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ARVO Annual Meeting Abstract June 2023

Low-dose efavirenz rescues retinal function and decreases intraocular pressure in Apoj -/ - mice

Nicole EL-Darzi; Natalia Mast; Brian Dailey; Min Hyung Kang; Brian James Liu; Hyunpil Lee; Douglas J. Rhee; Irina A Pikuleva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5453.

ARVO Annual Meeting Abstract June 2023

Bimatoprost Induction of Lymphangiogenesis as a Potential Mechanism of Sustained IOP Reduction

Archana Murali; Anoushka Gidh; Bridger Jepsen; Hyunpil Lee; Shigemi Matsuyama; Douglas J. Rhee

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3483.

Glaucoma March 2023

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

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W. Daniel Stamer; Kristin M. Perkumas; Min H. Kang; Mohammed Dibas; Michael R. Robinson; Douglas J. Rhee
TAGS: bimatoprost, implants, intraocular pressure, gene expression, interstitial collagenase
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):15. https://doi.org/10.1167/iovs.64.3.15

Includes: Supplemental Content

Glaucoma June 2022

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells

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William W. MacDonald; Swarup S. Swaminathan; Jae Young Heo; Alexandra Castillejos; Jessica Hsueh; Brian J. Liu; Diane Jo; Annie Du; Hyunpil Lee; Min Hyung Kang; Douglas J. Rhee
TAGS: intraocular pressure, mice, proteins, sparc study, body tissue, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):8. https://doi.org/10.1167/iovs.63.6.8

ARVO Annual Meeting Abstract June 2021

Differential effects of bimatoprost vs. bimatoprost free acid on outflow cell MMPs

Kristin Perkumas; Douglas J Rhee; Daniel W Stamer

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):551.

ARVO Annual Meeting Abstract June 2020

Regulation and role of clusterin, a secretory chaperone protein, on intraocular pressure

Avinash Soundararajan; Joshua William Buzzard; Haarika Reddy; Min Hyung Kang; Douglas J Rhee; Padmanabhan P Pattabiraman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3208.

ARVO Annual Meeting Abstract June 2020

Collagen binding site in SPARC is required for chaperone activity

Brian James Liu; Caroline Christina Sachse; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1010.

Glaucoma March 2020

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology

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Ajay Ashok; Suman Chaudhary; Alexander E. Kritikos; Min H. Kang; Dallas McDonald; Douglas J. Rhee; Neena Singh
TAGS: hepcidin, iron, trabecular meshwork, cattle, glaucoma, feedforward, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):24. https://doi.org/10.1167/iovs.61.3.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Clusterin-Cathepsin K Signaling in Trabecular Meshwork Outflow Pathway Regulates Intraocular Pressure

Padmanabhan P Pattabiraman; Sai Supriya Vuda; Jaeyoung Heo; Haarika Reddy; Carol B Toris; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5157.

ARVO Annual Meeting Abstract July 2019

Glycosylation of SPARC is Critical for Binding to Extracellular Matrix Proteins and Protection from Matrix Metalloproteinase Degradation

Nathaniel Fox; Brian Liu; Kurt Scavelli; Alexandra Castillejos; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5150.

ARVO Annual Meeting Abstract July 2019

Adenoviral Gene Transfer of TGF-β2 Upregulates Intraocular Pressure through SPARC and Integrin-Linked Kinase in Mice

Jaeyoung Heo; Emily Ahadizadeh; Yuxi Zheng; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5156.

ARVO Annual Meeting Abstract July 2019

Suppression of SPARC in human trabecular meshwork cells upregulates Plasminogen Activator Inhibitor-1

William MacDonald; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5141.

ARVO Annual Meeting Abstract July 2018

TGF-β2 upregulates the extracellular proteins through SPARC and Integrin-Linked Kinase in Human Trabecular Meshwork

Jaeyoung Heo; Emily Ahadizadeh; Min Hyung Kang; Yuxi Zheng; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3529.

