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Glaucoma January 2022

Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

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Rory Murphy; Mustapha Irnaten; Alan Hopkins; Jeffrey O'Callaghan; W. Daniel Stamer; Abbot F. Clark; Deborah Wallace; Colm J. O'Brien
TAGS: glaucoma, proteins, verteporfin, cribriform plate, mechanotransduction, cellular
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):16. https://doi.org/10.1167/iovs.63.1.16

ARVO Annual Meeting Abstract June 2021

Elucidating the role of p53 and MDM2 in glaucomatous lamina cribrosa cells.

Kealan McElhinney; Mustapha Irnaten; Deborah Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1642.

ARVO Annual Meeting Abstract June 2020

Methylation regulates Lysyl oxidase like 1 (LOXL1) expression in Pseudoexfoliation Glaucoma

Alison G Greene; Sarah Eivers; Fiona McDonnell; Edward Dervan; Colm J O'Brien; Deborah Wallace

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1231.

ARVO Annual Meeting Abstract June 2020

The mechanical rigidity of the extracellular matrix regulates the structure, proliferation and stiffness of human trabecular meshwork cells

Sarah Eivers; Baiyun Liu; Jason Kilpatrick; Bartlomiej Lukasz; Suzanne Jarvis; Abbot F Clark; Deborah Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3457.

ARVO Annual Meeting Abstract July 2019

The Role of Yes-Associated Protein (YAP) in Mechanotransduction at the Lamina Cribrosa and its Potential as a Novel Therapeutic Target In Glaucoma.

Rory Murphy; Alan Hopkins; Mustapha Irnaten; W Daniel Stamer; Abbot F Clark; Deirdre Brennan; Deborah Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1786.

ARVO Annual Meeting Abstract July 2019

Biomimetic modelling of the lamina cribrosa region using tissue engineered scaffolds - a novel 3D model for glaucoma research

Deirdre Brennan; Deirdre Clissmann; Rory Murphy; Deborah Wallace; Irina Pascu; Alan Hibbitts; Fergal J O'Brien; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6168.

Glaucoma February 2018

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

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Baiyun Liu; Jason I. Kilpatrick; Bartlomiej Lukasz; Suzanne P. Jarvis; Fiona McDonnell; Deborah M. Wallace; Abbot F. Clark; Colm J. O'Brien
TAGS: actins, cribriform plate, cues, glaucoma, phenotype, vinculin, myofibroblasts, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):803-814. https://doi.org/10.1167/iovs.17-22400

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2015

Statins modify the fibrotic response of human trabecular meshwork and lamina cribrosa cells to mechanical stretch.

Olya Pokrovskaya; Deborah Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3545.

ARVO Annual Meeting Abstract June 2015

Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cell

Fiona McDonnell; Abbot F Clark; Colm J O'Brien; Deborah Wallace

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3657.

ARVO Annual Meeting Abstract June 2015

Reduced Expression of the Cell Cycle Inhibitors p27 and p57 and Increased Proliferation in Glaucoma Lamina Cribrosa Cells

Colm J O'Brien; Sara McNally; Ruaidhri Kirwan; Abbot F Clark; Deborah Wallace

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3675.

ARVO Annual Meeting Abstract June 2015

Altered Elasticity of Normal and Glaucoma Lamina Cribrosa (NLC and GLC) Cells in Response to Biophysical Stimuli

Baiyun Liu; Jason Kilpatrick; Deborah Wallace; Colm J O'Brien; Suzi Jarvis

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4824.

ARVO Annual Meeting Abstract April 2014

Modulation of the fibrotic response of the human lamina cribrosa cell to cyclical mechanical stretch using the Rho kinase inhibitor Y-27632

Olya Pokrovskaya; Deborah M Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5032.

ARVO Annual Meeting Abstract April 2014

The Role of Hypoxia in Inducing Aberrant Epigenetic and Fibrotic States in Glaucoma

Fiona McDonnell; Abbot F Clark; Colm J O'Brien; Deborah M Wallace

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5716.

Glaucoma December 2013

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

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Deborah M. Wallace; Abbot F. Clark; Kenneth E. Lipson; Darrell Andrews; John K. Crean; Colm J. O'Brien
TAGS: antibodies, body tissue, connective tissue growth factor, cribriform plate, extracellular matrix, glaucoma, growth factor, open-angle glaucoma, trabecular meshwork, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):7836-7848. https://doi.org/10.1167/iovs.13-12494

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

An analysis of normal and glaucomatous human lamina cribrosa and trabecular meshwork cell behaviours as determined by the surrounding extracellular matrix

Sara McNally; Deborah Wallace; Colm O'Brien

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1603.

