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ARVO Annual Meeting Abstract June 2017

Safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration following a phase 2a randomized clinical trial

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Martyn French; Steve Butler; Samuel Barone; Steven D Schwartz; Mark Blumenkranz; Mariapia Degli-Esposti; Ian Constable

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4476.

ARVO Annual Meeting Abstract September 2016

Association of serum neutralizing antibodies with safety and efficacy outcomes in a Phase 2a trial of rAAV.sFlt-1 in the treatment of wet AMD

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Martyn French; Samuel Bradley Barone; Steven D Schwartz; Mark Blumenkranz; Mariapia Degli-Esposti; Ian J Constable

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):526.

ARVO Annual Meeting Abstract June 2015

One-year analysis of sFlt-1 and VEGF proteins and immunological markers in the bodily fluids of subjects participating in the Phase I rAAV.sFlt-1 trial.

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Matthew Wikstrom; Martyn French; Steven D Schwartz; Mark S Blumenkranz; Thomas Walter Chalberg; Mariapia Degli-Espoti; Ian J Constable

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1281.

ARVO Annual Meeting Abstract April 2014

One Year Follow-Up Report on the rAAV.sFlt-1 Phase I Gene Therapy Trial for Exudative Age-Related Macular Degeneration

Elizabeth P Rakoczy; May Lai; Aaron L Magno; Martyn French; Thomas Walter Chalberg; Mark Blumenkranz; Steven D Schwartz; Ian J Constable

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1309.

Immunology and Microbiology January 2013

The Effects of Age and Cx 3 cr1 Deficiency on Retinal Microglia in the Ins2 Akita Diabetic Mouse

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Jelena Marie Kezic; Xiangting Chen; Elizabeth P. Rakoczy; Paul G. McMenamin
TAGS: diabetes mellitus, mice, microglia
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):854-863. https://doi.org/10.1167/iovs.12-10876

Includes: Multimedia, Supplemental Content

Immunology and Microbiology March 2012

Changes in Murine Hyalocytes Are Valuable Early Indicators of Ocular Disease

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Nina N. Vagaja; Holly R. Chinnery; Nicolette Binz; Jelena M. Kezic; Elizabeth P. Rakoczy; Paul G. McMenamin
TAGS: eye, eye diseases, ligands, mice, phenotype, vascular endothelial growth factor a, vitreous body, toll-like receptor 9, toll-like receptor 4, macrophages
Invest. Ophthalmol. Vis. Sci.. 2012; 53(3):1445-1451. https://doi.org/10.1167/iovs.11-8601

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract April 2010

Assessment of Endothelin-2 Expression in Hyperglycemic and Retinal Neovascularisation Mouse Models

I. S. Ali Rahman; C.-M. Lai; N. Binz; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):116.

ARVO Annual Meeting Abstract April 2010

A Non-Invasive in vivo Assessment of the Akimba Mouse Eye

M. C. Lai; I. S. Ali Rahman; C. Li; N. Vagaja; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3663.

ARVO Annual Meeting Abstract April 2010

Correlation Between Protein Stability And Retinitis Pigmentosa

E. P. Rakoczy; C. Kiel; R. McKeone; F. Stricher; L. Serrano-Pubull

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):4094.

ARVO Annual Meeting Abstract April 2010

The Response of the Retina to Systemic Inflammatory Stimuli in a Model of Background Non-Proliferative Diabetic Retinopathy

N. N. Vagaja; N. Binz; E. P. Rakoczy; P. G. McMenamin

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):5613.

Immunology and Microbiology September 2009

rAAV.sFlt-1 Gene Therapy Achieves Lasting Reversal of Retinal Neovascularization in the Absence of a Strong Immune Response to the Viral Vector

PDF

Chooi-May Lai; Marie J. Estcourt; Matthew Wikstrom; Robyn P. Himbeck; Nigel L. Barnett; Meliha Brankov; Lisa B. G. Tee; Sarah A. Dunlop; Mariapia A. Degli-Esposti; Elizabeth P. Rakoczy
TAGS: eye, gene therapy, immune response, mice, retinal neovascularization, viral vector, vascular endothelial growth factor a, proteins
Invest. Ophthalmol. Vis. Sci.. 2009; 50(9):4279-4287. https://doi.org/10.1167/iovs.08-3253

ARVO Annual Meeting Abstract May 2008

Preclinical Evaluation of rAAV.sFlt-1 in Monkeys: Toxicity and Biodistribution

E. P. Rakoczy; C.-M. Lai; S. Lee; I. Yeo; R. Himbeck; M. Escourt; L. Chi; C. Ang; M. Degli-Espoti

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):1132.

ARVO Annual Meeting Abstract May 2008

Characterization of the Akimba Mouse: A Diabetic Mouse With Ocular and Renal Changes

M. C. Lai; N. Binz; J. A. Eade; M. de Pinho; R. P. Himbeck; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3996.

ARVO Annual Meeting Abstract May 2008

Long-Term Upregulation of Endothelin-2 in a VEGF-Driven Mouse Model (trVEGF029) of Retinal Neovascularisation (RNV)

I. S. Ali Rahman; C.-M. Lai; N. Binz; J. A. Eade; P. E. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3061.

ARVO Annual Meeting Abstract May 2007

Retinal and Choroidal Vascular Changes in VEGF Transgenic Models of Retinal Neovascularisation

M. C. Lai; L. Tee; M. Penrose; J. E. O’Shea,; E. P. Rakoczy; S. A. Dunlop

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3412.

