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Cornea March 2025

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

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Tatsuya Nakagawa; Tetsuro Honda; Taichi Yuasa; Go Nishiuchi; Masakazu Sato; Ayumi Tokunaga; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Prema Padmanabhan; Amit Chatterjee; Gajanan Sathe; Vivek Ghose; Narayanan Janakiraman; Derek J. Blake; Noriko Koizumi; Sailaja Elchuri; Naoki Okumura
TAGS: apoptosis, cornea, endothelial cells, endothelium, genes, hereditary corneal dystrophy, pathogenesis, proteins, western blotting, liquid chromatography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):16. https://doi.org/10.1167/iovs.66.3.16

Includes: Supplemental Content

Cornea June 2024

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

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Tetsuro Honda; Tatsuya Nakagawa; Taichi Yuasa; Yuichi Tokuda; Masakazu Nakano; Kei Tashiro; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Koji Yamamoto; Noriko Koizumi; Naoki Okumura
TAGS: hereditary corneal dystrophy, protein isoforms, rna-seq, exons, cornea, endothelial cells, endothelium, datasets
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):27. https://doi.org/10.1167/iovs.65.6.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Functional Characterization of Rare Genetic Variants in the LOXL1 Gene Associated with Pseudoexfoliation Syndrome/Glaucoma

Iris Kerker; Ursula Hoja; Valentin Nelea; Matthias Zenkel; Andreas Gießl; Friedrich E Kruse; Dieter Reinhardt; Francesca Pasutto; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):665.

ARVO Annual Meeting Abstract June 2024

Elucidating the asymmetric manifestation of pseudoexfoliation syndrome by RNA-sequencing and pathway analysis

Matthias Zenkel; Sai Pulasani; Steffen Uebe; Arif Ekici; Friedrich E Kruse; Francesca Pasutto; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):633.

ARVO Annual Meeting Abstract June 2024

Insulin for treatment of neurotrophic ulcers: Clinical evidence and potential mechanism

Victoria Elisabeth Birgit Zeisberg; Matthias Zenkel; Andreas Gießl; Ursula Schlötzer-Schrehardt; Theofilos Tourtas; Julia M Weller; Victor A. Augustin; Friedrich E Kruse

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):56.

ARVO Annual Meeting Abstract June 2024

Effects of limbal niche cells-derived melanosomes and exosomes on human limbal epithelial stem/progenitor cells

Andreas Gießl; Julia Khorolskaya; Günter Lochnit; Thomas Timm; Jan Van Deun; Matthias Zenkel; Andreas Baur; Friedrich E Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1997.

ARVO Annual Meeting Abstract June 2024

Comparison of refractive outcomes after Descemet membrane endothelial keratoplasty (DMEK) combined with phacoemulsification using two different methods of intraocular lens power calculation

Maximilian Peter Michael Angerer; Lisa Hübner; Julia M Weller; Friedrich E Kruse; Theofilos Tourtas

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1493.

ARVO Annual Meeting Abstract June 2024

Descemet membrane endothelial keratoplasty for endothelial dysfunction caused by primary angle closure

Eva Roy-Chowdhury; Theofilos Tourtas; Friedrich E Kruse; Julia M Weller

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1085.

ARVO Annual Meeting Abstract June 2024

Late graft failure after Descemet membrane endothelial keratoplasty (DMEK): clinical characteristics and ultrastructural findings of failed grafts

Julia M Weller; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Theofilos Tourtas

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1081.

ARVO Annual Meeting Abstract June 2024

Limbal melanocytes mediate immunosuppressive effects in the corneal epithelial stem cell niche through IDO1/TGF-ß/TRAIL

Yiqun Fan; Andreas Gießl; Matthias Zenkel; Nina Eisenhauer; Simon Voelkl; Friedrich E Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2000.

ARVO Annual Meeting Abstract June 2024

Investigation of the TCF4 Aberrant Splicing in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Taichi Yuasa; Naoki Okumura; Tatsuya Nakagawa; Tetsuro Honda; Ayana Tateishi; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5814.

ARVO Annual Meeting Abstract June 2024

Feasibility of using a novel endoplasmic reticulum stress inhibitor as potential therapy for Fuchs endothelial corneal dystrophy

Kanna Hasegawa; Naoki Okumura; Ryo Hirota; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Masahiro Abo; Motonari Uesugi; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5810.

ARVO Annual Meeting Abstract June 2024

Establishment of cellular models of Fuchs endothelial corneal dystrophy with and without the expansion of a trinucleotide repeat in TCF4

Keita Miyadai; Naoki Okumura; Mari Yasunaga; Tatsuya Nakagawa; Renya Kamada; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Makiko Nakahara; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5806.

