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Biochemistry and Molecular Biology July 2024

The First Steps of the Visual Cycle in Human Rod and Cone Photoreceptors

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Chunhe Chen; Leopold Adler, IV; Cole Milliken; Bushra Rahman; Masahiro Kono; Lynn Poole Perry; Federico Gonzalez-Fernandez; Yiannis Koutalos
TAGS: photoreceptors, vertebrate, retinal cone, rod photoreceptors, vitamin a, fluorescence, rhodopsin, eye, kinetics, retina, rate constants
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):9. https://doi.org/10.1167/iovs.65.8.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Hypoxia and hyperglycemia Mitigate IRBP Expression in Cultured Retinoblastoma Cells

Andrew T C Tsin; Arianna L Lizbeth Rodriguez; Laura Leanne Valdez; David Flores; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):871.

ARVO Annual Meeting Abstract June 2024

Interphotoreceptor Retinoid Binding Protein (IRBP, RBP3) is susceptible to non-enzymatic glycation –implications to function, stability, and role in diabetic retinopathy (DR)

Ernest Moses Lam; Michael R. Fracchia; Oliver Liu; Laura Leanne Valdez; David Flores; Susan Weintraub; Debashis Gosh; Andrew T C Tsin; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1271.

ARVO Annual Meeting Abstract June 2024

Novel distribution of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) in the human retina – Henle fiber and external plexiform layers

Peter Carlos Martin; Robert Balie Crim; Veronica Gonzalez-Fernandez; Thomas Bell; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1270.

ARVO Annual Meeting Abstract June 2024

Beyond the vitamin A cycle – IRBP’s (RBP3) role as an ocular free radical scavenger

Federico Gonzalez-Fernandez; Ernest Moses Lam; Jason Newbaker; Sun Dongjin; Priscilla Bates

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4983.

ARVO Annual Meeting Abstract June 2024

Optimizing histopathological processing of human eyes - fixative conditions

Avery Watson; Veronica Gonzalez-Fernandez; Robert Balie Crim; Gregory Grossman; Saboor Shad; Sarah Xin Zhang; Thomas Bell; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4433.

ARVO Annual Meeting Abstract June 2023

Purification of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) from globes of separate donors

Veronica Gonzalez-Fernandez; Avery Watson; Jason Newbaker; darrian Kelly; Laura Valdez; Andrew T C Tsin; Federico Gonzalez-Fernandez; Gregory Grossman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5205.

ARVO Annual Meeting Abstract June 2023

Differential Expression of IRBP by cultured rod and cone cells in presence of hypoxia and hyperglycemia

Jose Elias Martinez; Laura Leanne Valdez; Kevin Abraham; Federico Gonzalez-Fernandez; Andrew T C Tsin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1831.

ARVO Annual Meeting Abstract June 2023

Creating a Human Ocular Pathology Resource by Creating a Relational Database

Ali Alzeghoul; John Dehnel; Veronica Gonzalez-Fernandez; Saboor Shad; Sarah Xin Zhang; Gregory H Grossman; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2130.

ARVO Annual Meeting Abstract June 2023

Beyond the IPM – understanding the extraretinal roles of interphotoreceptor retinoid-binding protein (IRBP / RBP3)

Oliver Liu; Peter Martin; Sabrina Yen; Scott Murphy; Tomeka Nailer; Darrian Kelly; Veronica Gonzalez-Fernadez; Gregory H Grossman; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4468.

ARVO Annual Meeting Abstract June 2023

IRBP protects retinoids from photodecomposition and effect of glycation – Pump-probe paradigm using an integrated cavity light toxicity chamber and rapid scanning spectrophotometry

Ernest Moses Lam; Jason Newbaker; Elisabeth Millsap; Laura Leanne Valdez; Andrew T C Tsin; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4456.

ARVO Annual Meeting Abstract June 2022

Absence of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) in Transgenic Rats Causes Photoreceptor Degeneration and Myopia

Chaimae Gouya; Darrian Kelly; Min Kim; Veronica Wilburn; Oliver Liu; Ernest Lam; Brian Tieu; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1873 – A0002.

ARVO Annual Meeting Abstract June 2022

Detecting Molecular Features of the Interphotoreceptor Matrix and Outer Segments with Multiple Attenuated Internal Reflectance (MAIR) Infrared (IR) Spectroscopy

Darrian Kelly; Chaimae Gouya; Min Kim; Oliver Liu; Amol Janorkar; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3903 – A0105.