ARVO Annual Meeting Abstract May 2007

Identification of a New Angiogenesis Associated Gene in the Retina

E. P. Rakoczy; J. Eade; N. Binz; J. Mills; K. Simpson; T. Speed; C.-M. Lai; C. Graham

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):4964.

ARVO Annual Meeting Abstract May 2007

Inhibition of Retinal Vascular Leakage in a Transgenic Vegf Mouse Model Following Intravitreal Bevacizumab

T. Isaacs; C.-M. Lai; M. Brankov; P. E. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3405.

Visual Psychophysics and Physiological Optics October 2006

Early Vascular and Neuronal Changes in a VEGF Transgenic Mouse Model of Retinal Neovascularization

PDF

Pauline E. van Eeden; Lisa B. G. Tee; Sherralee Lukehurst; Chooi-May Lai; Elizabeth P. Rakoczy; Lyn D. Beazley; Sarah A. Dunlop
TAGS: mice, transgenic, retinal neovascularization, vascular endothelial growth factor a, vascular lesions, blood capillaries, retina, rhodopsin
Invest. Ophthalmol. Vis. Sci.. 2006; 47(10):4638-4645. https://doi.org/10.1167/iovs.06-0251

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology September 2005

Correlation between Inactive Cathepsin D Expression and Retinal Changes in mcd2 / mcd2 Transgenic Mice

PDF

Dan Zhang; Meliha Brankov; Mahindra T. Makhija; Terry Robertson; Erik Helmerhorst; John M. Papadimitriou; Piroska E. Rakoczy
TAGS: aspartic acid endopeptidases, cathepsin d, mice, mice, transgenic, retinal pigment cell, retina, proteins, polymerase chain reaction, immunohistochemistry, fundus photography
Invest. Ophthalmol. Vis. Sci.. 2005; 46(9):3031-3038. https://doi.org/10.1167/iovs.04-1510

Retina April 2003

Functional and Structural Recovery of the Retina after Gene Therapy in the RPE65 Null Mutation Dog

PDF

Kristina Narfström; Martin L. Katz; Ragnheidur Bragadottir; Mathias Seeliger; Ana Boulanger; T. Michael Redmond; Lynette Caro; Chooi-May Lai; P. Elizabeth Rakoczy
TAGS: dog, domestic, eye, gene therapy, mutation, retina, recovery of function, surgical procedures, operative, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2003; 44(4):1663-1672. https://doi.org/10.1167/iovs.02-0595

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Safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration following a phase 2a randomized clinical trial

Association of serum neutralizing antibodies with safety and efficacy outcomes in a Phase 2a trial of rAAV.sFlt-1 in the treatment of wet AMD

One-year analysis of sFlt-1 and VEGF proteins and immunological markers in the bodily fluids of subjects participating in the Phase I rAAV.sFlt-1 trial.

One Year Follow-Up Report on the rAAV.sFlt-1 Phase I Gene Therapy Trial for Exudative Age-Related Macular Degeneration

The Effects of Age and Cx 3 cr1 Deficiency on Retinal Microglia in the Ins2 Akita Diabetic Mouse

Changes in Murine Hyalocytes Are Valuable Early Indicators of Ocular Disease

Assessment of Endothelin-2 Expression in Hyperglycemic and Retinal Neovascularisation Mouse Models

A Non-Invasive in vivo Assessment of the Akimba Mouse Eye

Correlation Between Protein Stability And Retinitis Pigmentosa

The Response of the Retina to Systemic Inflammatory Stimuli in a Model of Background Non-Proliferative Diabetic Retinopathy

rAAV.sFlt-1 Gene Therapy Achieves Lasting Reversal of Retinal Neovascularization in the Absence of a Strong Immune Response to the Viral Vector

Preclinical Evaluation of rAAV.sFlt-1 in Monkeys: Toxicity and Biodistribution

Characterization of the Akimba Mouse: A Diabetic Mouse With Ocular and Renal Changes

Long-Term Upregulation of Endothelin-2 in a VEGF-Driven Mouse Model (trVEGF029) of Retinal Neovascularisation (RNV)

Retinal and Choroidal Vascular Changes in VEGF Transgenic Models of Retinal Neovascularisation

Identification of a New Angiogenesis Associated Gene in the Retina

Inhibition of Retinal Vascular Leakage in a Transgenic Vegf Mouse Model Following Intravitreal Bevacizumab

Early Vascular and Neuronal Changes in a VEGF Transgenic Mouse Model of Retinal Neovascularization

Correlation between Inactive Cathepsin D Expression and Retinal Changes in mcd2 / mcd2 Transgenic Mice

Functional and Structural Recovery of the Retina after Gene Therapy in the RPE65 Null Mutation Dog

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