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ARVO Annual Meeting Abstract June 2023

Nonclinical safety and pharmacokinetic assessment of SPVN06, an AAV-based gene therapy for the treatment of rod-cone dystrophies.

Anne-Sophie Gautron; Melanie Marie; Lucie Churet; Hanen Khabou; Gregg Prawdzik; Thierry Léveillard; José-Alain Sahel; Florence Lorget

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):773.

ARVO Annual Meeting Abstract June 2023

Mouse model selection for pharmacological evaluation of AAV-based therapeutic agents for the treatment of Rod-Cone Dystrophies (RCD)

Melanie MARIE; Lucie Churet; Hanen Khabou; Daniel C Chung; Jose Sahel; Thierry Léveillard; Florence Lorget

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2591.

ARVO Annual Meeting Abstract June 2022

SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

Florence Lorget; Melanie Marie; Hanen Khabou; Cardillia Simon; Didier Nuno; Phillip Vanlandingham; Alain Quiambao; Rafal Farjo; Deniz Dalkara; Jose Alain Sahel; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):56 – A0029.

ARVO Annual Meeting Abstract June 2021

A 1-Month Toxicology and Biodistribution NHP Pilot Study Evaluating a Single Subretinal Bilateral Administration of SPVN06 - A Novel AAV-Based Gene Therapy for the Treatment of Rod-Cone Dystrophies Agnostic of the Causative Mutation

Melanie MARIE; Myriam Marussig; Pierre-Axel VINOT; Thomas VIHTELIC; Ryan F. Boyd; Lauren KNUPP; Jennifer LAMOUREUX; Thierry D Leveillard; Jose Alain Sahel; Florence LORGET

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):194.

ARVO Annual Meeting Abstract June 2021

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Jennifer Noel; archana jalligampala; Myriam Marussig; Pierre-Axel VINOT; Melanie MARIE; Melanie Butler; Florence LORGET; Stephane Boissel; Thierry D Leveillard; Jose Alain Sahel; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1189.

ARVO Annual Meeting Abstract July 2018

The Presence of Protein in Formulation Ameliorates Retinal Changes Observed on OCT Following Intravitreal Administration of Hyperosmotic Solution in Cynomolgus Monkeys

Nardos Tassew; Vladimir Bantseev; Aija McKenzie; Roxanne Andaya; Debbie O'Connor; Daniel Sheinson; Carol A Rasmussen; T Michael Nork; Tim Streit; Helen S Booler; Florence Lorget

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5828.

ARVO Annual Meeting Abstract July 2018

Retinal toxicity in rabbits administered intravitreal TSG-6-rabbit FAb fusion proteins

Steven Thomas Laing; Devin Tesar; Susan Crowell; Julia Gray; Kelly Loyet; Roxanne Andaya; Aija McKenzie; Florence Lorget; Bob Kelley

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):216.

ARVO Annual Meeting Abstract July 2018

Ocular and Systemic Pharmacokinetics of a PEGylated-anti-Factor D Fab Multimer in Cynomolgous Monkeys

Daniela Bumbaca Yadav; Whitney B Shatz; danielle mandikian; C. Andrew Boswell; Aija McKenzie; Daniel Sheinson; Hong Liu; Isabel Figueroa; Bob Kelley; Devin Tesar; Michelle Dion; Amrita kamath; Florence Lorget; Susan Crowell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):242.

ARVO Annual Meeting Abstract July 2018

In vivo Effects of CCFD9260S Following Intravitreal Administration to Cynomolgus Monkeys

Helen S Booler; Nardos Tassew; Aija MacKenzie; Hong Liu; Deborah O'Connor; Florence Lorget; Paul E Miller; Tim Streit; T Michael Nork; James N Ver Hoeve; Cinzia Stella; Yanqiu Liu; Daniela Bumbaca; Vladimir Bantseev

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):80.

ARVO Annual Meeting Abstract July 2018

Intravitreal Administrations of pH 4.0-5.5 Vehicle Solutions are Well Tolerated in NZW rabbits

Florence Lorget; Steven Thomas Laing; Chris Schuetz; Isabella De Jong; Jeff Aaronson; Nardos Tassew

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2652.

Physiology and Pharmacology August 2017

Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response

PDF

Evan A. Thackaberry; Cindy Farman; Fiona Zhong; Florence Lorget; Karin Staflin; Angelique Cercillieux; Paul E. Miller; Chris Schuetz; Debby Chang; Amin Famili; Ann L. Daugherty; Karthik Rajagopal; Vladimir Bantseev
TAGS: microspheres, oryctolagus cuniculus, rod photoreceptors, toxic effect, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4274-4285. https://doi.org/10.1167/iovs.16-21334

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Characterization of the pH and Temperature in the Rabbit Vitreous: Key Parameters for the Development of Long Acting Delivery of Drugs to the Posterior Segment of the Eye

Florence LORGET; Chris Schuetz; Simon Authier; Michel Carrier; Audrey Parenteau; Ann Daughety; Vladimir Bantseev; Evan A. Thackaberry

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):146.

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