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ARVO Annual Meeting Abstract June 2025

Towards Scalable Retinal Organoid Production: A Simplified 2D-3D Protocol Enhances Efficiency

Samir Malhotra; Andrew Browne; Dorota Skowronska-Krawczyk; William C. Tang; Magdalene J Seiler

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5306.

ARVO Annual Meeting Abstract June 2025

ELOVL2-mediated polyunsaturated fatty acid metabolism alters membrane integrity and lysosomal function in the RPE during aging

Emily Tom; Fangyuan Gao; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):6258.

ARVO Annual Meeting Abstract June 2025

The impact of discrete IOP challenge on retinal ganglion cell (RGC) function in old nonhuman primates (NHPs)

Christina M Nicou; Lisa Hethcox; Jalen Boynton; Jack Albert; Dorota Skowronska-Krawczyk; J Crawford C Downs

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5720.

ARVO Annual Meeting Abstract June 2025

Intravitreal administration of AAV8 ELOVL2/ELOVL4 combination as a novel therapeutic approach for Retinopathy of Prematurity

Fadeela Sheini; Sergio Li Calzi; Dorota Skowronska-Krawczyk; Julia V Busik; Maria B Grant

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2571.

ARVO Annual Meeting Abstract June 2025

Progressive DNA Methylation Changes Regulate Retinal Pigment Epithelium Dysfunction in ABCA4-deficient Mouse Model

Arpita Dave; Anela Tosevska; Marco Morselli; Zhichun Jiang; Matteo Pellegrini; Dorota Skowronska-Krawczyk; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1251.

ARVO Annual Meeting Abstract June 2024

Colchicine as a Novel Neuroprotective Drug for Stress-Related Neurodegeneration.

Maria Holubowicz; Cezary Rydz; William Cho; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):704.

ARVO Annual Meeting Abstract June 2024

Exploring the role of Adiponectin Receptor 1 in the dynamics of omega-3 fatty acid metabolism

Dominik Lewandowski; Fangyuan Gao; Sanae Imanishi; Aleksander Tworak; Marco Bassetto; Zhiqian Dong; Antonio FM Pinto; Marcin Tabaka; Philip David Kiser; Yoshikazu Imanishi; Dorota Skowronska-Krawczyk; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):185.

ARVO Annual Meeting Abstract June 2024

Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation

Fangyuan Gao; Cezary Rydz; Emily Tom; William Cho; Alexander V Kolesnikov; Vladimir J Kefalov; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2106.

ARVO Annual Meeting Abstract June 2024

Exploring mechanism of stress induced accelerated aging under repetitive stress.

Cezary Rydz; William Cho; Naghmeh Shabani; Audria Tran; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3817.

ARVO Annual Meeting Abstract June 2024

Molecular Dynamics in Aging Patterns and Stress Resilience in Neuroretina and RPE

Dorota Skowronska-Krawczyk; Emily Tom; Juozas Gurdevicius; Robert Brooke

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4986.

ARVO Annual Meeting Abstract June 2024

Epigenetic modifiers and their interactions with genetic polymorphisms in Intraocular Pressure and glaucoma

Xiaofan Jiang; Omar Abdul Rahman Mahroo; Dorota Skowronska-Krawczyk; Christopher J Hammond; Chris G Bell; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4626.

ARVO Annual Meeting Abstract June 2024

AAV8-ELOVL2 gene therapy increases retinal levels of very long chain polyunsaturated fatty acids and improves fatty acid n3/n6 ratios in African Green Monkeys - a potential treatment for dry age-related macular degeneration (AMD)

Martin Emanuele; Christopher Chavez; Fangyuang Gao; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5336.

ARVO Annual Meeting Abstract June 2024

Age-related decline in polyunsaturated fatty acid levels alters lysosomal lipid trafficking in RPE cells

Emily Tom; Fangyuan Gao; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6738.

ARVO Annual Meeting Abstract June 2023

Pharmacological reduction of ceramides increases levels of long-chain polyunsaturated fatty acids in the mouse retina

Dominik Lewandowski; Fangyuan Gao; Yoshikazu Imanishi; Sanae Imanishi; Aleksander Tworak; Marco Bassetto; Zhiqian Dong; Philip David Kiser; Dorota Skowronska-Krawczyk; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5455.

