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ARVO Annual Meeting Abstract June 2025

Identification of Gene network changes in lens epithelial cells induced by Metformin

Eri Kubo; Yu Sasaki; Teppei Shibata; Hidetoshi Ishida; Bhavana Chhunchha; Hiroshi Sasaki; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1272.

ARVO Annual Meeting Abstract June 2025

Loss of Prdx6 Induces Lens Epithelial Cells Ferroptosis Via Reduction in Gpx4

Dhirendra P Singh; Priyanka Thakur; Eri Kubo; Bhavana Chhunchha

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1267.

ARVO Annual Meeting Abstract June 2025

Prdx6 Inhibits Oxidative Stress-Driven Txnip-Nlrp3 Inflammasome Activation And Mitigates Pyroptosis In Iens Epithelial Cells

Bhavana Chhunchha; Renuka Ramalingam Manoharan; Deepali Lehri; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1266.

ARVO Annual Meeting Abstract June 2024

Inhibition of lens opacity by N-acetylcysteine amide (NACA) and its effect on endogenous antioxidant enzymes

HIDETOSHI ISHIDA; Teppei Shibata; Shun Takeda; Toru Ikoma; Hiroshi Sasaki; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3236.

ARVO Annual Meeting Abstract June 2024

Metformin promotes Prdx6 transcription By Enriching Bmal1-Nrf2 heterodimers at E-Box and ARE Sequences And Provides Cytoprotection

Dhirendra P Singh; Eri Kubo; Ronald R Krueger; Bhavana Chhunchha

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3233.

ARVO Annual Meeting Abstract June 2024

Prdx6 Impedes Lens Epithelial Cell From Klf9/Nlrp3 Inflammasome Activation-Driven Pyroptotic Cell Death In Aging/Oxidative Stress

Bhavana Chhunchha; Eri Kubo; Ronald R Krueger; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3223.

ARVO Annual Meeting Abstract June 2024

Interaction between Periostin and Decorin to induce epithelial-mesenchymal transition in the lens

Eri Kubo; Teppei Shibata; Hidetoshi Ishida; Ryo Sakasai; Yasuo Yoshitomi; Hideto Yonekura; Kuniyoshi Iwabuchi; Dhirendra P Singh; Hiroshi Sasaki

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3221.

ARVO Annual Meeting Abstract June 2023

Metformin-activated AMPK boosts the Nrf2/Prdx6 signaling axis and cytoprotection via negative regulation of Bach1

Dhirendra P Singh; Bhavana Chhunchha; Dhavalkumar Shukal; Ronald R Krueger; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1222.

ARVO Annual Meeting Abstract June 2023

Klf9 amplifies Nlrp3 inflammasome-mediated inflammatory death signaling in lens epithelial cells via transactivation of Nlrp3 gene

Bhavana Chhunchha; Eri Kubo; Kumar Rakesh; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4144.

Clinical and Epidemiologic Research November 2022

Vision With Retrodots and Factors for Declining Visual Function

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Natsuko Hatsusaka; Naoki Tanimura; Mai Yamazaki; Norihiro Mita; Yuki Ukai; Yusuke Seki; Hisanori Miyashita; Tsuyoshi Mito; Eri Kubo; Hiroshi Sasaki
TAGS: cataract, eye, respiratory distress syndrome, newborn, vision, developmental venous anomaly, cerebral
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):17. https://doi.org/10.1167/iovs.63.12.17

ARVO Annual Meeting Abstract June 2022

Topical instillation of Metformin Prevents Oxidative Stress-Induced Eye Lens Opacity Through Induction of AMPK-Nrf2-Mediated Antioxidant Pathway

Dhirendra P Singh; Bhavana Chhunchha; Ronald R krueger; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):18.

ARVO Annual Meeting Abstract June 2022

Lens epithelial cell Prdx6 deficiency activates ROS-Inflammasome pathway-driven cell death

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):663 – F0018.

Lens February 2022

Analyzing Effect of Waterclefts on Visual Functions Via Optical Simulations

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Yusuke Seki; Takushi Kawamorita; Naoki Yamamoto; Takashi Tanigawa; Norihiro Mita; Natsuko Hatsusaka; Eri Kubo; Hiroshi Sasaki
TAGS: optics, vision, lens, crystalline, eye, shape, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):22. https://doi.org/10.1167/iovs.63.2.22

ARVO Annual Meeting Abstract June 2021

Prdx6-Loaded PLGA Nanoparticles Protect Lens Epithelial Cells From Oxidative Stress And Prevent Lens Opacity

Bhavana Chhunchha; Eri Kubo; Prerna Singh; Uday B Kompella; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2088.

