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Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Calculating Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells in an Active 3D Fluid-Structure Interaction Culture Setting

Alireza Karimi; Mini Aga; Taaha Khan; Siddharth Daniel D'costa; Omkar C Thaware; Mary J Kelley; Haiyan Gong; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):396.

ARVO Annual Meeting Abstract June 2024

Impact of Matrix Stiffness and Active Flow on Actin Stress Fiber Formation in Normal and Glaucomatous Trabecular Meshwork Cells: 2D and 3D Culture Models

Mini Aga; Omkar C Thaware; Mary J Kelley; Haiyan Gong; Ted S Acott; Alireza Karimi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5168.

ARVO Annual Meeting Abstract June 2024

Segmental Uveoscleral Outflow and its Relationship with Trabecular Outflow in Monkey Eyes

Hoi-Lam Li; Shan Fan; Carol B Toris; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2816.

ARVO Annual Meeting Abstract June 2024

Effect of Thrombospondin-1 on Outflow Facility, Outflow Pattern and Morphology in Porcine Eyes

Haiyan Gong; Hoi-Lam Li; David L Swain; Lucia Yang; Sujeoung Kim; Michelle Yung; Abid Khan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1260.

Physiology and Pharmacology December 2023

Segmental Unconventional Outflow in Mouse Eyes

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Hoi-Lam Li; Ruiyi Ren; Haiyan Gong
TAGS: eye, mice
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):26. https://doi.org/10.1167/iovs.64.15.26

ARVO Annual Meeting Abstract June 2023

Endothelial Glycocalyx in the Different Flow Regions of Trabecular Outflow Pathway in Bovine Eyes

Haiyan Gong; Neil Liu; Shayna Sosnowik; Hoi Lam Li; Michelle Yung

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1886.

ARVO Annual Meeting Abstract June 2023

Comparison of Giant Vacuoles in the Inner Wall Endothelium of Schlemm’s Canal in Human Eyes between High and Physiologic Pressures

Isaac Goodman; Varun Bhalla; Benjamin Soares; Thuy D. Le; David L Swain; Tate Valero; Irving Zhao; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1885.

ARVO Annual Meeting Abstract June 2023

Uveal outflow is segmental

Hoi-Lam Li; Ruiyi Ren; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1889.

Physiology and Pharmacology February 2023

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes

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Ruiyi Ren; Anne A. Humphrey; Casey Kopczynski; Haiyan Gong
TAGS: eye, filtration, intraocular pressure, kinase inhibitors, mice, ocular hypertension, steroids, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2023; 64(2):7. https://doi.org/10.1167/iovs.64.2.7

ARVO Annual Meeting Abstract June 2022

Comparison of giant vacuole type and size in the inner wall endothelium of Schlemm’s canal in human eyes perfused at 7 and 15 mmHg using serial block-face scanning electron microscopy

Benjamin Soares; David L Swain; Thuy Duong Le; Senila Yasmin; Beatriz Fernandes; Indira Dasgupta; Tate Valerio; Irving Zhao; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1289 – F0104.

ARVO Annual Meeting Abstract June 2022

Decreased Coverage and Thickness of the Endothelial Glycocalyx in the Trabecular Outflow Pathway of Monkey Eyes with Laser-Induced Ocular Hypertension

Shayna Sosnowik; David L Swain; Neil Liu; Shan Fan; Carol B Toris; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1287 – F0102.

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

Morphological Changes to Schlemm’s Canal and the Distal Aqueous Outflow Pathway in Monkey Eyes with Laser-Induced Ocular Hypertension

Shayna Sosnowik; David L Swain; Shan Fan; Carol B Toris; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):466.

ARVO Annual Meeting Abstract June 2021

TSP1 Deficiency Inhibits Steroid-induced IOP Elevation in Mouse Eyes

Ruiyi Ren; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2779.

ARVO Annual Meeting Abstract June 2020

Factors affecting functional giant vacuole formation in Schlemm’s canal endothelial cells

David L Swain; Thuy Duong Le; Senila Yasmin; Beatriz Fernandes; Ganimete Lamaj; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2717.

ARVO Annual Meeting Abstract June 2020

Rho Kinase Inhibitor AR-12286 Reverses Steroid-induced Changes in Mouse Eyes

Ruiyi Ren; Anne A. Humphrey; Casey Kopczynski; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2720.

ARVO Annual Meeting Abstract June 2020

Are Thrombospondin-1 SNPs associated with steroid response and expression levels in saliva?

Shweta Paresh Kitchloo; Paul Gabriel; Manishi Desai; Haiyan Gong; Hyunjoo Jean Lee

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1012.

ARVO Annual Meeting Abstract July 2019

Density and volume of giant vacuoles with and without pores in the inner wall endothelium of Schlemm’s canal with increasing pressures

David L Swain; Thuy Duong Le; Beatriz Fernandes; Himeno Yamada; Ganimete Lamaj; Senila Yasmin; Indira Dasgupta; Haiyan Gong

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2187.

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Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Calculating Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells in an Active 3D Fluid-Structure Interaction Culture Setting

Impact of Matrix Stiffness and Active Flow on Actin Stress Fiber Formation in Normal and Glaucomatous Trabecular Meshwork Cells: 2D and 3D Culture Models

Segmental Uveoscleral Outflow and its Relationship with Trabecular Outflow in Monkey Eyes

Effect of Thrombospondin-1 on Outflow Facility, Outflow Pattern and Morphology in Porcine Eyes

Segmental Unconventional Outflow in Mouse Eyes

Endothelial Glycocalyx in the Different Flow Regions of Trabecular Outflow Pathway in Bovine Eyes

Comparison of Giant Vacuoles in the Inner Wall Endothelium of Schlemm’s Canal in Human Eyes between High and Physiologic Pressures

Uveal outflow is segmental

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes

Comparison of giant vacuole type and size in the inner wall endothelium of Schlemm’s canal in human eyes perfused at 7 and 15 mmHg using serial block-face scanning electron microscopy

Decreased Coverage and Thickness of the Endothelial Glycocalyx in the Trabecular Outflow Pathway of Monkey Eyes with Laser-Induced Ocular Hypertension

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Morphological Changes to Schlemm’s Canal and the Distal Aqueous Outflow Pathway in Monkey Eyes with Laser-Induced Ocular Hypertension

TSP1 Deficiency Inhibits Steroid-induced IOP Elevation in Mouse Eyes

Factors affecting functional giant vacuole formation in Schlemm’s canal endothelial cells

Rho Kinase Inhibitor AR-12286 Reverses Steroid-induced Changes in Mouse Eyes

Are Thrombospondin-1 SNPs associated with steroid response and expression levels in saliva?

Density and volume of giant vacuoles with and without pores in the inner wall endothelium of Schlemm’s canal with increasing pressures

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