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ARVO Annual Meeting Abstract June 2024

Suppression of Integrin-Linked Kinase Inhibits SPARC’s Effect on Extracellular Matrix and Intraocular Pressure

Charles Wei Guo; Emily N Ahadizadeh; Jaeyoung Heo; Bridger Paul Jeppesen; Yuxi Zheng; Alexandra Castillejos; Lin Ni; Archana Murali; Min Hyung Kang; Hyunpil Lee; Shigemi Matsuyama; Douglas Rhee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6459.

ARVO Annual Meeting Abstract June 2024

Pathological Implications of Extracellular Matrix Regulation by ILK in Primary Open-Angle Glaucoma

Bridger Paul Jeppesen; Charles Guo; Shigemi Matsuyama; Hyunpil Lee; Archana Murali; Jonah Scott-McKean; Douglas Rhee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4068.

ARVO Annual Meeting Abstract June 2023

Low-dose efavirenz rescues retinal function and decreases intraocular pressure in Apoj -/ - mice

Nicole EL-Darzi; Natalia Mast; Brian Dailey; Min Hyung Kang; Brian James Liu; Hyunpil Lee; Douglas J. Rhee; Irina A Pikuleva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5453.

ARVO Annual Meeting Abstract June 2023

Bimatoprost Induction of Lymphangiogenesis as a Potential Mechanism of Sustained IOP Reduction

Archana Murali; Anoushka Gidh; Bridger Jepsen; Hyunpil Lee; Shigemi Matsuyama; Douglas J. Rhee

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3483.

Glaucoma March 2023

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

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W. Daniel Stamer; Kristin M. Perkumas; Min H. Kang; Mohammed Dibas; Michael R. Robinson; Douglas J. Rhee
TAGS: bimatoprost, implants, intraocular pressure, gene expression, interstitial collagenase
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):15. https://doi.org/10.1167/iovs.64.3.15

Includes: Supplemental Content

Glaucoma June 2022

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells

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William W. MacDonald; Swarup S. Swaminathan; Jae Young Heo; Alexandra Castillejos; Jessica Hsueh; Brian J. Liu; Diane Jo; Annie Du; Hyunpil Lee; Min Hyung Kang; Douglas J. Rhee
TAGS: intraocular pressure, mice, proteins, sparc study, body tissue, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):8. https://doi.org/10.1167/iovs.63.6.8

ARVO Annual Meeting Abstract June 2022

Effect of Bimatoprost Treatment on Lymphangiogenesis in Human Ciliary Body Smooth Muscle Cells

Blake Boehm; Anoushka Gidh; Douglas Rhee

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3306 – A0406.

ARVO Annual Meeting Abstract June 2022

α-Synuclein modulates extracellular matrix proteins in the trabecular meshwork

Neena Singh; Alexander Kritikos; Dallas McDonald; Sachin Pillai; Shu Chen; Min H Kang; Douglas Rhee; Ewald Lindner; Ajay Ashok

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3309 – A0409.

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

Differential effects of bimatoprost vs. bimatoprost free acid on outflow cell MMPs

Kristin Perkumas; Douglas J Rhee; Daniel W Stamer

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):551.

ARVO Annual Meeting Abstract June 2020

Regulation and role of clusterin, a secretory chaperone protein, on intraocular pressure

Avinash Soundararajan; Joshua William Buzzard; Haarika Reddy; Min Hyung Kang; Douglas J Rhee; Padmanabhan P Pattabiraman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3208.

ARVO Annual Meeting Abstract June 2020

Collagen binding site in SPARC is required for chaperone activity

Brian James Liu; Caroline Christina Sachse; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1010.

Glaucoma March 2020

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology

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Ajay Ashok; Suman Chaudhary; Alexander E. Kritikos; Min H. Kang; Dallas McDonald; Douglas J. Rhee; Neena Singh
TAGS: hepcidin, iron, trabecular meshwork, cattle, glaucoma, feedforward, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):24. https://doi.org/10.1167/iovs.61.3.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Clusterin-Cathepsin K Signaling in Trabecular Meshwork Outflow Pathway Regulates Intraocular Pressure

Padmanabhan P Pattabiraman; Sai Supriya Vuda; Jaeyoung Heo; Haarika Reddy; Carol B Toris; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5157.

