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Retina May 2019

Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology

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Virpi Alarautalahti; Symantas Ragauskas; Jenni J. Hakkarainen; Hannele Uusitalo-Järvinen; Hannu Uusitalo; Jari Hyttinen; Giedrius Kalesnykas; Soile Nymark
TAGS: photoreceptors, mice, retina, tissue preparation, morphology, language morphology
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1914-1927. doi: 10.1167/iovs.18-25156

ARVO Annual Meeting Abstract July 2018

Aflibercept shows strong dose-dependency when administered intravitreally in the mouse CNV model

Ruta Maciulaitiene; Symantas Ragauskas; Anna Mari Haapaniemi; Simon Kaja; Ingrida Januleviciene; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2631. doi:

ARVO Annual Meeting Abstract July 2018

Utility of approved dry-eye drugs as reference compounds in SiccaSystem TM - a standardized mouse desiccating stress model for dry-eye disease

Simon Kaja; Symantas Ragauskas; Agne Ziniauskaite; Anna Mari Haapaniemi; Jenni J. Hakkarainen; Henna Martiskainen; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2673. doi:

ARVO Annual Meeting Abstract July 2018

Neuroprotection of retinal ganglion cells via NMDA-dependent mechanism in the mouse non-arteritic anterior ischemic optic neuropathy (NAION) model

Symantas Ragauskas; Agne Ziniauskaite; Simon Kaja; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3204. doi:

ARVO Annual Meeting Abstract July 2018

Pre-clinical efficacy of OCU300 nanoemulsion for the treatment of ocular graft versus host disease (oGVHD).

Rasappa Arumugham; Gopalam Somasekhar; Arun K Upadhyay; Giedrius Kalesnykas; Simon Kaja; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3287. doi:

ARVO Annual Meeting Abstract July 2018

Combining ISTH0036, an antisense oligonucleotide targeting Transforming Growth Factor beta 2 (TGF-β2) mRNA, with aflibercept as novel treatment strategy for neovascular retinal diseases

Michel Janicot; Giedrius Kalesnykas; Eugen Leo; Petra Fettes; Simon Kaja; Katja Wosikowski

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):236. doi:

Cornea June 2018

Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome

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Agnė Žiniauskaitė; Symantas Ragauskas; Jenni J. Hakkarainen; Cadmus C. Rich; Rudolf Baumgartner; Giedrius Kalesnykas; David S. Albers; Simon Kaja

Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3088-3093. doi: 10.1167/iovs.18-24432

ARVO Annual Meeting Abstract June 2017

Targeting Transforming Growth Factor beta 2 (TGF-β2) mRNA with ISTH0036 as Novel Therapeutic Intervention in Neovascular Ocular Disease

Katja Wosikowski; Inge van Hoven; Jooseppi Puranen; Lies de Groef; Anne Mari Haapaniemi; Jurgen Sergeys; Simon Kaja; Giedrius Kalesnykas; Lieve K M Moons; Michel Janicot

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1948. doi:

ARVO Annual Meeting Abstract June 2017

Assessment of the effects of systemically administered levetiracetam in an ocular model for neuroprotection.

Ruta Maciulaitiene; Symantas Ragauskas; Giedre Pakuliene; Simon Kaja; Ingrida Januleviciene; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2571. doi:

ARVO Annual Meeting Abstract June 2017

Development of an artificial cornea for testing drug candidate permeability in early stages of drug development

Jenni J. Hakkarainen; Vytautas Cepla; Agne Ziniauskaite; Ramunas Valiokas; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4337. doi:

ARVO Annual Meeting Abstract September 2016

Intravitreal injection of PBS reduces retinal neovascularization in the mouse oxygen-induced retinopathy model

Maria Vähätupa; Hannele Uusitalo-Järvinen; Tero Järvinen; Hannu M T Uusitalo; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3649. doi:

ARVO Annual Meeting Abstract September 2016

hiPSC-derived RPE cells: Characterization of blood-retinal barrier properties and drug permeability

Jenni J. Hakkarainen; Julien Maruotti; Aila Seppänen; Brigitte Onteniente; Giedrius Kalesnykas; Mika Reinisalo

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):268. doi:

ARVO Annual Meeting Abstract September 2016

Simultaneous pattern ERG-VEP recording after optic nerve crush in albino rats

Henri Olavi Leinonen; Symantas Ragauskas; Heikki Tanila; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5763. doi:

ARVO Annual Meeting Abstract September 2016

Age-related differences in light sensitivity in BALB/c mice

Giedrius Kalesnykas; Symantas Ragauskas; Simon Kaja; Heikki Tanila; Henri Olavi Leinonen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5004. doi:

ARVO Annual Meeting Abstract September 2016

Subretinal injection of poly(IC) causes acute photoreceptor cell death in the mouse retinal detachment model

Symantas Ragauskas; Sabine Grüner; Ludovic Collin; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5377. doi:

ARVO Annual Meeting Abstract September 2016

Restasis® prevents lacrimal gland pathology in the novel SiccaSystem TM standardized experimental platform for experimental dry-eye disease research

Agne Ziniauskaite; Symantas Ragauskas; Jooseppi Puranen; Anne Mari Haapaniemi; Giedrius Kalesnykas; Simon Kaja

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5690. doi:

ARVO Annual Meeting Abstract June 2015

Retinal dysfunction precedes motor symptoms by several months in a CLN5 mouse model of Neuronal Ceroid Lipofuscinosis

Henri Olavi Leinonen; Anne Mari Haapaniemi; Jooseppi Puranen; Symantas Ragauskas; Kestutis Gurevicius; Juho Koponen; Giedrius Kalesnykas; Jari Koistinaho; Heikki Tanila; Katja Kanninen

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4257. doi:

ARVO Annual Meeting Abstract April 2014

Heat shock protein 25 kDa gene therapy alleviates retinal ganglion cell dysfunction after optic nerve crush in mice

Henri Olavi Leinonen; Symantas Ragauskas; Jooseppi Puranen; Adrian Smedowski; Kari Airenne; Seppo Ylä-Herttuala; Heikki Tanila; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6195. doi:

ARVO Annual Meeting Abstract April 2014

Morphological and functional evaluation of retinal ganglion cells in R6/2 mice

Symantas Ragauskas; Henri Olavi Leinonen; Jooseppi Puranen; Soile Nymark; Arto Lipponen; Kestutis Gurevicius; Outi Kontkanen; Jukka Puoliväli; Heikki Tanila; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6196. doi:

ARVO Annual Meeting Abstract April 2014

Increased expression of PSA-NCAM in the optic nerve of experimental glaucoma

Jooseppi Puranen; Anne-Mari Haapaniemi; Sunna Lappalainen; Giedrius Kalesnykas

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2273. doi:

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Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology

Aflibercept shows strong dose-dependency when administered intravitreally in the mouse CNV model

Utility of approved dry-eye drugs as reference compounds in SiccaSystem TM - a standardized mouse desiccating stress model for dry-eye disease

Neuroprotection of retinal ganglion cells via NMDA-dependent mechanism in the mouse non-arteritic anterior ischemic optic neuropathy (NAION) model

Pre-clinical efficacy of OCU300 nanoemulsion for the treatment of ocular graft versus host disease (oGVHD).

Combining ISTH0036, an antisense oligonucleotide targeting Transforming Growth Factor beta 2 (TGF-β2) mRNA, with aflibercept as novel treatment strategy for neovascular retinal diseases

Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome

Targeting Transforming Growth Factor beta 2 (TGF-β2) mRNA with ISTH0036 as Novel Therapeutic Intervention in Neovascular Ocular Disease

Assessment of the effects of systemically administered levetiracetam in an ocular model for neuroprotection.

Development of an artificial cornea for testing drug candidate permeability in early stages of drug development

Intravitreal injection of PBS reduces retinal neovascularization in the mouse oxygen-induced retinopathy model

hiPSC-derived RPE cells: Characterization of blood-retinal barrier properties and drug permeability

Simultaneous pattern ERG-VEP recording after optic nerve crush in albino rats

Age-related differences in light sensitivity in BALB/c mice

Subretinal injection of poly(IC) causes acute photoreceptor cell death in the mouse retinal detachment model

Restasis® prevents lacrimal gland pathology in the novel SiccaSystem TM standardized experimental platform for experimental dry-eye disease research

Retinal dysfunction precedes motor symptoms by several months in a CLN5 mouse model of Neuronal Ceroid Lipofuscinosis

Heat shock protein 25 kDa gene therapy alleviates retinal ganglion cell dysfunction after optic nerve crush in mice

Morphological and functional evaluation of retinal ganglion cells in R6/2 mice

Increased expression of PSA-NCAM in the optic nerve of experimental glaucoma

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