ARVO Annual Meeting Abstract June 2013

The Influence of Substrate Stiffness on the Proliferation and Mechanical Properties of Normal and Glaucoma Trabecular Meshwork (NTM and GTM) Cells

Baiyun Liu; Jason Kilpatrick; Bartlomiej Lukasz; Deborah Wallace; Abbot Clark; Colm O'Brien; Suzanne Jarvis

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):60.

ARVO Annual Meeting Abstract June 2013

Connective Tissue Growth Factor Induction of Lysl Oxidase (LOX) Enzyme Expression in Human Trabecular Meshwork Cells is reduced by FG-3019

Deborah Wallace; Abbot Clark; Noelynn Oliver; John Crean; Colm O'Brien

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):763.

ARVO Annual Meeting Abstract June 2013

The retinal pigmented epithelial cell and peripapillary atrophy: potential mediators of glaucomatous optic disc cupping?

Emily Hughes; Neil Docherty; John Crean; Abbot Clark; Deborah Wallace; Colm O'Brien

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):764.

ARVO Annual Meeting Abstract March 2012

Integrated Signalling Between CTGF And TGF-β2 Leads To Divergent Activation Of Canonical And Non-canonical Pathways Controlling EMT In ARPE-19 Cells: Implications For The Pathogenesis Of Proliferative Vitreoretinopathy

Darrell C. Andrews; John Browne; Helen O' Donovan; Noel Faherty; Noelynn Oliver; Deborah Wallace; Emily Hughes; Colm O' Brien; John Crean

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1150.

ARVO Annual Meeting Abstract March 2012

Differential Expression of Key Epigenetic Re-programming Genes in Human Lamina Cribrosa Cells in Glaucoma

Colm J. O'Brien; Fiona McDonnell; Abbot F. Clark; Deborah M. Wallace

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2810.

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Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

Elucidating the role of p53 and MDM2 in glaucomatous lamina cribrosa cells.

Methylation regulates Lysyl oxidase like 1 (LOXL1) expression in Pseudoexfoliation Glaucoma

The mechanical rigidity of the extracellular matrix regulates the structure, proliferation and stiffness of human trabecular meshwork cells

The Role of Yes-Associated Protein (YAP) in Mechanotransduction at the Lamina Cribrosa and its Potential as a Novel Therapeutic Target In Glaucoma.

Biomimetic modelling of the lamina cribrosa region using tissue engineered scaffolds - a novel 3D model for glaucoma research

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

Statins modify the fibrotic response of human trabecular meshwork and lamina cribrosa cells to mechanical stretch.

Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGFβ1 Expression in Human Trabecular Meshwork Cell

Reduced Expression of the Cell Cycle Inhibitors p27 and p57 and Increased Proliferation in Glaucoma Lamina Cribrosa Cells

Altered Elasticity of Normal and Glaucoma Lamina Cribrosa (NLC and GLC) Cells in Response to Biophysical Stimuli

Modulation of the fibrotic response of the human lamina cribrosa cell to cyclical mechanical stretch using the Rho kinase inhibitor Y-27632

The Role of Hypoxia in Inducing Aberrant Epigenetic and Fibrotic States in Glaucoma

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells

An analysis of normal and glaucomatous human lamina cribrosa and trabecular meshwork cell behaviours as determined by the surrounding extracellular matrix

The Influence of Substrate Stiffness on the Proliferation and Mechanical Properties of Normal and Glaucoma Trabecular Meshwork (NTM and GTM) Cells

Connective Tissue Growth Factor Induction of Lysl Oxidase (LOX) Enzyme Expression in Human Trabecular Meshwork Cells is reduced by FG-3019

The retinal pigmented epithelial cell and peripapillary atrophy: potential mediators of glaucomatous optic disc cupping?

Integrated Signalling Between CTGF And TGF-β2 Leads To Divergent Activation Of Canonical And Non-canonical Pathways Controlling EMT In ARPE-19 Cells: Implications For The Pathogenesis Of Proliferative Vitreoretinopathy

Differential Expression of Key Epigenetic Re-programming Genes in Human Lamina Cribrosa Cells in Glaucoma

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