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Physiology and Pharmacology June 2017

Subconjunctival Delivery of p75 NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy

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Alba Galan; Pablo F. Barcelona; Hinyu Nedev; Marinko V. Sarunic; Yifan Jian; H. Uri Saragovi
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, injection of therapeutic agent, mice, retina, antagonists, subconjunctival route
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2852-2862. doi: 10.1167/iovs.16-20988

ARVO Annual Meeting Abstract September 2016

Modulation Of ProNGF/p75 NTR Pathway Prevents Microvascular Degeneration In Diabetic Retinopathy

Riyaz Mohamed; Ahmed Y. Shanab; Sally Elshaer; H Uri Saragovi; Azza B. El-Remessy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2724. doi:

ARVO Annual Meeting Abstract September 2016

Elevated α 2 M in the aqueous humor is associated with Glaucoma but not with PXF alone.

Maya Eiger-Moscovich; Pablo F. Barcelona; Michal Schaap-Fogler; H Uri Saragovi; Michal Kramer

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6023. doi:

ARVO Annual Meeting Abstract June 2015

A novel therapeutic target for treating neurodegeneration and vascular permeability in Diabetic Retinopathy

H Uri Saragovi; Sean Jmaeff; Alba Galan; Gema Esquiva; Nicolas Cuenca; Pablo Barcelona

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2468. doi:

ARVO Annual Meeting Abstract June 2015

α 2 Macroglobulin differentially regulates ligand-dependent p75 and TrkA receptor activation ex vivo and in retina

Pablo Fedrico Barcelona; H Uri Saragovi

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):160. doi:

ARVO Annual Meeting Abstract April 2014

Retinal neuroprotection using small molecule GDNF mimetics

H Uri Saragovi; Yulia Sidorova; Mart Saarma; Sean Jmaeff

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5754. doi:

ARVO Annual Meeting Abstract April 2014

Targeted modulation of the glial inflammatory response in Retinitis Pigmentosa attenuates photoreceptor cell death.

Enrique J de la Rosa; Catalina Hernández-Sánchez; Alberto M Hernández-Pinto; María Platón; Miguel Marchena; Noemí Álvarez-Lindo; Ana I Arroba; Sean Jmaeff; Pablo F Barcelona; H Uri Saragovi

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6197. doi:

ARVO Annual Meeting Abstract June 2013

Pro-NGF induces endothelial cell death via the P75 neurotrophin receptor (P75NTR) in a mouse model of oxygen-induced retinopathy (OIR)

Nicholas Sitaras; H. Uri Saragovi; Sylvain Chemtob; Przemyslaw Sapieha

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6346. doi:

ARVO Annual Meeting Abstract March 2012

Overexpression of ProNGF Induces Apoptosis and Acellular Capillary Formation Via Activation of P75NTR

Azza B. El-Remessy; Mohammed M. Al-Gayyar; Suraporn Matragoon; H Uri Saragovi

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5770. doi:

Glaucoma July 2011

During Glaucoma, α2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

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Yujing Bai; Delia Sivori; Sang B. Woo; Kenneth E. Neet; S. Fabian Lerner; H. Uri Saragovi
TAGS: glaucoma, macroglobulins, nerve growth factors, aqueous humor, intraocular pressure, proteins, retina, neuroprotection, binding (molecular function)
Invest. Ophthalmol. Vis. Sci.. 2011; 52(8):5260-5265. doi: 10.1167/iovs.10-6691

ARVO Annual Meeting Abstract April 2011

A Balance of Neuroprotective versus Neurotoxic Mechanisms in Experimental and Human Glaucoma

H Uri Saragovi; Marinko V. Sarunic; Pauline Dergham; Hinyu Nedev; Alba Galan; Mei Young; Delia Sivori; Kenneth E. Neet; Fabian S Lerner; Yujing Bai

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3108. doi:

ARVO Annual Meeting Abstract April 2011

ProNGF Stimulates Retinal Inflammation Via Activation of p75NTR

Azza B. El-Remessy; Mohammed M. Al-Gayyar; Mohammed A. Abdelsaid; Suraporn Matragoon; Bindu A. Pillai; H Uri Saragovi

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1001. doi:

Physiology and Pharmacology December 2010

In Glaucoma the Upregulated Truncated TrkC.T1 Receptor Isoform in Glia Causes Increased TNF-α Production, Leading to Retinal Ganglion Cell Death

