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ARVO Annual Meeting Abstract June 2020

mTORC1 is needed for maintenance of retinal microglia numbers and dendritic arbors but is not necessary for their proliferation in response to retinal injury

Steven F Abcouwer; Sumathi Shanmugam; Heather Hager; Dejuan Kong; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):704. doi:

ARVO Annual Meeting Abstract June 2020

Super resolution microscopy and mutational analysis reveal novel role of occludin in VEGF-driven neovascularization

David A Antonetti; Xuwen Liu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2371. doi:

Retina June 2020

All- trans -Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

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Alyssa Dreffs; Cheng-Mao Lin; Xuwen Liu; Sumathi Shanmugam; Steven F. Abcouwer; Timothy S. Kern; David A. Antonetti
TAGS: endothelial cells, ischemia, mice, permeability, physiologic reperfusion, reperfusion therapy, retinaldehyde, vascular permeability, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2020; 61(6):8. doi: https://doi.org/10.1167/iovs.61.6.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Endothelial expression of permeability-resistant occludin mutant preserves visual function in diabetes

Cheng-mao Lin; Andreia Goncalves; Jason M Keil; Sarah Sheskey; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2692. doi:

ARVO Annual Meeting Abstract July 2019

The tight junction protein occludin regulates endothelial cell proliferation

Xuwen Liu; Madeline Merlino; Lu Gao; Stephen I Lentz; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1639. doi:

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002. doi:

ARVO Annual Meeting Abstract July 2018

Disheveled localizes at tight junction sites and interacts with ZO1 in BREC

Monica Diaz-Coranguez; Cheng-mao Lin; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4617. doi:

ARVO Annual Meeting Abstract July 2018

Automated Algorithmic Analysis of OCT Scans for Vitreous Hyperreflective Foci in Patients with Retinal Vein Occlusion

Edward Korot; Pearse Keane; Karsten Kortum; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1671. doi:

ARVO Annual Meeting Abstract July 2018

Trapping all trans retinal is protective to vascular damage in ischemia reperfusion

David A Antonetti; Chengmao Lin; Timothy S Kern; Steven F Abcouwer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3582. doi:

ARVO Annual Meeting Abstract July 2018

Contribution of occludin S490 phosphorylation on blood retinal barrier integrity and visual function.

Andreia Goncalves; Jason Keil; Sarah Sheskey; Chengmao Lin; David Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3008. doi:

ARVO Annual Meeting Abstract June 2017

Algorithmic Analysis of Vitreous Hyperreflective Foci in OCT Scans of Patients with Uveitis as a Correlate of Inflamation and Visual Acuity

Edward Korot; Vaidehi Dedania; Thiran Jayasundera; Grant Michael Comer; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1866. doi:

ARVO Annual Meeting Abstract June 2017

Signal interaction between Norrin and VEGF promotes blood-retinal barrier restoration

Monica Diaz Coranguez; Chengmao Lin; Stefan Liebner; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2519. doi:

ARVO Annual Meeting Abstract June 2017

Diabetes hinders resolution of inflammation and reestablishment of the inner blood-retinal barrier following retinal ischemia-reperfusion injury

Sumathi Shanmugam; Cheng-mao Lin; Dejuan Kong; Heather Hager; David A Antonetti; Steven F Abcouwer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2527. doi:

ARVO Annual Meeting Abstract June 2017

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Nermin Kady; Xuwen Liu; Todd Lydic; Segey Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William Hauswirth; Maria B Grant; David Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4034. doi:

ARVO Annual Meeting Abstract June 2017

Rap1 activation promotes vascular blood-retinal barrier

Carla Jhoana Ramos; Xuwen Liu; Chengmao Lin; David Antonetti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4048. doi:

ARVO Annual Meeting Abstract September 2016

Onset and resolution of neuroinflammation and inner blood-retinal barrier disruption in a mouse retinal ischemia-reperfusion injury model

Steven F Abcouwer; Arivalagan Muthusamy; Sumathi Shanmugam; Cheng-mao Lin; Heather Hager; Dejuan Kong; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Vascular endothelial growth factor (VEGF) and bradykinin induce increased electroretinogram amplitude and decreased visual acuity.

Allen C Clermont; Nivetha Murugesan; Cheng-mao Lin; Sarah R Sheskey; David A Antonetti; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

Physiology and Pharmacology May 2016

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation

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Andreia Gonçalves; Cheng-Mao Lin; Arivalagan Muthusamy; Carlos Fontes-Ribeiro; António F. Ambrósio; Steven F. Abcouwer; Rosa Fernandes; David A. Antonetti
TAGS: blood-retinal barrier, glucagon-like peptide 1, inflammation, ischemia, microglia, pathophysiology, permeability, physiologic reperfusion, reperfusion therapy, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2584-2592. doi: https://doi.org/10.1167/iovs.15-19006

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Overexpression of hELOVL4 prevents diabetes-induced blood-retinal barrier breakdown through an increase in very long chain ceramides

Nermin Kady; Xuwen Liu; Todd Lydic; Sergey Seregin; Andrea Amalfitano; Vince Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4292. doi:

ARVO Annual Meeting Abstract June 2015

Ischemia-reperfusion injury as a model of activation and resolution of retinal neuroinflammation and vascular permeability

Steven F Abcouwer; Sumathi Shanmugam; Cheng-mao Lin; Heather Lindner; Dolly Ann Padovani-Claudio; Prathiba Jayaguru; Arivalagan Muthusamy; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3101. doi:

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mTORC1 is needed for maintenance of retinal microglia numbers and dendritic arbors but is not necessary for their proliferation in response to retinal injury

Super resolution microscopy and mutational analysis reveal novel role of occludin in VEGF-driven neovascularization

All- trans -Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

Endothelial expression of permeability-resistant occludin mutant preserves visual function in diabetes

The tight junction protein occludin regulates endothelial cell proliferation

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Disheveled localizes at tight junction sites and interacts with ZO1 in BREC

Automated Algorithmic Analysis of OCT Scans for Vitreous Hyperreflective Foci in Patients with Retinal Vein Occlusion

Trapping all trans retinal is protective to vascular damage in ischemia reperfusion

Contribution of occludin S490 phosphorylation on blood retinal barrier integrity and visual function.

Algorithmic Analysis of Vitreous Hyperreflective Foci in OCT Scans of Patients with Uveitis as a Correlate of Inflamation and Visual Acuity

Signal interaction between Norrin and VEGF promotes blood-retinal barrier restoration

Diabetes hinders resolution of inflammation and reestablishment of the inner blood-retinal barrier following retinal ischemia-reperfusion injury

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Rap1 activation promotes vascular blood-retinal barrier

Onset and resolution of neuroinflammation and inner blood-retinal barrier disruption in a mouse retinal ischemia-reperfusion injury model

Vascular endothelial growth factor (VEGF) and bradykinin induce increased electroretinogram amplitude and decreased visual acuity.

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation

Overexpression of hELOVL4 prevents diabetes-induced blood-retinal barrier breakdown through an increase in very long chain ceramides

Ischemia-reperfusion injury as a model of activation and resolution of retinal neuroinflammation and vascular permeability

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