ARVO Annual Meeting Abstract June 2021

Topical Application of Hydralazine Induces Resistance Against Oxidative Stress In Eye Lenses By Activating Nrf2-mediated Antioxidant Response Genes

Dhirendra P Singh; Bhavana Chhunchha; Hiroshi Sasaki; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2068.

ARVO Annual Meeting Abstract June 2021

Elevated expression of Decorin inhibits injury-driven epithelial-mesenchymal transition in mouse lens

Eri Kubo; Shinsuke Shibata; Naoko Shibata; Satoshi Ohtsuka; Yasuhito Yoshitomi; Etsuko Kiyokawa; Yasuhito Ishigaki; Hideto Yonekura; Hiroshi Sasaki; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2059.

Articles June 2021

UV Index Does Not Predict Ocular Ultraviolet Exposure

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Natsuko Hatsusaka; Yusuke Seki; Norihiro Mita; Yuki Ukai; Hisanori Miyashita; Eri Kubo; David Sliney; Hiroshi Sasaki
TAGS: ultraviolet rays, crowns, tooth crowns, ultraviolet b radiation
Trans. Vis. Sci. Tech.. 2021; 10(7):1. https://doi.org/10.1167/tvst.10.7.1

Vision Sciences Society Annual Meeting Abstract September 2019

Atypical topography of high-level visual cortex is associated with reading difficulty

Emily Kubota; Jason D Yeatman

Journal of Vision. 2019; 19(10):34a. https://doi.org/10.1167/19.10.34a

Vision Sciences Society Annual Meeting Abstract September 2019

Linking occipital callosal white matter to cortical responses and reading skill

Elizabeth Huber; Emily C Kubota; Jason D Yeatman

Journal of Vision. 2019; 19(10):172a. https://doi.org/10.1167/19.10.172a

Clinical and Epidemiologic Research August 2019

Visual Function and Functional Decline in Patients With Waterclefts

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Naoki Tanimura; Natsuko Hatsusaka; Hisanori Miyashita; Teppei Shibata; Hidetoshi Ishida; Akane Kunisho; Eri Kubo; Hiroshi Sasaki
TAGS: vision, developmental venous anomaly, cerebral, eye, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3652-3658. https://doi.org/10.1167/iovs.19-26793

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Identification of Gene network changes in lens epithelial cells induced by Metformin

Loss of Prdx6 Induces Lens Epithelial Cells Ferroptosis Via Reduction in Gpx4

Prdx6 Inhibits Oxidative Stress-Driven Txnip-Nlrp3 Inflammasome Activation And Mitigates Pyroptosis In Iens Epithelial Cells

Inhibition of lens opacity by N-acetylcysteine amide (NACA) and its effect on endogenous antioxidant enzymes

Metformin promotes Prdx6 transcription By Enriching Bmal1-Nrf2 heterodimers at E-Box and ARE Sequences And Provides Cytoprotection

Prdx6 Impedes Lens Epithelial Cell From Klf9/Nlrp3 Inflammasome Activation-Driven Pyroptotic Cell Death In Aging/Oxidative Stress

Interaction between Periostin and Decorin to induce epithelial-mesenchymal transition in the lens

Metformin-activated AMPK boosts the Nrf2/Prdx6 signaling axis and cytoprotection via negative regulation of Bach1

Klf9 amplifies Nlrp3 inflammasome-mediated inflammatory death signaling in lens epithelial cells via transactivation of Nlrp3 gene

Vision With Retrodots and Factors for Declining Visual Function

Topical instillation of Metformin Prevents Oxidative Stress-Induced Eye Lens Opacity Through Induction of AMPK-Nrf2-Mediated Antioxidant Pathway

Lens epithelial cell Prdx6 deficiency activates ROS-Inflammasome pathway-driven cell death

Analyzing Effect of Waterclefts on Visual Functions Via Optical Simulations

Prdx6-Loaded PLGA Nanoparticles Protect Lens Epithelial Cells From Oxidative Stress And Prevent Lens Opacity

Topical Application of Hydralazine Induces Resistance Against Oxidative Stress In Eye Lenses By Activating Nrf2-mediated Antioxidant Response Genes

Elevated expression of Decorin inhibits injury-driven epithelial-mesenchymal transition in mouse lens

UV Index Does Not Predict Ocular Ultraviolet Exposure

Atypical topography of high-level visual cortex is associated with reading difficulty

Linking occipital callosal white matter to cortical responses and reading skill

Visual Function and Functional Decline in Patients With Waterclefts

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