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Biochemistry and Molecular Biology February 2021

Relative Contributions of All- Trans and 11- Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium

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Nicholas P. Boyer; Debra A. Thompson; Yiannis Koutalos
TAGS: lipofuscin, mice, retinal pigment epithelium, retinoids
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):1. doi: https://doi.org/10.1167/iovs.62.2.1

Review June 2020

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

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Debra A. Thompson; Alessandro Iannaccone; Robin R. Ali; Vadim Y. Arshavsky; Isabelle Audo; James W. B. Bainbridge; Cagri G. Besirli; David G. Birch; Kari E. Branham; Artur V. Cideciyan; Steven P. Daiger; Deniz Dalkara; Jacque L. Duncan; Abigail T. Fahim; John G. Flannery; Roberto Gattegna; John R. Heckenlively; Elise Heon; K. Thiran Jayasundera; Naheed W. Khan; Henry Klassen; Bart P. Leroy; Robert S. Molday; David C. Musch; Mark E. Pennesi; Simon M. Petersen-Jones; Eric A. Pierce; Rajesh C. Rao; Thomas A. Reh; Jose A. Sahel; Dror Sharon; Paul A. Sieving; Enrica Strettoi; Paul Yang; David N. Zacks; The Monaciano Consortium
TAGS: outcome measures, retinal diseases, surrogate endpoints, genetics, vision, natural history, ethics, gene therapy
Trans. Vis. Sci. Tech.. 2020; 9(7):2. doi: https://doi.org/10.1167/tvst.9.7.2

Retinal Cell Biology August 2019

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

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Qitao Zhang; Feriel Presswalla; Melissa Calton; Carol Charniga; Jeffrey Stern; Sally Temple; Douglas Vollrath; David N. Zacks; Robin R. Ali; Debra A. Thompson; Jason M. L. Miller
TAGS: fetus, lipofuscin, toxic effect
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3468-3479. doi: https://doi.org/10.1167/iovs.19-26690

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Primary fetal RPE cultures resist accumulation and toxicity of lipofuscin-like material, and accumulated material can be further reduced by autophagy induction.

Qitao Zhang; Feriel Presswalla; Anne McCusker; Carol Charniga; Melissa A Calton; Douglas Vollrath; sally Temple; Jeffrey Stern; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1718. doi:

ARVO Annual Meeting Abstract July 2019

Elevated levels of A2E and lipofuscin fluorescence in the retinal pigment epithelium of mice that lack retinol dehydrogenase RDH8 are decreased by dark rearing

Yiannis Koutalos; Nicholas P Boyer; Debra A Thompson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2334. doi:

ARVO Annual Meeting Abstract July 2019

Protective effect of shifting protein degradation from autophagy to proteasome on retinal degeneration in P23H mice

Jingyu Yao; Yaoyan Qiu; Lin Jia; Kecia Feathers; Debra A Thompson; David N Zacks

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4208. doi:

ARVO Annual Meeting Abstract July 2018

Measuring and Modulating Lipid Handling Pathways in the RPE: Implications for Age-Related Macular Degeneration

Jason Miller; Feriel Presswalla; Qitao Zhang; David N Zacks; Debra A Thompson

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4032. doi:

ARVO Annual Meeting Abstract June 2017

Automated Quantification of Subcellular Structures in the RPE: Lipid Droplets, Autophagic Vacuoles, and Lipofuscin

Feriel K. Presswalla; Qitao Zhang; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1041. doi:

ARVO Annual Meeting Abstract June 2017

Lipid Handling by RPE Predicts Certain Features of Age-Related Macular Degeneration

Qitao Zhang; Feriel K. Presswalla; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2293. doi:

ARVO Annual Meeting Abstract June 2017

Hyperautophagy in response to protein misfolding contributes to photoreceptor cell death in Pro23His-rhodopsin mice

Jingyu Yao; Lin Jia; Eric Frontera; Naheed Khan; Debra A Thompson; David N Zacks

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2487. doi:

ARVO Annual Meeting Abstract September 2016

Mertk-mediated phagocytosis inhibits the inflammatory response to TLR4 activation in a novel microglial cell line exhibiting temperature-induced quiescence and differentiation

Sumathi Shanmugam; Dejuan Kong; Debra A Thompson; Steven F Abcouwer

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2234. doi:

ARVO Annual Meeting Abstract September 2016

A primary retinal pigment epithelial culture model for evaluating therapeutic targets in dry macular degeneration

Qitao Zhang; Feriel Presswalla; Carol Charniga; Jeffrey Stern; Sally Temple; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5015. doi:

ARVO Annual Meeting Abstract June 2015

Evaluating Retinal Pigment Epithelium Cultures for Establishing Automated, Live-Cell Tracking of Outer Segment Degradation

Jason Miller; Qitao Zhang; Steve Rowe; Daniel Peisach; David N Zacks; Sami Barmada; Debra A Thompson

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4225. doi:

ARVO Annual Meeting Abstract June 2015

Dose-response effect of RPE65 gene therapy on retinoid levels and correlation with clinical rescue in Rpe65-deficient dogs.

