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Clinical and Epidemiologic Research March 2025

Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

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Alexis O'Neil; Roshan A. Welikala; Sarah Barman; Christopher G. Owen; Alicja R. Rudnicka; Mohan Rakesh; Marie-Hélène Roy-Gagnon; David Maberley; Ellen E. Freeman
TAGS: aging, longitudinal studies, retinal vessels, obesity, diabetes mellitus, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):13. https://doi.org/10.1167/iovs.66.3.13

Cornea & External Disease March 2025

Corneal Resistance to Enzymatic Digestion After Rose Bengal and Combined Rose Bengal/Riboflavin Cross-Linking Is Oxygen Independent

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M. Enes Aydemir; Nikki L. Hafezi; Nan-Ji Lu; Emilio A. Torres-Netto; Mark Hillen; Carina Koppen; Farhad Hafezi
TAGS: cornea, corneal collagen cross-linking, cross-linking, digestion, oxygen, riboflavin, rose bengal
Trans. Vis. Sci. Tech.. 2025; 14(3):1. https://doi.org/10.1167/tvst.14.3.1

Retina February 2025

Preferential Locations of Polypoidal Lesions and Adjacent Pigment Epithelium Detachments in Polypoidal Choroidal Vasculopathy in a Japanese Population

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Takahiro Kogo; Yuki Muraoka; Masayuki Hata; Masaharu Ishikura; Naomi Nishigori; Yuki Akiyama; Naoko Ueda-Arakawa; Manabu Miyata; Sotaro Ooto; Ayako Takahashi; Masahiro Miyake; Akitaka Tsujikawa
TAGS: discharge, body substance, drainage procedure, epithelium, eye, fovea centralis, japanese, pigment, polypoidal choroidal vasculopathy, drusen, face
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):70. https://doi.org/10.1167/iovs.66.2.70

Includes: Supplemental Content

Lens February 2025

Depth and Strain-Dependent Structural Responses of Mouse Lens Fiber Cells During Whole Lens Shape Changes

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Sepideh Cheheltani; Mahbubul H. Shihan; Justin Parreno; Sondip K. Biswas; Woo-Kuen Lo; Velia M. Fowler
TAGS: lens (device), lens, crystalline, shape, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):53. https://doi.org/10.1167/iovs.66.2.53

Includes: Supplemental Content

Glaucoma February 2025

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Ka Wai Kam; Mary Ho; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: glaucoma, pulmonary function, pulmonary function tests, respiratory physiology, uk biobank, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):48. https://doi.org/10.1167/iovs.66.2.48

Includes: Supplemental Content

Lens January 2025

Age-Related Changes in Lens Elasticity Contribute More to Accommodative Decline Than Shape Change

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Yutian Pu; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Kehao Wang; Barbara K. Pierscionek
TAGS: lens (device), lens, crystalline, shape
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):16. https://doi.org/10.1167/iovs.66.1.16

Includes: Supplemental Content

Immunology and Microbiology January 2025

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

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Verena Behnke; Anne Wolf; Mandy Hector; Thomas Langmann
TAGS: anaphylatoxins, mice, retina, retinal degeneration, white light, complement system proteins, complement membrane attack complex
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):15. https://doi.org/10.1167/iovs.66.1.15

Includes: Supplemental Content

Retina December 2024

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Mary Ho; Xiu Juan Zhang; Ka Wai Kam; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: age-related macular degeneration, incidence, metabolites, metabolomics, uk biobank, biological markers, polygenic risk score, lipids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):43. https://doi.org/10.1167/iovs.65.14.43

Includes: Supplemental Content

Article December 2024

Attention moderates the motion silencing effect for dynamic orientation changes in a discrimination task

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Tabea-Maria Haase; Anina N. Rich; Iain D. Gilchrist; Christopher Kent
TAGS: attention, motion, visual spatial attention
Journal of Vision. 2024; 24(13):13. https://doi.org/10.1167/jov.24.13.13

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Genetics November 2024

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

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Mikko Liukkonen; Hanna Heloterä; Leea Siintamo; Bishwa Ghimire; Pirkko Mattila; Niko Kivinen; Joanna Kostanek; Cezary Watala; Maria Hytti; Juha Hyttinen; Ali Koskela; Janusz Blasiak; Kai Kaarniranta
TAGS: cohort studies, finnish, genes, inflammation, oxidative stress, rna, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):30. https://doi.org/10.1167/iovs.65.13.30

