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Physiology and Pharmacology February 2011

In Vitro Synergism of Trifluorothymidine and Ganciclovir against HSV-1

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Jeffery A. Hobden; Manish Kumar; Herbert E. Kaufman; Christian Clement; Emily D. Varnell; Partha S. Bhattacharjee; James M. Hill
TAGS: acyclovir, antiviral agents, ganciclovir, human herpesvirus 1, trifluridine
Invest. Ophthalmol. Vis. Sci.. 2011; 52(2):830-833. https://doi.org/10.1167/iovs.10-5671

Immunology and Microbiology September 2010

Effect of High versus Low Oral Doses of Valacyclovir on Herpes Simplex Virus-1 DNA Shedding into Tears of Latently Infected Rabbits

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Manish Kumar; Herbert E. Kaufman; Christian Clement; Partha S. Bhattacharjee; Tashfin S. Huq; Emily D. Varnell; Hilary W. Thompson; James M. Hill
TAGS: dna, herpes simplex infection, oryctolagus cuniculus, valacyclovir, viruses, human herpesvirus 1, simplexvirus
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4703-4706. https://doi.org/10.1167/iovs.09-4884

Clinical and Epidemiologic Research December 2009

A Double-Blind Placebo-Controlled Study to Evaluate Valacyclovir Alone and with Aspirin for Asymptomatic HSV-1 DNA Shedding in Human Tears and Saliva

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Manish Kumar; James M. Hill; Christian Clement; Emily D. Varnell; Hilary W. Thompson; Herbert E. Kaufman
TAGS: aspirin, dna, human herpesvirus 1, placebos, saliva, valacyclovir
Invest. Ophthalmol. Vis. Sci.. 2009; 50(12):5601-5608. https://doi.org/10.1167/iovs.09-3729

Includes: Supplemental Content

Immunology and Microbiology June 2009

Heat-Induced Reactivation of HSV-1 in Latent Mice: Upregulation in the TG of CD83 and Other Immune Response Genes and Their LAT-ICP0 Locus

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Christian Clement; Partha S. Bhattacharjee; Herbert E. Kaufman; James M. Hill
TAGS: genes, heat (physical force), human herpesvirus 1, immune response, mice, up-regulation (physiology), gene expression, stress, hyperthermia, heat stress disorders
Invest. Ophthalmol. Vis. Sci.. 2009; 50(6):2855-2861. https://doi.org/10.1167/iovs.08-2430

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2008

Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model

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Partha S. Bhattacharjee; Donna M. Neumann; Timothy P. Foster; Christian Clement; Gyanendra Singh; Hilary W. Thompson; Herbert E. Kaufman; James M. Hill
TAGS: apolipoprotein e, eye, mice, peptides, treatment effectiveness, human herpesvirus 1
Invest. Ophthalmol. Vis. Sci.. 2008; 49(10):4263-4268. https://doi.org/10.1167/iovs.08-2077

ARVO Annual Meeting Abstract May 2008

In vitro Combination Efficacies of Antiviral Drugs Against Hsv-1

M. Kumar; H. W. Thompson; E. D. Varnell; H. E. Kaufman

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):5131.

ARVO Annual Meeting Abstract May 2008

Comparison of Ganciclovir Ophthalmic Gel and Trifluridine Drops for the Treatment of Experimental Herpetic Keratitis

E. D. Varnell; H. E. Kaufman

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):2491.

ARVO Annual Meeting Abstract May 2008

Spontaneous Shedding of HSV-1 DNA of High and Low Phenotypic Reactivating Strains in the Rabbit Eye Model Support an Emerging Paradigm

H. S. Toma; G. Singh; D. M. Neumann; P. S. Bhattacharjee; S. Bouhnik; H. E. Kaufman; J. M. Hill

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):493.

ARVO Annual Meeting Abstract May 2007

Deep Anterior Lamellar Keratoplasty With and Without Exposure of Descemet’s Membrane: Clinical and Confocal Microscopic Study

H. E. Kaufman; A. A. Abdelkader

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):1135.

ARVO Annual Meeting Abstract May 2007

Human Apolipoprotein E (ApoE) Allele 4 Regulates the Resolution and Recurrence of HSV Stromal Keratitis (HSK) in the Mouse Eye

J. M. Hill; D. M. Neumann; S. Bouhanik; A. Ephraim; M. Kumar; B. Khoobehi; H. W. Thompson; H. E. Kaufman; P. S. Bhattacharjee

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3165.

ARVO Annual Meeting Abstract May 2007

Enhanced Green Fluorescing Protein HSV-1 Keratitis With Healing Time Correlation in Rabbit Models

E. S. Atwal; M. Kumar; E. D. Varnell; H. E. Kaufman

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):5989.

ARVO Annual Meeting Abstract May 2007

Efficacy of a Helicase-Primase Inhibitor in Animal Models of Ocular HSV-1 Infection

E. D. Varnell; H. E. Kaufman; B. M. Gebhardt; G. Kleymann; H. W. Thompson; E. S. Atwal

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):2665.

ARVO Annual Meeting Abstract May 2007

Regulation of Primary Herpes Stromal Keratitis (HSK) by Human Apolipoprotein E (ApoE) Alleles 3 and 4 in the Mouse Eye

P. Bhattacharjee; D. M. Neumann; S. Bouhanik; A. Ephraim; M. Kumar; B. Khoobehi; H. W. Thompson; H. E. Kaufman; J. M. Hill

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):2667.

