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Meeting Abstract (36)
Journal Articles (4)

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Investigative Ophthalmology & Visual Science (40)

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ARVO Annual Meeting Abstract (36)
Lens (2)
Retina (1)
Retinal Cell Biology (1)

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Eye Anatomy and Disorders (3)
Lens (3)
Retina (2)
Biochemistry and Molecular Biology (1)
Imaging (1)
Pharmacology (1)
Retinal Cell Biology (1)
Retinal Imaging (1)

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epithelium (2)
growth factor (2)
lens, crystalline (2)
photoreceptors (2)
proteins (2)
cell nucleus (1)
dna (1)
electroretinography (1)
embryo (1)
eye (1)

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ARVO Annual Meeting Abstract June 2022

Topical instillation of Metformin Prevents Oxidative Stress-Induced Eye Lens Opacity Through Induction of AMPK-Nrf2-Mediated Antioxidant Pathway

Dhirendra P Singh; Bhavana Chhunchha; Ronald R krueger; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):18. doi:

ARVO Annual Meeting Abstract June 2022

Lens epithelial cell Prdx6 deficiency activates ROS-Inflammasome pathway-driven cell death

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):663 – F0018. doi:

ARVO Annual Meeting Abstract June 2021

Prdx6-Loaded PLGA Nanoparticles Protect Lens Epithelial Cells From Oxidative Stress And Prevent Lens Opacity

Bhavana Chhunchha; Eri Kubo; Prerna Singh; Uday B Kompella; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2088. doi:

ARVO Annual Meeting Abstract June 2021

Topical Application of Hydralazine Induces Resistance Against Oxidative Stress In Eye Lenses By Activating Nrf2-mediated Antioxidant Response Genes

Dhirendra P Singh; Bhavana Chhunchha; Hiroshi Sasaki; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2068. doi:

ARVO Annual Meeting Abstract June 2021

Elevated expression of Decorin inhibits injury-driven epithelial-mesenchymal transition in mouse lens

Eri Kubo; Shinsuke Shibata; Naoko Shibata; Satoshi Ohtsuka; Yasuhito Yoshitomi; Etsuko Kiyokawa; Yasuhito Ishigaki; Hideto Yonekura; Hiroshi Sasaki; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2059. doi:

ARVO Annual Meeting Abstract July 2019

Metformin Restores Impaired Antioxidant Defense Response In Aging Lens Epithelial Cells By Reactivating Nrf2/ARE/Prdx6 Axis

Bhavana Chhunchha; Eri Kubo; Sanjay P Singh; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1112. doi:

ARVO Annual Meeting Abstract July 2019

Gene expression profiling of lens epithelial cells in Shumiya cataract rats

Eri Kubo; Hidetoshi Ishida; Shinsuke Shibata; Teppei Shibata; Yuka Nakamura; Yasuhito Ishigaki; Dhirendra P Singh; Hiroshi Sasaki

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1121. doi:

ARVO Annual Meeting Abstract July 2019

Core Clock Protein Bmal 1 Controls Reactive Oxygen Species Homeostasis And Oxidative Responses By Transregulating Prdx6 Expression

Dhirendra P Singh; Eri Kubo; Bhavana Chhunchha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1127. doi:

ARVO Annual Meeting Abstract July 2019

Age-related changes of the lens in Tropomyosin 1 conditional knockout mice

Teppei Shibata; Shinsuke Shibata; Dhirendra P Singh; Etsuko Kiyokawa; Masahito Ikawa; Hiroshi Sasaki; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5697. doi:

ARVO Annual Meeting Abstract July 2018

Tropomyosin is required for normal lens development and differentiation

Eri Kubo; Teppei Shibata; Etsuko Kiyokawa; Masahito Ikawa; Dhirendra P Singh; Hiroshi Sasaki

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):890. doi:

ARVO Annual Meeting Abstract July 2018

Prdx6 Delivery Increases Lens Epithelial Cell Survival during Oxidative Stress by Reactivating Sp1-Prdx6 Transcription

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3041. doi:

ARVO Annual Meeting Abstract July 2018

Ginkgolic Acid Inhibits Aberrant Sumoylation-Mediated Dysregulation of Prdx6 and Sp1 to Protect Lens Epithelial Cells against Oxidative Injury

Dhirendra P Singh; Bhavana Chhunchha; gunho won; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5652. doi:

ARVO Annual Meeting Abstract June 2017

FGF2-mediated induction of microRNA29c and its regulation of Tropomyosin

Eri Kubo; Shinsuke Shibata; Teppei Shibata; Naoki Tanimura; Dhirendra P Singh; Hiroshi Sasaki

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1701. doi:

ARVO Annual Meeting Abstract June 2017

Switching Of Redox Signaling By Sulforaphane Determines Lens Epithelial Cells Fate By Hormetic Mechanisms Involving Prdx6/Nrf2 and Klf9 Pathways

Bhavana Chhunchha; Eri Kubo; Hiroshi Sasaki; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3174. doi:

ARVO Annual Meeting Abstract June 2017

Stabilization Of Prdx6 Activity By Targeted Mutation Of Sumoylation Sites Protects Trabecular Meshwork Cells From Oxidative Damage

Dhirendra P Singh; Bhavana Chhunchha; Prerna Singh; W Daniel Stamer; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4908. doi:

ARVO Annual Meeting Abstract September 2016

Sumoylation Motif Disruption Of Prdx6 (K122/142R) Enhances Protection Against Oxidative Stress In Lens Epithelial Cells By Potentiating GSH Peroxidase And aiPLA 2 Activities

Dhirendra P Singh; Bhavana Chhunchha; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2027. doi:

ARVO Annual Meeting Abstract September 2016

Sumoylation At K16 Of Specificity Protein 1 Represses Prdx6 Transcription Leading To Lens Epithelial Cell Death During Oxidative Stress And Aging

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2030. doi:

ARVO Annual Meeting Abstract September 2016

Knock-down of Tropomyosin 2 created by CRISPR-CAS9 in mouse induces age-related-cataract

Eri Kubo; Teppei Shibata; Shinsuke Shibata; Hiroshi Sasaki; Etsuko Kiyokawa; Masato Ikawa; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract June 2015

Nrf2 Accelerates Oxidative Stress And Lens Epithelial Cell Death Through Induction of KLF9-Driven Repression of Prdx6 In Response To Excessive Oxidative Load

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5601. doi:

ARVO Annual Meeting Abstract June 2015

Replicative Senescence of Trabecular Meshwork Cells Is Associated With Loss Of Prdx6 By Sumoylation

Dhirendra P Singh; Nigar Fatma; Bhavana Chhunchha; W Daniel Stamer; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3678. doi:

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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Copyright © 2015 Association for Research in Vision and Ophthalmology.

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