ARVO Annual Meeting Abstract June 2022

Essential role of ELOVL2 in maintenance of membrane structure in ARPE19 cells

Fangyuan Gao; Emily Tom; Qianlan Xu; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3886 – A0088.

ARVO Annual Meeting Abstract June 2022

Pharmacological Lowering Of Ceramide Buildup In AdipoR1 -/- Mice Increases Photoreceptor Survival And Improves Vision

Dominik Lewandowski; Andrzej Foik; Roman Smidak; Elliot H Choi; Jianye Zhang; Thanh Hoang; Aleksander Tworak; Susie Suh; Zhiqian Dong; Antonio F.M. Pinto; Emily Tom; Seth Blackshaw; David Lyon; Dorota Skowronska-Krawczyk; Marcin Tabaka; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):458.

ARVO Annual Meeting Abstract June 2022

Stress accelerates age related changes in mammalian vision

Qianlan Xu; Cezary Rydz; Irene Lee; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2704 – A0068.

ARVO Annual Meeting Abstract June 2022

“Aging mouse: functional vision decline and related molecular changes”

Cezary Rydz; Qianlan Xu; Vincent Duc-Vinh Mai; David Lyon; Andrzej Foik; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2563 – F0517.

ARVO Annual Meeting Abstract June 2022

Impaired polyunsaturated fatty acid (PUFA) synthesis disrupts RPE phagocytosis

Emily Tom; Fangyuan Gao; Qianlan Xu; Dorota Skowronska-Krawczyk

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3902 – A0104.

ARVO Annual Meeting Abstract June 2021

A disease-modifying therapy for retinal degenerations by drug repurposing

Henri Olavi Leinonen; Jianye Zhang; Fangyuan Gao; Elliot H Choi; Elliott E Einstein; David E Einstein; Laurence Mireille Occelli; Luis Felipe Marinho; Alexander V Kolesnikov; Vladimir Kefalov; Dorota Skowronska-Krawczyk; Seth Blackshaw; Simon M Petersen-Jones; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3157.

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Towards Scalable Retinal Organoid Production: A Simplified 2D-3D Protocol Enhances Efficiency

ELOVL2-mediated polyunsaturated fatty acid metabolism alters membrane integrity and lysosomal function in the RPE during aging

The impact of discrete IOP challenge on retinal ganglion cell (RGC) function in old nonhuman primates (NHPs)

Intravitreal administration of AAV8 ELOVL2/ELOVL4 combination as a novel therapeutic approach for Retinopathy of Prematurity

Progressive DNA Methylation Changes Regulate Retinal Pigment Epithelium Dysfunction in ABCA4-deficient Mouse Model

Colchicine as a Novel Neuroprotective Drug for Stress-Related Neurodegeneration.

Exploring the role of Adiponectin Receptor 1 in the dynamics of omega-3 fatty acid metabolism

Rescue of Age-related Vision Decline: Targeting ELOVL2-Mediated Fatty Acid Elongation

Exploring mechanism of stress induced accelerated aging under repetitive stress.

Molecular Dynamics in Aging Patterns and Stress Resilience in Neuroretina and RPE

Epigenetic modifiers and their interactions with genetic polymorphisms in Intraocular Pressure and glaucoma

AAV8-ELOVL2 gene therapy increases retinal levels of very long chain polyunsaturated fatty acids and improves fatty acid n3/n6 ratios in African Green Monkeys - a potential treatment for dry age-related macular degeneration (AMD)

Age-related decline in polyunsaturated fatty acid levels alters lysosomal lipid trafficking in RPE cells

Pharmacological reduction of ceramides increases levels of long-chain polyunsaturated fatty acids in the mouse retina

Essential role of ELOVL2 in maintenance of membrane structure in ARPE19 cells

Pharmacological Lowering Of Ceramide Buildup In AdipoR1 -/- Mice Increases Photoreceptor Survival And Improves Vision

Stress accelerates age related changes in mammalian vision

“Aging mouse: functional vision decline and related molecular changes”

Impaired polyunsaturated fatty acid (PUFA) synthesis disrupts RPE phagocytosis

A disease-modifying therapy for retinal degenerations by drug repurposing

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