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ARVO Annual Meeting Abstract June 2025

3D Human Blood-Retinal Barrier Model Demonstrates Senescent Phenotype Activation Under Hypoxic Conditions

Karen Yud Torrejon; Pujhitha Ramesh; Andrea M Unser; Hira Afzaal; Javier Estrada; Feryan Ahmed; Juan Andre Melendez

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4861.

ARVO Annual Meeting Abstract June 2024

Bioegineered 3D Blood-Retinal-Barrier Model Enhances Barrier Markers and Mfsd2a Expression Compared to Transwells

Karen Yud Torrejon; Andrea M Unser; Hira Afzaal; Feryan Ahmed; Pujhitha Ramesh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):874.

Glaucoma March 2024

ANGPTL7 and Its Role in IOP and Glaucoma

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Suzette Farber-Katz Brown; Hien Nguyen; Philip Mzyk; Michael L. De Ieso; Andrea M. Unser; Ian Brown; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Karen Y. Torrejon; Alan Nhan; Dalton Markrush; Tom Daly; Ellie Knecht; William McConaughy; Sara Halmos; Zhiquan Lucy Liu; Rachel Rennard; Andrew Peterson; W. Daniel Stamer
TAGS: antibodies, eye, glaucoma, intraocular pressure, mice, aqueous humor, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):22. https://doi.org/10.1167/iovs.65.3.22

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Bioengineered Blood-Retinal-Barrier 3D Model Depicts Microvascular Changes Under Hypoxic Conditions

Karen Yud Torrejon; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Andrea Unser

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1815.

ARVO Annual Meeting Abstract June 2023

ANGPTL7 and its role in IOP and glaucoma

Suzette Farber-Katz Brown; Hien Nguyen; Michael Lucio De Ieso; Andrea Unser; Karen Yud Torrejon; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Ian Brown; Lucy Liu; William McConaughy; Sara Halmos; Alan Nhan; Dalton Markrush; W Daniel Stamer; Andrew Peterson

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3766.

ARVO Annual Meeting Abstract June 2022

Blood-Retinal -Barrier 3D Model Using Microfabricated Porous Scaffolds

Karen Yud Torrejon; Andrea Unser; Hira Afzaal; Hunter Williams; Feryan Ahmed; Patricia A D'Amore

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3155 – F0429.

ARVO Annual Meeting Abstract June 2021

Use of a Novel Potassium Channel Opener in a 3D-Glaucomatous Human Trabecular Meshwork/Schlemm’s Canal Tissue Model

Karen Yud Torrejon; Andrea Unser; Feryan Ahmed; Vandhana Chari; Thurein Htoo; Cynthia Steel; Barbara M Wirostko

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2758.

ARVO Annual Meeting Abstract June 2021

Human Trabecular Meshwork Cells Appear Healthier & More Viable in Contact with Titanium Stents Than in Contact with Nickel-Titanium Stents

Hal Heitzmann; Barbara M Wirostko; Feryan Ahmed; Andrea Unser; Vandhana Chari; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3421.

ARVO Annual Meeting Abstract June 2021

Examining the Effects of Glaucoma Medications on the Trabecular Outflow Pathway Using Glauconix Bioscience’s 3D-HTM™ Tissue Constructs

Andrea Unser; Feryan Ahmed; Hira Afzaal; Hunter Williams; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):470.

Physiology and Pharmacology March 2021

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs

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Elena Bastia; Carol B. Toris; Stefania Brambilla; Corinna Galli; Nicoletta Almirante; Michael V. W. Bergamini; Emanuela Masini; Silvia Sgambellone; Andrea M. Unser; Feryan Ahmed; Karen Y. Torrejon; Tomas Navratil; Francesco Impagnatiello
TAGS: animal model, dog, domestic, intraocular pressure, ocular hypertension, oryctolagus cuniculus, nitric oxide, primates, donors, cyclic gmp
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):17. https://doi.org/10.1167/iovs.62.3.17

ARVO Annual Meeting Abstract June 2020

3D Human Trabecular Meshwork model as a potential tool for gene screening

Karen Y Torrejon; Cula N Dautriche; Andrea Unser; Mathew Kerr; Feryan Ahmed; Abbey Van Alstyne-Ponce; Dan Stamer; Susan T Sharfstein; Yubing Xie; John Danias

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3441.

ARVO Annual Meeting Abstract June 2020

Distinct pharmacological activities between cannabidiol (CBD) and cannabidiol analog (CBDVHS) in a 3D human trabecular meshwork model

Andrea Unser; Karen Y Torrejon; Feryan Ahmed; Abbey Van Alstyne-Ponce; Brian Murphy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3463.

