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ARVO Annual Meeting Abstract June 2021

Lacritin Proteoform Rescue of Epithelial Corneal Homeostasis Requires GPR87 Coupled to Syndecan-1

Karina Luiza Dias Teixeira; Jeff Romano; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1313. doi:

ARVO Annual Meeting Abstract June 2021

Topical lacritin C-terminal peptide 'Lacripep TM ' significantly reduces both inferior corneal staining and burning/stinging in primary Sjögren's Syndrome dry eye

Anil C Asrani; Marc G Odrich; Michelle A Carpenter; Mark B Logan; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1266. doi:

ARVO Annual Meeting Abstract June 2021

Lacritin Bactericidal Peptide N-104 Binds Surface-Exposed Lipoprotein YaiW, a Known Peptide Transporter

Mohammad Sharifian Gh.; Mihaela G Gadjeva; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):407. doi:

Articles August 2020

Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms

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Brooke M. Justis; Casey E. Coburn; Ethan M. Tyler; Ryan S. Showalter; Brianna J. Dissler; Melissa Li; Nancy A. McNamara; Gordon W. Laurie; Robert L. McKown
TAGS: antibodies, immunoassay, proteins, schirmer tear test procedure, protein measurement, total, western blotting, recovery of function, volume
Trans. Vis. Sci. Tech.. 2020; 9(9):13. doi: https://doi.org/10.1167/tvst.9.9.13

ARVO Annual Meeting Abstract June 2020

Putrescine Transporter Subunit 'PotH' is Essential for Lacritin Peptide 'N-104' Bactericidal Activity

Mohammad Sharifian Gh.; Fatemeh Norouzi; Mihaela G Gadjeva; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):404. doi:

ARVO Annual Meeting Abstract June 2020

Genome-Wide CRISPR/Cas9 Screen Towards Identification of the Lacritin Homeostasis Receptor

Karina Luiza Dias Teixeira; John Doench; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4705. doi:

ARVO Annual Meeting Abstract July 2019

Putative Carpet Accumulation of Bactericidal Peptide N-104 on Model Gram-Negative and Positive Bacterial Membranes

Mohammad Sharifian Gh.; Margaret Ryan; Mirco Sorci; Georges Belfort; Georgi Georgiev; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5183. doi:

ARVO Annual Meeting Abstract July 2019

Topical Lacritin Peptides 'N-94/C-6' and 'N-94' Stabilize and Display Long Residence Time in the Tear Lipid Layer

Gordon W Laurie; Jeffrey Romano; Marc Odrich; Denise Ryan; Kay Sia; Georgi Georgiev

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4181. doi:

ARVO Annual Meeting Abstract July 2018

Immunomodulatory Activity of Tear Protein Lacritin

Afsaneh Amouzegar; Sharad Mittal; Mingshun Li; Robert L McKown; Gordon W Laurie; Sunil Chauhan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3323. doi:

ARVO Annual Meeting Abstract July 2018

Relative Deficiency of Active Lacritin, the Shed Form of Lacritin Co-Receptor Syndecan-1 and the Pro-Form of Syndecan-Activating Enzyme Heparanase in Dry Eye Tears, and Development of a Tear Interactome

Gordon W Laurie; Jeff Romano; Leran Mao; Karina Luiza Dias Teixeira; Robert L McKown; Denise Ryan; Bruce Rivers

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3828. doi:

ARVO Annual Meeting Abstract July 2018

Development of a Quantitative Multiplex Western Blot Assay for Tear Lacritin Proteins

Robert L McKown; Brooke M Justis; Casey E Coburn; Ronald W Raab; Bruce Rivers; Rose K Sia; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4914. doi:

ARVO Annual Meeting Abstract June 2017

Constitutive Release of Lacritin's Latent Bactericidal Activity Explored by MALDI-TOF Mass Spectrometry

Jeff Romano; Nick Sherman; Robert L McKown; Tadayuki Iwase; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2646. doi:

ARVO Annual Meeting Abstract June 2017

Contribution of Nonpolar Side Chains to Lacritin N-104 Bactericidal Activity

Gordon W Laurie; Margaret Ryan; Amber Watkins; Kevin-Jude Sankoorikal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2647. doi:

ARVO Annual Meeting Abstract June 2017

Evaluation of conjunctival and lacrimal gland inflammation after corneal herpes simplex virus-1 infection

Pushpa Rao; Subhash Gaddipati; Bala Burugula; Andrew Jerome; Robert L McKown; Gordon W Laurie; Susmit Suvas

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3620. doi:

ARVO Annual Meeting Abstract September 2016

Lacritin acutely enhances corneal nerve sensitivity to ocular surface dryness as a key stimulus for basal tear production: Implications for dry eye disease.