ARVO Annual Meeting Abstract June 2024

Development of an in vitro model for pseudoexfoliation syndrome

Ursula Schlötzer-Schrehardt; Robert Lämmer; Anselm Jünemann; Matthias Zenkel; Friedrich E Kruse; Francesca Pasutto; Sai Pulasani

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6138.

ARVO Annual Meeting Abstract June 2023

Investigation of the TCF4 Splicing and Isoform Expressions in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Tetsuro Honda; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Koji Yamamoto; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):OD23.

Cornea June 2023

Type II Diabetes Mellitus Causes Extracellular Matrix Alterations in the Posterior Cornea That Increase Graft Thickness and Rigidity

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Kenten D. Kingsbury; Jessica M. Skeie; Krista Cosert; Gregory A. Schmidt; Benjamin T. Aldrich; Christopher S. Sales; Julia Weller; Friedrich Kruse; Sara M. Thomasy; Ursula Schlötzer-Schrehardt; Mark A. Greiner
TAGS: body tissue, cornea, diabetes mellitus, diabetes mellitus, type 2, donors, muscle rigidity, proteins, tissue transplants, extracellular matrix, age
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):26. https://doi.org/10.1167/iovs.64.7.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Fuchs endothelial corneal dystrophy and epithelial basement membrane dystrophy - DMEK alone or combined with debridement of the corneal epithelium?

Victoria Elisabeth Birgit Zeisberg; Julia M. Weller; Theofilos Tourtas; Friedrich E. Kruse

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4792.

ARVO Annual Meeting Abstract June 2023

Descemet membrane endothelial keratoplasty (DMEK) in the management of late spontaneous detachment of Descemet’s membrane after penetrating keratoplasty

Theofilos Tourtas; Julia M. Weller; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4789.

ARVO Annual Meeting Abstract June 2023

Pattern electroretinogram, blue-yellow visual evoked potentials and the risk of developing visual field defects in glaucoma suspects: a longitudinal “survival” analysis

Cord R H Huchzermeyer; Robert Lämmer; Christian Y Mardin; Friedrich E. Kruse; Jan J Kremers; Folkert Horn

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5490.

ARVO Annual Meeting Abstract June 2023

Abnormalities in cholesterol homeostasis may contribute to pathogenesis of pseudoexfoliation syndrome/glaucoma.

Matthias Zenkel; Dieter Lütjohann; Anja Kerksiek; Andreas Giessl; Friedrich E. Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):51.

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The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

Functional Characterization of Rare Genetic Variants in the LOXL1 Gene Associated with Pseudoexfoliation Syndrome/Glaucoma

Elucidating the asymmetric manifestation of pseudoexfoliation syndrome by RNA-sequencing and pathway analysis

Insulin for treatment of neurotrophic ulcers: Clinical evidence and potential mechanism

Effects of limbal niche cells-derived melanosomes and exosomes on human limbal epithelial stem/progenitor cells

Comparison of refractive outcomes after Descemet membrane endothelial keratoplasty (DMEK) combined with phacoemulsification using two different methods of intraocular lens power calculation

Descemet membrane endothelial keratoplasty for endothelial dysfunction caused by primary angle closure

Late graft failure after Descemet membrane endothelial keratoplasty (DMEK): clinical characteristics and ultrastructural findings of failed grafts

Limbal melanocytes mediate immunosuppressive effects in the corneal epithelial stem cell niche through IDO1/TGF-ß/TRAIL

Investigation of the TCF4 Aberrant Splicing in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Feasibility of using a novel endoplasmic reticulum stress inhibitor as potential therapy for Fuchs endothelial corneal dystrophy

Establishment of cellular models of Fuchs endothelial corneal dystrophy with and without the expansion of a trinucleotide repeat in TCF4

Development of an in vitro model for pseudoexfoliation syndrome

Investigation of the TCF4 Splicing and Isoform Expressions in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Type II Diabetes Mellitus Causes Extracellular Matrix Alterations in the Posterior Cornea That Increase Graft Thickness and Rigidity

Fuchs endothelial corneal dystrophy and epithelial basement membrane dystrophy - DMEK alone or combined with debridement of the corneal epithelium?

Descemet membrane endothelial keratoplasty (DMEK) in the management of late spontaneous detachment of Descemet’s membrane after penetrating keratoplasty

Pattern electroretinogram, blue-yellow visual evoked potentials and the risk of developing visual field defects in glaucoma suspects: a longitudinal “survival” analysis

Abnormalities in cholesterol homeostasis may contribute to pathogenesis of pseudoexfoliation syndrome/glaucoma.

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