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ARVO Annual Meeting Abstract June 2022

"Mapping in time" the daily rhythmic transcriptome in the diabetic retina

Eleni Beli; Ryan P Silk; Hanagh R Winter; Vijay Tiwari; David Simpson; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):281 – F0326. doi:

ARVO Annual Meeting Abstract June 2021

The TGFβ2 induced microRNAome of the trabecular meshwork

Chelsey Doyle; Breedge Conwell; Megan Henry; Katarzyna Goljanek-Whysall; David Simpson; Carl Sheridan; Colin E Willoughby

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1654. doi:

ARVO Annual Meeting Abstract June 2021

Investigating the role of Plasminogen Activator Inhibitor-1 (PAI-1) in lamina cribrosa fibrosis using single cell RNA sequencing.

Caoimhe Normile; Mustapha Irnaten; David Simpson; Oisín Cappa; Abbot F Clark; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1650. doi:

ARVO Annual Meeting Abstract June 2021

TGFβ1 regulated gene expression in the trabecular meshwork

Breedge Conwell; Chelsey Doyle; Anton Roodnat; Megan Henry; Katarzyna Goljanek-Whysall; Sarah D. Atkinson; David Simpson; Colin E Willoughby

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1634. doi:

ARVO Annual Meeting Abstract June 2020

Characterization of the ageing of human primary RPE cells using single-cell RNA sequencing

Imre Lengyel; Oisín Cappa; David A Simpson; Eszter Emri

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2269. doi:

ARVO Annual Meeting Abstract June 2020

Single-Cell RNA Sequencing of Lamina Cribrosa Fibroblasts in Glaucoma

Caoimhe Normile; Mustapha Irnaten; David A Simpson; Oisín Cappa; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2002. doi:

ARVO Annual Meeting Abstract July 2019

Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma

Neeru Amrita Vallabh; Brian Lane; David A Simpson; Marc Fuchs; Anshoo Choudhary; David Criddle; Robert Cheeseman; Colin Willoughby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1613. doi:

ARVO Annual Meeting Abstract July 2019

Genome-wide Transcriptome Profiling of Human Trabecular Meshwork Cells treated with Dexamethasone

Srinivasan Senthilkumari; Karen Lester; Brian Lane; Kasia Whysall; Carl Sheridon; David A Simpson; Krishnadas S R; Muthukkaruppan VR; Colin Willoughby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5669. doi:

Physiology and Pharmacology October 2016

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

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Mary K. McGahon; José A. Fernández; Durga P. Dash; Jon McKee; David A. Simpson; Alex V. Zholos; J. Graham McGeown; Tim M. Curtis
TAGS: arteriole, cations, constriction procedure, hypotonicity
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5637-5647. doi: https://doi.org/10.1167/iovs.16-20279

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

Margaret Dellett; Eoin Brown; Jasenka Guduric-Fuchs; Reinhold Medina; David A Simpson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3658. doi:

ARVO Annual Meeting Abstract September 2016

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFxxxb isoforms

David A Simpson; Stephen Bridgett; Margaret Dellett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4785. doi:

ARVO Annual Meeting Abstract April 2014

REASSESS (REtinal ASSESment Scale) - A clinical grading scale for Inherited Retinal Degenerations

Sharon M Alexander; Catherine Hutchinson; David Simpson; Vittorio Silvestri; Mike Stevenson; Rui Chen; Feng Weng; Silvestri Giuliana

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1392. doi:

ARVO Annual Meeting Abstract April 2014

Deciphering the genetic architecture of retinitis pigmentosa through a combination of panel and whole exome sequencing

Feng Wang; Li Zhao; Hui Wang; David A Simpson; Stephen P Daiger; Silvestri Giuliana; Kang Zhang; Robert K Koenekoop; Ruifang Sui; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3269. doi:

Biochemistry and Molecular Biology December 2013

Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid

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Sudha Priya Soundara Pandi; Mei Chen; Jasenka Guduric-Fuchs; Heping Xu; David Arthur Simpson
TAGS: choroid, micrornas, retina, mice
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):8140-8151. doi: https://doi.org/10.1167/iovs.13-12631

