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ARVO Annual Meeting Abstract March 2012

Efficacious Clinical Outcome of an Ophthalmic Formulation of Phosphatidylserine- binding Monoclonal Antibody in a Rabbit Model of Acute HSV-1 Keratitis

Christian Clement; Hilary W. Thompson; Partha S. Bhattacharjee; Harris E. McFerrin, Jr.; Walter J. Lukiw; Kara Corbin-Lickfett; Cyril J. Empig; Kyle Schlunegger; James M. Hill

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6155. doi:

ARVO Annual Meeting Abstract April 2011

Very High Oral Doses of Valacyclovir Significantly Inhibit HSV-1 DNA Shedding into Tears and Saliva of Herpes Simplex Virus Type-1 Latent Rabbits

James M. Hill; Christian Clement; Harris E. McFerrin, Jr.; Jeffery A. Hobden; Timothy P. Foster; Vaibhav Tiwari; Partha S. Bhattacharjee; Hilary W. Thompson

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3261. doi:

ARVO Annual Meeting Abstract April 2011

Neuroinvasiveness of HSV-1 High and Low Phenotypic Reactivators in Aged Infected Human Knock-in Homozygous ApoE4 Transgenic Mice

Christian Clement; Vaibhav Tiwari; Alberto Musto; Walter J. Lukiw; Partha S. Bhattacharjee; Harris E. McFerrin, Jr.; Hilary W. Thompson; James M. Hill

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5797. doi:

Immunology and Microbiology March 2011

Upregulation of Mouse Genes in HSV-1 Latent TG after Butyrate Treatment Implicates the Multiple Roles of the LAT-ICP0 Locus

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Christian Clement; Partha S. Bhattacharjee; Manish Kumar; Timothy P. Foster; Hilary W. Thompson; James M. Hill
TAGS: butyrates, genes, human herpesvirus 1, mice, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2011; 52(3):1770-1779. doi: https://doi.org/10.1167/iovs.09-5019

Includes: Supplemental Content

Cornea January 2011

Clinical and Antiviral Efficacy of an Ophthalmic Formulation of Dexamethasone Povidone-Iodine in a Rabbit Model of Adenoviral Keratoconjunctivitis

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Christian Clement; Joseph A. Capriotti; Manish Kumar; Jeffery A. Hobden; Timothy P. Foster; Partha S. Bhattacharjee; Hilary W. Thompson; Rashed Mahmud; Bo Liang; James M. Hill
TAGS: adenoviruses, antiviral agents, cidofovir, dexamethasone, eye, keratoconjunctivitis, oryctolagus cuniculus, povidone-iodine, viruses, balanced salt solutions
Invest. Ophthalmol. Vis. Sci.. 2011; 52(1):339-344. doi: https://doi.org/10.1167/iovs.10-5944

Includes: Supplemental Content

Immunology and Microbiology September 2010

Effect of High versus Low Oral Doses of Valacyclovir on Herpes Simplex Virus-1 DNA Shedding into Tears of Latently Infected Rabbits

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Manish Kumar; Herbert E. Kaufman; Christian Clement; Partha S. Bhattacharjee; Tashfin S. Huq; Emily D. Varnell; Hilary W. Thompson; James M. Hill
TAGS: dna, herpes simplex infection, oryctolagus cuniculus, valacyclovir, viruses, human herpesvirus 1, simplexvirus
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4703-4706. doi: https://doi.org/10.1167/iovs.09-4884

ARVO Annual Meeting Abstract April 2010

Viral Shedding Into Tears of HSV-1 Infected Transgenic C57BL/6 Mice With Human ApoE e4/e4 Knock-in Gene is Independent of High Phenotypic Reactivation Status

C. Clement; H. W. Thompson; J. M. Hill

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3865. doi:

ARVO Annual Meeting Abstract April 2010

Topical FST100 Dexamethasone 0.1% Containing Povidone-Iodine 0.4% Reduced the Clinical Signs and Infectious Viral Titers in a Rabbit Model of Adenoviral Conjunctivitis

J. M. Hill; C. Clement; M. Kumar; J. R. Palem; B. Liang; J. A. Capriotti; H. W. Thompson

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3878. doi:

Clinical and Epidemiologic Research December 2009

A Double-Blind Placebo-Controlled Study to Evaluate Valacyclovir Alone and with Aspirin for Asymptomatic HSV-1 DNA Shedding in Human Tears and Saliva

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Manish Kumar; James M. Hill; Christian Clement; Emily D. Varnell; Hilary W. Thompson; Herbert E. Kaufman
TAGS: aspirin, dna, human herpesvirus 1, placebos, saliva, valacyclovir
Invest. Ophthalmol. Vis. Sci.. 2009; 50(12):5601-5608. doi: https://doi.org/10.1167/iovs.09-3729

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2008

Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model

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Partha S. Bhattacharjee; Donna M. Neumann; Timothy P. Foster; Christian Clement; Gyanendra Singh; Hilary W. Thompson; Herbert E. Kaufman; James M. Hill
TAGS: apolipoprotein e, eye, mice, peptides, treatment effectiveness, human herpesvirus 1
Invest. Ophthalmol. Vis. Sci.. 2008; 49(10):4263-4268. doi: https://doi.org/10.1167/iovs.08-2077

ARVO Annual Meeting Abstract May 2008

In vitro Combination Efficacies of Antiviral Drugs Against Hsv-1

M. Kumar; H. W. Thompson; E. D. Varnell; H. E. Kaufman

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):5131. doi:

ARVO Annual Meeting Abstract May 2007

Efficacy of a Helicase-Primase Inhibitor in Animal Models of Ocular HSV-1 Infection

E. D. Varnell; H. E. Kaufman; B. M. Gebhardt; G. Kleymann; H. W. Thompson; E. S. Atwal

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):2665. doi:

ARVO Annual Meeting Abstract May 2007

Regulation of Primary Herpes Stromal Keratitis (HSK) by Human Apolipoprotein E (ApoE) Alleles 3 and 4 in the Mouse Eye

P. Bhattacharjee; D. M. Neumann; S. Bouhanik; A. Ephraim; M. Kumar; B. Khoobehi; H. W. Thompson; H. E. Kaufman; J. M. Hill

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):2667. doi:

ARVO Annual Meeting Abstract May 2007

Human Apolipoprotein E (ApoE) Allele 4 Regulates the Resolution and Recurrence of HSV Stromal Keratitis (HSK) in the Mouse Eye

J. M. Hill; D. M. Neumann; S. Bouhanik; A. Ephraim; M. Kumar; B. Khoobehi; H. W. Thompson; H. E. Kaufman; P. S. Bhattacharjee

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3165. doi:

Immunology and Microbiology January 2005

HSV-1 DNA in Tears and Saliva of Normal Adults

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Herbert E. Kaufman; Ann M. Azcuy; Emily D. Varnell; Gregory D. Sloop; Hilary W. Thompson; James M. Hill
TAGS: dna, human herpesvirus 1, saliva, adult, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2005; 46(1):241-247. doi: https://doi.org/10.1167/iovs.04-0614

Biochemistry and Molecular Biology October 2003

Coordinate Activation of HIF-1 and NF-κB DNA Binding and COX-2 and VEGF Expression in Retinal Cells by Hypoxia

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Walter J. Lukiw; Anna Ottlecz; George Lambrou; Monika Grueninger; Joelle Finley; Hilary W. Thompson; Nicolas G. Bazan
TAGS: cyclooxygenase-2, dna, hypoxia, vascular endothelial growth factor a, transcription factor ap-1
Invest. Ophthalmol. Vis. Sci.. 2003; 44(10):4163-4170. doi: https://doi.org/10.1167/iovs.02-0655

Glaucoma February 2003

Deformation of the Lamina Cribrosa and Anterior Scleral Canal Wall in Early Experimental Glaucoma

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Anthony J. Bellezza; Christopher J. Rintalan; Hilary W. Thompson; J. Crawford Downs; Richard T. Hart; Claude F. Burgoyne
TAGS: cercopithecidae, eye, glaucoma, sclera, cribriform plate, intraocular pressure, optic disk, perfusion
Invest. Ophthalmol. Vis. Sci.. 2003; 44(2):623-637. doi: https://doi.org/10.1167/iovs.01-1282