ARVO Annual Meeting Abstract July 2019

Glycosylation of SPARC is Critical for Binding to Extracellular Matrix Proteins and Protection from Matrix Metalloproteinase Degradation

Nathaniel Fox; Brian Liu; Kurt Scavelli; Alexandra Castillejos; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5150.

ARVO Annual Meeting Abstract July 2019

Adenoviral Gene Transfer of TGF-β2 Upregulates Intraocular Pressure through SPARC and Integrin-Linked Kinase in Mice

Jaeyoung Heo; Emily Ahadizadeh; Yuxi Zheng; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5156.

ARVO Annual Meeting Abstract July 2019

Suppression of SPARC in human trabecular meshwork cells upregulates Plasminogen Activator Inhibitor-1

William MacDonald; Min Hyung Kang; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5141.

ARVO Annual Meeting Abstract July 2018

Variability of tensile strength during microsurgical knot construction: A comparative study of polyglactin 910 and lactomer suture

Abayomi Fabunmi; Douglas Rhee

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):486.

ARVO Annual Meeting Abstract July 2018

TGF-β2 upregulates the extracellular proteins through SPARC and Integrin-Linked Kinase in Human Trabecular Meshwork

Jaeyoung Heo; Emily Ahadizadeh; Min Hyung Kang; Yuxi Zheng; Douglas J Rhee

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3529.

Glaucoma February 2018

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

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Jessica N. Cooke Bailey; Puya Gharahkhani; Jae H. Kang; Mariusz Butkiewicz; David A. Sullivan; Robert N. Weinreb; Hugues Aschard; R. Rand Allingham; Allison Ashley-Koch; Richard K. Lee; Sayoko E. Moroi; Murray H. Brilliant; Gadi Wollstein; Joel S. Schuman; John H. Fingert; Donald L. Budenz; Tony Realini; Terry Gaasterland; William K. Scott; Kuldev Singh; Arthur J. Sit; Robert P. Igo, Jr; Yeunjoo E. Song; Lisa Hark; Robert Ritch; Douglas J. Rhee; Douglas Vollrath; Donald J. Zack; Felipe Medeiros; Thasarat S. Vajaranant; Daniel I. Chasman; William G. Christen; Margaret A. Pericak-Vance; Yutao Liu; Peter Kraft; Julia E. Richards; Bernard A. Rosner; Michael A. Hauser; Jamie E. Craig; Kathryn P. Burdon; Alex W. Hewitt; David A. Mackey; Jonathan L. Haines; Stuart MacGregor; Janey L. Wiggs; Louis R. Pasquale; for the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
TAGS: genes, glaucoma, metabolism, open-angle glaucoma, testosterone, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):629-636. https://doi.org/10.1167/iovs.17-22708

Includes: Supplemental Content

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Suppression of Integrin-Linked Kinase Inhibits SPARC’s Effect on Extracellular Matrix and Intraocular Pressure

Pathological Implications of Extracellular Matrix Regulation by ILK in Primary Open-Angle Glaucoma

Low-dose efavirenz rescues retinal function and decreases intraocular pressure in Apoj -/ - mice

Bimatoprost Induction of Lymphangiogenesis as a Potential Mechanism of Sustained IOP Reduction

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells

Effect of Bimatoprost Treatment on Lymphangiogenesis in Human Ciliary Body Smooth Muscle Cells

α-Synuclein modulates extracellular matrix proteins in the trabecular meshwork

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Differential effects of bimatoprost vs. bimatoprost free acid on outflow cell MMPs

Regulation and role of clusterin, a secretory chaperone protein, on intraocular pressure

Collagen binding site in SPARC is required for chaperone activity

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology

Clusterin-Cathepsin K Signaling in Trabecular Meshwork Outflow Pathway Regulates Intraocular Pressure

Glycosylation of SPARC is Critical for Binding to Extracellular Matrix Proteins and Protection from Matrix Metalloproteinase Degradation

Adenoviral Gene Transfer of TGF-β2 Upregulates Intraocular Pressure through SPARC and Integrin-Linked Kinase in Mice

Suppression of SPARC in human trabecular meshwork cells upregulates Plasminogen Activator Inhibitor-1

Variability of tensile strength during microsurgical knot construction: A comparative study of polyglactin 910 and lactomer suture

TGF-β2 upregulates the extracellular proteins through SPARC and Integrin-Linked Kinase in Human Trabecular Meshwork

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

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