Immunology and Microbiology January 2005

HSV-1 DNA in Tears and Saliva of Normal Adults

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Herbert E. Kaufman; Ann M. Azcuy; Emily D. Varnell; Gregory D. Sloop; Hilary W. Thompson; James M. Hill
TAGS: dna, human herpesvirus 1, saliva, adult, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2005; 46(1):241-247. https://doi.org/10.1167/iovs.04-0614

Cornea May 2004

Corneal Healing after Uncomplicated LASIK and Its Relationship to Refractive Changes: A Six-Month Prospective Confocal Study

PDF

Avni Murat Avunduk; Carl Joseph Senft; Sherif Emerah; Emily D. Varnell; Herbert E. Kaufman
TAGS: cornea, keratomileusis, laser in situ, healing process, wound healing, surgical flaps
Invest. Ophthalmol. Vis. Sci.. 2004; 45(5):1334-1339. https://doi.org/10.1167/iovs.03-1025

Lecture May 2002

Can We Prevent Recurrences of Herpes Infections without Antiviral Drugs? The Weisenfeld Lecture

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Herbert E. Kaufman
TAGS: antiviral agents, infections, recurrence, simplexvirus
Invest. Ophthalmol. Vis. Sci.. 2002; 43(5):1325-1329.

Cornea January 2001

Increased Severity of HSV-1 Keratitis and Mortality in Mice Lacking the 2–5A-dependent RNase L Gene

PDF

Xiaodong Zheng; Robert H. Silverman; Aimin Zhou; Tomoko Goto; Byoung Se Kwon; Herbert E. Kaufman; James M. Hill
TAGS: endoribonucleases, human herpesvirus 1, mice, ribonucleases, mortality, keratitis, genes, mice, knockout
Invest. Ophthalmol. Vis. Sci.. 2001; 42(1):120-126.

Cornea October 1999

HSV-1 Migration in Latently Infected and Naive Rabbits after Penetrating Keratoplasty

PDF

Xiaodong Zheng; Mary E. Marquart; Jeannette M. Loustch; Pulin Shah; Bruno Sainz; Arnab Ray; Richard J. O’Callaghan; Herbert E. Kaufman; James M. Hill
TAGS: cornea, dna, human herpesvirus 1, keratoplasty, penetrating, oryctolagus cuniculus, tissue transplants, iontophoresis, viruses, epinephrine, keratoplasty
Invest. Ophthalmol. Vis. Sci.. 1999; 40(11):2490-2497.

Articles May 1995

Cold stress-induced recurrences of herpetic keratitis in the squirrel monkey.

PDF

E D Varnell; H E Kaufman; J M Hill; H W Thompson
TAGS: cold sensation, cold temperature, common cold, keratitis, herpetic, recurrence, saimiri, stress
Invest. Ophthalmol. Vis. Sci.. 1995; 36(6):1181-1183.

Articles April 1989

Trifluridine decreases ocular HSV-1 recovery, but not herpetic lesions after timolol iontophoresis.

PDF

D S Rootman; J M Hill; Y Haruta; J J Reidy; H E Kaufman
TAGS: herpetic eruption, human herpesvirus 1, iontophoresis, recovery of function, timolol, trifluridine
Invest. Ophthalmol. Vis. Sci.. 1989; 30(4):678-683.

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In Vitro Synergism of Trifluorothymidine and Ganciclovir against HSV-1

Effect of High versus Low Oral Doses of Valacyclovir on Herpes Simplex Virus-1 DNA Shedding into Tears of Latently Infected Rabbits

A Double-Blind Placebo-Controlled Study to Evaluate Valacyclovir Alone and with Aspirin for Asymptomatic HSV-1 DNA Shedding in Human Tears and Saliva

Heat-Induced Reactivation of HSV-1 in Latent Mice: Upregulation in the TG of CD83 and Other Immune Response Genes and Their LAT-ICP0 Locus

Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model

In vitro Combination Efficacies of Antiviral Drugs Against Hsv-1

Comparison of Ganciclovir Ophthalmic Gel and Trifluridine Drops for the Treatment of Experimental Herpetic Keratitis

Spontaneous Shedding of HSV-1 DNA of High and Low Phenotypic Reactivating Strains in the Rabbit Eye Model Support an Emerging Paradigm

Deep Anterior Lamellar Keratoplasty With and Without Exposure of Descemet’s Membrane: Clinical and Confocal Microscopic Study

Human Apolipoprotein E (ApoE) Allele 4 Regulates the Resolution and Recurrence of HSV Stromal Keratitis (HSK) in the Mouse Eye

Enhanced Green Fluorescing Protein HSV-1 Keratitis With Healing Time Correlation in Rabbit Models

Efficacy of a Helicase-Primase Inhibitor in Animal Models of Ocular HSV-1 Infection

Regulation of Primary Herpes Stromal Keratitis (HSK) by Human Apolipoprotein E (ApoE) Alleles 3 and 4 in the Mouse Eye

HSV-1 DNA in Tears and Saliva of Normal Adults

Corneal Healing after Uncomplicated LASIK and Its Relationship to Refractive Changes: A Six-Month Prospective Confocal Study

Can We Prevent Recurrences of Herpes Infections without Antiviral Drugs? The Weisenfeld Lecture

Increased Severity of HSV-1 Keratitis and Mortality in Mice Lacking the 2–5A-dependent RNase L Gene

HSV-1 Migration in Latently Infected and Naive Rabbits after Penetrating Keratoplasty

Cold stress-induced recurrences of herpetic keratitis in the squirrel monkey.

Trifluridine decreases ocular HSV-1 recovery, but not herpetic lesions after timolol iontophoresis.

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