Glaucoma July 2002

Peripapillary Scleral Thickness in Perfusion-Fixed Normal Monkey Eyes

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J. Crawford Downs; Richard A. Blidner; Anthony J. Bellezza; Hilary W. Thompson; Richard T. Hart; Claude F. Burgoyne
TAGS: eye, sclera, cercopithecidae, perfusion
Invest. Ophthalmol. Vis. Sci.. 2002; 43(7):2229-2235. doi:

Immunology and Microbiology June 2002

Effect of Immunosuppression on Gene Expression in the HSV-1 Latently Infected Mouse Trigeminal Ganglion

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Shiro Higaki; Bryan M. Gebhardt; Walter J. Lukiw; Hilary W. Thompson; James M. Hill
TAGS: gene expression, genes, human herpesvirus 1, mice, natural immunosuppression, reverse transcriptase polymerase chain reaction, therapeutic immunosuppression, trigeminal ganglion, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2002; 43(6):1862-1869. doi:

Immunology and Microbiology April 2002

Corneal Pathogenesis of Staphylococcus aureus Strain Newman

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Joseph J. Dajcs; Megan S. Austin; Gregory D. Sloop; Judy M. Moreau; Emma B. H. Hume; Hilary W. Thompson; Fionnuala M. McAleese; Timothy J. Foster; Richard J. O’Callaghan
TAGS: cornea, toxins, infections, pathogenesis, staphylococcus aureus, oryctolagus cuniculus, virulence
Invest. Ophthalmol. Vis. Sci.. 2002; 43(4):1109-1115. doi:

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Efficacious Clinical Outcome of an Ophthalmic Formulation of Phosphatidylserine- binding Monoclonal Antibody in a Rabbit Model of Acute HSV-1 Keratitis

Very High Oral Doses of Valacyclovir Significantly Inhibit HSV-1 DNA Shedding into Tears and Saliva of Herpes Simplex Virus Type-1 Latent Rabbits

Neuroinvasiveness of HSV-1 High and Low Phenotypic Reactivators in Aged Infected Human Knock-in Homozygous ApoE4 Transgenic Mice

Upregulation of Mouse Genes in HSV-1 Latent TG after Butyrate Treatment Implicates the Multiple Roles of the LAT-ICP0 Locus

Clinical and Antiviral Efficacy of an Ophthalmic Formulation of Dexamethasone Povidone-Iodine in a Rabbit Model of Adenoviral Keratoconjunctivitis

Effect of High versus Low Oral Doses of Valacyclovir on Herpes Simplex Virus-1 DNA Shedding into Tears of Latently Infected Rabbits

Viral Shedding Into Tears of HSV-1 Infected Transgenic C57BL/6 Mice With Human ApoE e4/e4 Knock-in Gene is Independent of High Phenotypic Reactivation Status

Topical FST100 Dexamethasone 0.1% Containing Povidone-Iodine 0.4% Reduced the Clinical Signs and Infectious Viral Titers in a Rabbit Model of Adenoviral Conjunctivitis

A Double-Blind Placebo-Controlled Study to Evaluate Valacyclovir Alone and with Aspirin for Asymptomatic HSV-1 DNA Shedding in Human Tears and Saliva

Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model

In vitro Combination Efficacies of Antiviral Drugs Against Hsv-1

Efficacy of a Helicase-Primase Inhibitor in Animal Models of Ocular HSV-1 Infection

Regulation of Primary Herpes Stromal Keratitis (HSK) by Human Apolipoprotein E (ApoE) Alleles 3 and 4 in the Mouse Eye

Human Apolipoprotein E (ApoE) Allele 4 Regulates the Resolution and Recurrence of HSV Stromal Keratitis (HSK) in the Mouse Eye

HSV-1 DNA in Tears and Saliva of Normal Adults

Coordinate Activation of HIF-1 and NF-κB DNA Binding and COX-2 and VEGF Expression in Retinal Cells by Hypoxia

Deformation of the Lamina Cribrosa and Anterior Scleral Canal Wall in Early Experimental Glaucoma

Peripapillary Scleral Thickness in Perfusion-Fixed Normal Monkey Eyes

Effect of Immunosuppression on Gene Expression in the HSV-1 Latently Infected Mouse Trigeminal Ganglion

Corneal Pathogenesis of Staphylococcus aureus Strain Newman

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