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Yujing Bai; ZhiHua Shi; Yehong Zhuo; Jing Liu; Andrey Malakhov; Eunhwa Ko; Kevin Burgess; Henry Schaefer; Pedro F. Esteban; Lino Tessarollo; H. Uri Saragovi
TAGS: tumor necrosis factors, glaucoma, neurotrophic tyrosine kinase receptor type 3, mice
Invest. Ophthalmol. Vis. Sci.. 2010; 51(12):6639-6651. doi: 10.1167/iovs.10-5431

Physiology and Pharmacology September 2010

An Agonistic TrkB mAb Causes Sustained TrkB Activation, Delays RGC Death, and Protects the Retinal Structure in Optic Nerve Axotomy and in Glaucoma

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Yujing Bai; Jing Xu; Fouad Brahimi; Yehong Zhuo; Marinko V. Sarunic; H. Uri Saragovi
TAGS: glaucoma, monoclonal antibodies, axotomy, brain-derived neurotrophic factor, neurotrophic tyrosine kinase receptor type 2, retina
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4722-4731. doi: 10.1167/iovs.09-5032

ARVO Annual Meeting Abstract April 2009

Neurotrophins Peptidomimetics Protect Retinal Pigment Epithelial (RPE) Cells Against Oxidative Stress-induced Apoptosis

P. K. Mukherjee; K. Meerovitch; T. Lama; H. U. Saragovi; N. G. Bazan

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):2163. doi:

ARVO Annual Meeting Abstract April 2009

Glaucoma Experimental Therapeutics: Neuroprotection Using Receptor-Selective Neurotrophin Analogues and Peptidomimetics

Y. Bai; Z. Shi; K. Burgess; K. E. Neet; S. Woo; H. Mehta; Y. Zhuo; H. U. Saragovi

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):3089. doi:

ARVO Annual Meeting Abstract April 2009

An NGF Mimetic, MIM-D3, Demonstrates Therapeutic Efficacy in a Rat Model of Scopoloamine-Induced Dry Eye

R. Li; K. Meerovitch; T. Lama; P. Jain; H. U. Saragovi; G. Cumberlidge

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):3661. doi:

ARVO Annual Meeting Abstract April 2009

Non-invasive Quantitative Measurement of Axotomy-induced Retinal Degeneration in Rats Using Fourier Domain Optical Coherence Tomography

J. Xu; A. Yazdanpanah; M. Young; S. Lee; E. Gibson; Y. Bai; Z. Shi; F. Beg; H. U. Saragovi; M. V. Sarunic

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):346. doi:

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Subconjunctival Delivery of p75 NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy

Modulation Of ProNGF/p75 NTR Pathway Prevents Microvascular Degeneration In Diabetic Retinopathy

Elevated α 2 M in the aqueous humor is associated with Glaucoma but not with PXF alone.

A novel therapeutic target for treating neurodegeneration and vascular permeability in Diabetic Retinopathy

α 2 Macroglobulin differentially regulates ligand-dependent p75 and TrkA receptor activation ex vivo and in retina

Retinal neuroprotection using small molecule GDNF mimetics

Targeted modulation of the glial inflammatory response in Retinitis Pigmentosa attenuates photoreceptor cell death.

Pro-NGF induces endothelial cell death via the P75 neurotrophin receptor (P75NTR) in a mouse model of oxygen-induced retinopathy (OIR)

Overexpression of ProNGF Induces Apoptosis and Acellular Capillary Formation Via Activation of P75NTR

During Glaucoma, α2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection

A Balance of Neuroprotective versus Neurotoxic Mechanisms in Experimental and Human Glaucoma

ProNGF Stimulates Retinal Inflammation Via Activation of p75NTR

In Glaucoma the Upregulated Truncated TrkC.T1 Receptor Isoform in Glia Causes Increased TNF-α Production, Leading to Retinal Ganglion Cell Death

An Agonistic TrkB mAb Causes Sustained TrkB Activation, Delays RGC Death, and Protects the Retinal Structure in Optic Nerve Axotomy and in Glaucoma

Neurotrophins Peptidomimetics Protect Retinal Pigment Epithelial (RPE) Cells Against Oxidative Stress-induced Apoptosis

Glaucoma Experimental Therapeutics: Neuroprotection Using Receptor-Selective Neurotrophin Analogues and Peptidomimetics

An NGF Mimetic, MIM-D3, Demonstrates Therapeutic Efficacy in a Rat Model of Scopoloamine-Induced Dry Eye

Non-invasive Quantitative Measurement of Axotomy-induced Retinal Degeneration in Rats Using Fourier Domain Optical Coherence Tomography

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