Valentina Dallacasagrande; Harumitsu Hirata; Kamila K Mizerska; Toin H. van Kuppevelt; Robert L McKown; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):424. doi:

ARVO Annual Meeting Abstract September 2016

Lacritin Enhances Cell Proliferation in Mouse Lacrimal Gland

Helen P Makarenkova; Daren Lui; Driss Zoukhri; Robert L McKown; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5709. doi:

ARVO Annual Meeting Abstract September 2016

Release of Lacritin’s C-Terminal Bactericidal Domain by Esp, a Serine Protease Highly Expressed in Coagulase Negative Clinical Isolates from Bacterial Keratitis, but not from Endophthalmitis or Blepharitis

Jeff Romano; Robert L McKown; Regis P Kowalski; Tadayuki Iwase; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6190. doi:

ARVO Annual Meeting Abstract June 2015

Anti-Stress and Basal Tear Stimulatory Tear Factor ‘Lacritin’ Promotes Acetylation of ATG101-Associated Proteins but has No Apparent Effect on Transepithelial Resistance

Gordon W Laurie; Ningning Wang; Jeffrey Romano; Robert L McKown

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2490. doi:

ARVO Annual Meeting Abstract June 2015

Canine Tear Lacritin is Down Regulated in Clinical Dry Eye

Robert L McKown; Alan C. Tate; Alison M. Enghauser; Cara L. Soyars; Ronald W. Raab; Gordon W Laurie; Ian P. Herring

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):288. doi:

ARVO Annual Meeting Abstract June 2015

Lacritin’s active C-terminal peptide, ‘Lacripep’, as an efficient and innovative therapeutic for the treatment of aqueous-deficient dry eye.

Feeling Yu Ting Chen; Denise Stephens; Shaokui Ge; Trinka Vijmasi; Gordon W Laurie; Sarah Knox; Nancy A McNamara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):300. doi:

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Lacritin Proteoform Rescue of Epithelial Corneal Homeostasis Requires GPR87 Coupled to Syndecan-1

Topical lacritin C-terminal peptide 'Lacripep TM ' significantly reduces both inferior corneal staining and burning/stinging in primary Sjögren's Syndrome dry eye

Lacritin Bactericidal Peptide N-104 Binds Surface-Exposed Lipoprotein YaiW, a Known Peptide Transporter

Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms

Putrescine Transporter Subunit 'PotH' is Essential for Lacritin Peptide 'N-104' Bactericidal Activity

Genome-Wide CRISPR/Cas9 Screen Towards Identification of the Lacritin Homeostasis Receptor

Putative Carpet Accumulation of Bactericidal Peptide N-104 on Model Gram-Negative and Positive Bacterial Membranes

Topical Lacritin Peptides 'N-94/C-6' and 'N-94' Stabilize and Display Long Residence Time in the Tear Lipid Layer

Immunomodulatory Activity of Tear Protein Lacritin

Relative Deficiency of Active Lacritin, the Shed Form of Lacritin Co-Receptor Syndecan-1 and the Pro-Form of Syndecan-Activating Enzyme Heparanase in Dry Eye Tears, and Development of a Tear Interactome

Development of a Quantitative Multiplex Western Blot Assay for Tear Lacritin Proteins

Constitutive Release of Lacritin's Latent Bactericidal Activity Explored by MALDI-TOF Mass Spectrometry

Contribution of Nonpolar Side Chains to Lacritin N-104 Bactericidal Activity

Evaluation of conjunctival and lacrimal gland inflammation after corneal herpes simplex virus-1 infection

Lacritin acutely enhances corneal nerve sensitivity to ocular surface dryness as a key stimulus for basal tear production: Implications for dry eye disease.

Lacritin Enhances Cell Proliferation in Mouse Lacrimal Gland

Release of Lacritin’s C-Terminal Bactericidal Domain by Esp, a Serine Protease Highly Expressed in Coagulase Negative Clinical Isolates from Bacterial Keratitis, but not from Endophthalmitis or Blepharitis

Anti-Stress and Basal Tear Stimulatory Tear Factor ‘Lacritin’ Promotes Acetylation of ATG101-Associated Proteins but has No Apparent Effect on Transepithelial Resistance

Canine Tear Lacritin is Down Regulated in Clinical Dry Eye

Lacritin’s active C-terminal peptide, ‘Lacripep’, as an efficient and innovative therapeutic for the treatment of aqueous-deficient dry eye.

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