev

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1799.

ARVO Annual Meeting Abstract July 2019

Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Association with Polymorphisms in Protein Stabilities

Jie J Zheng; Tarin Tanji; Emily Cohen; Darrick Shen; Fei Yu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5162.

Retinal Cell Biology November 2016

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa

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Paul A. Nakamura; Shibing Tang; Andy A. Shimchuk; Sheng Ding; Thomas A. Reh
TAGS: dimethyl sulfoxide, mice, photoreceptors, retina, retinitis pigmentosa, rhodopsin, rod photoreceptors, small molecule, retinal cone, genes
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):6407-6415. https://doi.org/10.1167/iovs.16-20177

ARVO Annual Meeting Abstract September 2016

Manipulating photoreceptor gene expression with putative Nr2e3 modulators

Paul A Nakamura; Shibing Tang; Sheng Ding; Thomas A Reh

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):580.

ARVO Annual Meeting Abstract June 2015

Antibiotic Treatment Exacerbates Focal Retinal Degeneration in a Mouse Model of AMD

Liliana Guedez; Nicholas Popp; DeFen Shen; Haohua Qian; Yichao Li; Chi-Chao Chan

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):276.

Vision Sciences Society Annual Meeting Abstract August 2014

Local Structure Drives Human Scene Categorization: Converging Evidence from Computational Analysis, Behavior, and Neural Decoding

Heeyoung Choo; Dandan Shen; Dirk Walther

Journal of Vision. 2014; 14(10):1124. https://doi.org/10.1167/14.10.1124

ARVO Annual Meeting Abstract April 2014

Characterization of ocular lesions in gp91phox-/- and p47phox-/- mice with ocular pathological features of human chronic granulomatous disease

Yujuan Wang; Emilia L Falcone; Defen Shen; Mones S Abu-Asab; Alexander Ogilvy; Steven M Holland; Chi-Chao Chan

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2868.

ARVO Annual Meeting Abstract April 2014

The involvement of IL-17RC pathway in the inflammatory stimuli of the multipotent retinal stem cells

Shida Chen; Defen Shen; Nicholas Popp; Jingsheng Tuo; Mones S Abu-Asab; Ting Xie; Chi-Chao Chan

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3984.

ARVO Annual Meeting Abstract April 2014

Is There a Relationship Between Extranuclear DNA and Degenerative Mitochondria?

Alexander Ogilvy; De Fen Shen; Chi-Chao Chan; Mones S Abu-Asab

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6324.

Vision Sciences Society Annual Meeting Abstract July 2013

Viewpoint Independence in Implicit Scene Learning

Zhongting Wang; Shiyi Li; Haibo Yang; Deli Shen; Xuejun Bai; Hong-jin Sun

Journal of Vision. 2013; 13(9):219. https://doi.org/10.1167/13.9.219

Vision Sciences Society Annual Meeting Abstract July 2013

Structural, not spectral properties underlie human categorization of natural scenes

Dirk Walther; Dandan Shen

Journal of Vision. 2013; 13(9):1054. https://doi.org/10.1167/13.9.1054

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Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

Regulatory T cells promotes corneal epithelial wound healing through exosomal CD47

Pegcetacoplan vs avacincaptad pegol in geographic atrophy: an anchored matching-adjusted indirect comparison of three phase 3 trials

Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease

NEAT1 Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway

Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction

NGM621 is a Potent Inhibitory Anti-Complement C3 Antibody in Development for Treatment of Geographic Atrophy

Efficacy of Complement C3 Inhibition in Preclinical Models of Wet Age-related Macular Degeneration (AMD)

Age at Glaucoma Diagnosis in Germline Myocilin Mutation Patients: Association with Polymorphisms in Protein Stabilities

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa

Manipulating photoreceptor gene expression with putative Nr2e3 modulators

Antibiotic Treatment Exacerbates Focal Retinal Degeneration in a Mouse Model of AMD

Local Structure Drives Human Scene Categorization: Converging Evidence from Computational Analysis, Behavior, and Neural Decoding

Characterization of ocular lesions in gp91phox-/- and p47phox-/- mice with ocular pathological features of human chronic granulomatous disease

The involvement of IL-17RC pathway in the inflammatory stimuli of the multipotent retinal stem cells

Is There a Relationship Between Extranuclear DNA and Degenerative Mitochondria?

Viewpoint Independence in Implicit Scene Learning

Structural, not spectral properties underlie human categorization of natural scenes

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