Includes: Supplemental Content

Genetics August 2013

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

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Judith Lechner; Ha Ae Bae; Jasenka Guduric-Fuchs; Aine Rice; Gowthaman Govindarajan; Salina Siddiqui; Layal Abi Farraj; Shea Ping Yip; Maurice Yap; Manoranjan Das; Emmanuelle Souzeau; Doug Coster; Richard A. Mills; Richard Lindsay; Tony Phillips; Paul Mitchell; Manir Ali; Chris F. Inglehearn; Periasamy Sundaresan; Jamie E. Craig; David A. Simpson; Kathryn P. Burdon; Colin E. Willoughby
TAGS: keratoconus, mutation, mutation analysis, myopia
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5266-5272. doi: https://doi.org/10.1167/iovs.13-12035

ARVO Annual Meeting Abstract June 2013

Manipulation of the MicroRNA Content of Endothelial Progenitor Cell-derived Extracellular Vesicles

David Simpson; Eoin Brown; Christina O'Neill; Reinhold Medina; Jasenka Guduric-Fuchs

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1586. doi:

ARVO Annual Meeting Abstract June 2013

Senescent endothelial progenitor cells show impaired vasoregenerative capacity in the ischemic retina

Emma Reid; Reinhold Medina; Michelle O'Doherty; Christina O'Neill; Sarah Wilson; Jasenka Guduric-Fuchs; Jessica Neisen; David Waugh; David Simpson; Alan Stitt

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4539. doi:

Genetics May 2013

Mutational Spectrum of the ZEB1 Gene in Corneal Dystrophies Supports a Genotype–Phenotype Correlation

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Judith Lechner; Durga P. Dash; Dorota Muszynska; Mohsen Hosseini; Fani Segev; Sonia George; David G. Frazer; Jonathan E. Moore; Stephen B. Kaye; Terri Young; David A. Simpson; Amanda J. Churchill; Elise Héon; Colin E. Willoughby
TAGS: cornea, genes, genotype-phenotype associations, hereditary corneal dystrophy, keratoconus, keratocytes, mutation, phenotype, proteins, mutation analysis
Invest. Ophthalmol. Vis. Sci.. 2013; 54(5):3215-3223. doi: https://doi.org/10.1167/iovs.13-11781

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Age Alters MicroRNA Expression Profile in Mouse Retinal Pigment Epithelium (RPE)/choroid

Sudha Priya Soundara Pandi; Mei Chen; Jasenka Guduric-Fuchs; David Simpson; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5132. doi:

ARVO Annual Meeting Abstract March 2012

Direct Sequencing of miR-184 and miR-205 in Sporadic Keratoconus

Judith Lechner; Durga Dash; Kathryn P. Burdon; Jamie E. Craig; Aine Rice; Chris F. Inglehearn; David A. Simpson; Colin E. Willoughby

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4219. doi:

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"Mapping in time" the daily rhythmic transcriptome in the diabetic retina

The TGFβ2 induced microRNAome of the trabecular meshwork

Investigating the role of Plasminogen Activator Inhibitor-1 (PAI-1) in lamina cribrosa fibrosis using single cell RNA sequencing.

TGFβ1 regulated gene expression in the trabecular meshwork

Characterization of the ageing of human primary RPE cells using single-cell RNA sequencing

Single-Cell RNA Sequencing of Lamina Cribrosa Fibroblasts in Glaucoma

Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma

Genome-wide Transcriptome Profiling of Human Trabecular Meshwork Cells treated with Dexamethasone

TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFxxxb isoforms

REASSESS (REtinal ASSESment Scale) - A clinical grading scale for Inherited Retinal Degenerations

Deciphering the genetic architecture of retinitis pigmentosa through a combination of panel and whole exome sequencing

Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid

Mutational Analysis of MIR184 in Sporadic Keratoconus and Myopia

Manipulation of the MicroRNA Content of Endothelial Progenitor Cell-derived Extracellular Vesicles

Senescent endothelial progenitor cells show impaired vasoregenerative capacity in the ischemic retina

Mutational Spectrum of the ZEB1 Gene in Corneal Dystrophies Supports a Genotype–Phenotype Correlation

Age Alters MicroRNA Expression Profile in Mouse Retinal Pigment Epithelium (RPE)/choroid

Direct Sequencing of miR-184 and miR-205 in Sporadic Keratoconus

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