ARVO Annual Meeting Abstract July 2019

Investigation of the Mechanism of Action and IOP Lowering Ability of CB1 Agonists using Glauconix Biosciences’ 3D-HTM TM Tissue Model

Andrea Unser; Aishwarya Panneerselvam; Feryan Ahmed; George Torrejon; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5159.

ARVO Annual Meeting Abstract July 2018

Tandem-pore domain potassium channels are components of intracellular signaling pathways, determinants of pH sensitivity and mechanosensitivity of human trabecular meshwork cells.

Oleg Yarishkin; Tam Phuong; Jackson M Baumann; Alan S Crandall; Feryan Ahmed; Karen Yud Torrejon; David Krizaj

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1660.

ARVO Annual Meeting Abstract July 2018

Nitric Oxide Induces Changes in the Cytoskeleton and ECM of TGFβ2-treated Trabecular Meshwork and Schlemm’s canal cells

Karen Yud Torrejon; Ellen L Papke; Andrea Unser; Matthew Kerr; W Daniel Stamer; Feryan Ahmed

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4708.

Physiology and Pharmacology January 2018

Trabodenoson, an Adenosine Mimetic With A 1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice

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Guorong Li; Karen Y. Torrejon; Andrea M. Unser; Feryan Ahmed; Iris D. Navarro; Rudolf A. Baumgartner; David S. Albers; W. Daniel Stamer
TAGS: adenosine, eye, intraocular pressure, mice, gelatinase a, body tissue, proteins, placebos, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):383-392. https://doi.org/10.1167/iovs.17-23212

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Human microvascular endothelial cells (HMVECs) assume Schlemm’s canal (HSC) cell characteristics after co-culture with human trabecular meshwork (HTM) cells and can be used to model conventional outflow

Karen Y Torrejon; Ellen Papke; Dhruba J Bharali; Magnus Bergkvist; W Daniel Stamer; Susan T Sharfstein; Yubing Xie; Feryan Ahmed; John Danias

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3471.

ARVO Annual Meeting Abstract September 2016

Anti-fibrotic Effects of AR-13324 in a 3D Bioengineered Human Trabecular Meshwork Model of Steroid-induced Glaucoma

Casey Kopczynski; Feryan Ahmed; Dhruba Bharali; Karen Torrejon; Cheng-Wen Lin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5639.

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3D Human Blood-Retinal Barrier Model Demonstrates Senescent Phenotype Activation Under Hypoxic Conditions

Bioegineered 3D Blood-Retinal-Barrier Model Enhances Barrier Markers and Mfsd2a Expression Compared to Transwells

ANGPTL7 and Its Role in IOP and Glaucoma

Bioengineered Blood-Retinal-Barrier 3D Model Depicts Microvascular Changes Under Hypoxic Conditions

ANGPTL7 and its role in IOP and glaucoma

Blood-Retinal -Barrier 3D Model Using Microfabricated Porous Scaffolds

Use of a Novel Potassium Channel Opener in a 3D-Glaucomatous Human Trabecular Meshwork/Schlemm’s Canal Tissue Model

Human Trabecular Meshwork Cells Appear Healthier & More Viable in Contact with Titanium Stents Than in Contact with Nickel-Titanium Stents

Examining the Effects of Glaucoma Medications on the Trabecular Outflow Pathway Using Glauconix Bioscience’s 3D-HTM™ Tissue Constructs

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs

3D Human Trabecular Meshwork model as a potential tool for gene screening

Distinct pharmacological activities between cannabidiol (CBD) and cannabidiol analog (CBDVHS) in a 3D human trabecular meshwork model

Investigation of the Mechanism of Action and IOP Lowering Ability of CB1 Agonists using Glauconix Biosciences’ 3D-HTM TM Tissue Model

Tandem-pore domain potassium channels are components of intracellular signaling pathways, determinants of pH sensitivity and mechanosensitivity of human trabecular meshwork cells.

Nitric Oxide Induces Changes in the Cytoskeleton and ECM of TGFβ2-treated Trabecular Meshwork and Schlemm’s canal cells

Trabodenoson, an Adenosine Mimetic With A 1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice

Human microvascular endothelial cells (HMVECs) assume Schlemm’s canal (HSC) cell characteristics after co-culture with human trabecular meshwork (HTM) cells and can be used to model conventional outflow

Anti-fibrotic Effects of AR-13324 in a 3D Bioengineered Human Trabecular Meshwork Model of Steroid-induced Glaucoma

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