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ARVO Annual Meeting Abstract May 2006

Preferential Expression of Peroxiredoxins 5 and 6 in Rat Diabetic Retinopathy: Assigning the Role in the Attenuation of Hyperglycemia–Induced Pericyte Apoptosis

E. Kubo; T. Miyazawa; N. Fatma; D.P. Singh; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):1708.

ARVO Annual Meeting Abstract May 2006

Smad3–Mediated TGFß Signaling: A Critical Modulator of NFkB Activation of Prdx6 Gene Transcription in Lens Epithelial Cells During Oxidative Stress

N. Fatma; E. Kubo; K. Ishihara; Y. Takamura; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):2558.

ARVO Annual Meeting Abstract May 2006

Role for Sumo–1 Modification in Transcriptional Modulation of Small Heat Shock Protein Genes by LEDGF and Its Interaction to Trimeric Hsf1

K. Ishihara; N. Fatma; Y. Takamura; E. Kubo; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):2562.

ARVO Annual Meeting Abstract May 2006

ATF4 Binds to and Regulates the Promoter of the LEDGF Gene During the Unfolded Protein Response

M. Mulhern; K. Ikesugi; R. Yamamoto; N. Fatma; D.P. Singh; T. Shinohara

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):3516.

ARVO Annual Meeting Abstract May 2005

LEDGF and HSF1 Exclusively and Cooperatively Transactivate the Small Heat Shock Protein (Hsp) Genes and Provide Cellular Protection From Stress

N. Fatma; E. Kubo; Y. Takamura; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):3852.

ARVO Annual Meeting Abstract May 2005

TAT–Mediated Protein Transduction of Prdx6 into Lens Epithelial Cells and Ocular Lenses: A Tool to Postpone Cataractogenesis

D.P. Singh; E. Kubo; Y. Akagi; N. Fatma

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):3858.

ARVO Annual Meeting Abstract May 2005

Peroxiredoxin6–Deficient Mouse Lens Epithelial Cells Exhibit an Increased Susceptibility to Hypergylycemia Induced Apoptosis

T. Miyazawa; E. Kubo; N. Fatma; Y. Kumamoto; D.P. Singh; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):3859.

ARVO Annual Meeting Abstract May 2005

Over–Expression of Aldose Reductase Gene Induces Apoptosis in Bovine Pericyte

H. Nambu; E. Kubo; T. Miyazawa; S. Tuduki; D.P. Singh; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):3952.

ARVO Annual Meeting Abstract May 2005

Upregulation of Peroxiredoxin 6, an Antioxidant, in Human Lens Epithelial Cells and Rat Lenses Following UV–B Exposure: Cellular Protection and Prevention of Cataractogenesis

E. Kubo; D.P. Singh; N. Fatma; T. Miyazawa; N. Ibaragi; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):4698.

ARVO Annual Meeting Abstract May 2005

Molecular Characterization of Novel Proteins, p132 and p128, Two Splice Variants of a Single Gene, Isolated From Human Lens Epithelial cDNA Library

Y. Takamura; N. Fatma; E. Kubo; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):1878.

ARVO Annual Meeting Abstract May 2004

LEDGF IS A CENTRAL TRANSCRIPTONAL ACTIVATOR FOR THE STRESS–RESISTANT GENE NETWORKS.

K. Ikesugi; M.L. Mulhern; R. Yamamoto; D.P. Singh; T. Shinohara

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):4540.

ARVO Annual Meeting Abstract May 2004

Regulation and Expression Pattern of Anti–oxidant protein2 (AOP2) in Eye lens

E. Kubo; T. Miyazawa; N. Fatma; Y. Akagi; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):391.

ARVO Annual Meeting Abstract May 2004

Induction of Heavy Subunit Chain of –Glutamylcysteine Synthetase Expression by Tumor Necrosis Factor in Mice Lens Epithelial Cells: Role of LEDGF

Y. Takamura; N. Fatma; E. Kubo; T. Shinohara; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):392.

ARVO Annual Meeting Abstract May 2004

DNA Binding Domains of LEDGF: Contribution of the Two Helix– Turn–Helix (HTH) and One Zinc Finger–Like Domains to the Trans–activation potential of LEDGF

D.P. Singh; E. Kubo; T. Shinohara; L.T. Chylack,Jr; N. Fatma

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):393.

ARVO Annual Meeting Abstract May 2004

Impaired Homeostasis and Phenotypic Abnormalities of Reactive Oxygen Species in AOP2–/– Mice Lens Epithelial Cells: Increased Expression and Activation of TGF ß1

N. Fatma; E. Kubo; D.A. Beier; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):1024.

ARVO Annual Meeting Abstract May 2004

Expression of P–glycoprotein/Multidrug Resistance 1 in Lens of Galactose–fed Rats and Its Associationwith Polyol pathway.

T. Miyazawa; E. Kubo; S. Tsuzuki; D.P. Singh; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):1701.

ARVO Annual Meeting Abstract May 2003

Antioxidant Protein 2 (aop2) Knockout Mice: Loss of Resistance to Heat and Oxidative Stress in Lens Epithelial Cells

N. Fatma; P. Sharma; E. Kubo; D.A. Beier; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2003; 44(13):309.

ARVO Annual Meeting Abstract May 2003

Decline of Insulin/igf Signaling Up-regulates Expression of Ledgf and a Stress-associated Gene Network in Lecs

T. Shinohara; D.P. Singh; N. Fatma; D. Magana-Arachchi

Invest. Ophthalmol. Vis. Sci.. 2003; 44(13):3138.

ARVO Annual Meeting Abstract May 2003

Changes in Gene Expression Profile of Early Diabetic Cataract Lenses of Rat and their Potentia Application

E. Kubo; D.P. Singh; Y. Akagi

Invest. Ophthalmol. Vis. Sci.. 2003; 44(13):3472.

ARVO Annual Meeting Abstract May 2003

Over-Expression of Aldose Reductase Gene Induces Apoptosis in Human Lens Epithelial Cells: Involvement of Polyol Pathway Dependent Osmotic and Oxidative Stress

T. Miyazawa; Y. Takamura; S. Aoki; Y. Akagi; D.P. Singh

Invest. Ophthalmol. Vis. Sci.. 2003; 44(13):3477.

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