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Lens April 2025

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

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Matthieu Duot; Sarah Y. Coomson; Sanjaya K. Shrestha; M. V. Murali Krishna Nagulla; Yann Audic; Ruteja A. Barve; Hongzhan Huang; Carole Gautier-Courteille; Luc Paillard; Salil A. Lachke
TAGS: datasets, embryo, epithelium, genes, lens epithelium, meta-analysis, mice, lens (device), lens, crystalline, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):42. https://doi.org/10.1167/iovs.66.4.42

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu
TAGS: angiogram, atypical, eye, genetics, retinal capillary hemangioma, von hippel-lindau syndrome, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):34. https://doi.org/10.1167/iovs.66.4.34

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK

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Kaiyan Huang; Mi Xia; Qianwen Gong; Kexin Li; Yijie Xu; Hui Wang; Yuzhou Wang; Jiawei Zhou; Liang Hu
TAGS: eye, imbalance, spatial frequency
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):32. https://doi.org/10.1167/iovs.66.4.32

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Cornea & External Disease April 2025

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

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Jad F. Assaf; Jiachi Hong; Yan Li; David Huang
TAGS: cornea, incidence, optical coherence tomography, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(4):7. https://doi.org/10.1167/tvst.14.4.7

Cornea & External Disease March 2025

Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

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Jiachi Hong; Afshan A. Nanji; Richard D. Stutzman; Winston D. Chamberlain; Xubo Song; David Huang; Yan Li
TAGS: artificial intelligence, cornea, keratomileusis, laser in situ, maps, optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(3):17. https://doi.org/10.1167/tvst.14.3.17

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Review March 2025

Advances in OCT Angiography

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Tristan T. Hormel; David Huang; Yali Jia
TAGS: angiogram, artifacts, diagnostic imaging, deep learning, fluid flow, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(3):6. https://doi.org/10.1167/tvst.14.3.6

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2025

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

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Jiangtao Lou; Hailu Huang; Yiyi Peng; Chunxiao Wang; Meiping Xu; Xinping Yu
TAGS: muscle of orbit, oryctolagus cuniculus, postoperative care, surgical procedures, operative, embryo, russell-silver syndrome, surgery specialty, somatostatin receptor scintigraphy, preoperative care
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):12. https://doi.org/10.1167/iovs.66.3.12

Includes: Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Cornea February 2025

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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Xiao Zhou; Lingjuan Xu; Yongyao Tan; Wei Wang; Xiaoyu Huang; Guigang Li
TAGS: language morphology, morphology, phenotype, translocation (genetics), diffuse idiopathic skeletal hyperostosis, cornea, stem cells, proteins, western blotting, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):43. https://doi.org/10.1167/iovs.66.2.43

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

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Qiuxuan Du; Ying Zhang; Yusen Huang
TAGS: cataract, cataract, childhood, chinese (other dialects), chinese people, eye, growth rate, intraocular lens implantation procedure, multifocal intraocular lenses, refraction, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):33. https://doi.org/10.1167/iovs.66.2.33

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Glaucoma January 2025

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

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Qian Ying; Hongdou Luo; Zhi Xie; Yi Huang; Haijian Hu; Ming Jin; Ke Xu; Yulian Pang; Yuning Song; Xu Zhang
TAGS: glutamate, glutamates, mitochondria, neuroglia, optic atrophy, autosomal dominant, proteins, retina, wounds and injuries, n-methylaspartate, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):62. https://doi.org/10.1167/iovs.66.1.62

Retina January 2025

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

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Jinlian Zhan; Chen Chen; Tong Wang; Qi Zhang; Xia Huang; Lin Lu; Xiujuan Zhao
TAGS: epiretinal membrane, perfusion, postoperative care, preoperative care, recovery of function, retinal vasculature, vision, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(1):19. https://doi.org/10.1167/tvst.14.1.19

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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Jie Chen; Tianyu Zhu; Ziyue Huang; Renbing Jia; Shiqiong Xu
TAGS: cohort studies, eye, orbit evisceration, sebaceous adenocarcinoma, sebaceous adenocarcinoma of eyelid, neoplasm metastasis, surgical procedures, operative, recurrence, selenocysteine, cerebral arterial thrombosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):40. https://doi.org/10.1167/iovs.66.1.40

Includes: Supplemental Content

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Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Advances in OCT Angiography

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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