Glaucoma February 2018

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

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Jessica N. Cooke Bailey; Puya Gharahkhani; Jae H. Kang; Mariusz Butkiewicz; David A. Sullivan; Robert N. Weinreb; Hugues Aschard; R. Rand Allingham; Allison Ashley-Koch; Richard K. Lee; Sayoko E. Moroi; Murray H. Brilliant; Gadi Wollstein; Joel S. Schuman; John H. Fingert; Donald L. Budenz; Tony Realini; Terry Gaasterland; William K. Scott; Kuldev Singh; Arthur J. Sit; Robert P. Igo, Jr; Yeunjoo E. Song; Lisa Hark; Robert Ritch; Douglas J. Rhee; Douglas Vollrath; Donald J. Zack; Felipe Medeiros; Thasarat S. Vajaranant; Daniel I. Chasman; William G. Christen; Margaret A. Pericak-Vance; Yutao Liu; Peter Kraft; Julia E. Richards; Bernard A. Rosner; Michael A. Hauser; Jamie E. Craig; Kathryn P. Burdon; Alex W. Hewitt; David A. Mackey; Jonathan L. Haines; Stuart MacGregor; Janey L. Wiggs; Louis R. Pasquale; for the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
TAGS: genes, glaucoma, metabolism, open-angle glaucoma, testosterone, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):629-636. https://doi.org/10.1167/iovs.17-22708

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Suppression of Parvin-a in Human Trabecular Meshwork Downregulates Extracellular Matrix Components

Alexandra Goulart Castillejos; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3493.

ARVO Annual Meeting Abstract September 2016

Aging changes in aqueous humor dynamics and ocular biometrics of SPARC null mice

Sruthi Sampathkumar; Yuxi Zheng; Min Hyung Kang; Douglas J Rhee; Carol B Toris

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6427.

ARVO Annual Meeting Abstract September 2016

Suppression of Integrin-Linked Kinase in Human Trabecular Meshwork Alters SPARC’s Effect on Extracellular Matrix and Intraocular Pressure

Emily Niloufar Ahadizadeh; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5626.

ARVO Annual Meeting Abstract September 2016

Suppression of thrombospondin-1 (TSP1) in Human Trabecular Meshwork Alters Extracellular Matrix

Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6024.

ARVO Annual Meeting Abstract September 2016

Treatment with AICAR decreases intraocular pressure in perfused ex vivo human anterior segments

Ayan Chatterjee; Guadalupe Villarreal; Dong-Jin Oh; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3542.

ARVO Annual Meeting Abstract June 2015

The outflow facility of SPARC KO and WT mice

Dong-Jin Oh; Ling Yu; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2003.

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Low-dose efavirenz rescues retinal function and decreases intraocular pressure in Apoj -/ - mice

Bimatoprost Induction of Lymphangiogenesis as a Potential Mechanism of Sustained IOP Reduction

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells

Differential effects of bimatoprost vs. bimatoprost free acid on outflow cell MMPs

Regulation and role of clusterin, a secretory chaperone protein, on intraocular pressure

Collagen binding site in SPARC is required for chaperone activity

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology

Clusterin-Cathepsin K Signaling in Trabecular Meshwork Outflow Pathway Regulates Intraocular Pressure

Glycosylation of SPARC is Critical for Binding to Extracellular Matrix Proteins and Protection from Matrix Metalloproteinase Degradation

Adenoviral Gene Transfer of TGF-β2 Upregulates Intraocular Pressure through SPARC and Integrin-Linked Kinase in Mice

Suppression of SPARC in human trabecular meshwork cells upregulates Plasminogen Activator Inhibitor-1

TGF-β2 upregulates the extracellular proteins through SPARC and Integrin-Linked Kinase in Human Trabecular Meshwork

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Suppression of Parvin-a in Human Trabecular Meshwork Downregulates Extracellular Matrix Components

Aging changes in aqueous humor dynamics and ocular biometrics of SPARC null mice

Suppression of Integrin-Linked Kinase in Human Trabecular Meshwork Alters SPARC’s Effect on Extracellular Matrix and Intraocular Pressure

Suppression of thrombospondin-1 (TSP1) in Human Trabecular Meshwork Alters Extracellular Matrix

Treatment with AICAR decreases intraocular pressure in perfused ex vivo human anterior segments

The outflow facility of SPARC KO and WT mice

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