Includes: Supplemental Content

Retina November 2024

Interpericyte Tunneling Nanotubes Are Nonuniformly Distributed in the Human Macula

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Martin Hein; Hassanain Qambari; Paula Yu; Dao-Yi Yu; Chandrakumar Balaratnasingam
TAGS: macula lutea, blood capillaries, pericytes, donors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):28. https://doi.org/10.1167/iovs.65.13.28

Includes: Multimedia, Supplemental Content

Glaucoma November 2024

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

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Kenzo Yamamura; Hidetoshi Mano; Masahiro Fuwa; Ryo Iwamura; Noriko Odani-Kawabata
TAGS: cercopithecidae, drug or chemical tissue distribution, macaca fascicularis, omidenepag, oryctolagus cuniculus, radioactivity, cornea, eye, aqueous humor, administration, topical
Trans. Vis. Sci. Tech.. 2024; 13(11):6. https://doi.org/10.1167/tvst.13.11.6

Cornea November 2024

Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells

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Sonali Pal-Ghosh; Beverly A. Karpinski; Himani Datta-Majumdar; Soneha Datta; Shelly Dimri; Jordan Hally; Hugo Wehmeyer; Mary Ann Stepp
TAGS: mitochondria, mitochondrial donation, phagocytosis, corneal epithelial cells, neurons, cell adhesion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):10. https://doi.org/10.1167/iovs.65.13.10

Includes: Supplemental Content

Retina October 2024

Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina

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Marion Haug; Sara A. Haddad-Velioglu; Manuela Berger; Anja Enz; Jingjing Zang; Stephan C F. Neuhauss
TAGS: electroretinography, retina, zebrafish, proteins, retinal cone, antibodies, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):44. https://doi.org/10.1167/iovs.65.12.44

Includes: Supplemental Content

Lens October 2024

TiO 2 -Nanoparticle–Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism

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Yuanyuan Li; Pingjun Chang; Liming Xu; Zehui Zhu; Man Hu; Jiaying Cen; Siyan Li; Yun-e Zhao
TAGS: ferroptosis, nanoparticles, opacification, prevention, ultrasonics, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):24. https://doi.org/10.1167/iovs.65.12.24

Includes: Supplemental Content

Cornea October 2024

ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo

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Beverly A. Karpinski; Sonali Pal-Ghosh; Himani Datta-Majumdar; Shelly Dimri; Soneha Datta; Mary Ann Stepp
TAGS: axon, cornea, mice, neuronal outgrowth, neurons, reinnervation, sensory nerves, wounds and injuries, debridement, integrins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):31. https://doi.org/10.1167/iovs.65.12.31

Includes: Supplemental Content

Lens October 2024

Impact of Calcium and Phosphorus Levels on Optical Deterioration in Primary and Secondary Intraocular Lens Calcification

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Leoni Britz; Maximilian Hammer; Grzegorz Łabuz; Agnieszka Zielinska; Fabian Jester; Jan Freudenberg; Uwe Bunz; Christian Scholz; Gerd Uwe Auffarth; Timur Mert Yildirim
TAGS: calcification, calcium, intraocular lens implant device, optics, phosphorus, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2024; 13(10):18. https://doi.org/10.1167/tvst.13.10.18

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Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging

Corneal Resistance to Enzymatic Digestion After Rose Bengal and Combined Rose Bengal/Riboflavin Cross-Linking Is Oxygen Independent

Preferential Locations of Polypoidal Lesions and Adjacent Pigment Epithelium Detachments in Polypoidal Choroidal Vasculopathy in a Japanese Population

Depth and Strain-Dependent Structural Responses of Mouse Lens Fiber Cells During Whole Lens Shape Changes

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

Age-Related Changes in Lens Elasticity Contribute More to Accommodative Decline Than Shape Change

C3aR1-Deletion Delays Retinal Degeneration in a White-Light Damage Mouse Model

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

Attention moderates the motion silencing effect for dynamic orientation changes in a discrimination task

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Interpericyte Tunneling Nanotubes Are Nonuniformly Distributed in the Human Macula

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells

Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina

TiO 2 -Nanoparticle–Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism

ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo

Impact of Calcium and Phosphorus Levels on Optical Deterioration in Primary and Secondary Intraocular Lens Calcification

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