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ARVO Annual Meeting Abstract June 2020

Insulin Receptor signaling potentiation by proinsulin preserves photoreceptors and rod synapses in the rd10 mouse model of retinitis pigmentosa

Alonso Sanchez-Cruz; Alberto Hernández-Pinto; Concepción Lillo; Carolina Isiegas; Miguel Marchena; Fatima Bosch; Lizasoain Ignacio; Pedro de la Villa; Enrique J De La Rosa; Catalina Hernández-Sánchez

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4049.

ARVO Annual Meeting Abstract June 2017

Retinal ganglion cell death is attenuated by a PI3K activating synthetic peptide

Enrique J De La Rosa; A. M. Hernandez-Pinto; M. Marchena; J. L. M. San-Martin; P. Fernandez; F. de Pablo; M. Morales

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1750.

ARVO Annual Meeting Abstract June 2017

TLR4 deficiency delays photoreceptor cell loss and visual function decline in the rd10 mouse model of retinitis pigmentosa.

Catalina Hernandez- Sanchez; Alonso Sanchez-Cruz; Pedro de la Villa; Lizasoaín Ignacio; Enrique J De La Rosa

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3247.

ARVO Annual Meeting Abstract September 2016

Visual decline in aged mice is delayed by proinsulin.

Enrique J De La Rosa; Alberto M Hernandez-Pinto; Javier Vicente-Tejedor; Laura Ramírez; Eduard Ayuso; Patricia Boya; Catalina Hernandez- Sanchez; Fátima Bosch; Pedro de la Villa

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4392.

ARVO Annual Meeting Abstract September 2016

A GSK-3b modulator delays photoreceptor cell death and preserves visual function in the rd10 mouse model of retinitis pigmentosa.

Catalina Hernandez- Sanchez; Beatriz Villarejo; Josefa Zaldivar; Miguel Marchena; Carmen Gil; Pedro de la Villa; Ana Martínez; Enrique J De La Rosa

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4396.

Retina July 2016

Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in the rd10 Mouse Model of Retinitis Pigmentosa

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Carolina Isiegas; Jorge A. Marinich-Madzarevich; Miguel Marchena; José M. Ruiz; María J. Cano; Pedro de la Villa; Catalina Hernández-Sánchez; Enrique J. de la Rosa; Flora de Pablo
TAGS: blindness, history of present illness, intravitreal injections, mice, microspheres, photoreceptors, proinsulin, retina, retinitis pigmentosa
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3610-3618. https://doi.org/10.1167/iovs.16-19300

ARVO Annual Meeting Abstract June 2015

Proinsulin formulated in PLGA microspheres delays vision loss and activates survival pathways in the rd10 mouse model of retinitis pigmentosa.

Catalina Hernandez- Sanchez; María Jesús Cano; Jorge Marinich; Jose María Ruiz; Carolina Isiegas; Miguel Marchena; Flora de Pablo; Pedro de la Villa; Enrique J De La Rosa

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3649.

ARVO Annual Meeting Abstract June 2015

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

Patricia Boya; Natalia Rodriguez-Muela; Alberto M Hernandez-Pinto; Ana Serrano-Puebla; Lucia Garcia-Ledo; Sergio Latorre; Enrique J De La Rosa

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4267.

ARVO Annual Meeting Abstract June 2015

PEDF-derived Peptides delay Photoreceptor Cell Death in two Experimental Models of Retinitis Pigmentosa.

Alberto M Hernandez-Pinto; Preeti Subramanian; Federica Polato; Andrés de la Rocha; Enrique J De La Rosa; Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5413.

ARVO Annual Meeting Abstract April 2014

Targeted modulation of the glial inflammatory response in Retinitis Pigmentosa attenuates photoreceptor cell death.

Enrique J de la Rosa; Catalina Hernández-Sánchez; Alberto M Hernández-Pinto; María Platón; Miguel Marchena; Noemí Álvarez-Lindo; Ana I Arroba; Sean Jmaeff; Pablo F Barcelona; H Uri Saragovi

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6197.

