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ARVO Annual Meeting Abstract June 2021

CRISPR base editing as a potential therapeutic approach for Kir7.1 channelopathy

Meha Kabra; Pawan K Shahi; ALLISON SPILLANE; Yuyuan Wang; Divya Sinha; Gregory A Newby; Shivani Saxena; Krishanu Saha; Mariya Moosajee; David Gamm; David R. Liu; Shaoqin Gong; Bikash R Pattnaik

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1483. doi:

ARVO Annual Meeting Abstract June 2021

The role of a novel scaffold protein in mediating RPE phagocytosis of photoreceptor outer segment

Catharina Grubaugh; Anuradha Dhingra; Brian Thomas Kendrick; Divya Sinha; Brent A. Bell; Hsin-Yao Tang; David Gamm; Gustavo D Aguirre; Kathleen Boesze-Battaglia; Karina E Guziewicz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2224. doi:

ARVO Annual Meeting Abstract June 2020

Genome-Edited LCA16 iPSC-RPE Shows Rescue of Kir7.1 Channel

Pawan Shahi; Meha Kabra; Amr A Abdeen; Yuyuan Wang; Kim Edwards; Divya Sinha; David M Gamm; Krishanu Saha; Sarah Gong; Bikash R Pattnaik

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2453. doi:

ARVO Annual Meeting Abstract June 2020

Ultrathin micro-molded biodegradable scaffolds for outer retina reconstruction

Allison Ludwig; Joe Phillips; Inkyu Lee; Alex Xie; Juhwan Lee; Divya Sinha; Kim Edwards; Sarah Gong; Jack Ma; David M Gamm

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2509. doi:

ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

Sayan Ghosh; Hai Tao Liu; Peng Shang; Meysam Yazdankhah; Nadezda A Stepicheva; Joseph Weiss; Christopher Scott Fitting; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2794. doi:

ARVO Annual Meeting Abstract June 2020

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Peng Shang; Christopher Scott Fitting; Meysam Yazdankhah; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Joseph Weiss; Stacey L Hose; J. Samuel Zigler; Simon Watkins; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4152. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Characterization of interphotoreceptor matrix proteins expressed by human pluripotent stem cell derived retinal cells

Steven Mayerl; Elizabeth E. Capowski; Divya Sinha; Joe Phillips; Kimberly L Edwards; David M Gamm

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3339. doi:

ARVO Annual Meeting Abstract July 2019

Gene therapies differentially rescue disease phenotype in patient-specific hiPSC-RPE models of Best disease

Divya Sinha; Benjamin Steyer; Pawan K Shahi; Rasa Valiauga; Kimberly L Edwards; Cole Bacig; Bikash R Pattnaik; Krishanu Saha; David M Gamm

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3390. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, epithelial to mesenchymal transition, retinal pigment cell, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: https://doi.org/10.1167/iovs.18-24132

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

P2X7R inhibition activates autophagy and impairs the inflammasome response in the RPE

James T Handa; Hanna Eilken; Charles Eberhart; Marcus Karlstetter; Hartmut Schirok; Meysam Yazdankhah; Peng Shang; Marisol del Valle Cano; Jeff S Mumm; Alexander Zink; Carsten Terjung; Bernd Kalthof; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):64. doi:

ARVO Annual Meeting Abstract July 2018

A negative feedback loop between Angiogenin and Telomerase in AMD pathogenesis

Anuprita Ghosh; Swaminathan Sethu; Ganesh Ram Sahu; santosh gopi krishna gadde; Naresh Kumar Yadav; Rupesh Agrawal; Debasish Sinha; Arkasubhra Ghosh

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):358. doi:

ARVO Annual Meeting Abstract July 2018

Rescue of Kir7.1 function by gene augmentation in LCA16 patient derived iPSC-RPE cells

Pawan K Shahi; Divya Sinha; Sabrina Stulo; De-Ann M Pillers; David M Gamm; Bikash R Pattnaik

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1196. doi:

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CRISPR base editing as a potential therapeutic approach for Kir7.1 channelopathy

The role of a novel scaffold protein in mediating RPE phagocytosis of photoreceptor outer segment

Genome-Edited LCA16 iPSC-RPE Shows Rescue of Kir7.1 Channel

Ultrathin micro-molded biodegradable scaffolds for outer retina reconstruction

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Characterization of interphotoreceptor matrix proteins expressed by human pluripotent stem cell derived retinal cells

Gene therapies differentially rescue disease phenotype in patient-specific hiPSC-RPE models of Best disease

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

P2X7R inhibition activates autophagy and impairs the inflammasome response in the RPE

A negative feedback loop between Angiogenin and Telomerase in AMD pathogenesis

Rescue of Kir7.1 function by gene augmentation in LCA16 patient derived iPSC-RPE cells

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