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ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

Sayan Ghosh; Hai Tao Liu; Peng Shang; Meysam Yazdankhah; Nadezda A Stepicheva; Joseph Weiss; Christopher Scott Fitting; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2794. doi:

ARVO Annual Meeting Abstract June 2020

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Peng Shang; Christopher Scott Fitting; Meysam Yazdankhah; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Joseph Weiss; Stacey L Hose; J. Samuel Zigler; Simon Watkins; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4152. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, epithelial to mesenchymal transition, retinal pigment cell, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: https://doi.org/10.1167/iovs.18-24132

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

P2X7R inhibition activates autophagy and impairs the inflammasome response in the RPE

James T Handa; Hanna Eilken; Charles Eberhart; Marcus Karlstetter; Hartmut Schirok; Meysam Yazdankhah; Peng Shang; Marisol del Valle Cano; Jeff S Mumm; Alexander Zink; Carsten Terjung; Bernd Kalthof; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):64. doi:

ARVO Annual Meeting Abstract July 2018

A negative feedback loop between Angiogenin and Telomerase in AMD pathogenesis

Anuprita Ghosh; Swaminathan Sethu; Ganesh Ram Sahu; santosh gopi krishna gadde; Naresh Kumar Yadav; Rupesh Agrawal; Debasish Sinha; Arkasubhra Ghosh

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):358. doi:

ARVO Annual Meeting Abstract July 2018

A potent LXR (liver X receptor) agonist can restore lysosome-mediated clearance in RPE cells from a mouse model with AMD-like phenotype

Debasish Sinha; Meysam Yazdankhah; Peng Shang; Cyrille Maugeais; Hasane Ratni; Stacey L Hose; Imran Ahmed Bhutto; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2448. doi:

ARVO Annual Meeting Abstract July 2018

NRF-2/PGC-1α deficiency induces retinal degeneration in mice

Niko Kivinen; Szabolcs Felszeghy; Jussi Paterno; Johanna Viiri; Mei Chen; Debasish Sinha; Deborah A. Ferrington; Ram Kannan; Anu Kauppinen; Kai Kaarniranta

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2455. doi:

ARVO Annual Meeting Abstract July 2018

αB-crystallin is active in Signaling, Autophagy, and Apoptosis in Ocular Melanoma

Gregory Konar; Peng Shang; Subrata Mishra; Sayan Ghosh; James T Handa; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3169. doi:

ARVO Annual Meeting Abstract July 2018

Targeting neutrophils as a novel approach for AMD therapy

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Stacey L Hose; Gerard A Lutty; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3472. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin is necessary for intracellular protein trafficking in mature RPE cells

Peng Shang; Meysam Yazdankhah; Nadezda Stepicheva; Stacey L Hose; Sayan Ghosh; Imran Ahmed Bhutto; J Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3994. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin affects circadian rhythm of the retinal pigmented epithelium through regulation of GSK3β expression

Nadezda Stepicheva; Peng Shang; Imran Ahmed Bhutto; J Samuel Zigler; Stacey L Hose; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3996. doi:

ARVO Annual Meeting Abstract July 2018

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Stacey L Hose; Sayan Ghosh; Meysam Yazdankhah; Imran Ahmed Bhutto; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4594. doi:

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Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

P2X7R inhibition activates autophagy and impairs the inflammasome response in the RPE

A negative feedback loop between Angiogenin and Telomerase in AMD pathogenesis

A potent LXR (liver X receptor) agonist can restore lysosome-mediated clearance in RPE cells from a mouse model with AMD-like phenotype

NRF-2/PGC-1α deficiency induces retinal degeneration in mice

αB-crystallin is active in Signaling, Autophagy, and Apoptosis in Ocular Melanoma

Targeting neutrophils as a novel approach for AMD therapy

βA3/A1-crystallin is necessary for intracellular protein trafficking in mature RPE cells

βA3/A1-crystallin affects circadian rhythm of the retinal pigmented epithelium through regulation of GSK3β expression

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

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