ARVO Annual Meeting Abstract March 2012

Additional Neuroprotective Effects Of Proinsulin On Vision And Retinal Structure In The Rd10 Mouse Model Of Retinitis Pigmentosa

Enrique J. de la Rosa; Nuria Forns; Miguel Marchena; Alberto Hernandez-Pinto; Ryan Steel; Carolina Isiegas; Eduard Ayuso; Flora de Pablo; Fátima Bosch; Pedro de la Villa

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6447.

Retina November 2011

Microglia-Mediated IGF-I Neuroprotection in the rd10 Mouse Model of Retinitis Pigmentosa

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Ana I. Arroba; Noemí Álvarez-Lindo; Nico van Rooijen; Enrique J. de la Rosa
TAGS: insulin-like growth factor i, mice, microglia, neuroprotection, retinitis pigmentosa, retina
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):9124-9130. https://doi.org/10.1167/iovs.11-7736

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2011

Proinsulin Delays Retinal Degeneration and Vision Loss in the P23H Rat

Carolina Isiegas; Pedro Lax; Laura Fernández-Sánchez; María Jesús Cano; José María Ruiz; Eduard Ayuso; Fátima Bosch; Flora de Pablo; Enrique J. de la Rosa; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4357.

ARVO Annual Meeting Abstract April 2011

Molecular and Cellular Events Leading to Photoreceptor Cell Death in Retinitis Pigmentosa

Alberto M. Hernandez-Pinto; Natalia Rodriguez-Muela; Patricia Boya; Enrique J. de la Rosa

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5413.

ARVO Annual Meeting Abstract April 2011

Requirement of DNA Double-strand Break Repair in Retinal Neurogenesis and Axonogenesis

Enrique J. de la Rosa; Jimena Baleriola; Noemi Alvarez; Jose L. San-Martin; Teresa Suarez; Gloria Terrados; Beatriz Escudero; Antonio Bernad; Luis Blanco

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):6002.

Retinal Cell Biology September 2008

Attenuation of Vision Loss and Delay in Apoptosis of Photoreceptors Induced by Proinsulin in a Mouse Model of Retinitis Pigmentosa

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Silvia Corrochano; Rima Barhoum; Patricia Boya; Ana I. Arroba; Natalia Rodríguez-Muela; Violeta Gómez-Vicente; Fátima Bosch; Flora de Pablo; Pedro de la Villa; Enrique J. de la Rosa
TAGS: blindness, history of present illness, mice, photoreceptors, proinsulin, retinitis pigmentosa, apoptosis, vision, attenuation, animals, transgenic
Invest. Ophthalmol. Vis. Sci.. 2008; 49(9):4188-4194. https://doi.org/10.1167/iovs.08-2182

Includes: Supplemental Content

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Insulin Receptor signaling potentiation by proinsulin preserves photoreceptors and rod synapses in the rd10 mouse model of retinitis pigmentosa

Retinal ganglion cell death is attenuated by a PI3K activating synthetic peptide

TLR4 deficiency delays photoreceptor cell loss and visual function decline in the rd10 mouse model of retinitis pigmentosa.

Visual decline in aged mice is delayed by proinsulin.

A GSK-3b modulator delays photoreceptor cell death and preserves visual function in the rd10 mouse model of retinitis pigmentosa.

Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in the rd10 Mouse Model of Retinitis Pigmentosa

Proinsulin formulated in PLGA microspheres delays vision loss and activates survival pathways in the rd10 mouse model of retinitis pigmentosa.

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

PEDF-derived Peptides delay Photoreceptor Cell Death in two Experimental Models of Retinitis Pigmentosa.

Targeted modulation of the glial inflammatory response in Retinitis Pigmentosa attenuates photoreceptor cell death.

Additional Neuroprotective Effects Of Proinsulin On Vision And Retinal Structure In The Rd10 Mouse Model Of Retinitis Pigmentosa

Microglia-Mediated IGF-I Neuroprotection in the rd10 Mouse Model of Retinitis Pigmentosa

Proinsulin Delays Retinal Degeneration and Vision Loss in the P23H Rat

Molecular and Cellular Events Leading to Photoreceptor Cell Death in Retinitis Pigmentosa

Requirement of DNA Double-strand Break Repair in Retinal Neurogenesis and Axonogenesis

Attenuation of Vision Loss and Delay in Apoptosis of Photoreceptors Induced by Proinsulin in a Mouse Model of Retinitis Pigmentosa

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