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ARVO Annual Meeting Abstract June 2022

PITPβ/βA3/A1-crystallin complex is critical for PIP metabolism in retinal pigment epithelium (RPE)

Emma Rose Mahally; Rachel Daley; Kenneth Teel; Austin McCauley; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Olivia Chowdhury; Anastasiia Strizhakova; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Raju V S Rajala; Debasish Sinha; PENG SHANG

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2473 – F0180. doi:

ARVO Annual Meeting Abstract June 2022

Looking for hidden cues: can the function of the moonlighting ocular protein βA3/A1-crystallin be regulated by the signals hidden in its coding sequence?

Nadezda A Stepicheva; Ekaterina Volkova; Victoria Koontz; PENG SHANG; Haitao Liu; Sayan Ghosh; Anastasiia Strizhakova; Olivia Chowdhury; Rachel Daley; J. Samuel Zigler; Stacey L Hose; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2300. doi:

ARVO Annual Meeting Abstract June 2022

Inhibiting mTOR-independent TFEB activity in RPE alleviates the early AMD-like phenotype in a mouse model

Mihir Nemani; Haitao Liu; PENG SHANG; Olivia Chowdhury; Victoria Koontz; Nadezda A Stepicheva; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha; Sayan Ghosh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3038 – F0409. doi:

ARVO Annual Meeting Abstract June 2022

Activation of mTOR signaling in the RPE cells induces alterations in melanogenesis thereby triggering oxidative stress

Olivia Chowdhury; Vishnu Maddipatla; Sayan Ghosh; Haitao Liu; PENG SHANG; Victoria Koontz; Nadezda A Stepicheva; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3033 – F0404. doi:

ARVO Annual Meeting Abstract June 2022

Akt2 signaling in diabetes-induced dysfunction of the outer blood retina barrier

Rachel Daley; Sayan Ghosh; PENG SHANG; Nadezda A Stepicheva; Anastasiia Strizhakova; Olivia Chowdhury; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Debasish Sinha; Haitao Liu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3599 – A0054. doi:

ARVO Annual Meeting Abstract June 2022

HDAC11 is a crucial regulator for visual cycle genes and retinal function

Peng Shang; Rachel Daley; Emma Rose Mahally; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Anastasiia Strizhakova; Olivia Chowdhury; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Jiang Qian; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4115 – F0352. doi:

ARVO Annual Meeting Abstract June 2022

Crosstalk between metabolism and inflammation in dry age-related macular degeneration

Sayan Ghosh; PENG SHANG; Nadezda A Stepicheva; Haitao Liu; Olivia Chowdhury; Victoria Koontz; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4625 – F0417. doi:

ARVO Annual Meeting Abstract June 2022

Lipocalin-2 homodimer variant: Role in dry age-related macular degeneration

Urvi Gupta; Sayan Ghosh; PENG SHANG; Haitao Liu; Anastasiia Strizhakova; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4602 – F0394. doi:

ARVO Annual Meeting Abstract June 2022

The Role of the STING/Type I IFN Signaling Pathway in Age-Related Macular Degeneration(AMD)

Chao Huang; Gabriella Widmer; Pamela Strassburger; Mirjana Lazendic; Sabine Gruener; Haitao Liu; Alan Proia; Eleonora Lad; Peter Westenskow; Nikolaos Mitrousis; Debasish Sinha; Derrick Feenstra

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4598 – F0390. doi:

ARVO Annual Meeting Abstract June 2022

The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy

Haitao Liu; Anastasiia Strizhakova; Stacey L Hose; Chao Huang; Pamela Strassburger; Gabriella Widmer; Alan D Proia; Eleonora Lad; Peter Westenskow; Nikolaos Mitrousis; Derrick Feenstra; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):413. doi:

ARVO Annual Meeting Abstract June 2022

The differential role of distinct astrocyte populations in Persistent Fetal Vasculature (PFV) disease

Victoria Koontz; Sayan Ghosh; Nadezda A Stepicheva; Haitao Liu; PENG SHANG; Olivia Chowdhury; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Meysam Yazdankhah; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):266 – F0311. doi:

ARVO Annual Meeting Abstract June 2022

Peroxisomal β-oxidation deficiency in RPE leads to progressive RPE dedifferentiation and retinal degeneration

Sai Kocherlakota; Yannick Das; Danielle Swinkels; Debasish Sinha; Frédéric Vaz; Marc Fransen; Myriam Baes

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):869. doi:

ARVO Annual Meeting Abstract June 2022

βA3/A1-crystallin may link lysosomal clearance and the circadian rhythm in the RPE

Anastasiia Strizhakova; Adithya Sreenivas; Victoria Koontz; Peng Shang; Haitao Liu; Sayan Ghosh; Olivia Chowdhury; Stacey L Hose; J. Samuel Zigler; Nadezda A Stepicheva; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):778 – F0337. doi:

ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

Sayan Ghosh; Hai Tao Liu; Peng Shang; Meysam Yazdankhah; Nadezda A Stepicheva; Joseph Weiss; Christopher Scott Fitting; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2794. doi:

ARVO Annual Meeting Abstract June 2020

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Peng Shang; Christopher Scott Fitting; Meysam Yazdankhah; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Joseph Weiss; Stacey L Hose; J. Samuel Zigler; Simon Watkins; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4152. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

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PITPβ/βA3/A1-crystallin complex is critical for PIP metabolism in retinal pigment epithelium (RPE)

Looking for hidden cues: can the function of the moonlighting ocular protein βA3/A1-crystallin be regulated by the signals hidden in its coding sequence?

Inhibiting mTOR-independent TFEB activity in RPE alleviates the early AMD-like phenotype in a mouse model

Activation of mTOR signaling in the RPE cells induces alterations in melanogenesis thereby triggering oxidative stress

Akt2 signaling in diabetes-induced dysfunction of the outer blood retina barrier

HDAC11 is a crucial regulator for visual cycle genes and retinal function

Crosstalk between metabolism and inflammation in dry age-related macular degeneration

Lipocalin-2 homodimer variant: Role in dry age-related macular degeneration

The Role of the STING/Type I IFN Signaling Pathway in Age-Related Macular Degeneration(AMD)

The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy

The differential role of distinct astrocyte populations in Persistent Fetal Vasculature (PFV) disease

Peroxisomal β-oxidation deficiency in RPE leads to progressive RPE dedifferentiation and retinal degeneration

βA3/A1-crystallin may link lysosomal clearance and the circadian rhythm in the RPE

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

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