ARVO Annual Meeting Abstract June 2022

Extra-retinal localization of retinol binding protein 3 (RBP3) suggests novel functions beyond the visual cycle

Oliver Liu; Sabrina Yen; Scott Murphy; Darrian Kelly; Tomeka Nailer; Ernest Lam; Kaitlyn Kunkle; Brian Tieu; Gregory H Grossman; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3893 – A0095.

ARVO Annual Meeting Abstract June 2021

Reduced Expression of Interphotoreceptor-Retinoid Binding Protein (IRBP) in Diabetic Retinopathy – Cell and Postmortem Study

Andrew T C Tsin; Reanna Raye Rodriguez; Daniela Gonzalez; Tianle Zou; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2979.

ARVO Annual Meeting Abstract June 2021

Coup and Counter Coup Injury in a Focal Unilateral Ocular Blast Injury in Rats

Darrian Kelly; Manish Harrigill; Brandon Grayson; Robby Chen; Hong Zhu; Federico Gonzalez-Fernandez

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3101.

ARVO Annual Meeting Abstract June 2020

Diverse, variable ocular disease in a non-congenital murine model of Zika virus infection

Sean Carter; Federico Gonzalez-Fernandez; Fengwei Bai; Xavier Montagutelli; Gladys Maestre; Anavaj Sakuntabhai; Caroline Manet; Gabriel Gonzalez-Fernandez; Biswas Neupane

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):439.

ARVO Annual Meeting Abstract June 2020

Rat CRISPR/Cas9 knockout of Interphotoreceptor retinoid-binding protein (IRBP, RBP3) suggests role in maintaining lamellar disc outer segment stability

Federico Gonzalez-Fernandez; John Kenneth Lippincott; Asyvia M. Powell; Taylor Coleman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1528.

ARVO Annual Meeting Abstract July 2018

Formation of all- trans retinol after bleaching in isolated human cone photoreceptors

Cole Milliken; Chunhe Chen; Patrice Goletz; Federico Gonzalez-Fernandez; Yiannis Koutalos

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4510.

ARVO Annual Meeting Abstract July 2018

Interphotoreceptor retinoid binding protein (IRBP) reduces but does not fully prevent the formation of lipofuscin precursors from 11- cis retinal in human rod photoreceptor outer segments

Leopold Adler; Chunhe Chen; Patrice Goletz; Federico Gonzalez-Fernandez; Yiannis Koutalos

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4512.

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The First Steps of the Visual Cycle in Human Rod and Cone Photoreceptors

Hypoxia and hyperglycemia Mitigate IRBP Expression in Cultured Retinoblastoma Cells

Interphotoreceptor Retinoid Binding Protein (IRBP, RBP3) is susceptible to non-enzymatic glycation –implications to function, stability, and role in diabetic retinopathy (DR)

Novel distribution of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) in the human retina – Henle fiber and external plexiform layers

Beyond the vitamin A cycle – IRBP’s (RBP3) role as an ocular free radical scavenger

Optimizing histopathological processing of human eyes - fixative conditions

Purification of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) from globes of separate donors

Differential Expression of IRBP by cultured rod and cone cells in presence of hypoxia and hyperglycemia

Creating a Human Ocular Pathology Resource by Creating a Relational Database

Beyond the IPM – understanding the extraretinal roles of interphotoreceptor retinoid-binding protein (IRBP / RBP3)

IRBP protects retinoids from photodecomposition and effect of glycation – Pump-probe paradigm using an integrated cavity light toxicity chamber and rapid scanning spectrophotometry

Absence of Interphotoreceptor Retinoid-Binding Protein (IRBP, RBP3) in Transgenic Rats Causes Photoreceptor Degeneration and Myopia

Detecting Molecular Features of the Interphotoreceptor Matrix and Outer Segments with Multiple Attenuated Internal Reflectance (MAIR) Infrared (IR) Spectroscopy

Extra-retinal localization of retinol binding protein 3 (RBP3) suggests novel functions beyond the visual cycle

Reduced Expression of Interphotoreceptor-Retinoid Binding Protein (IRBP) in Diabetic Retinopathy – Cell and Postmortem Study

Coup and Counter Coup Injury in a Focal Unilateral Ocular Blast Injury in Rats

Diverse, variable ocular disease in a non-congenital murine model of Zika virus infection

Rat CRISPR/Cas9 knockout of Interphotoreceptor retinoid-binding protein (IRBP, RBP3) suggests role in maintaining lamellar disc outer segment stability

Formation of all- trans retinol after bleaching in isolated human cone photoreceptors

Interphotoreceptor retinoid binding protein (IRBP) reduces but does not fully prevent the formation of lipofuscin precursors from 11- cis retinal in human rod photoreceptor outer segments

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