Freya Mowat; Kecia L Feathers; Alexander J Smith; Debra A Thompson; Simon M Petersen-Jones; James W B Bainbridge; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2064. doi:

Review February 2015

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium

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Debra A. Thompson; Robin R. Ali; Eyal Banin; Kari E. Branham; John G. Flannery; David M. Gamm; William W. Hauswirth; John R. Heckenlively; Alessandro Iannaccone; K. Thiran Jayasundera; Naheed W. Khan; Robert S. Molday; Mark E. Pennesi; Thomas A. Reh; Richard G. Weleber; David N. Zacks; for the Monaciano Consortium
TAGS: retinal degeneration, retinal dystrophies, gene therapy, universities, comprehension, transplantation
Invest. Ophthalmol. Vis. Sci.. 2015; 56(2):918-931. doi: https://doi.org/10.1167/iovs.14-16049

Retinal Cell Biology May 2014

Circadian and Noncircadian Modulation of Autophagy in Photoreceptors and Retinal Pigment Epithelium

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Jingyu Yao; Lin Jia; Shameka J. Shelby; Anna M. Ganios; Kecia Feathers; Debra A. Thompson; David N. Zacks
TAGS: autophagy, mice, photoreceptors, retina, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2014; 55(5):3237-3246. doi: https://doi.org/10.1167/iovs.13-13336

ARVO Annual Meeting Abstract April 2014

Targeting aging: Geroprotective Drug Metformin Reduces Risk of Adult-onset Open-angle Glaucoma

Julia E Richards; Hsien-Chang Lin; Bin Nan; Nidhi Talwar; David Childers; Paula Anne Newman-Casey; Debra A Thompson; Joshua D Stein; BI

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1668. doi:

ARVO Annual Meeting Abstract April 2014

MERTK Interactions with Src Family Kinases in the Retinal Pigment Epithelium

Anna Ganios; Shameka J Shelby; Kecia L Feathers; Lin Jia; Debra A Thompson

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):401. doi:

ARVO Annual Meeting Abstract April 2014

Autophagy in the retinal pigment epithelium: Insights into age-related macular degeneration

Jingyu Yao; Lin Jia; Naheed W Khan; Cheng-mao Lin; Joshua L Dunaief; Michael E Boulton; Daniel Klionsky; Jun-Lin Guan; Debra A Thompson; David N Zacks

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4560. doi:

ARVO Annual Meeting Abstract March 2012

AAV-mediated Expression Of Human Rdh12 in Mouse Retina

Debra A. Thompson; Lin Jia; Jingyu Yao; Kecia L. Feathers; Selina A. Azam; Alexander J. Smith; Robin R. Ali

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1916. doi:

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Relative Contributions of All- Trans and 11- Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

Primary fetal RPE cultures resist accumulation and toxicity of lipofuscin-like material, and accumulated material can be further reduced by autophagy induction.

Elevated levels of A2E and lipofuscin fluorescence in the retinal pigment epithelium of mice that lack retinol dehydrogenase RDH8 are decreased by dark rearing

Protective effect of shifting protein degradation from autophagy to proteasome on retinal degeneration in P23H mice

Measuring and Modulating Lipid Handling Pathways in the RPE: Implications for Age-Related Macular Degeneration

Automated Quantification of Subcellular Structures in the RPE: Lipid Droplets, Autophagic Vacuoles, and Lipofuscin

Lipid Handling by RPE Predicts Certain Features of Age-Related Macular Degeneration

Hyperautophagy in response to protein misfolding contributes to photoreceptor cell death in Pro23His-rhodopsin mice

Mertk-mediated phagocytosis inhibits the inflammatory response to TLR4 activation in a novel microglial cell line exhibiting temperature-induced quiescence and differentiation

A primary retinal pigment epithelial culture model for evaluating therapeutic targets in dry macular degeneration

Evaluating Retinal Pigment Epithelium Cultures for Establishing Automated, Live-Cell Tracking of Outer Segment Degradation

Dose-response effect of RPE65 gene therapy on retinoid levels and correlation with clinical rescue in Rpe65-deficient dogs.

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium

Circadian and Noncircadian Modulation of Autophagy in Photoreceptors and Retinal Pigment Epithelium

Targeting aging: Geroprotective Drug Metformin Reduces Risk of Adult-onset Open-angle Glaucoma

MERTK Interactions with Src Family Kinases in the Retinal Pigment Epithelium

Autophagy in the retinal pigment epithelium: Insights into age-related macular degeneration

AAV-mediated Expression Of Human Rdh12 in Mouse Retina

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